Recent advances in drug delivery and formulation最新文献

Enhanced Oral Bioavailability and Stability Studies of Loratadine TabletsBased on Solid Dispersion of Modified Ziziphus spina-christi Gum 基于改性酸枣仁胶固体分散体的氯雷他定片口服生物利用度和稳定性研究

Recent advances in drug delivery and formulation Pub Date : 2024-06-06 DOI: 10.2174/0126673878288535240530113418

Ameen M. Alwossabi, E. S. Elamin, Elhadi M. M. Ahmed, Eman A. Ismail, A. Ashour, W. Osman, A. E. Sherif, Amira Mira, Rawan Bafail, Yusra Saleh Andijani, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Mohammed Abdelrahman

{"title":"Enhanced Oral Bioavailability and Stability Studies of Loratadine Tablets\u0000Based on Solid Dispersion of Modified Ziziphus spina-christi Gum","authors":"Ameen M. Alwossabi, E. S. Elamin, Elhadi M. M. Ahmed, Eman A. Ismail, A. Ashour, W. Osman, A. E. Sherif, Amira Mira, Rawan Bafail, Yusra Saleh Andijani, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Mohammed Abdelrahman","doi":"10.2174/0126673878288535240530113418","DOIUrl":"https://doi.org/10.2174/0126673878288535240530113418","url":null,"abstract":"\u0000\u0000Solid dispersion is a common technique used for solubility enhancement of\u0000poorly soluble drugs.\u0000\u0000\u0000\u0000In this study, loratadine (LOR), a class II biopharmaceutical classification system (BCS),\u0000was formulated as solid dispersion tablets using modified Ziziphus spina-christi gum (MZG) as a\u0000carrier.\u0000\u0000\u0000\u0000The solvent evaporation method was used for LOR-MZG solid dispersion (SD) preparation.\u0000A variety of tests were conducted to characterize and optimize the formulation. Solubility,\u0000Fourier transform infrared (FTIR) analysis, Differential Scanning Calorimetry (DSC), X-Ray Diffraction\u0000(X-RD), and Scanning Electron Micrograph (SEM) of solid dispersions were carried out.\u0000Accelerated stability testing and pharmacokinetic studies of formulated tablets were also performed\u0000using albino Wistar rats.\u0000\u0000\u0000\u0000Solid dispersion improved the solubility of LOR by 51 folds. FTIR spectra excluded drugpolymer\u0000interactions, and results obtained by DSC, X-RD, and SEM proved the transition from the\u0000crystalline to the amorphous state. The stability of LOR-MZG solid dispersion tablets was found to\u0000be better when the Alu-Alu package was used. The pharmacokinetics of LOR-MZG compared to\u0000MZG-free loratadine tablets (LOR pure) and commercial loratadine tablets (LOR-TM) following\u0000oral administration revealed that about 6 folds and 10 folds bioavailability were achieved with\u0000LOR-MZG compared to LOR pure and LOR-TM, respectively.\u0000\u0000\u0000\u0000Such promising results encourage more studies on MZG to be used for improving the\u0000aqueous solubility and bioavailability of a wide range of poorly soluble drugs.\u0000","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"22 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Development of Enteric-Coated Tablets of the Probiotic Lactobacillus fermentum LF-G89: A Possible Approach to Intestinal Colonization. 益生菌发酵乳杆菌 LF-G89 肠溶片的体外开发：肠道定植的一种可能方法。

Recent advances in drug delivery and formulation Pub Date : 2024-04-24 DOI: 10.2174/0126673878286133240418114629

Paola Spínello, Pamela do Nascimento, Verônica Cristina da Silveira, Tatiana Staudt, Hamid Omidian, Ana Caroline Tissiani, Charise Dellazen Bertol

