Romanian journal of ophthalmology最新文献

{"title":"A study of conjunctival impression cytology in patients undergoing allogeneic hematopoietic stem cell transplantation and its relationship with Ocular Graft versus Host Disease.","authors":"Thanuja Gopal Pradeep, Deepthi Rameshbabu Honniganur, Santhosh Kumar Devadas","doi":"10.22336/rjo.2025.12","DOIUrl":"https://doi.org/10.22336/rjo.2025.12","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the proportion of patients with dry eye syndrome and to examine the changes in conjunctival impression cytology (CIC) in all patients undergoing hematopoietic stem cell transplantation (HSCT) by employing CIC as a diagnostic tool for ocular graft vs. host disease (oGVHD).</p><p><strong>Materials and methods: </strong>Every patient who received HSCT underwent a thorough ophthalmic examination, which included visual acuity, an assessment of dry eyes using objective tests such as Schirmer's I test, tear film break-up time, and subjective tests such as the Ocular Surface Disease Index (OSDI) questionnaire. Conjunctival impression cytology was conducted after that, following informed consent.</p><p><strong>Results: </strong>This study included 24 eyes from 12 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT), with a mean age of 31.4 ± 11.06 years. Dry eye disease was observed in 28.8% of the cases. Based on the symptoms, 16 eyes (66.67%) were diagnosed with oGVHD. The Ocular Surface Disease Index (OSDI) indicated mild symptoms in 4 eyes (16.67%), moderate symptoms in 11 eyes (45.33%), and severe symptoms in 1 eye (4.17%) in individuals with ocular GVHD. In contrast, 93.55% of eyes without oGVHD exhibited mild symptoms, while 6.71% showed moderate symptoms (p = 0.002).Objective assessments indicated that Schirmer's I score was ≤ 5 mm in 50% of the eyes (n = 12), and tear film breakup time was less than 5 seconds (3.85 ± 2.18 seconds) in 29.17% of eyes with oGVHD (p = 0.05). The conjunctival impression cytology (CIC) was abnormal in 9 eyes (37.5%, p = 0.05), revealing changes in cell morphology, such as decreased goblet cell density, reduced cytoplasmic mucin, and inflammatory cells. The average goblet cell density was measured at 190.63 ± 81.00 cells/mm² in 6 eyes (p = 0.05), showing a correlation with the time since HSCT; specifically, when the interval from HSCT to CIC assessment was 40.67 ± 5.01 months, the goblet cell density significantly decreased to 181.00 ± 76.62 (p = 0.04).Changes in morphology were observed in 8 eyes with oGVHD (91.7%) compared to 2 eyes without oGVHD (16.67%), with abnormal CIC results in 66.67% of cases (p = 0.02).</p><p><strong>Discussion: </strong>This study highlights the significant prevalence of dry eye disease (DED) and ocular surface alterations in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly in those diagnosed with ocular graft-versus-host disease (oGVHD). The findings align with previous research, indicating that oGVHD is a leading cause of post-HSCT ocular morbidity, with symptoms ranging from mild irritation to severe ocular surface damage. The significantly higher Ocular Surface Disease Index (OSDI) scores, reduced Schirmer's I test values, and shorter tear film breakup times (TBUT) in oGVHD patients corroborate established diagnostic criteria for severe tear dysfunction. Moreover,","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 1","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Axial Length on Macular Vascular Density in Eyes with High Myopia.","authors":"Mustafa Kayabaşi, Seher Köksaldi, Neslihan Demirel, Ali Osman Saatci","doi":"10.22336/rjo.2025.15","DOIUrl":"https://doi.org/10.22336/rjo.2025.15","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between optical coherence tomography angiography (OCTA) findings and axial length (AL) in eyes with high myopia.</p><p><strong>Materials and methods: </strong>A total of 122 eyes from 78 patients were included. Seventy-five eyes with an AL ranging between 26.00 and 27.49 mm comprised Group 1, and 47 with an AL of ≥ 27.50 mm comprised Group 2. Spectral-domain OCT was performed to measure the central macular thickness, subfoveal choroidal thickness (SCT) and swept-source OCTA was utilized to obtain the data on foveal avascular zone (FAZ) and vascular density (VD) values at the superficial and deep capillary plexuses (SCP and DCP), outer retina (OuR), and choriocapillaris (CC) segments.