Recent advances in drug delivery and formulation最新文献

{"title":"Isoquinoline Quaternary Alkaloid (IQA) Nano-dressings: A Comprehensive Review on Design Strategies, Therapeutic Applications, and Advancements in Transdermal Delivery for Chronic Wound Management.","authors":"Iram Jahan, Jiyaul Hak, Suraj Mandal, Shadab Ali, Sayad Ahad Ali, Nasiruddin Ahmad Farooqui","doi":"10.2174/0126673878330005250326060103","DOIUrl":"https://doi.org/10.2174/0126673878330005250326060103","url":null,"abstract":"<p><strong>Introduction: </strong>Transdermal delivery systems and wound dressings are critical components of modern healthcare, continually undergoing refinement to enhance efficacy, biocompatibility, and cost-effectiveness. Natural compounds, particularly those sourced from plants, have emerged as promising candidates for advancing these systems.</p><p><strong>Aim and objective: </strong>This study aims to investigate the design, therapeutic potentials, and comparative advancements of Isoquinoline Quaternary Alkaloid (IQA) nano-dressings.</p><p><strong>Materials and methods: </strong>The paper offers a comprehensive analysis of IQA's therapeutic potentials, fabrication techniques, and a comparative assessment against traditional wound care approaches, positioning IQA nano dressings as a paradigm shift in chronic wound management with the potential to enhance patient outcomes significantly.</p><p><strong>Result: </strong>This review delves into the transformative capabilities of dissolving Isoquinoline Quaternary Alkaloid (IQA) nano dressings, showcasing their potential to revolutionize chronic wound care beyond conventional therapies.</p><p><strong>Conclusion: </strong>Through the amalgamation of nanotechnology with IQA's intrinsic attributes, such as antimicrobial and anti-inflammatory properties, biocompatibility, and sustained drug release, these nanodressings exhibit promising outcomes in tissue regeneration while minimizing the need for frequent dressing changes.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Canagliflozin Hemihydrate-loaded Nanostructured Lipid Carriers Using Box-Behnken Design: Physicochemical Characterization, Ex-vivo Analysis, and In-vivo Pharmacokinetics.","authors":"Ravindra Kamble, Mohit Kumar, Vaibhav Shinde, C Bothiraja, Amol Muthal, Ashwin Mali","doi":"10.2174/0126673878343297250325060051","DOIUrl":"https://doi.org/10.2174/0126673878343297250325060051","url":null,"abstract":"<p><strong>Background: </strong>Type 2 Diabetes Mellitus (T2DM) is a prevalent metabolic disease significantly impacting healthcare, characterized by increased blood glucose levels from the average level due to insulin resistance or a lack of insulin production. Canagliflozin Hemihydrate (CGN) is one of the drugs of choice in the treatment of the disease. However, CGN belongs to BCS class IV making it difficult to formulate into suitable dosage form.</p><p><strong>Objective: </strong>The purpose of the present study was to systematically optimize and explore the potential of Nanostructured Lipid Carriers (NLCs) to improve the solubility and bioavailability of CGN.</p><p><strong>Methods: </strong>The emulsification and ultrasonication methods were used for the preparation of CGNloaded NLCs (CGN-NLCs) by employing the Box-Behnken design. The solid lipid to liquid lipid ratio (X1), surfactant concentration (X2), and sonication time (X3) were independent variables, while particle size (Y1) and entrapment efficiency (EE) (Y2) were selected as dependent variables.</p><p><strong>Results: </strong>The optimized batch showed particle size, zeta potential, Polydispersity Index (PDI), and EE of 221.2 ± 2.25 nm, -37 mV, 0.268 ± 0.024, and 98.2 ± 1.62%. The TEM revealed a homogeneous spherical shape of CGN-NLCs. Further, the DSC and XRD studies revealed reduced crystallinity with complete encapsulation of CGN in NLCs. The in vitro drug release study in simulated intestinal fluid (pH 6.8) showed significant CGN release from CGN-NLCs compared to CGN dispersion. Further, the ex vivo intestinal permeability and in vivo pharmacokinetic study showed a 1.33- fold and 3.81-fold increase in permeability and bioavailability along with improvement in Cmax, Tmax, and [AUC]0-24 as compared to CGN dispersion.</p><p><strong>Conclusion: </strong>Thus, the prepared CGN-NLCs could be a better viable option for T2DM with improved therapeutic efficacy.