Recent advances in drug delivery and formulation最新文献

{"title":"Next-Generation Phospholipid Nanocomplexes for Precision Neurotherapeutics: Harnessing Endogenous Blood-Brain Barrier Transport Mechanisms to Revolutionize the Treatment of Neurodegenerative Diseases.","authors":"Dhruv Pratap SIngh Jaitawat, Indu Singh, Shikha Baghel Chauhan","doi":"10.2174/0126673878361646250623062415","DOIUrl":"10.2174/0126673878361646250623062415","url":null,"abstract":"<p><p>The treatment of neurodegenerative illnesses remains a substantial problem due to the blood-brain barrier's restrictive nature, which restricts therapeutic agent penetration. Phospholipid Nanocomplexes (PNCs) have emerged as next-generation neurotherapeutics, utilizing natural BBB transport pathways to improve drug delivery. These nanocarriers, with lipid-based architectures, allow for receptor-mediated transcytosis, lipid raft-mediated transport, and adsorptive-mediated endocytosis, resulting in precise and sustained drug release inside the central nervous system. Recent preclinical and clinical studies have shown that PNC-based formulations of neurotrophic factors, antioxidants, and gene-silencing therapies significantly improve neuronal survival, cognitive function, and neuroprotection in conditions like Alzheimer's Disease (AD), Parkinson's Disease (PD), Glioblastoma (GBM), and multiple sclerosis. Despite the positive outcomes, issues such as scalability, long-term safety, and regulatory approval remain. This study critically assesses the present status of PNC-based neurotherapeutics, emphasizing their benefits over traditional therapies, analyzing the most recent clinical trial outcomes, and assessing difficulties and future prospects. To improve PNC effectiveness, the potential for artificial intelligence-driven medication design, multifunctionalized nanocarriers, and hybrid biomaterial methods is investigated. As biocompatible and patientspecific nanomedicine advances, PNCs represent a breakthrough approach to precision neuroscience, providing tailored, efficient, and safer therapies for neurodegenerative diseases.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"250-269"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DoE-Optimized Minitabs: Fabricating a Promising Modified-Release Sprinkle Formulation.","authors":"Suman R Borsadiya, Dharmik M Mehta","doi":"10.2174/0126673878371241250705123006","DOIUrl":"10.2174/0126673878371241250705123006","url":null,"abstract":"<p><strong>Introduction: </strong>Dysphagia is a challenging medical condition that significantly affects individuals' swallowing function, quality of life, and overall well-being, especially in geriatric and pediatric populations. Sprinkle formulations are emerging as a broadly accepted solution to this challenge. However, such formulations are quite challenging to formulate as modified-release delivery systems. The present study aims to resolve this issue by formulating modified-release minitabs of the model drug etoricoxib as a sprinkle formulation.</p><p><strong>Methods: </strong>A fabricated metal mold and punch system was used to manually manufacture minitabs with a diameter of 3.2 mm and a weight of approximately 22 mg. The formulation derived from trial batches was further optimized using a 3 × 2 complete factorial design, as implemented in Stat- Ease Design Expert 7.0 software (trial version). Independent factors HPMC K4M (X1) and K100M (X2) were optimized against dependent factors: Hardness (R1), Friability (R2), and Drug release at 2 hrs (R3), 4 hrs (R4), and 8 hrs (R5).</p><p><strong>Result: </strong>The derived, optimized formulation, based on a desirability function, sustained drug release for up to 8 hours and met all the acceptance criteria. The final dosage form was designed as a hard gelatin capsule filled with approximately 22 minitabs, in the form of a sprinkle formulation, to be sprinkled over soft foods for administration.</p><p><strong>Discussion: </strong>The study demonstrated that factorial design can be effectively employed to develop sprinkle minitabs with modified drug release. Using different grades of HPMC helped in controlling the drug release over time. This approach offers a promising strategy for developing patientfriendly formulations, particularly for individuals with swallowing difficulties.</p><p><strong>Conclusion: </strong>As the formulation was designed using a model drug, further investigations with other drugs can also be done with relevant changes in the optimized formulation. In summary, it can also be utilized as a platform for developing modified-release sprinkle formulations of other drugs.