</p><p><strong>Results: </strong>While no significant differences were found in terms of the mean superficial-FAZ and deep-FAZ areas (<i>p</i>=0.284 and <i>p</i>=0.952, respectively), there were significant differences between the groups in terms of the mean foveal VD in the SCP (<i>p</i>=0.001), the mean total VD (<i>p</i>=0.045) and foveal VD in the DCP (<i>p</i><0.001), the mean foveal VD (<i>p</i>=0.019) and superior parafoveal VD in the OuR (<i>p</i>=0.008), the mean total (<i>p</i>=0.005), temporal parafoveal (<i>p</i>=0.034), inferior parafoveal (<i>p</i>=0.029), and nasal parafoveal VDs in the CC segments (<i>p</i>=0.005).</p><p><strong>Discussion: </strong>The findings of the present study highlight the complex interplay between axial elongation and retinal microvasculature, suggesting that factors beyond mechanical stretching may contribute to these alterations. The variability in the existing literature on this topic arises from inconsistencies in the definition of high myopia, the use of different OCTA devices, and heterogeneous study populations. By including eyes with myopic maculopathy and employing axial length-based classification, this study provides a broad representation of high myopia. However, its retrospective design, single-center setting, and monoracial cohort represent limitations. Future large-scale, prospective studies involving diverse populations are needed to elucidate further the pathophysiology of high myopia and its impact on retinal and choroidal microcirculation.</p><p><strong>Conclusions: </strong>Our study revealed that high-myopic eyes with longer ALs exhibited increased total VD in the DCP and increased foveal VD in the SCP, DCP, and OuR segments, while they showed decreased total VD and temporal, inferior, and nasal parafoveal VDs in the CC segment compared to high-myopic eyes with shorter ALs.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 1","pages":"88-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative technologies for the treatment of dry age-related macular degeneration (AMD) - modern therapeutic perspectives and their future.","authors":"Przemysław Ciszewski, Alicja Drelichowska, Damian Pikor, Emilia Wiśniewska, Michał Azierski","doi":"10.22336/rjo.2025.03","DOIUrl":"https://doi.org/10.22336/rjo.2025.03","url":null,"abstract":"<p><strong>Purpose: </strong>This review explores modern therapeutic options for the dry form of age-related macular degeneration (AMD), a condition representing one of the most significant challenges in ophthalmology due to its progressive nature and lack of effective treatment. The study discusses innovative approaches, evaluates available methods, and examines the potential of emerging technologies to improve patients' quality of life.</p><p><strong>Methods: </strong>A comprehensive review of current literature was conducted, being focused on therapies for dry AMD, including classical methods such as AREDS/AREDS2 supplementation, molecularly targeted drugs, gene therapy, cell transplants, tissue engineering, nanotechnology, and light-based therapies. Emerging tools leveraging artificial intelligence for personalized treatment and predictive modeling were also evaluated.</p><p><strong>Results: </strong>AREDS/AREDS2 therapies effectively slow disease progression but cannot reverse retinal damage. Advances include molecularly targeted therapies (Pegcetacoplan, Avacincaptad Pegol) that reduce inflammation, gene therapy (HMR59) protecting RPE cells, and mitochondria-targeted drugs (SS-31) mitigating oxidative stress. Using scaffolds, nanoparticles, tissue engineering, and nanotechnology enhances RPE regeneration and drug delivery. Light-based therapies (LLLT, adaptive phototherapy) improve mitochondrial function, while AI aids in predicting disease progression and personalizing treatment.</p><p><strong>Conclusions: </strong>Modern therapeutic approaches for dry AMD provide promising avenues to slow disease progression and protect vision. However, further clinical trials are needed to optimize these strategies, assess long-term outcomes, and expand patient access to effective treatments. These advancements have the potential to significantly improve the quality of life for individuals affected by dry AMD.