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Polyphenols and Novel Delivery Strategies for Effective Treatment of Breast Cancer.","authors":"Varneet Sandhu, Ayushi Taneja, Sonia Dhiman, Thakur Gurjeet Singh, Inderbir Singh","doi":"10.2174/0126673878329992250112190329","DOIUrl":"10.2174/0126673878329992250112190329","url":null,"abstract":"<p><p>Breast cancer continues to pose a significant global health challenge, with conventional therapies frequently hindered by resistance mechanisms and undesirable side effects. This review investigates the therapeutic potential of polyphenols-naturally occurring compounds recognized for their antioxidant, anti-inflammatory, and anti-cancer properties-as alternative or complementary treatments for breast cancer. We examine the molecular pathways through which polyphenols exert their effects, including their influence on oxidative stress modulation, inflammatory responses, cellular proliferation, apoptosis, and estrogen receptor signalling. Additionally, this review addresses innovative nano-based drug delivery systems such as nanoparticles, liposomes, niosomes, and phytosomes that enhance the stability, bioavailability, and targeted delivery of polyphenols. These advanced formulations aim to overcome challenges related to polyphenol degradation, low solubility, and rapid systemic clearance, thereby enhancing their therapeutic efficacy. Through a detailed analysis, we assess the contributions of various nanocarriers in optimizing the delivery of polyphenols specifically to breast cancer cells while minimizing systemic toxicity. The evidence presented highlights the potential of polyphenols in breast cancer management, further supported by nanoformulations that improve both stability and delivery efficiency.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"127-141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agomelatine Transdermal System Product Cycle: Development, Material/ Process Screening, Optimization, Characterization, Delivery Mechanics and Irritation study on Rat.","authors":"Punitkumar Rathod, Anita Lalwani","doi":"10.2174/0126673878339412250213043818","DOIUrl":"10.2174/0126673878339412250213043818","url":null,"abstract":"<p><strong>Introduction: </strong>Agomelatine (AGT) is used for the treatment of major depressive disorder in adults. Agomelatine is highly susceptible to first-pass metabolism, and it has less than 5% oral bioavailability. Therapy for major depressive disorder extends for a long period and every time, additional caregivers are required to remind and manage the timely dosing of oral medicine to patients. In such cases, once a week, administration of agomelatine via transdermal patch dosage form provides major patient benefits and lowers overall therapy costs.</p><p><strong>Methods: </strong>An agomelatine transdermal patch was prepared using the solvent evaporation method using the LTE-S Werner Mathis AG coater and dryer. A patch was prepared using silicon adhesive after screening different pressure-sensitive adhesives like acrylate, polyisobutylene, and silicon. To make a crystal-free patch, the concentration of povidone k-29/32 was optimized in preliminary trials. To deliver the drug over a 7-day period, propylene glycol monolaurate (PGML) was identified from different penetration enhancers. Three factors optimization was carried out, like the concentration of povidone k-29/32, the concentration of PGML, and the mixing time of the blend using the Box Behnken design. 3D surface response curves and contour plots were derived using Design Expert and Minitab software. From overlay plots, design spaces were identified.</p><p><strong>Results: </strong>The optimized AGT patch has good adhesion properties along with a desirable flux of 4.63 μg/cm²/h on human cadaver skin along with a lower residual drug. There was no impact of heat flux studies on normal conditions, hence justifying the in-use condition of the patient population during hot showers, baths, and saunas. AGT Patch was also non-irritating in skin irritation studies performed on Wistar albino rats.</p><p><strong>Conclusion: </strong>It was concluded that agomelatine transdermal patches can be manufactured using silicon adhesive, povidone k-29/32, and propylene glycol monolaurate for the treatment of major depressive disorder and will be the most convenient and cost-effective therapy for the patient.