Recent advances in drug delivery and formulation最新文献

{"title":"Precision Oncology: Advances in Drug Delivery and Imaging.","authors":"Suraj Kumar, Sathvik Belagodu Sridhar, Rishabha Malviya, Bhupendra G Prajapati","doi":"10.2174/0126673878332787241210102302","DOIUrl":"10.2174/0126673878332787241210102302","url":null,"abstract":"<p><p>The development of precise and reliable cancer treatments has been a long-standing goal in oncology. Conventional therapies often affect healthy tissues, leading to significant side effects. To overcome these challenges, researchers are exploring new methodologies that combine advanced drug delivery systems with state-of-the-art imaging technologies to target tumors more effectively. This study aims to investigate a novel approach that integrates smart drug delivery systems with real-time imaging modalities. The goal is to enhance the targeted delivery of therapeutic agents to cancer cells, minimizing damage to healthy tissues while improving the overall efficacy of cancer treatments. Smart drug delivery systems are designed to transport medications directly to tumor sites, enhancing treatment precision. When combined with real-time imaging tools such as MRI, CT, PET, and molecular imaging, these systems offer real-time data on the tumor's location, size, and response to treatment. This allows for immediate adjustments in therapy, ensuring optimal drug delivery and reducing side effects. However, the implementation of this approach also faces challenges, including the need for stringent safety protocols and adherence to regulatory standards. The integration of advanced drug delivery systems with cutting-edge imaging technologies presents a promising approach to cancer therapy. By enabling more precise treatment targeting and reducing adverse effects, this strategy has the potential to significantly improve patient outcomes in the fight against cancer.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"194-220"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes from Different Sources in Promoting Wound Healing.","authors":"Ruiqi Yi, Xiaolu Yang, Ya Tian, Fen Zhang, Umer Anayyat, Xiaoting Zhang, Xiaomei Wang","doi":"10.2174/0126673878366772250116082511","DOIUrl":"10.2174/0126673878366772250116082511","url":null,"abstract":"<p><p>Exosomes are nanoscale extracellular vesicles with various biological activities that can accelerate wound healing by regulating inflammatory responses, promoting cell proliferation and angiogenesis, and other mechanisms. Among them, plant and animal exosomes have demonstrated unique advantages due to their biological characteristics. Plant exosomes have gradually become a research hotspot due to their wide source, high biosafety, and low production cost, demonstrating significant pro-healing potential. In addition, animal exosomes, especially human-derived stem cell exosomes, have shown excellent results in promoting wound repair and have become the focus of clinical research. This review explores the mechanism of action of these exosomes and their application prospects in wound healing, providing theoretical support for future research and clinical applications.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"221-234"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Extract-Loaded Herbal Patches: Assessment for Biomedical Application.","authors":"Shaheen Ansari, Pragya, Sikha Srivastava, Poonam Parashar","doi":"10.2174/0126673878330303241230102355","DOIUrl":"10.2174/0126673878330303241230102355","url":null,"abstract":"<p><strong>Introduction: </strong>Medicinal plants like <i>Moringa</i> and <i>Selaginella</i> have gained attention for their potential in wound healing including antimicrobial and antioxidant attributes. Extracts from these plants have shown promise in accelerating wound healing processes, enhancing fibroblast cell proliferation and migration, and providing antioxidant benefits. The objective of this work was to assess the therapeutic potential of extracts loaded patches for biomedical applications.</p><p><strong>Methods: </strong><i>Selaginella bryopteris L.</i> and <i>Moringa oleifera Lam</i>. extracts were prepared using the cold maceration method. The prepared extracts were evaluated for antibacterial activity and antioxidant potential. Additionally, patches were prepared using polyvinyl alcohol and hydroxypropyl methylcellulose as polymers and evaluated for <i>in vitro</i> release, cell viability and biocompatibility characteristics.</p><p><strong>Result: </strong>The extract of both plants showed good antioxidant potency against ascorbic acid. Antibacterial activity revealed that <i>Selaginella</i> and <i>Moringa</i> extracts as well as patches consistently outperformed P. aeruginosa, B. subtilis, and S. aureus at varying concentrations. Physiochemical evaluation of patches indicated good weight uniformity, thickness, and folding endurance, with slight moisture uptake. Drug release profiles showed significant results for all formulations. The results of cell viability for patches showed an increased cell proliferation and were nontoxic.