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 1","pages":"10-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroretinitis and chorioretinitis in a cat-scratched young boy: a case report.","authors":"Cristina-Ariadna Nicula, Adina-Ioana Lăpuște, Ariana-Ioana Lăpușan","doi":"10.22336/rjo.2025.17","DOIUrl":"https://doi.org/10.22336/rjo.2025.17","url":null,"abstract":"<p><p>Neuroretinitis is an inflammatory type of optic nerve damage evidenced by the appearance of papillary edema. It also involves inflammation of the retinal layers, as evidenced by the thickening of these layers and the presence of intra- and subretinal fluid. Chorioretinitis is a condition in which inflammation of the posterior component of the uvea, the choroid, leads to further damage to the retina, causing it to become inflamed. The most common causes of neuroretinitis and chorioretinitis in the pediatric population are represented by infectious etiologies. Most cases of neuroretinitis in children are caused by cat scratch disease, which is typically attributed to the bacterium Borrelia burgdorferi. We present the case of a 10-year-old child who presented to our service complaining of a sudden decrease in vision and the appearance of a central scotoma two days before he was referred to our service. Our first diagnosis was of optic neuritis, based on the presence of objective papillary edema on fundus examination. Subsequently, the appearance of chorioretinal foci completely changed the diagnosis and treatment in this case.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 1","pages":"110-114"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum Toxin Injection in Acute Sixth Nerve Palsy in a 1-Year-Old Child: Case Report, Management Strategy, and Review of Literature.","authors":"Corina-Ioana Merticariu, Mircea Merticariu, Mihaela Sorina Dragomir","doi":"10.22336/rjo.2025.05","DOIUrl":"https://doi.org/10.22336/rjo.2025.05","url":null,"abstract":"<p><p>Sixth nerve palsy in children is a rare yet clinically significant condition that can result in strabismus and developmental complications. The acute onset of sixth nerve palsy can lead to esotropia, a sudden inward deviation of the eye due to impaired abduction. While most cases resolve spontaneously, botulinum toxin injection is gaining ground as a therapeutic intervention, particularly in pediatric patients with persistent or severe misalignment.</p><p><strong>Objective: </strong>To evaluate the effectiveness of botulinum toxin injection in managing acute sixth nerve palsy in a 1-year-old child with esotropia. The therapeutic outcomes and a review of current evidence are discussed, focusing on the efficacy, safety, and timing of botulinum toxin therapy in pediatric sixth nerve palsy. <b>Methods</b>: We report the case of a 1-year-old child diagnosed with acute sixth nerve palsy and treated with botulinum toxin injection to the medial rectus muscle. Follow-up assessments were conducted at 1 week, 3 weeks, and 8 weeks to monitor ocular alignment and visual development. <b>Results</b>: At the one-week follow-up, esotropia decreased from 50 to 20 prism diopters, with moderate upper eyelid ptosis. At eight weeks, ocular alignment was normal, with mild residual ptosis and improvement in amblyopia.</p><p><strong>Discussion: </strong>Sixth nerve palsy in children is uncommon but can arise from various underlying causes. In most cases, it resolves within a few months, but in severe or persistent cases, therapeutic interventions such as botulinum toxin injections can alleviate symptoms. The clinical case highlights that early intervention with botulinum toxin is a safe and effective method for improving ocular alignment.</p><p><strong>Conclusion: </strong>Botulinum toxin injection effectively improved ocular alignment and facilitated amblyopia recovery in this pediatric case of sixth nerve palsy, supporting its use as a safe adjunctive treatment in early intervention.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 1","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study to compare the safety and efficacy of toric intra-ocular lens vs. opposite clear corneal incision in patients undergoing phacoemulsification for age-related cataract with pre-existing corneal astigmatism.","authors":"Sandeep Gupta, Nidhi Kalra, Ankita Singh, Avinash Mishra, Jaya Kaushik","doi":"10.22336/rjo.2025.13","DOIUrl":"10.22336/rjo.2025.13","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the safety and efficacy of toric intra ocular lens (IOL) implantation vs. opposite clear corneal incision (OCCI) during cataract surgery to correct preexisting corneal astigmatism in patients with age related cataract by comparing the postoperative residual astigmatism, the uncorrected distance visual acuity and the adverse effects following both the procedures.</p><p><strong>Methods: </strong>A pilot prospective study was conducted at a tertiary hospital among patients undergoing cataract surgery over two years. A total of 150 eyes with pre-existing corneal astigmatism between 1 to 2.5 D were divided into two groups of 75 each by permuted block randomization. Group A underwent implantation of <i>AcrySof Toric IOLSN6AT4</i> (Alcon Labs, Fort Worth, Tx), and Group B underwent implantation of normal non-toric aspheric <i>AcrySof IOL SN60WF with</i> OCCI on steep axis. Both groups were followed up for 24 weeks.