Recent advances in drug delivery and formulation最新文献

{"title":"Drug Delivery through Co-amorphous Solid Dispersions: A Comprehensive and Updated Review on Physicochemical Characteristics and Biological Potential.","authors":"Shailender Mohan, Abdul Hafeez","doi":"10.2174/0126673878351727250409094214","DOIUrl":"https://doi.org/10.2174/0126673878351727250409094214","url":null,"abstract":"<p><p>New chemical entities with low aqueous solubility and permeability encounter significant challenges in formulation development. Low solubility is further accompanied by slow dissolution and poor bioavailability, which in turn leads to unpredictability in terms of both bioavailability and toxicity. Therefore, a significant amount of exertion is necessary to enhance solubility, dissolution, and eventually bioavailability. Additionally, to enhance the solubility properties and amorphous stability of BCS Class II medications and ultimately increase drug bioavailability, coamorphization has emerged as a promising strategy. Co-amorphous solid dispersions (CASD) are multi-component single-phase amorphous solid dispersions comprising two or more small molecules (usually known as co-formers) that might be a combination of drug-drug or drug-excipients. The selection of appropriate co-formers is critical, and the surface properties of co-amorphous formulations must be carefully evaluated, as they influence physical and chemical stability in addition to dissolution performance. Scaling up and processing co-amorphous formulations into the final dosage forms presents challenges that need to be addressed. This review will largely concentrate on the challenges, improvements, and innovations in physicochemical properties, biological characterization, and advancements of co-amorphous systems. This review will also furnish a comprehensive explanation of both established and emerging approaches utilized in the estimation of physicochemical attributes and characterization of CASD (in vitro and in vivo). Regarding CASD's potential to improve patient outcomes and therapeutic efficacy, it has emerged as a viable approach for drug candidates posing the problems of solubility and bioavailability. This approach has also increased the physical stability of drugs.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoquinoline Quaternary Alkaloid (IQA) Nano-dressings: A Comprehensive Review on Design Strategies, Therapeutic Applications, and Advancements in Transdermal Delivery for Chronic Wound Management.","authors":"Iram Jahan, Jiyaul Hak, Suraj Mandal, Shadab Ali, Sayad Ahad Ali, Nasiruddin Ahmad Farooqui","doi":"10.2174/0126673878330005250326060103","DOIUrl":"https://doi.org/10.2174/0126673878330005250326060103","url":null,"abstract":"<p><strong>Introduction: </strong>Transdermal delivery systems and wound dressings are critical components of modern healthcare, continually undergoing refinement to enhance efficacy, biocompatibility, and cost-effectiveness. Natural compounds, particularly those sourced from plants, have emerged as promising candidates for advancing these systems.</p><p><strong>Aim and objective: </strong>This study aims to investigate the design, therapeutic potentials, and comparative advancements of Isoquinoline Quaternary Alkaloid (IQA) nano-dressings.</p><p><strong>Materials and methods: </strong>The paper offers a comprehensive analysis of IQA's therapeutic potentials, fabrication techniques, and a comparative assessment against traditional wound care approaches, positioning IQA nano dressings as a paradigm shift in chronic wound management with the potential to enhance patient outcomes significantly.</p><p><strong>Result: </strong>This review delves into the transformative capabilities of dissolving Isoquinoline Quaternary Alkaloid (IQA) nano dressings, showcasing their potential to revolutionize chronic wound care beyond conventional therapies.</p><p><strong>Conclusion: </strong>Through the amalgamation of nanotechnology with IQA's intrinsic attributes, such as antimicrobial and anti-inflammatory properties, biocompatibility, and sustained drug release, these nanodressings exhibit promising outcomes in tissue regeneration while minimizing the need for frequent dressing changes.