{"title":"In Vitro Development of Enteric-Coated Tablets of the Probiotic Lactobacillus fermentum LF-G89: A Possible Approach to Intestinal Colonization.","authors":"Paola Spínello, Pamela do Nascimento, Verônica Cristina da Silveira, Tatiana Staudt, Hamid Omidian, Ana Caroline Tissiani, Charise Dellazen Bertol","doi":"10.2174/0126673878286133240418114629","DOIUrl":"https://doi.org/10.2174/0126673878286133240418114629","url":null,"abstract":"BACKGROUND\u0000Probiotics must be able to withstand the demanding environment of the gastrointestinal system to adhere to the intestinal epithelium, promoting health benefits. The use of probiotics can prevent or attenuate the effects of dysbiosis that have a deleterious effect on health, promoting anti-inflammatory, immunomodulatory, and antioxidant effects.\u0000\u0000\u0000OBJECTIVE\u0000The aim of the study was to prepare tablets containing Lactobacillus fermentum LF-G89 coated with 20% Acryl-Eze II® or Opadry® enteric polymers.\u0000\u0000\u0000METHOD\u0000Tablet dissolution was evaluated under acidic and basic pH conditions, and aliquots of the dissolution medium were plated to count the Colony-forming Units (CFU). The free probiotic's tolerance to pH levels of 1.0, 2.0, 3.0, and 4.0, as well as to pepsin, pancreatin, and bile salts, was assessed.\u0000\u0000\u0000RESULTS\u0000The probiotic was released from tablets coated after they withstood the pH 1.2 acid stage for 45 minutes. The release was higher with the Acry-Eze II® polymer in the basic stage. The amount of CFU of free probiotics at pH 1.0 to 4.0 as well as pepsin reduced over time, indicating cell death. Conversely, the CFU over time with pancreatin and bile salts increased, demonstrating the resistance of L. fermentum to these conditions due to hydrolases.\u0000\u0000\u0000CONCLUSION\u0000Both coating polymers were able to withstand the acid step, likely ensuring the release of the probiotic in the small intestine, promoting colonization. Coating with enteric material is a simple and effective process to increase the survival of probiotics, offering a promising alternative to mitigate the negative effects of the dysbiosis process.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"51 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crisaborole-Enthused Glycerosomal Gel for an Augmented Skin Permeation. 用于增强皮肤渗透性的克利博罗浸润甘油囊凝胶

Recent advances in drug delivery and formulation Pub Date : 2024-04-24 DOI: 10.2174/0126673878283299240418112318

Ragini Singh, Anshu Singh, Dipti Srivastava, Zeeshan Fatima, Ramani Prasad

{"title":"Crisaborole-Enthused Glycerosomal Gel for an Augmented Skin Permeation.","authors":"Ragini Singh, Anshu Singh, Dipti Srivastava, Zeeshan Fatima, Ramani Prasad","doi":"10.2174/0126673878283299240418112318","DOIUrl":"https://doi.org/10.2174/0126673878283299240418112318","url":null,"abstract":"BACKGROUND\u0000Crisaborole (CB), a boron-based compound, is the first topical PDE4 inhibitor to be approved by the US Food and Drug Administration (2016) for the treatment of Atopic Dermatitis. It is marketed as a 2% ointment (Eucrisa, Pfizer). However, CB is insoluble in water; therfore, CB glycersomes were formulated to enhance its permeation flux across the skin.\u0000\u0000\u0000OBJECTIVE\u0000We developed a glycerosomal gel of CB and compared its in vitro release and permeation flux with the 2% conventional ointment.\u0000\u0000\u0000METHODS\u0000Glycerosomes were prepared using a thin film hydration method employing CB, soya phosphatidylcholine, and cholesterol. The formed film was further hydrated employing a mixture of phosphate buffer pH 7.4 /glycerin solution containing varying percentages (20,30, 40, and 50 %) of glycerol. The glycerosomes obtained were characterized by their size, polydispersity index (PDI), and Zeta potential. The entrapment efficiency of the optimized formulation (F 1) was determined. The in vitro release of F1 was compared with its 2% conventional ointment. F1 was further incorporated into carbopol 934 P gel. The gel was characterized by pH, viscosity, spreadability, and drug content. The permeability flux of the glycerosomal gel was compared with its 2% conventional ointment.\u0000\u0000\u0000RESULTS\u0000The optimized CB glycerosomes had a vesicle size of 137.5 ± 50.58 nm, PDI 0.342, and zeta potential -65.4 ± 6.75 mV. CB glycerosomal gel demonstrated a 2.13-fold enhancement in the permeation flux.\u0000\u0000\u0000CONCLUSION\u0000It can thereby be concluded that glycerosomes can be an effective delivery system to enhance the penetration of CB across the skin.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"33 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation Consideration of Medicated Chewing Gum: A Review. 药用口香糖的配方考虑：综述。