</p><p><strong>Results: </strong>In the OCCI Group, the difference between mean K1-K2 preoperative and 12 weeks postoperative (mean ± SD) of patients was 1.55 ± 0.17D. In the TORIC IOL Group, the difference between the mean K1-K2 preoperative and 12-week postoperative values (mean ± SD) for patients was 0.53 ± 0.11. The difference in mean K1-K2 pre-operatively and at 12 weeks was statistically significant for both groups (p < 0.0001). There was a significant reduction in corneal astigmatism in the OCCI group at 01 week.</p><p><strong>Discussion: </strong>In our study, the difference in mean K1-K2 at 1 week between the two Groups was statistically significant (p < 0.0001), as OCCI acts directly on the corneal plane, whereas Toric IOLs reduce astigmatism at the lens plane without affecting corneal curvature. There was a significant reduction in corneal astigmatism in the OCCI group at 1 week. This reduction continued to stabilize at 12 weeks. The corneal astigmatism remained stable in the post-operative period in the Toric IOL group. The decrease in astigmatism was more significant in the toric IOL group than in the OCCI group.</p><p><strong>Conclusions: </strong>These results demonstrate a similar efficacy of OCCI in reducing corneal astigmatism of up to 1.5 D compared to Toric IOLs. The uncorrected visual acuity was superior in the Toric IOL group. However, this difference was reduced significantly by 12 weeks.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 1","pages":"74-82"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-induced glaucoma in kidney transplant recipients: a prospective cross-sectional study.","authors":"Vaibhav Kumar Jain, Rachna Agarwal, Lubna Maroof, Manas Ranjan Behera, Jaya Kaushik, Sushil Ojha","doi":"10.22336/rjo.2024.66","DOIUrl":"10.22336/rjo.2024.66","url":null,"abstract":"<p><strong>Objective/aim: </strong>To determine the incidence of steroid induced glaucoma and treatment characteristics in kidney transplant patients in a tertiary level multispecialty institution.</p><p><strong>Methods: </strong>In this prospective cross-sectional study, the patients who underwent kidney transplant were enrolled and underwent comprehensive ophthalmological evaluation including intraocular pressure (IOP) measurement with Goldmann Applanation tonometry, visual field examination with Humphrey Field Analyzer, and gonioscopy. Cases with IOP > 21 mm Hg, visual field defect, and optic disc cupping > 0.7 or asymmetry of 0.2 or more were labeled as glaucoma, whereas IOP > 21 mm Hg with a normal visual field was designated as ocular hypertension (OHT).</p><p><strong>Results: </strong>The mean age of patients was 39 ± 9 (range: 25-60) years. Out of 72 patients with kidney transplants, 7 (9.72%) patients were diagnosed with steroid-induced glaucoma, and 9 (12.5%) patients had ocular hypertension (OHT). Four (5.55%) patients underwent trabeculectomy to control IOP whereas 3 (4.16%) patients were controlled on anti-glaucoma medications. Best-corrected visual acuity < 6/9 was noted in 23 (31.94%) patients in at least one eye. The average follow-up was 30 months with interquartile range of 18-84 months. There was a significant association of cumulative dosage of steroid and development of cataract and OHT and glaucoma (P < 0.01).</p><p><strong>Conclusion: </strong>Kidney transplant patients must be screened for glaucoma and other ocular abnormality and should be on routine ophthalmological follow-up due to the possibility of steroid induced glaucoma.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 4","pages":"362-366"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetrachromacy and advertising: a new way of visual perception in marketing.","authors":"Consuela-Mădălina Gheorghe","doi":"10.22336/rjo.2024.63","DOIUrl":"https://doi.org/10.22336/rjo.2024.63","url":null,"abstract":"","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 4","pages":"341-342"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear meniscus height comparison between AS-OCT and Oculus Keratograph® K5M.","authors":"Angeline Lim Pei Yik, Fakhruddin Shamsheer Barodawala","doi":"10.22336/rjo.2024.72","DOIUrl":"10.22336/rjo.2024.72","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the agreement between Spectral-Domain Optical Coherence Tomography (AS-OCT) and Oculus Keratograph® 5M in measuring tear meniscus height (TMH) and to assess the impact of contact lens wear on these measurements. <b>Materials and methods</b>: TMH was measured in 54 healthy eyes using AS-OCT (3D OCT-1 Maestro, Topcon, Tokyo, Japan) and Oculus Keratograph® 5M (OCULUS Optikgeräte, Wetzlar, Germany), with and without contact lens wear. Bland-Altman analysis was used to assess agreement between the two devices. Delefilcon A, water-gradient, daily disposable contact lenses were used, and measurements were carried out after a 20-minute adaptation period.