Recent advances in drug delivery and formulation最新文献

{"title":"Precision Oncology: Advances in Drug Delivery and Imaging.","authors":"Suraj Kumar, Sathvik Belagodu Sridhar, Rishabha Malviya, Bhupendra G Prajapati","doi":"10.2174/0126673878332787241210102302","DOIUrl":"https://doi.org/10.2174/0126673878332787241210102302","url":null,"abstract":"<p><p>The development of precise and reliable cancer treatments has been a long-standing goal in oncology. Conventional therapies often affect healthy tissues, leading to significant side effects. To overcome these challenges, researchers are exploring new methodologies that combine advanced drug delivery systems with state-of-the-art imaging technologies to target tumors more effectively. This study aims to investigate a novel approach that integrates smart drug delivery systems with real-time imaging modalities. The goal is to enhance the targeted delivery of therapeutic agents to cancer cells, minimizing damage to healthy tissues while improving the overall efficacy of cancer treatments. Smart drug delivery systems are designed to transport medications directly to tumor sites, enhancing treatment precision. When combined with real-time imaging tools such as MRI, CT, PET, and molecular imaging, these systems offer real-time data on the tumor's location, size, and response to treatment. This allows for immediate adjustments in therapy, ensuring optimal drug delivery and reducing side effects. However, the implementation of this approach also faces challenges, including the need for stringent safety protocols and adherence to regulatory standards. The integration of advanced drug delivery systems with cutting-edge imaging technologies presents a promising approach to cancer therapy. By enabling more precise treatment targeting and reducing adverse effects, this strategy has the potential to significantly improve patient outcomes in the fight against cancer.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Nanostructured Lipid Carriers: Innovations and Applications in Breast Cancer Treatment.","authors":"Prathamesh Mirajkar, Priyanka Ahlawat, Asha Patel, Shruti Patel, Drishti Panjwani","doi":"10.2174/0126673878313086241031154146","DOIUrl":"https://doi.org/10.2174/0126673878313086241031154146","url":null,"abstract":"<p><p>Nanostructured Lipid Carriers (NLCs) represent a promising advancement in the treatment of breast cancer, addressing the significant challenges posed by conventional chemotherapy, such as poor drug solubility, short half-lives, and high toxicity. This review delves into the potential of NLCs to overcome these limitations, highlighting their unique structure comprising a solid and lipid liquid core stabilized by surfactants. By examining diverse lipid blends used in the preparation of NLCs, the article emphasizes their suitability for targeted drug delivery. Various facets of NLC configuration, categorization, composition, and formulation approaches are systematically explored to provide a comprehensive understanding of their attributes. The findings reveal that NLCs possess a high capacity for lipophilic drugs and offer advantages over traditional lipid-based nanocarriers. The review underscores the pivotal role of NLCs in enhancing drug delivery efficiency for breast cancer therapy while minimizing systemic toxicity. Conclusively, this review positions NLCs as a key player in the evolution of drug delivery systems for breast cancer treatment, providing a detailed outlook on their transformative potential and contributing to a nuanced understanding of their significance in advancing the field of breast cancer treatment.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan: Microsphere Formulation and Characterization for Slow - release Prebiotic Activities in Gut Microbiota Remodelling.","authors":"Sunny Kumar, Zeel Bhatia, Sriram Seshadri","doi":"10.2174/0126673878305913241122114556","DOIUrl":"https://doi.org/10.2174/0126673878305913241122114556","url":null,"abstract":"<p><strong>Introduction: </strong>Chitosan is a biocompatible, mucoadhesive, and biodegradable polymer widely used for various purposes due to its biological activity and safety. The current study aimed to formulate Chitosan microspheres and conduct an in-vitro evaluation of their cytotoxicity. The concept is focused on targeted gut delivery and biological activities in gut microbiota remodelling.</p><p><strong>Methods: </strong>The formulations were comprehensively characterized, encompassing SEM for surface morphology, particle size analysis, and FT-IR for structural understanding. Along with biological activity and cytotoxicity studies, dissolution efficiency was considered to understand release kinetics potential and accelerated stability studies to predict formulation shelf-life.