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Canagliflozin Hemihydrate-loaded Nanostructured Lipid Carriers Using Box-Behnken Design: Physicochemical Characterization, Ex-vivo Analysis, and In-vivo Pharmacokinetics.","authors":"Ravindra Kamble, Mohit Kumar, Vaibhav Shinde, C Bothiraja, Amol Muthal, Ashwin Mali","doi":"10.2174/0126673878343297250325060051","DOIUrl":"https://doi.org/10.2174/0126673878343297250325060051","url":null,"abstract":"<p><strong>Background: </strong>Type 2 Diabetes Mellitus (T2DM) is a prevalent metabolic disease significantly impacting healthcare, characterized by increased blood glucose levels from the average level due to insulin resistance or a lack of insulin production. Canagliflozin Hemihydrate (CGN) is one of the drugs of choice in the treatment of the disease. However, CGN belongs to BCS class IV making it difficult to formulate into suitable dosage form.</p><p><strong>Objective: </strong>The purpose of the present study was to systematically optimize and explore the potential of Nanostructured Lipid Carriers (NLCs) to improve the solubility and bioavailability of CGN.</p><p><strong>Methods: </strong>The emulsification and ultrasonication methods were used for the preparation of CGNloaded NLCs (CGN-NLCs) by employing the Box-Behnken design. The solid lipid to liquid lipid ratio (X1), surfactant concentration (X2), and sonication time (X3) were independent variables, while particle size (Y1) and entrapment efficiency (EE) (Y2) were selected as dependent variables.</p><p><strong>Results: </strong>The optimized batch showed particle size, zeta potential, Polydispersity Index (PDI), and EE of 221.2 ± 2.25 nm, -37 mV, 0.268 ± 0.024, and 98.2 ± 1.62%. The TEM revealed a homogeneous spherical shape of CGN-NLCs. Further, the DSC and XRD studies revealed reduced crystallinity with complete encapsulation of CGN in NLCs. The in vitro drug release study in simulated intestinal fluid (pH 6.8) showed significant CGN release from CGN-NLCs compared to CGN dispersion. Further, the ex vivo intestinal permeability and in vivo pharmacokinetic study showed a 1.33- fold and 3.81-fold increase in permeability and bioavailability along with improvement in Cmax, Tmax, and [AUC]0-24 as compared to CGN dispersion.</p><p><strong>Conclusion: </strong>Thus, the prepared CGN-NLCs could be a better viable option for T2DM with improved therapeutic efficacy.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Potential Use of Banana Peel Extract (Musa Species) as a New Polymer to Create Sustainable Materials and Innovative Drug Delivery Applications: An Updated Review.","authors":"Abhinav Trivedi, Shashi Verma, Ritesh Kumar Tiwari","doi":"10.2174/0126673878329777250311072638","DOIUrl":"https://doi.org/10.2174/0126673878329777250311072638","url":null,"abstract":"<p><strong>Background: </strong>The Musa genus, which includes bananas and plantains, offers a natural source of polymers. These polymers are finding applications in various industries, such as pharmaceuticals, where they are used as drug delivery systems. Additionally, Musa species are used in the creation of biopolymer composites, which are eco-friendly materials, and in the production of nanocellulose, a nanomaterial with promising properties. The versatility of Musa species makes it a valuable resource for developing sustainable materials and exploring new applications.</p><p><strong>Objective: </strong>This review aims to highlight recent advances in the applications of bio-polymers, biocomposites, nanocellulose, and novel drug delivery systems using Musa species.</p><p><strong>Method: </strong>The review likely examines existing literature, research studies, and experimental findings related to Musa species. It may analyze the characterization, treatment, and fabrication techniques of Musa species for these applications.</p><p><strong>Result: </strong>The multifaceted role of Musa species is emphasized, including its contribution to pharmaceutical advancements, eco-friendly polymer production, and innovative nanocellulose applications.</p><p><strong>Conclusion: </strong>In summary, this review paper explores how Musa species can be harnessed for various technological and scientific purposes, particularly in the fields of biopolymers, biocomposites, and drug delivery systems. The tropical plant's versatility and significance are underscored throughout the review.