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"193-201"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric Nanocarriers with pH-Dependent Release for Tumor-Specific Delivery.","authors":"Chintan Aundhia, Ghanshyam Parmar, Chitrali Talele, Piyushkumar Sadhu, Avinashkumar Seth","doi":"10.2174/0126673878366151250815012551","DOIUrl":"10.2174/0126673878366151250815012551","url":null,"abstract":"<p><p>The acidic nature of tumor microenvironments presents a unique opportunity for the targeted delivery of therapeutics using pH-responsive polymeric nanocarriers. These smart nanocarriers are designed to release their payload specifically in response to the low pH found in tumor tissues, thereby enhancing drug accumulation at the tumor site while minimizing systemic side effects. This review provides a comprehensive overview of the design principles, fabrication methods, and applications of pH-responsive polymeric nanocarriers for targeted drug delivery in tumor microenvironments. Key topics include the mechanisms of pH-responsive drug release, engineering strategies for developing pH-sensitive polymers, and recent advancements in exploiting tumor acidity for improved therapeutic outcomes. Additionally, the review discusses the clinical potential and the challenges associated with the translation of these nanocarriers from bench to bedside.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"270-287"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements and Challenges in Gastroretentive Drug Delivery Systems: A Comprehensive Review of Research Innovation, Technologies, and Clinical Applications.","authors":"Ayush Dubey, Mohammad Ovais, Amol Chhatrapati Bisen, Anandhan Rajendiran","doi":"10.2174/0126673878342430250414114531","DOIUrl":"10.2174/0126673878342430250414114531","url":null,"abstract":"<p><p>Gastroretentive drug delivery systems (GRDDS) have emerged as a focal point of research and development, attracting substantial attention due to their potential to revolutionize oral drug administration. Their ability to enhance the bioavailability and therapeutic effectiveness of orally administered medications, particularly those with narrow absorption windows or susceptible to gastrointestinal degradation, has spurred considerable interest. By extending gastric residence time, GRDDS offers a pathway to optimize drug absorption while minimizing dosing frequency, thereby improving patient compliance and therapeutic outcomes. This comprehensive review delves into the diverse array of gastroretentive drug delivery approaches, providing in-depth insights into their classification, mechanisms of retention, recent innovations with patented technologies, and existing marketed formulations of the domain. Furthermore, it meticulously examines the challenges inherent in GRDDS implementation and elucidates effective strategies to surmount them. From novel formulation techniques to ingenious drug-carrier systems, this review explores the multifaceted landscape of GRDDS development, shedding light on promising avenues for future research and development. By advancing current knowledge and anticipating future trends, this review serves as a valuable resource for researchers, clinicians, and pharmaceutical professionals navigating the dynamic terrain of gastroretentive drug delivery.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"41-65"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized Formulation of Sulfasalazine and Probiotic-Loaded Carrageenan Microparticles Using Design of Experiments for Effective Colitis Management.","authors":"Sarmili Sahoo, Akshita Arora, Simranjeet Kaur, Diksha, Rohit Bhatia, Shamsher Singh, Raj Kumar Narang, Rajveer Singh, Naresh Kumar Rangra, Amandeep Singh","doi":"10.2174/0126673878363141250731125303","DOIUrl":"10.2174/0126673878363141250731125303","url":null,"abstract":"<p><strong>Introduction: </strong>Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by mucosal inflammation and epithelial barrier dysfunction. Sulfasalazine, a standard antiinflammatory drug, and probiotics, known for gut microbiota modulation, have both shown efficacy in UC management. However, their combined delivery to the colon remains underexplored. This study aimed to develop a colon-targeted microparticulate formulation containing sulfasalazine and a probiotic strain to enhance anti-inflammatory action and therapeutic effectiveness against UC.</p><p><strong>Methods: </strong>Microparticles were prepared using a Design of Experiments (DoE) approach, optimizing carrageenan and calcium chloride dihydrate concentrations and stirring speed. The probiotic was co-encapsulated to maintain viability during processing. In vitro evaluations included drug release studies and Caco-2 cell line assays for epithelial integrity, ROS generation, and NF-κB expression. In vivo efficacy was assessed using an acetic acid-induced colitis model, with evaluations based on inflammation severity, tissue damage and histopathology.</p><p><strong>Results: </strong>Optimized microparticles ensured sustained sulfasalazine release and preserved probiotic viability. In vitro, the formulation improved epithelial barrier function, reduced ROS and proinflammatory cytokines, and suppressed NF-κB expression. In vivo, treated animals showed significant reduction in colitis severity, improved tissue integrity and better histopathological outcomes compared to controls.</p><p><strong>Discussion: </strong>The combined sulfasalazine-probiotic microparticles effectively addressed both symptomatic relief and the inflammatory cascade in UC. Probiotics enhanced gut barrier protection, while sustained sulfasalazine release ensured localized therapeutic action. The synergy between drug and probiotic delivery offers a novel approach over conventional therapies.