Recent advances in drug delivery and formulation Pub Date : 2024-04-17 DOI: 10.2174/0126673878281000240411073412

Kishan Bobe, Yoesh Suryawanshi, Virendra Gomase, Muizz Kachhi, Chandrashekhar Bobade

{"title":"Formulation Consideration of Medicated Chewing Gum: A Review.","authors":"Kishan Bobe, Yoesh Suryawanshi, Virendra Gomase, Muizz Kachhi, Chandrashekhar Bobade","doi":"10.2174/0126673878281000240411073412","DOIUrl":"https://doi.org/10.2174/0126673878281000240411073412","url":null,"abstract":"In recent times, technological and scientific advances have been made in studying and developing orally delivered medication. Such studies demonstrate the importance of the oral route among patients. The accuracy of drug delivery is very important to achieve a successful therapeutic effect in the case of various pharmaceutical products. A novel drug delivery system adds new benefits or advantages to a drug. This review covers all the aspects of medicated chewing gum (MCG) as a new drug delivery method, including the benefits and drawbacks, manufacturing methods, type of MCG, composition of chewing gum, evaluation parameters, factors that affected the release of API, its pharmaceutical significance, various marketed chewing gum and chewing gum packaging. Chewing gum as a drug delivery system has the potential to cure or prevent various indications, such as analgesic, CNS stimulation, smoking cessation, motion sickness, and treatment and prevention of dental caries or gingivitis. Pharmaceutical distribution to the oral mucosa can be made more convenient and enticing with the help of MCG. Compared to conventional techniques, this delivery system has a longer-lasting effect, which makes it a viable option for treating digestive problems, headaches, migraines, coughing, anxiety, and allergies.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic Impact of Naringenin-Loaded Solid Lipid Nanoparticles on RIN5F Pancreatic β Cells via Autophagy Blockage. 柚皮苷载体固体脂质纳米颗粒通过自噬阻断对 RIN5F 胰腺 β 细胞的细胞毒性影响

Recent advances in drug delivery and formulation Pub Date : 2024-01-01 DOI: 10.2174/0126673878297658240804192222

Pardis Mohammadi Pour, Zeinab Nouri, Dariush Ghasemi, Soraya Sajadimajd, Mohammad Hosein Farzaei

{"title":"Cytotoxic Impact of Naringenin-Loaded Solid Lipid Nanoparticles on RIN5F Pancreatic β Cells via Autophagy Blockage.","authors":"Pardis Mohammadi Pour, Zeinab Nouri, Dariush Ghasemi, Soraya Sajadimajd, Mohammad Hosein Farzaei","doi":"10.2174/0126673878297658240804192222","DOIUrl":"10.2174/0126673878297658240804192222","url":null,"abstract":"Background: Autophagy plays a crucial role in modulating the proliferation of cancer diseases. However, the application of Naringenin (Nar), a compound with potential benefits against these diseases, has been limited due to its poor solubility and bioavailability.Objective: This study aimed to develop solid lipid nanoparticles (Nar-SLNs) loaded with Nar to enhance their therapeutic impact.Methods: In vitro experiments using Rin-5F cells exposed to Nar and Nar-SLNs were carried out to investigate the protective effects of Nar and its nanoformulation against the pancreatic cancer cell line of Rin-5F.Results: Treatment with Nar and Nar-SLN led to an increase in autophagic markers (Akt, LC3, Beclin1, and ATG genes) and a decrease in the level of miR-21. Both Nar and Nar-SLN treatments inhibited cell proliferation and reduced the expression of autophagic markers. Notably, Nar-SLNs exhibited greater efficacy compared to free Nar.Conclusion: These findings suggest that SLNs effectively enhance the cytotoxic impact of Nar, making Nar-SLNs a promising candidate for suppressing or preventing Rin-5F cell growth.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"18 4","pages":"304-314"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric Vehicles for Nucleic Acid Delivery: Enhancing the Therapeutic Efficacy and Cellular Uptake. 用于核酸递送的聚合物载体：增强疗效和细胞吸收。