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmaceutical Manufacturing with Additive Technology: A Key Driver of Industry 4.0 Integration.","authors":"Manjoo Rani","doi":"10.2174/0126673878339327250227021950","DOIUrl":"https://doi.org/10.2174/0126673878339327250227021950","url":null,"abstract":"<p><p>Additive Manufacturing (AM) has emerged as a transformative force in the pharmaceutical industry, establishing itself as a cornerstone of Industry 4.0. This review explores the capability of 3D printing (3DP) technologies that facilitate the creation of individualized dosage forms, precise drug release control, and customized drug delivery systems. These innovations have significantly improved treatment outcomes and efficiency. The study identifies key challenges hindering the widespread adoption of AM in pharmaceuticals, including issues related to material selection, regulatory compliance, and process efficiency. By analyzing the interrelationship between AM and the fundamental pillars of Industry 4.0, we demonstrate how AM can optimize manufacturing costs, reduce production time, and minimize waste. The review also presents a strategic roadmap for future research, emphasizing the need for interdisciplinary collaboration to overcome regulatory barriers, develop medical-grade materials, and optimize manufacturing processes through advanced computational models and machine learning. This approach aims to accelerate the integration of AM into pharmaceutical manufacturing, ultimately enhancing personalized patient care and therapeutic effectiveness.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and Efficacy Assessment of a Combination of Polyherbal Facewash Gels for the Treatment of Propionibacterium acnes.","authors":"Suman Shrivastava, Saurabh Shrivastava, Rakesh Tirkey","doi":"10.2174/0126673878340038250224063731","DOIUrl":"https://doi.org/10.2174/0126673878340038250224063731","url":null,"abstract":"<p><strong>Introduction: </strong>Azadirachta indica is also referred to as margosa or neem. It is found throughout the Indian subcontinent. Aegle marmelos L. (family: Rutaceae), sometimes referred to as Bael in Hindi, is a crucial food plant in India. The fruit has traditionally been used for the treatment of inflammation, diabetes, respiratory disorders, diarrhea, and dysentery. Aegle marmelos fruits are abundant in coumarins, carotenoids, terpenoids, and flavonoids. The plant referred to as Camellia sinensis, or tea, is part of the Theaceae family and is often grown in tropical and subtropical regions.</p><p><strong>Objective: </strong>Acne is a prolonged inflammatory condition of the skin that has a significant negative influence on patients' quality of life all over the world. Although it is most commonly seen in young people, it may impact people of any age. Herbal anti-acne facewash gels were prepared using Carbopol 934 and extracts from Azadirachta indica, Aegle marmelos L., and Camellia sinensis.</p><p><strong>Materials and methods: </strong>The anti-acne facewash gel formulations were prepared in five different concentrations of 1%, 0.90%, 0.80%, 0.60%, and 0.50%, labeled as F1, F2, F3, F4, and F5, respectively.</p><p><strong>Results: </strong>The anti-acne properties of the formulations were evaluated. The outcomes demonstrated gels to have an excellent spreading coefficient, a great physical appearance, and be non-irritating. Standard commercial formulations were used to investigate the effectiveness.</p><p><strong>Conclusion: </strong>Unlike marketed formulations, the developed formulation 3 (F3) demonstrated an excellent spreading coefficient and good % extrudability. It has been shown to be a more potent and effective polyherbal anti-acne facewash gel for treating acne. In recent years, there has been a rise in the patenting of herbal formulations, and several in vitro and in vivo studies have produced scientific proof of their medicinal efficacy. This work discusses many patented herbal compositions and how they might be used therapeutically to treat different diseases.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation Development and Permeation Studies of Vancomycin Hydrochloride-Loaded Nanostructured Lipid Carrier Incorporated Thermoresponsive In-Situ Gel: A Box-Behnken Design Implemented Approach for Ocular Delivery in Endophthalmitis.","authors":"Amit Kumar Singh, Prabhat Kumar Upadhyay, Manish Kumar","doi":"10.2174/0126673878339109250219072409","DOIUrl":"https://doi.org/10.2174/0126673878339109250219072409","url":null,"abstract":"<p><strong>Background: </strong>Endophthalmitis, an inflammatory condition of the intraocular cavity, poses a significant challenge in ophthalmology due to its rapid progression and potential for vision loss. Conventional treatment modalities, such as systemic antibiotics or oral administration, often face limitations in achieving the required therapeutic levels at the target site. Hence, repeated intravitreal injections of antibiotics are currently the most preferred and recommended therapy for the management of endophthalmitis, which is an invasive technique and has certain shortcomings, elevated intraocular pressure, bleeding inside the eye, heightened likelihood of retinal detachment, retinal toxicity, and many more. Vancomycin is the first choice drug for the management of endophthalmitis and is given through intravitreal injection.