</p><p><strong>Conclusion: </strong>This study presents a promising colon-targeted microparticulate system combining sulfasalazine and probiotics for effective UC management. The dual-action formulation offers enhanced anti-inflammatory efficacy, reduced tissue damage, and better disease control, supporting its potential in future clinical applications.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"323-341"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Enteric-coated Microspheres Formulation Development and Mangiferin Drug Delivery for the Treatment of Ulcerative Colitis.","authors":"Swati Yadav, Ranjit K Harwansh, Rupa Mazumder","doi":"10.2174/0126673878362674250630062020","DOIUrl":"10.2174/0126673878362674250630062020","url":null,"abstract":"<p><strong>Introduction: </strong>Ulcerative colitis, an inflammatory disease of the colon, is prone to recurrence. Research into novel therapies for this condition is urgently required. The current investigation aims to ascertain the protective impact of microspheres loaded with mangiferin in acetic acidinduced ulcerative colitis (UC).</p><p><strong>Methods: </strong>The formulation significantly reduced inflammatory alterations, ulcer activity scores, and oxidative stress. Colitis was induced by injecting 1 mL of a 4% acetic acid solution. In addition to a macroscopical and gross evaluation, colon samples were tested for catalase and glutathione (GSH) activity.</p><p><strong>Results: </strong>Microspheres loaded with mangiferin reduced the severity of ulcerative colitis caused by acetic acid, as indicated by improvements in weight loss, macroscopic score, ulcer area, and histological score.</p><p><strong>Discussion: </strong>This work emphasizes the use of dual-polymer microspheres to deliver mangiferin to the colon, allowing for pH-dependent and prolonged drug release. By increasing stability and sitespecific activity, this method may be used to treat ulcerative colitis.</p><p><strong>Conclusion: </strong>These findings suggest that enteric-coated microspheres loaded with mangiferin exhibit a protective effect against colon ulcers in rats and offer delayed-release properties compared to plain mangiferin.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"311-322"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needle-Free Future: Revolutionizing Immunization with Vaccine Creams.","authors":"Dinesh Kumar, Vrinda Gupta, Rajni Tanwar, Sonia Gupta","doi":"10.2174/0126673878398533250825152040","DOIUrl":"10.2174/0126673878398533250825152040","url":null,"abstract":"<p><p>For centuries, injections have been the primary method for vaccination; however, these traditional approaches present challenges due to pain, fear, and difficulties in administration. Scientists from Stanford University have developed vaccine creams, representing a revolutionary approach to the field of vaccination. Genetically modified Staphylococcus epidermidis forms the basis of these cream products, which support skin-based, painless vaccination without invasive procedures, while playing an essential role in the immune response. Scientists using tetanus as a test subject have obtained positive data from animal studies demonstrating effective immune responses to vaccination, indicating potential future applications for treating diseases, such as influenza, COVID-19, and cancer. Vaccination creams outperform classic injections in several ways, as they eliminate needle-related concerns while reducing adverse reactions, streamlining mass vaccination programs, and making the delivery of immunizations simpler, especially for populations that lack regular access to healthcare. Several key barriers continue to hinder the development of vaccine creams, including regulatory hurdles, stability concerns, production scalability, and public acceptance. Research discusses how vaccine creams revolutionize immunization processes by improving treatment accessibility, affordability, and broader acceptance rates.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"203-206"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement in Nanotablet Research: An Overview.","authors":"Aparna Gupta, Gaurav Thakur, Peeyush Kaushik, Sandhya Jaiswal, Jyoti Singh, Saurabh Sharma, Sunny Dhiman, Supriya Agnihotri","doi":"10.2174/0126673878330529250324042529","DOIUrl":"10.2174/0126673878330529250324042529","url":null,"abstract":"<p><p>Modern technologies such as nanotechnology are being applied in almost every sector to deliver affordable, environmentally friendly products. The integration of nanotechnology in medicine has revolutionized drug delivery systems, with nanotechnology emerging as a promising frontier. This review explores the synthesis and characterization of nanotablet drug formulations designed to enhance their potential across various applications. By employing characterization techniques such as X-ray diffraction, electron microscopy, and physisorption analysis, researchers have developed innovative drug delivery systems like Sophora Alopecuroides nanotablets to treat deadly diseases such as cancer. Evaluation of pre- and post-compression results indicated that nanotablets exhibited good hardness and flow properties, making these formulations potential drug delivery systems for enhanced bioavailability and sustained release properties. Specifically, sublingual sufentanil nanotablets, such as Zalviso®, have demonstrated efficacy in managing moderate to severe pain in healthcare settings when used in conjunction with a PCA device. However, recent regulatory updates indicate changes in the marketing authorization status of Zalviso®. In conclusion, this novel approach for synthesizing nanotablets presents a promising avenue for diverse applications, and based on the results, it is worth considering for future work.