</p><p><strong>Conclusion: </strong>The study suggests that both extract and patch show excellent antibacterial activity against Staphylococcus aureus. The characterization results showed that the patches were uniform in their drug content, weight, and thickness, and they also indicated the reproducibility of the method used. In the <i>in vitro</i> release study of <i>Selaginella bryopteris L.</i> and Moringa oleifera Lam. patches were fitted to the Higuchi model and also patches were found harmless for the cells as well as increased proliferation of cells.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"156-167"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and Efficacy Assessment of a Combination of Polyherbal Facewash Gels for the Treatment of <i>Propionibacterium acnes</i>.","authors":"Suman Shrivastava, Saurabh Shrivastava, Rakesh Tirkey","doi":"10.2174/0126673878340038250224063731","DOIUrl":"10.2174/0126673878340038250224063731","url":null,"abstract":"<p><strong>Introduction: </strong>Azadirachta indica is also referred to as margosa or neem. It is found throughout the Indian subcontinent. <i>Aegle marmelos</i> L. (family: <i>Rutaceae</i>), sometimes referred to as Bael in Hindi, is a crucial food plant in India. The fruit has traditionally been used for the treatment of inflammation, diabetes, respiratory disorders, diarrhea, and dysentery. <i>Aegle marmelos</i> fruits are abundant in coumarins, carotenoids, terpenoids, and flavonoids. The plant referred to as <i>Camellia sinensis</i>, or tea, is part of the <i>Theaceae</i> family and is often grown in tropical and subtropical regions. Acne is a prolonged inflammatory condition of the skin that has a significant negative influence on patients' quality of life all over the world. Although it is most commonly seen in young people, it may impact people of any age. Herbal anti-acne facewash gels were prepared using Carbopol 934 and extracts from <i>Azadirachta indica, Aegle marmelos</i> L., and <i>Camellia sinensis</i>.</p><p><strong>Methods: </strong>The anti-acne facewash gel formulations were prepared in five different concentrations of 1%, 0.90%, 0.80%, 0.60%, and 0.50%, labeled as F1, F2, F3, F4, and F5, respectively.</p><p><strong>Results: </strong>The anti-acne properties of the formulations were evaluated. The outcomes demonstrated gels to have an excellent spreading coefficient, a great physical appearance, and be non-irritating. Standard commercial formulations were used to investigate the effectiveness.</p><p><strong>Conclusion: </strong>Unlike marketed formulations, the developed formulation 3 (F3) demonstrated an excellent spreading coefficient and good % extrudability. It has been shown to be a more potent and effective polyherbal anti-acne facewash gel for treating acne. In recent years, there has been a rise in the patenting of herbal formulations, and several <i>in vitro</i> and <i>in vivo</i> studies have produced scientific proof of their medicinal efficacy. This work discusses many patented herbal compositions and how they might be used therapeutically to treat different diseases.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"251-261"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Characterization of Vitamin C Aquasomes.","authors":"Fernando Bwalya, Liban Barre, Murat Erdem, Mustafa Sinan Kaynak","doi":"10.2174/0126673878352032250325002719","DOIUrl":"10.2174/0126673878352032250325002719","url":null,"abstract":"<p><strong>Introduction: </strong>Aquasomes are water-based nanocarriers widely used in pharmaceutical applications for the delivery of various molecules.</p><p><strong>Aim: </strong>This research examines the preparation and characterization of vitamin C-loaded aquasomes.</p><p><strong>Methods: </strong>The aquasomes were prepared by using colloidal precipitation and sonication methods. Various characterizations, including particle size, polydispersity index (PDI), and zeta potential, were performed on the core, lactose coating, and final formulation of vitamin C-loaded aquasomes. Further analysis was carried out using Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), and Differential Scanning Calorimetry (DSC). Additionally, the in vitro release profile of vitamin C from the aquasomes was compared with that of a commercially available vitamin C formulation and a shelf-life analysis was conducted.</p><p><strong>Results: </strong>The addition of lactose and vitamin C led to an increase in the particle size of the core, from 348 nm to 654 nm, while the zeta potential decreased from -31.9 mV to -12.8 mV. The percent payload was found to be 52.63%. TGA results indicated weight loss in HAP, suggesting thermal degradation, while DSC analysis revealed the melting points of lactose sugars and the thermal behavior of vitamin C. The dissolution results show that vitamin C-loaded aquasomes released 4- 6% more of the vitamin in acidic (pH 1.2) and phosphate buffer (pH 6.8) environments over 90 minutes, compared to commercial vitamin C products. The aquasomes exhibited excellent stability, maintaining over 90% of their potency over 90 days.