Recent advances in drug delivery and formulation最新文献

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Nanoemulsion-Based Strategy for Maximizing Nitrofurantoin Absorption: In-vitro and In-vivo Investigations. 基于纳米乳液的呋喃妥因最大吸收策略：体外和体内研究。

Recent advances in drug delivery and formulation Pub Date : 2023-01-01 DOI: 10.2174/0126673878259374230921045432

Gouri Prasad Nanda, Mrunali Patel, Rashmin Patel

{"title":"Nanoemulsion-Based Strategy for Maximizing Nitrofurantoin Absorption: In-vitro and In-vivo Investigations.","authors":"Gouri Prasad Nanda, Mrunali Patel, Rashmin Patel","doi":"10.2174/0126673878259374230921045432","DOIUrl":"10.2174/0126673878259374230921045432","url":null,"abstract":"Background: The main objective of the current research work is to improve the absorption of Nitrofurantoin (NFT) by minimizing gastrointestinal (GI) intolerance and variations in its absorption by formulating the drug into a nanoemulsion (NE).Method: Based on the highest saturation solubility of NFT, soybean oil, transcutol HP, and labrafil M1944CS were selected as oil, co-surfactant, and surfactant, and a Smix ratio of 1:2 was selected based on pseudoternary phase diagrams. The formulation prepared with an equal ratio of oil and Smix exhibited the lowest globule size, highest zeta potential, and higher drug release and hence was selected for further evaluation.Result: Optimized formulation (NF5) showed improved membrane permeability against pure drug suspension (2.30 times) and marketed suspension formulation (1.43 times). NF5 exhibited similar % cell viability and % cell toxicity in Caco-2 cell lines compared to the marketed suspension. The relative bioavailability of NFT-NE was enhanced by 1.10 and 1.17 times compared to the marketed and pure drug suspension, respectively.Conclusion: Thus, it can be concluded that the optimized nanoemulsion formulation of NFT exhibited improved membrane permeability, comparable cell viability, and increased relative bioavailability. These findings suggest the potential of the nanoemulsion approach as a strategy to overcome the variability of oral absorption and GI intolerance of NFT.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"241-253"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Concise Review of Carbon Dots and their Pharmaceutical and Biomedical Applications. 碳点及其药物和生物医学应用简评。

Recent advances in drug delivery and formulation Pub Date : 2023-01-01 DOI: 10.2174/0126673878237423230919070049

Ashish Kumar Parashar, Krishna Kumar Verma, Rajeev Kumar, Vandana Arora

{"title":"A Concise Review of Carbon Dots and their Pharmaceutical and Biomedical Applications.","authors":"Ashish Kumar Parashar, Krishna Kumar Verma, Rajeev Kumar, Vandana Arora","doi":"10.2174/0126673878237423230919070049","DOIUrl":"10.2174/0126673878237423230919070049","url":null,"abstract":"For the last two decades, carbon dots, a revolutionary type of carbon nanomaterial with less than 10 nm diameter, have attracted considerable research interest. CDs exhibit various physicochemical properties and favorable characteristics, including excellent water solubility, unique optical properties, low cost, eco-friendliness, an abundance of reactive surface groups, and high stability. As a result, the synthesis of CDs and their applications in pharmaceutical and related disciplines have received increasing interest. Since CDs are biocompatible and biodegradable with low toxicity, they are a promising healthcare tool. CDs are extensively employed for numerous applications to date, including theranostics, bioimaging, drug delivery, biosensing, gene delivery, cancer therapy, electrochemical biosensing, and inflammatory treatment. This comprehensive review aims to explore various synthesis methods of carbon dots, including top-down and bottom-up approaches, as well as highlight the characterization techniques employed to assess their physicochemical and biological properties. Additionally, the review delves into carbon dots' pharmaceutical and biomedical applications, showcasing their potential in drug delivery, bioimaging, diagnostics, and therapeutics.","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"183-192"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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