</p><p><strong>Aim: </strong>The work aims to design, develop, and evaluate Vancomycin-loaded NLCs incorporated into an in-situ gel offering a new non-invasive therapeutic option for the management of Endophthalmitis.</p><p><strong>Method: </strong>The Vancomycin-loaded NLCs were successfully produced through a double emulsion/ solvent evaporation method employing a Box Behnken design. The optimized formulations were incorporated into an in-situ gel system by varying the concentration of Pluronic F127. The formulated gels were characterized for several parameters such as physical appearance, pH, viscosity, gelling strength, gelation temperature, in vitro release profile, and ex-vivo permeation study.</p><p><strong>Results: </strong>The result revealed that the formulation had a smooth appearance with a pH range from 7 to 7.5, was near the physiological pH of the eye, had content in the range of 97.5 ± 1.0 %to 99.2 ± 1.0 % and gelation temperature near body temperature. The data of release study formulation (VISG2) revealed sustained drug release compared to the control gel. The data ex vivo permeation study revealed that there was approximately a 3 folds increase in permeation of drug form (VISG2) compared to control gel (p˂0.0001) and significant (2.02folds) permeation compared to commercially available formulation (p˂0.0001).</p><p><strong>Conclusion: </strong>In conclusion, the Vancomycin-loaded NLCs incorporated in-situ gel may serve as a feasible alternative to invasive intravitreal injection for the management of endophthalmitis.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agomelatine Transdermal System Product Cycle: Development, Material/Process Screening, Optimization, Characterization, Delivery Mechanics and Irritation study on Rat.","authors":"Punitkumar Rathod, Anita Lalwani","doi":"10.2174/0126673878339412250213043818","DOIUrl":"https://doi.org/10.2174/0126673878339412250213043818","url":null,"abstract":"<p><strong>Introduction/objective: </strong>Agomelatine (AGT) is used for the treatment of major depressive disorder in adults. Agomelatine is highly susceptible to first-pass metabolism, and it has less than 5% oral bioavailability. Therapy for major depressive disorder extends for a long period and every time, additional caregivers are required to remind and manage the timely dosing of oral medicine to patients. In such cases, once a week, administration of agomelatine via transdermal patch dosage form provides major patient benefits and lowers overall therapy costs.</p><p><strong>Methods: </strong>An agomelatine transdermal patch was prepared using the solvent evaporation method using the LTE-S Werner Mathis AG coater and dryer. A patch was prepared using silicon adhesive after screening different pressure-sensitive adhesives like acrylate, polyisobutylene, and silicon. To make a crystal-free patch, the concentration of povidone k-29/32 was optimized in preliminary trials. To deliver the drug over a 7-day period, propylene glycol monolaurate (PGML) was identified from different penetration enhancers. Three factors optimization was carried out, like the concentration of povidone k-29/32, the concentration of PGML, and the mixing time of the blend using the Box Behnken design. 3D surface response curves and contour plots were derived using Design Expert and Minitab software. From overlay plots, design spaces were identified.</p><p><strong>Result: </strong>The optimized AGT patch has good adhesion properties along with a desirable flux of 4.63 μg/cm2/h on human cadaver skin along with a lower residual drug. There was no impact of heat flux studies on normal conditions, hence justifying the in-use condition of the patient population during hot showers, baths, and saunas. AGT Patch was also non-irritating in skin irritation studies performed on Wistar albino rats.</p><p><strong>Conclusion: </strong>It was concluded that agomelatine transdermal patches can be manufactured using silicon adhesive, povidone k-29/32, and propylene glycol monolaurate for the treatment of major depressive disorder and will be the most convenient and cost-effective therapy for the patient.