</p><p><strong>Conclusion: </strong>Vitamin C-loaded aquasomes have been successfully prepared and demonstrated better performance compared to commercial products. This study suggests that aquasomes keep vitamin C stable and may improve its absorption in the body.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"19 3","pages":"290-302"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12606598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Rheumatoid Arthritis By Development of Nanocarriers and their Significance Over Conventional Dosage Forms.","authors":"Hafsa Khan, Nita Yadav, Shipra Sharma, Reetika Rawat","doi":"10.2174/0126673878324613240805065651","DOIUrl":"https://doi.org/10.2174/0126673878324613240805065651","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid Arthritis is one of the most common auto-immune diseases that cause inflammation. It is characterized by pain, stiffness, tenderness, and swelling in joints, which may even lead to heart, lungs, or brain-related problems where age is the major factor involved, as around 55% older adults have been affected by it. Treatments including non-steroidal anti- inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs) etc., that are modified and formulated as nanocarriers for enhanced bioavailability, majorly aim at enhancing the rate and extent of drug reaching the bloodstream such as solid-lipid nanoparticles, liposomes, polymeric- micelles, polymeric nanoparticles etc. are used in the management of rheumatoid arthritis.</p><p><strong>Methods: </strong>The following tools (Pubmed, Scopus, Google search engine, Google Scholar, Medline Search Engine, Elsevier) were used in the literature search.</p><p><strong>Results: </strong>Through the literature review, the development of nanocarrier shows a promising approach in the management of rheumatoid arthritis as compared to the conventional drug treatment such as biologic agents and non-steroidal anti-inflammatory drugs etc. Conclusion: Rheumatoid Arthritis is a condition that occurs when the immune system, which normally helps to protect the body from infection and disease, attacks its own tissues. The disease causes pain, swelling as well as loss of function in joints. Therefore, life-long management is required by reducing the dose frequency and dosage regimen, which can be effectively approached by the development of a nano-carrier for significant drug uptake and low toxicity.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"19 1","pages":"2-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific and Technological Prospecting on Polymeric Particles Containing Extracellular Matrix Peptides for the Treatment of Duchenne Muscular Dystrophy.","authors":"Livia Alves Filgueiras, Francisco Thiago Bandeira Silva, Francisco das Chagas Alves Lima, Anderson Nogueira Mendes","doi":"10.2174/0126673878329404250106065202","DOIUrl":"10.2174/0126673878329404250106065202","url":null,"abstract":"<p><p>Duchenne muscular dystrophy is a neuromuscular disease with an overall incidence of between 1 in 5,000 newborn males. Carriers may manifest progressive muscle weakness, resulting from the progressive degeneration of skeletal muscles, generating cardiac and respiratory disorders. Considering the lack of effective treatments, different therapeutic approaches have been developed, such as protein synthesis and extracellular matrix derivatives that can be used to improve muscle regeneration, maintenance, or repair. At the same time, the use of other anti-inflammatory drugs or biological agents to replace corticosteroids conjugated to these extracellular matrix derivatives may act more effectively in controlling the progression of Duchenne muscular dystrophy. Extracellular matrix-derived peptides (e.g. laminin-111 derivatives) and the use of essential oils with antiinflammatory activity in polymeric particles for application in the treatment of Duchenne muscular dystrophy are discussed. For this purpose, the literature of patents and scientific articles from 2012- 2024 on LM-111 peptides and Duchenne muscular dystrophy was reviewed. Many patents focus on palliative technologies that seek to prolong the progressive effects of the disease, considering the control of the inflammatory process. The technological and scientific prospecting suggests the need for continuous research on systems that can serve as a treatment for Dystrophy.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"105-126"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan: Microsphere Formulation and Characterization for Slow - Release Prebiotic Activities in Gut Microbiota Remodelling.","authors":"Sunny Kumar, Zeel Bhatia, Sriram Seshadri","doi":"10.2174/0126673878305913241122114556","DOIUrl":"10.2174/0126673878305913241122114556","url":null,"abstract":"<p><strong>Introduction: </strong>Chitosan is a biocompatible, mucoadhesive, and biodegradable polymer widely used for various purposes due to its biological activity and safety. The current study aimed to formulate Chitosan microspheres and conduct an in-vitro evaluation of their cytotoxicity. The concept is focused on targeted gut delivery and biological activities in gut microbiota remodelling.