</p><p><strong>Results: </strong>The formulation showed smooth spherical surface morphology with an average size range of 30.0 ± 5.0 μm and a charge of 20.35 ± 0.35 mV. Further, functional and thermal properties were determined using FT-IR and DSC, respectively. The microspheres showed a potent prebiotic potential in gut flora isolated and processed from a faecal sample of Wistar rats with prolonged release characteristics in the dissolution study. A cytotoxicity study using rat intestinal epithelial cells (IEC6) indicated that 40 mg /kg of microspheres could be considered an optimal dose for an in-vivo study.</p><p><strong>Conclusion: </strong>The formulation demonstrated promising pharmaceutical applicability due to its potential prebiotic nature and slow release into the gut environment. After a thorough in vivo study, the microspheres can be broadly used to restore gut dysbiosis due to their potential prebiotic activities in various diseases and disorders, including but not limited to obesity, type-2 diabetes, cardiometabolic disease, and non-alcoholic fatty liver disease.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Ionic Surfactant Vesicles (Niosomes): Structure, Functions, Classification and its Advances in Enhanced Drug Delivery.","authors":"PavanKumar Padarthi, Kalvimoorthi V, Ranadheer Reddy Challa, Bhaskar Vallamkonda, Neelima Grandhe, Lakshman Kumar Dogiparthi, Rajaganapathy Kaliyaperumal","doi":"10.2174/0126673878322982241126103404","DOIUrl":"https://doi.org/10.2174/0126673878322982241126103404","url":null,"abstract":"<p><p>Non-ionic surfactant vesicles, commonly known as niosomes, have gained significant attention in the field of drug delivery because of their unique properties and advantages. Niosomes are self-assembled vesicles composed of non-ionic surfactants and cholesterol that can entrap both hydrophilic and hydrophobic drugs within their aqueous core or bilayer. This versatile drug delivery system offers improved stability, prolonged release profiles, reduced toxicity, and enhanced efficacy for a wide range of therapeutic agents. This comprehensive article delves into the structure, function, classification, and advances in niosomes for enhanced drug delivery. It explores various nonionic surfactants used for niosome formulation and discusses their impact on encapsulation efficiency and stability. Moreover, it highlights the application of niosomes in the delivery of small molecules, proteins, and plant-derived natural products. This article provides an overview of the different formulation methods employed for niosome preparation and discusses recent advancements that have expanded their potential applications in targeted drug delivery systems.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Burn Infections With Topical Delivery of Positively Charged Norfloxacin-Loaded Lipid-Polymer Hybrid Nanoparticles.","authors":"Kamilia H A Mohammed, Fatma Rasslan, Marwa A Abd El-Fattah, Seham Shawky, Omnya M Amin, Heba A Eassa","doi":"10.2174/0126673878316672241122041157","DOIUrl":"https://doi.org/10.2174/0126673878316672241122041157","url":null,"abstract":"<p><strong>Background: </strong>Norfloxacin (NFX) is a wide-spectrum antibacterial agent that suffers from low water solubility and first-pass metabolism. This diminishes its oral bioavailability by 60-70%.</p><p><strong>Objective: </strong>This work aims to formulate a topical gel of NFX-loaded lipid polymer hybrid nanoparticles (NFX-LPHNPs) that combine the merits of liposomes and polymeric nanoparticles to overcome these problems.</p><p><strong>Methods: </strong>NFX-LPHNPs formulations were developed using Precirol ATO (lipid) and Eudragit RL100 (polymer). They were characterized for particle size, uniformity of distribution, entrapment efficiency, zeta potential, and in-vitro release. Box-Behnken design was applied to study sequentially different variables' impact on material attributes. Then the optimized formula was re-evaluated, and incorporated in an HPMC-gel formulation. The gel formulation was evaluated for its physical properties, in vitro-release, and antibacterial activity.</p><p><strong>Results: </strong>NFX-LPHNPs exhibited particle sizes ranging from 28.92 to 730.30 nm. Particles were uniformly distributed with a positively charged surface (indicated by zeta potential with values from +3.91 to +60.2 mV). Formulations showed a % cumulative drug release of 87.9-100% in 8 h. The optimized formula showed a satisfied fit of measured-to-predicted responses with 159 nm particle size, 92.61% release and 79.2% entrapment efficiency. Gel formulation showed a sustained release over 24h. Antibacterial testing against Staphylococcus aureus, Acinetobacter baumannii and Pseudomonas aeruginosa revealed enhanced activity of NFX-LPHNPs against these pathogens compared to bare NFX loaded gel.</p><p><strong>Conclusion: </strong>These results illustrated the high potential of lipid-polymer hybrid nanoparticles to improve NFX activity against resistant pathogens common in burn infections. Moreover, the topical application helps overcome Norfloxacin oral-associated problems.