Recent advances in drug delivery and formulation Pub Date : 2024-01-01 DOI: 10.2174/0126673878324536240805060143

Parul Gupta, Anjali Sharma, Vishnu Mittal

{"title":"Polymeric Vehicles for Nucleic Acid Delivery: Enhancing the Therapeutic Efficacy and Cellular Uptake.","authors":"Parul Gupta, Anjali Sharma, Vishnu Mittal","doi":"10.2174/0126673878324536240805060143","DOIUrl":"10.2174/0126673878324536240805060143","url":null,"abstract":"Background: Therapeutic gene delivery may be facilitated by the use of polymeric carriers. When combined with nucleic acids to form nanoparticles or polyplexes, a variety of polymers may shield the cargo from in vivo breakdown and clearance while also making it easier for it to enter intracellular compartments.Aim and objectives: Polymer synthesis design choices result in a wide variety of compounds and vehicle compositions. Depending on the application, these characteristics may be changed to provide enhanced endosomal escape, longer-lasting distribution, or stronger connection with nucleic acid cargo and cells. Here, we outline current methods for delivering genes in preclinical and clinical settings using polymers.Methodology: Significant therapeutic outcomes have previously been attained using genetic material- delivering polymer vehicles in both in-vitro and animal models. When combined with nucleic acids to form nanoparticles or polyplexes, a variety of polymers may shield the cargo from in vivo breakdown and clearance while also making it easier for it to enter intracellular compartments. Many innovative diagnoses for nucleic acids have been investigated and put through clinical assessment in the past 20 years.Results: Polymer-based carriers have additional delivery issues due to their changes in method and place of biological action, as well as variances in biophysical characteristics. We cover recent custom polymeric carrier architectures that were tuned for nucleic acid payloads such genomemodifying nucleic acids, siRNA, microRNA, and plasmid DNA.Conclusion: In conclusion, the development of polymeric carriers for gene delivery holds promise for therapeutic applications. Through careful design and optimization, these carriers can overcome various challenges associated with nucleic acid delivery, offering new avenues for treating a wide range of diseases.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"18 4","pages":"276-293"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, Optimization and In Vitro Characterization of Fluticasoneloaded Mixed Micelles Based on Stearic Acid-g-chitosan as a Pulmonary Delivery System. 硬脂酸-壳聚糖混合胶束作为肺部给药系统的制备、优化和体外表征

Recent advances in drug delivery and formulation Pub Date : 2024-01-01 DOI: 10.2174/0126673878262764240208054140

Shima Tasharoie, Seyed Naser Ostad, Mohsen Amini, Reyhaneh Sabourian, Kambiz Gilani

