Nanosponges in Detoxification: Strategy for Toxin Removal and Drug Overdose Management.

Abstract

A potential class of cutting-edge medication delivery devices, nanosponges have become an effective tool for managing drug overdoses and detoxification. The capacity to adsorb and sequester a variety of toxins, such as heavy metals, bacterial endotoxins, and medications, makes these highly porous, biocompatible, and biodegradable particles-which are usually made from crosslinked polymers-an effective way to remove toxins. Nanosponges' adaptability enables their use in a number of sectors, including drug-resistant illness treatment, environmental remediation, and acute poisoning treatment. Detoxification and targeted drug release for diseases like cancer, heart disease, and neurological problems are made possible by the controlled delivery of therapeutic substances using nanosponges. With a focus on their capacity to improve medication bioavailability and lower systemic toxicity, this study examines the mechanism of action, design approaches, and therapeutic potential of nanosponges in detoxification. The paper also discusses new developments in the sector, such as how they can be used to treat drug overdoses and how nanosponges can help stop and lessen the negative effects of environmental contaminants. Despite its potential, there are still obstacles to overcome in order to maximize nanosponges' manufacturing, scalability, and regulatory acceptance. In order to optimize their potential in therapeutic treatments, this review attempts to give a thorough overview of the most recent advancements in detoxifying nanosponges, their clinical uses, and future research objectives.