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Oral Bioavailability and Stability Studies of Loratadine Tablets\u0000Based on Solid Dispersion of Modified Ziziphus spina-christi Gum","authors":"Ameen M. Alwossabi, E. S. Elamin, Elhadi M. M. Ahmed, Eman A. Ismail, A. Ashour, W. Osman, A. E. Sherif, Amira Mira, Rawan Bafail, Yusra Saleh Andijani, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Mohammed Abdelrahman","doi":"10.2174/0126673878288535240530113418","DOIUrl":"https://doi.org/10.2174/0126673878288535240530113418","url":null,"abstract":"\u0000\u0000Solid dispersion is a common technique used for solubility enhancement of\u0000poorly soluble drugs.\u0000\u0000\u0000\u0000In this study, loratadine (LOR), a class II biopharmaceutical classification system (BCS),\u0000was formulated as solid dispersion tablets using modified Ziziphus spina-christi gum (MZG) as a\u0000carrier.\u0000\u0000\u0000\u0000The solvent evaporation method was used for LOR-MZG solid dispersion (SD) preparation.\u0000A variety of tests were conducted to characterize and optimize the formulation. Solubility,\u0000Fourier transform infrared (FTIR) analysis, Differential Scanning Calorimetry (DSC), X-Ray Diffraction\u0000(X-RD), and Scanning Electron Micrograph (SEM) of solid dispersions were carried out.\u0000Accelerated stability testing and pharmacokinetic studies of formulated tablets were also performed\u0000using albino Wistar rats.\u0000\u0000\u0000\u0000Solid dispersion improved the solubility of LOR by 51 folds. FTIR spectra excluded drugpolymer\u0000interactions, and results obtained by DSC, X-RD, and SEM proved the transition from the\u0000crystalline to the amorphous state. The stability of LOR-MZG solid dispersion tablets was found to\u0000be better when the Alu-Alu package was used. The pharmacokinetics of LOR-MZG compared to\u0000MZG-free loratadine tablets (LOR pure) and commercial loratadine tablets (LOR-TM) following\u0000oral administration revealed that about 6 folds and 10 folds bioavailability were achieved with\u0000LOR-MZG compared to LOR pure and LOR-TM, respectively.\u0000\u0000\u0000\u0000Such promising results encourage more studies on MZG to be used for improving the\u0000aqueous solubility and bioavailability of a wide range of poorly soluble drugs.\u0000","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"22 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Development of Enteric-Coated Tablets of the Probiotic Lactobacillus fermentum LF-G89: A Possible Approach to Intestinal Colonization.","authors":"Paola Spínello, Pamela do Nascimento, Verônica Cristina da Silveira, Tatiana Staudt, Hamid Omidian, Ana Caroline Tissiani, Charise Dellazen Bertol","doi":"10.2174/0126673878286133240418114629","DOIUrl":"https://doi.org/10.2174/0126673878286133240418114629","url":null,"abstract":"BACKGROUND\u0000Probiotics must be able to withstand the demanding environment of the gastrointestinal system to adhere to the intestinal epithelium, promoting health benefits. The use of probiotics can prevent or attenuate the effects of dysbiosis that have a deleterious effect on health, promoting anti-inflammatory, immunomodulatory, and antioxidant effects.\u0000\u0000\u0000OBJECTIVE\u0000The aim of the study was to prepare tablets containing Lactobacillus fermentum LF-G89 coated with 20% Acryl-Eze II® or Opadry® enteric polymers.\u0000\u0000\u0000METHOD\u0000Tablet dissolution was evaluated under acidic and basic pH conditions, and aliquots of the dissolution medium were plated to count the Colony-forming Units (CFU). The free probiotic's tolerance to pH levels of 1.0, 2.0, 3.0, and 4.0, as well as to pepsin, pancreatin, and bile salts, was assessed.\u0000\u0000\u0000RESULTS\u0000The probiotic was released from tablets coated after they withstood the pH 1.2 acid stage for 45 minutes. The release was higher with the Acry-Eze II® polymer in the basic stage. The amount of CFU of free probiotics at pH 1.0 to 4.0 as well as pepsin reduced over time, indicating cell death. Conversely, the CFU over time with pancreatin and bile salts increased, demonstrating the resistance of L. fermentum to these conditions due to hydrolases.\u0000\u0000\u0000CONCLUSION\u0000Both coating polymers were able to withstand the acid step, likely ensuring the release of the probiotic in the small intestine, promoting colonization. Coating with enteric material is a simple and effective process to increase the survival of probiotics, offering a promising alternative to mitigate the negative effects of the dysbiosis process.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"51 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crisaborole-Enthused Glycerosomal Gel for an Augmented Skin Permeation.","authors":"Ragini Singh, Anshu Singh, Dipti Srivastava, Zeeshan Fatima, Ramani Prasad","doi":"10.2174/0126673878283299240418112318","DOIUrl":"https://doi.org/10.2174/0126673878283299240418112318","url":null,"abstract":"BACKGROUND\u0000Crisaborole (CB), a boron-based compound, is the first topical PDE4 inhibitor to be approved by the US Food and Drug Administration (2016) for the treatment of Atopic Dermatitis. It is marketed as a 2% ointment (Eucrisa, Pfizer). However, CB is insoluble in water; therfore, CB glycersomes were formulated to enhance its permeation flux across the skin.