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"262-277"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Potential Use of Banana Peel Extract (Musa Species) as a New Polymer to Create Sustainable Materials and Innovative Drug Delivery Applications: An Updated Review.","authors":"Abhinav Trivedi, Shashi Verma, Ritesh Kumar Tiwari","doi":"10.2174/0126673878329777250311072638","DOIUrl":"10.2174/0126673878329777250311072638","url":null,"abstract":"<p><p>Introduction/ Objective: The Musa genus, which includes bananas and plantains, offers a natural source of polymers. These polymers are finding applications in various industries, such as pharmaceuticals, where they are used as drug delivery systems. Additionally, Musa species are used in the creation of biopolymer composites, which are eco-friendly materials, and in the production of nanocellulose, a nanomaterial with promising properties. The versatility of Musa species makes it a valuable resource for developing sustainable materials and exploring new applications. This review aims to highlight recent advances in the applications of bio-polymers, biocomposites, nanocellulose, and novel drug delivery systems using Musa species.</p><p><strong>Methods: </strong>The review likely examines existing literature, research studies, and experimental findings related to Musa species. It may analyze the characterization, treatment, and fabrication techniques of Musa species for these applications.</p><p><strong>Results: </strong>The multifaceted role of Musa species is emphasized, including its contribution to pharmaceutical advancements, eco-friendly polymer production, and innovative nanocellulose applications.</p><p><strong>Conclusion: </strong>In summary, this review paper explores how Musa species can be harnessed for various technological and scientific purposes, particularly in the fields of biopolymers, biocomposites, and drug delivery systems. The tropical plant's versatility and significance are underscored throughout the review.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"179-193"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation Development and Permeation Studies of Vancomycin Hydrochloride-Loaded Nanostructured Lipid Carrier Incorporated Thermoresponsive <i>In-Situ</i> Gel: A Box-Behnken Design Implemented Approach for Ocular Delivery in Endophthalmitis.","authors":"Amit Kumar Singh, Prabhat Kumar Upadhyay, Manish Kumar","doi":"10.2174/0126673878339109250219072409","DOIUrl":"10.2174/0126673878339109250219072409","url":null,"abstract":"<p><strong>Introduction: </strong>Endophthalmitis, an inflammatory condition of the intraocular cavity, poses a significant challenge in ophthalmology due to its rapid progression and potential for vision loss. Conventional treatment modalities, such as systemic antibiotics or oral administration, often face limitations in achieving the required therapeutic levels at the target site. Hence, repeated intravitreal injections of antibiotics are currently the most preferred and recommended therapy for the management of endophthalmitis, which is an invasive technique and has certain shortcomings, elevated intraocular pressure, bleeding inside the eye, heightened likelihood of retinal detachment, retinal toxicity, and many more. Vancomycin is the first choice drug for the management of endophthalmitis and is given through intravitreal injection.</p><p><strong>Aim: </strong>The work aims to design, develop, and evaluate Vancomycin-loaded NLCs incorporated into an in-situ gel offering a new non-invasive therapeutic option for the management of Endophthalmitis.</p><p><strong>Methods: </strong>The Vancomycin-loaded NLCs were successfully produced through a double emulsion/ solvent evaporation method employing a Box Behnken design. The optimized formulations were incorporated into an in-situ gel system by varying the concentration of Pluronic F127. The formulated gels were characterized for several parameters such as physical appearance, pH, viscosity, gelling strength, gelation temperature, in vitro release profile, and ex-vivo permeation study.</p><p><strong>Results: </strong>The result revealed that the formulation had a smooth appearance with a pH range from 7 to 7.5, was near the physiological pH of the eye, had content in the range of 97.5 ± 1.0 % to 99.2 ± 1.0 % and gelation temperature near body temperature. The data of release study formulation (VISG2) revealed sustained drug release compared to the control gel. The data ex vivo permeation study revealed that there was approximately a 3 folds increase in permeation of drug form (VISG2) compared to control gel (p<0.0001) and significant (2.02 folds) permeation compared to commercially available formulation (p<0.0001).