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Chlorophyllin-Based Ag Nanoparticles to Target Escherichia coli and Staphylococcus aureus.","authors":"Sandipa Podder, Saikat Saha, Arnob Chakrovorty, Banani Bhattacharjee, Sabir Hossen Molla, Debojyoti Tarafdar, Sisir Nandi, Asmita Samadder","doi":"10.2174/0126673878360429250207063902","DOIUrl":"https://doi.org/10.2174/0126673878360429250207063902","url":null,"abstract":"<p><strong>Background: </strong>Bacteria resist drugs by employing new resistance mechanisms, leading to prolonged infection and complexity in therapeutic prognosis that concordantly decreases drug efficacy. In recent years, nanotechnology has gained immense popularity for the development of drug delivery systems to combat the global pharmaceutical crisis of multi-drug resistance.</p><p><strong>Objective: </strong>The present work aimed to focus on the green chemistry-based synthesis of silver nanoparticles (AgNPs) using the phytocompound chlorophyllin to form chlorophyllin precipitated silver nanoparticles (NCHL) and elucidate their application against two pathologically significant bacterial species Escherichia coli and Staphylococcus aureus.</p><p><strong>Methods: </strong>After optimization of experimental parameters, the physico-chemical properties of the synthesized NCHL were determined using AFM, DLS, XRD, UV-Vis, SPR, and FTIR, respectively. The interaction of NCHL with ct-DNA was assessed using CD spectroscopy. The antimicrobial activity of the synthesized NCHL against Escherichia coli and Staphylococcus aureus was examined by a disc diffusion susceptibility test.</p><p><strong>Results: </strong>The NCHL was ascertained to be ~53.57 nm in size, having a spherical shape, smooth topology, negative zeta potential of -23.94 mV, and PDI value of 0.495. A sharp peak for silver as SPR and an XRD peak depicted the best fit metallic crystal synchronization. FTIR analysis revealed the presence of a similar functional group in NCHL and chlorophyllin (CHL). CD spectroscopy with ct-DNA in the presence of NCHL showed a change in spectral shift of the ct-DNA, indicating strong ct-DNA-NCHL interaction. NCHL successfully inhibited the growth of both bacterial strains, indicating broad spectrum activity of the synthesized nanoparticles.</p><p><strong>Conclusion: </strong>The promising results indicated that NCHL could be utilized as a potential therapeutic molecule against Escherichia coli and Staphylococcus aureus infections and help in combating bacterial drug resistance, which is of high medical priority.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Extract-Loaded Herbal Patches: Assessment for Biomedical Application.","authors":"Shaheen Ansari, Pragya, Shikha Srivastava, Poonam Parashar","doi":"10.2174/0126673878330303241230102355","DOIUrl":"https://doi.org/10.2174/0126673878330303241230102355","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Medicinal plants like Moringa and Selaginella have gained attention for their potential in wound healing including antimicrobial and antioxidant attributes. Extracts from these plants have shown promise in accelerating wound healing processes, enhancing fibroblast cell proliferation and migration, and providing antioxidant benefits. The objective of this work was to assess the therapeutic potential of extracts loaded patches for biomedical applications.</p><p><strong>Methods: </strong>Selaginella bryopteris L. and Moringa oleifera Lam. extracts were prepared using the cold maceration method. The prepared extracts were evaluated for antibacterial activity and antioxidant potential. Additionally, patches were prepared using Polyvinyl Alcohol and Hydroxypropyl Methylcellulose as polymers and evaluated for in vitro release and cell viability and biocompatibility characteristics.</p><p><strong>Result: </strong>The extract of both plants showed good antioxidant potency against ascorbic acid. Antibacterial activity revealed that Selaginella and Moringa extracts and patches consistently outperformed P. aeruginosa, B. subtilis, and S. aureus at varying concentrations. Physiochemical evaluation of patches indicated good weight uniformity, thickness, and folding endurance, with slight moisture uptake. Drug release profiles showed significant results for all formulations. The results of cell viability for patches showed an increased cell proliferation and were nontoxic.</p><p><strong>Conclusion: </strong>The study suggests that both extract and patch show excellent antibacterial activity against Staphylococcus aureus. The characterization results showed that the patches were uniform in their drug content, weight, and thickness, and they also indicated the reproducibility of the method used. In the in vitro release study of Selaginella bryopteris L. and Moringa oleifera Lam. patches were fitted to the Higuchi model and also patches were found harmless for the cells as well as increased proliferation of cells.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}