\u0000\u0000\u0000OBJECTIVE\u0000We developed a glycerosomal gel of CB and compared its in vitro release and permeation flux with the 2% conventional ointment.\u0000\u0000\u0000METHODS\u0000Glycerosomes were prepared using a thin film hydration method employing CB, soya phosphatidylcholine, and cholesterol. The formed film was further hydrated employing a mixture of phosphate buffer pH 7.4 /glycerin solution containing varying percentages (20,30, 40, and 50 %) of glycerol. The glycerosomes obtained were characterized by their size, polydispersity index (PDI), and Zeta potential. The entrapment efficiency of the optimized formulation (F 1) was determined. The in vitro release of F1 was compared with its 2% conventional ointment. F1 was further incorporated into carbopol 934 P gel. The gel was characterized by pH, viscosity, spreadability, and drug content. The permeability flux of the glycerosomal gel was compared with its 2% conventional ointment.\u0000\u0000\u0000RESULTS\u0000The optimized CB glycerosomes had a vesicle size of 137.5 ± 50.58 nm, PDI 0.342, and zeta potential -65.4 ± 6.75 mV. CB glycerosomal gel demonstrated a 2.13-fold enhancement in the permeation flux.\u0000\u0000\u0000CONCLUSION\u0000It can thereby be concluded that glycerosomes can be an effective delivery system to enhance the penetration of CB across the skin.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"33 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation Consideration of Medicated Chewing Gum: A Review.","authors":"Kishan Bobe, Yoesh Suryawanshi, Virendra Gomase, Muizz Kachhi, Chandrashekhar Bobade","doi":"10.2174/0126673878281000240411073412","DOIUrl":"https://doi.org/10.2174/0126673878281000240411073412","url":null,"abstract":"In recent times, technological and scientific advances have been made in studying and developing orally delivered medication. Such studies demonstrate the importance of the oral route among patients. The accuracy of drug delivery is very important to achieve a successful therapeutic effect in the case of various pharmaceutical products. A novel drug delivery system adds new benefits or advantages to a drug. This review covers all the aspects of medicated chewing gum (MCG) as a new drug delivery method, including the benefits and drawbacks, manufacturing methods, type of MCG, composition of chewing gum, evaluation parameters, factors that affected the release of API, its pharmaceutical significance, various marketed chewing gum and chewing gum packaging. Chewing gum as a drug delivery system has the potential to cure or prevent various indications, such as analgesic, CNS stimulation, smoking cessation, motion sickness, and treatment and prevention of dental caries or gingivitis. Pharmaceutical distribution to the oral mucosa can be made more convenient and enticing with the help of MCG. Compared to conventional techniques, this delivery system has a longer-lasting effect, which makes it a viable option for treating digestive problems, headaches, migraines, coughing, anxiety, and allergies.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Impact of Naringenin-Loaded Solid Lipid Nanoparticles on RIN5F Pancreatic β Cells <i>via</i> Autophagy Blockage.","authors":"Pardis Mohammadi Pour, Zeinab Nouri, Dariush Ghasemi, Soraya Sajadimajd, Mohammad Hosein Farzaei","doi":"10.2174/0126673878297658240804192222","DOIUrl":"10.2174/0126673878297658240804192222","url":null,"abstract":"<p><strong>Background: </strong>Autophagy plays a crucial role in modulating the proliferation of cancer diseases. However, the application of Naringenin (Nar), a compound with potential benefits against these diseases, has been limited due to its poor solubility and bioavailability.</p><p><strong>Objective: </strong>This study aimed to develop solid lipid nanoparticles (Nar-SLNs) loaded with Nar to enhance their therapeutic impact.</p><p><strong>Methods: </strong><i>In vitro</i> experiments using Rin-5F cells exposed to Nar and Nar-SLNs were carried out to investigate the protective effects of Nar and its nanoformulation against the pancreatic cancer cell line of Rin-5F.</p><p><strong>Results: </strong>Treatment with Nar and Nar-SLN led to an increase in autophagic markers (Akt, LC3, Beclin1, and ATG genes) and a decrease in the level of miR-21. Both Nar and Nar-SLN treatments inhibited cell proliferation and reduced the expression of autophagic markers. Notably, Nar-SLNs exhibited greater efficacy compared to free Nar.</p><p><strong>Conclusion: </strong>These findings suggest that SLNs effectively enhance the cytotoxic impact of Nar, making Nar-SLNs a promising candidate for suppressing or preventing Rin-5F cell growth.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"18 4","pages":"304-314"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}