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"8-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, Characterization, and In Vitro Analysis of a Curcumin-Loaded Lecithin-Coconut Oil-Based Emulgel for Enhanced Burn Management","authors":"Vishal, Sourav Dhandi, Yeshna, Monika Singh, Monika, Rahul Pratap Singh, Vikas Jhawat","doi":"10.2174/0126673878362007250707054437","DOIUrl":"10.2174/0126673878362007250707054437","url":null,"abstract":"<p><strong>Background: </strong>Effective burn management is essential for alleviating patient discomfort and promoting recovery. Curcumin has been shown to possess anti-inflammatory and antimicrobial properties, offering potential benefits in burn management. Coconut oil has also been reported to possess skin-moisturizing, antimicrobial, and anti-inflammatory properties. This study aimed to develop and evaluate curcumin-loaded coconut oil-based emulgel formulations to improve therapeutic outcomes in burn management.</p><p><strong>Methods: </strong>Eight emulgel formulations (F1-F8) were prepared utilizing lecithin, hyaluronic acid, and coconut oil. The developed formulations were evaluated for their organoleptic properties, including color, odor, texture, and phase separation, as well as their physicochemical characteristics, such as pH, viscosity, spreadability, drug content, and in vitro drug release. Light microscopy and scanning electron microscopy were used to analyse the morphological characteristics.</p><p><strong>Results and discussion: </strong>The formulations exhibited a bi-continuous system with a threedimensional polymeric network structure. The developed formulations exhibited pH values (5.40- 6.35), viscosities (3840-5369 cps), spreadability (7-8 cm), drug contents (82-95%), and in vitro drug release (88-93%) over 24 hours, showing promising results for topical delivery. Among the formulations, F3 demonstrated the highest drug release, whereas F8 exhibited the highest viscosity and drug content. The emulgel also provided cooling, moisturizing, anti-inflammatory, and antimicrobial effects, supporting wound healing and pain relief.</p><p><strong>Conclusion: </strong>The developed Curcumin-loaded coconut oil-based emulgel shows promise for burn management, offering enhanced topical drug delivery and therapeutic benefits. These findings support further research to optimize formulation parameters for improved clinical outcomes.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"182 - 192"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aprepitant: Review on Solubility Enhancement.","authors":"Lata Kothapalli, Navdeep Singh, Abhay Upare, Anil Kumar Rathour, Nisha Nikam, Asha Thomas, Sanjeevani S Deshkar","doi":"10.2174/0126673878374342250708153111","DOIUrl":"10.2174/0126673878374342250708153111","url":null,"abstract":"<p><strong>Introduction: </strong>Substance P and its neurokinin (NK-1) receptors are upregulated in different pathophysiological conditions. Overexpression of the NK-1 receptor in cancer conditions has provided a promising pathway for cancer treatment. Clinically, Aprepitant (APT) is used as the only NK-1 antagonist in chemotherapy-induced nausea and vomiting (CINV). Currently, investigations into using APT as a synergistic combination with radiation or standard chemotherapeutic drugs are underway. However, APT is categorised as a BCS Class IV drug, and therefore, solubility is one of the challenges when it must be delivered parenterally. The present review aims to understand the solubility enhancement techniques for better bioavailability.</p><p><strong>Methods: </strong>Research and review articles were sought to understand the chemistry and solubility enhancement techniques reported for APT. Search engines such as Science Direct, PubMed, Bentham, and Google Scholar were used with the keywords \"Aprepitant, solubility, NK1 receptor, parenteral dosage form.\"</p><p><strong>Results: </strong>The review comprehensively discusses the methods to improve the solubility of APT using innovative technologies, including nanotechnology.</p><p><strong>Discussion: </strong>The review highlights the challenges associated with the use of APT in treating chemotherapy- induced nausea and vomiting (CINV), as well as its potential as a promising anticancer agent. While various solubility enhancement techniques can be employed for the oral administration of APT, the appropriate use of excipients and stability are essential for its safe clinical use in parenteral dosage forms.</p><p><strong>Conclusion: </strong>The available solubility enhancement techniques discussed come with benefits and limitations. Fosaprepitant, a prodrug, is preferably used as an IV dosage form. Similarly, modification to a prodrug and solubility-enhancing excipients for nanoformulation can help make APT a promising therapy.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"288-299"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}