</p><p><strong>Methods: </strong>The formulations were comprehensively characterized, encompassing SEM for surface morphology, particle size analysis, and FT-IR for structural understanding. Along with biological activity and cytotoxicity studies, dissolution efficiency was considered to understand release kinetics potential and accelerated stability studies to predict formulation shelf-life.</p><p><strong>Results: </strong>The formulation showed smooth spherical surface morphology with an average size range of 30.0 ± 5.0 μm and a charge of 20.35 ± 0.35 mV. Further, functional and thermal properties were determined using FT-IR and DSC, respectively. The microspheres showed a potent prebiotic potential in gut flora isolated and processed from a faecal sample of Wistar rats with prolonged release characteristics in the dissolution study. A cytotoxicity study using rat intestinal epithelial cells (IEC6) indicated that 40 mg /kg of microspheres could be considered an optimal dose for an <i>in-vivo</i> study.</p><p><strong>Conclusion: </strong>The formulation demonstrated promising pharmaceutical applicability due to its potential prebiotic nature and slow release into the gut environment. After a thorough in vivo study, the microspheres can be broadly used to restore gut dysbiosis due to their potential prebiotic activities in various diseases and disorders, including but not limited to obesity, type-2 diabetes, cardiometabolic disease, and non-alcoholic fatty liver disease.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking Dendrimers Future Potential for Brain-Specific Drug Delivery in Cerebroanoreach.","authors":"Aditya Jain, Shikha Yadav, Javed Khan","doi":"10.2174/0126673878303735240906065735","DOIUrl":"https://doi.org/10.2174/0126673878303735240906065735","url":null,"abstract":"<p><p>The Blood-Brain Barrier (BBB) makes it extremely difficult to get drugs to the brain, yet highly branching macromolecules known as dendrimers show a lot of promise in this regard. This review delves into the current and future prospects of dendrimers in facilitating brain-specific drug delivery within the framework of cerebroanoreach. The unique structural features of dendrimers allow for precise regulation of surface function, size, and shape, which are critical for targeting specific cell types in the brain and increasing blood-brain barrier permeability. Second, they can be conjugated with imaging agents, peptides, or pharmaceuticals thanks to their versatile surface chemistry, which enhances diagnostic capabilities and treatment efficacy. Recent advances in nanoformulations based on dendrimers have demonstrated promising improvements in the solubility, stability, and bioavailability of medications, suggesting their possible use in therapeutic contexts. Various obstacles, such as toxicity profiles and production bottlenecks that require scaling up are also addressed, with a focus on ongoing research projects and potential remedies. One potential solution to the problems with cerebroanoreach is the use of dendrimers for brain-specific drug delivery; this could revolutionize the treatment of neurological diseases and the precision of neurology diagnostics. By synthesizing current knowledge and future directions, this review urges the continuance of interdisciplinary collaboration, which is crucial for fully realizing the potential of dendrimers in neuroscience and therapeutic innovation.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"19 1","pages":"16-24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Ionic Surfactant Vesicles (Niosomes): Structure, Functions, Classification and its Advances in Enhanced Drug Delivery.","authors":"Pavan Kumar Padarthi, V Kalvimoorthi, Ranadheer Reddy Challa, Bhaskar Vallamkonda, Neelima Grandhe, Lakshman Kumar Dogiparthi, Rajaganapathy Kaliyaperumal","doi":"10.2174/0126673878322982241126103404","DOIUrl":"10.2174/0126673878322982241126103404","url":null,"abstract":"<p><p>Non-ionic surfactant vesicles, commonly known as niosomes, have gained significant attention in the field of drug delivery because of their unique properties and advantages. Niosomes are self-assembled vesicles composed of non-ionic surfactants and cholesterol that can entrap both hydrophilic and hydrophobic drugs within their aqueous core or bilayer. This versatile drug delivery system offers improved stability, prolonged release profiles, reduced toxicity, and enhanced efficacy for a wide range of therapeutic agents. This comprehensive article delves into the structure, function, classification, and advances in niosomes for enhanced drug delivery. It explores various nonionic surfactants used for niosome formulation and discusses their impact on encapsulation efficiency and stability. Moreover, it highlights the application of niosomes in the delivery of small molecules, proteins, and plant-derived natural products. This article provides an overview of the different formulation methods employed for niosome preparation and discusses recent advancements that have expanded their potential applications in targeted drug delivery systems.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"87-104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}