Advancements and Challenges in Gastroretentive Drug Delivery Systems: A Comprehensive Review of Research Innovation, Technologies, and Clinical Applications.

Abstract

Gastroretentive drug delivery systems (GRDDS) have emerged as a focal point of research and development, attracting substantial attention due to their potential to revolutionize oral drug administration. Their ability to enhance the bioavailability and therapeutic effectiveness of orally administered medications, particularly those with narrow absorption windows or susceptible to gastrointestinal degradation, has spurred considerable interest. By extending gastric residence time, GRDDS offers a pathway to optimize drug absorption while minimizing dosing frequency, thereby improving patient compliance and therapeutic outcomes. This comprehensive review delves into the diverse array of gastroretentive drug delivery approaches, providing in-depth insights into their classification, mechanisms of retention, recent innovations with patented technologies, and existing marketed formulations of the domain. Furthermore, it meticulously examines the challenges inherent in GRDDS implementation and elucidates effective strategies to surmount them. From novel formulation techniques to ingenious drug-carrier systems, this review explores the multifaceted landscape of GRDDS development, shedding light on promising avenues for future research and development. By advancing current knowledge and anticipating future trends, this review serves as a valuable resource for researchers, clinicians, and pharmaceutical professionals navigating the dynamic terrain of gastroretentive drug delivery.