{"title":"Preparation, Optimization and In Vitro Characterization of Fluticasoneloaded Mixed Micelles Based on Stearic Acid-g-chitosan as a Pulmonary Delivery System.","authors":"Shima Tasharoie, Seyed Naser Ostad, Mohsen Amini, Reyhaneh Sabourian, Kambiz Gilani","doi":"10.2174/0126673878262764240208054140","DOIUrl":"10.2174/0126673878262764240208054140","url":null,"abstract":"Purpose: The primary objective of this study was to optimize formulation variables and investigate the in vitro characteristics of fluticasone propionate (FP)-loaded mixed polymeric micelles, which were composed of depolymerized chitosan-stearic acid copolymer (DC-SA) in combination with either tocopheryl polyethylene glycol succinate or dipalmitoylphosphatidylcholine for pulmonary drug delivery.Methods: A D-optimal design was employed for the optimization procedure, considering lipid/ polymer ratio, polymer concentration, drug/ polymer ratio, and lipid type as independent variables. Dependent variables included particle size, polydispersion index, zeta potential, drug encapsulation efficiency, and loading efficiency of the polymeric micelles. Additionally, the nebulization efficacy and cell viability of the optimal FP-loaded DC-SA micellar formulations were evaluated.Results: The mixed polymeric micelles were successfully prepared with properties falling within the desired ranges, resulting in four optimized formulations. The release of FP from the optimal systems exhibited a sustained release profile over 72 hours, with 70% of the drug still retained within the core of the micelles. The nebulization efficiency of these optimal formulations reached up to 63%, and the fine particle fraction (FPF) ranged from 41% to 48%. Cellular viability assays demonstrated that FP-loaded DC-SA polymeric micelles exhibited lower cytotoxicity than the free drug but were slightly more cytotoxic than empty mixed micelles.Conclusion: In conclusion, this study suggests that DC-SA/ lipid mixed micelles have the potential to serve as effective carriers for nebulizing poorly soluble FP.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"61-76"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139743044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choc-Tadalafil Fusion: Unlocking Solubility and Taste Harmony with β-CD-Infused Medicated Chocolate. 巧克力-他达拉非融合：ß-CD浸泡药用巧克力的溶解性和口味和谐。

Recent advances in drug delivery and formulation Pub Date : 2024-01-01 DOI: 10.2174/0126673878280254240312053406

Chetna Modi, Manobika Sinha, Vaishali Thakkar, Hardik Rana, Dipika Chavda

{"title":"Choc-Tadalafil Fusion: Unlocking Solubility and Taste Harmony with β-CD-Infused Medicated Chocolate.","authors":"Chetna Modi, Manobika Sinha, Vaishali Thakkar, Hardik Rana, Dipika Chavda","doi":"10.2174/0126673878280254240312053406","DOIUrl":"10.2174/0126673878280254240312053406","url":null,"abstract":"Objective: The primary limitations of tadalafil in treating erectile dysfunction are its low solubility and unpleasant bitter taste, which ultimately result in inadequate patient adherence. The present study aimed to develop and characterize a medicated chocolate formulation containing Tadalafil and β-CD (solubility enhancer) employing the concept of Design of Experiment (DoE) using chocolate as a user-friendly excipient.Methods: An inclusion complex was formulated by incorporating the drug into β-CD using the kneading method for solubility improvement and also as a taste masker for Tadalafil. The ratio of drug: β-CD inclusion complex was selected based on a phase solubility study. The inclusion complex was molded into a chocolate base and optimized using the DoE approach. Further, drug excipient interaction was evaluated by DSC and FTIR study.Results: Phase solubility study suggested a 1:1 ratio of Tadalafil: β-CD for better solubility. DSC spectra suggested the conversion of crystalline structure into an amorphous state which indicates improvement of the drug solubility. DSC and FTIR studies revealed that there was no significant interaction between drug and excipients. Next, %CDR (cumulative drug release) at 30 min revealed the immediate effect of Tadalafil from chocolate formulation and free drug analysis (an unbound drug with β-CD) proved reduced bitterness of the drug in the complex. Additionally, the medicated chocolate was found to be stable at room temperature as per stability study.Conclusion: β-CD was found to be a promising multifunctional excipient as a solubility enhancement carrier and taste masker for bitter-tasting drugs.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"110-119"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing Brain Drug Delivery: Buccal Transferosomes on the Verge of a Breakthrough. 脑部给药革命：口腔转移体即将取得突破。