</p><p><strong>Results: </strong>The means of TMH without the contact lenses were 0.21 ± 0.06 mm and 0.20 ± 0.05 mm obtained from AS-OCT and Oculus K5M, respectively, and these measurements were not statistically significant (t (53) = 0.99, p = 0.33). No significant differences were observed in TMH compared to contact lenses (t (53) = 1.52, p = 0.13). Agreement between measurements obtained by both the instruments was assessed using Bland-Altman analysis. The limits of agreement were within clinically acceptable ranges (0.10 mm - 0.15 mm), with no evidence of significant bias (t = -0.32, r = 0.22). The results obtained with contact lenses were also not statistically significant (t (53) = 1.52, p < 0.05).</p><p><strong>Discussion: </strong>The present study compared tear meniscus height (TMH) measurements obtained from AS-OCT and Oculus K5M in subjects with and without contact lens wear. Both instruments showed good agreement, with AS-OCT consistently measuring slightly higher TMH values than Oculus K5M. The mean TMH values were similar to those of previous studies, indicating normal tear film in the subjects. Contact lens wear was found to reduce TMH slightly, but it returned to baseline after a short adaptation period. The Bland-Altman analysis confirmed good agreement between the two instruments, with most data points falling within the limits of agreement. These findings suggest that AS-OCT and Oculus K5M can be reliable tools for measuring TMH and can be used interchangeably for clinical practice.</p><p><strong>Conclusion: </strong>AS-OCT and Oculus Keratograph® 5M showed comparable results in measuring TMH, suggesting potential interchangeability in clinical practice. Further validation in broader clinical settings and diverse subject groups may be warranted.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 4","pages":"398-403"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of complications in patients with one eye during and after ocular surgery.","authors":"Tugce Horozoglu Ceran, Mehmet Citirik, Mehmet Yasin Teke","doi":"10.22336/rjo.2024.74","DOIUrl":"10.22336/rjo.2024.74","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined patients with permanent legal blindness in one eye after a previous eye surgery and those with permanent legal blindness in one eye for non-surgical reasons. The objective of this study was to assess the occurrence of complications both during and after surgery in patients undergoing phacoemulsification for cataracts or vitreoretinal surgery for retinal detachment in the fellow eye.</p><p><strong>Methods: </strong>A retrospective study included 62 patients (group 1) with legal blindness in one eye, compared to 62 control patients (group 2) undergoing similar surgeries. Complications, history of complex surgery leading to legal blindness, and demographic characteristics were analyzed.</p><p><strong>Results: </strong>In group 1, the complication rate was significantly higher in patients who underwent both phacoemulsification and vitreoretinal surgeries than in group 2 (p < 0.05). In group 1, complications developed during surgery in the other eye in 28.1% of the patients whose permanent legal blindness stemmed from a complication in the previous surgery. In contrast, complications arose in the surgery of the other eye in 10% of patients whose permanent legal blindness did not result from any complications in the previous surgery. A statistically significant difference was observed between the two groups (P < 0.05).</p><p><strong>Discussion: </strong>In our study, if the cause of eye loss in patients with permanent legal blindness in one eye was a surgical complication, the possibility of complications during surgery in the other eye was high. Surgery can be planned at higher visual acuity levels in a patient who has lost one eye for reasons other than surgery. In patients who have lost one eye due to previous surgery, surgery for the other can be planned at lower visual acuity levels.</p><p><strong>Conclusion: </strong>This is the first report to compare the rate of complications during and after surgery in patients with pre-existing permanent legal blindness in one eye who underwent cataract surgery and vitreoretinal surgery in the other.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 4","pages":"409-414"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}