Recent advances in drug delivery and formulation Pub Date : 2024-01-01 DOI: 10.2174/0126673878312336240802113811

Pavuluri Chandrasekhar, Rajaganapathy Kaliyaperumal

{"title":"Revolutionizing Brain Drug Delivery: Buccal Transferosomes on the Verge of a Breakthrough.","authors":"Pavuluri Chandrasekhar, Rajaganapathy Kaliyaperumal","doi":"10.2174/0126673878312336240802113811","DOIUrl":"10.2174/0126673878312336240802113811","url":null,"abstract":"The buccal cavity, also known as the oral cavity, is a complex anatomical structure that plays a crucial role in various physiological processes. It serves as a gateway to the digestive system and facilitates the initial stages of food digestion and absorption. However, its significance extends beyond mere digestion as it presents a promising route for drug delivery, particularly to the brain. Transferosomes are lipid-based vesicles that have gained significant attention in the field of drug delivery due to their unique structure and properties. These vesicles are composed of phospholipids that form bilayer structures capable of encapsulating both hydrophilic and lipophilic drugs. Strategies for the development of buccal transferosomes for brain delivery have emerged as promising avenues for pharmaceutical research. This review aims to explore the various approaches and challenges associated with harnessing the potential of buccal transferosomes as a means of enhancing drug delivery to the brain. By understanding the structure and function of both buccal tissue and transferosomes, researchers can develop effective formulation methods and characterization techniques to optimize drug delivery. Furthermore, strategic approaches and success stories in buccal transferosome development are highlighted, showcasing inspiring examples that demonstrate their potential to revolutionize brain delivery.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"18 4","pages":"262-275"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical Considerations, Applications, and Benefits of Organogels in Topical Drug Delivery Systems. 有机凝胶在局部给药系统中的技术考虑因素、应用和优势。

Recent advances in drug delivery and formulation Pub Date : 2024-01-01 DOI: 10.2174/0126673878277455240214110033

Abhishek Yadav, Vikas Jhawat, Rahul Pratap Singh, Sunita Chauhan, Rohit Dutt, Rajesh Goyal, Deependra Singh

{"title":"Technical Considerations, Applications, and Benefits of Organogels in Topical Drug Delivery Systems.","authors":"Abhishek Yadav, Vikas Jhawat, Rahul Pratap Singh, Sunita Chauhan, Rohit Dutt, Rajesh Goyal, Deependra Singh","doi":"10.2174/0126673878277455240214110033","DOIUrl":"10.2174/0126673878277455240214110033","url":null,"abstract":"Organogels represent semi-solid systems where an organic liquid phase is entrapped within a three-dimensional network formed by self-assembled, crosslinked, or entangled gelator fibers. These versatile materials find applications in a wide range of fields, including chemistry, pharmaceuticals, cosmetics, biotechnology, and food technology. Notably, in pharmacology, they serve as valuable platforms for drug and vaccine delivery, facilitating the transport of active ingredients through various routes such as transdermal, oral, and parenteral. However, their previous utility as drug delivery systems was hindered by the toxicity associated with the organic solvents used. The pharmacokinetics of medications delivered via organogels are primarily influenced by the distinctive properties of these materials, specifically their \"high permeability and poor aqueous solubility,\" which can impact the bioavailability of the drugs. Organogels can be employed topically or for the controlled release of medications through cutaneous administration and percutaneous absorption, expanding their scope of application beyond conventional drug delivery methods. Organogels hold significant promise as drug delivery vehicles due to their biocompatibility, non-irritating properties, and thermoremanent characteristics. They enable the formulation of diverse drug delivery systems by incorporating both hydrophilic and hydrophobic bioactive compounds within the gel matrix. This comprehensive review offers an overview of organogels, encompassing their nature, synthesis, characterization, and properties. Special attention is directed towards cutting-edge technologies employed in designing organogels as potential controlled delivery systems, with a focus on their emerging therapeutic applications.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0