</p><p><strong>Conclusion: </strong>In conclusion, the Vancomycin-loaded NLCs incorporated in-situ gel may serve as a feasible alternative to invasive intravitreal injection for the management of endophthalmitis.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"235-250"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Chlorophyllin-Based Ag Nanoparticles to Target <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>.","authors":"Sandipa Podder, Saikat Saha, Arnob Chakrovorty, Banani Bhattacharjee, Sabir Hossen Molla, Debojyoti Tarafdar, Sisir Nandi, Asmita Samadder","doi":"10.2174/0126673878360429250207063902","DOIUrl":"10.2174/0126673878360429250207063902","url":null,"abstract":"<p><strong>Introduction/objective: </strong>Bacteria resist drugs by employing new resistance mechanisms, leading to prolonged infection and complexity in therapeutic prognosis that concordantly decreases drug efficacy. In recent years, nanotechnology has gained immense popularity for the development of drug delivery systems to combat the global pharmaceutical crisis of multi-drug resistance. The present work aimed to focus on the green chemistry-based synthesis of silver nanoparticles (AgNPs) using the phytocompound chlorophyllin to form chlorophyllin precipitated silver nanoparticles (NCHL) and elucidate their application against two pathologically significant bacterial species <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>.</p><p><strong>Methods: </strong>After optimization of experimental parameters, the physico-chemical properties of the synthesized NCHL were determined using AFM, DLS, XRD, UV-Vis, SPR, and FTIR, respectively. The interaction of NCHL with ct-DNA was assessed using CD spectroscopy. The antimicrobial activity of the synthesized NCHL against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> was examined by a disc diffusion susceptibility test.</p><p><strong>Results: </strong>The NCHL was ascertained to be ~53.57 nm in size, having a spherical shape, smooth topology, negative zeta potential of -23.94 mV, and PDI value of 0.495. A sharp peak for silver as SPR and an XRD peak depicted the best fit metallic crystal synchronization. FTIR analysis revealed the presence of a similar functional group in NCHL and chlorophyllin (CHL). CD spectroscopy with ct-DNA in the presence of NCHL showed a change in spectral shift of the ct-DNA, indicating strong ct-DNA-NCHL interaction. NCHL successfully inhibited the growth of both bacterial strains, indicating broad spectrum activity of the synthesized nanoparticles.</p><p><strong>Conclusion: </strong>The promising results indicated that NCHL could be utilized as a potential therapeutic molecule against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> infections and help in combating bacterial drug resistance, which is of high medical priority.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"278-289"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QbD-driven Formulation Development and Evaluation of Genistein Nanoparticles for Prostate Cancer.","authors":"Nirav Patel, Priya Patel","doi":"10.2174/0126673878321778241010121358","DOIUrl":"https://doi.org/10.2174/0126673878321778241010121358","url":null,"abstract":"<p><strong>Background: </strong>Genistein (GEN) shows significant anticancer potential, particularly against prostate cancer. However, its clinical application is limited by poor water solubility, rapid metabolism and excretion, low bioavailability, and lack of targeted delivery to cancer cells, hindering its effectiveness as a chemopreventive or therapeutic agent.</p><p><strong>Objective: </strong>In this study, poly-ε-caprolactone (PCL) nanoparticles incorporating polyvinyl alcohol (PVA) as a stabilizer were engineered to encapsulate genistein (GEN) effectively. Utilizing a Quality by Design (QbD) methodology, the development and optimization of these nanoparticles were systematically approached.</p><p><strong>Methods: </strong>GEN-loaded PCL nanoparticles (NPs) were prepared using the Solvent Evaporation Technique, ideal for encapsulating hydrophobic drugs. A Plackett-Burman design (PBD) identified key factors, followed by a Box-Behnken design (BBD) to optimize nanoparticle quality. The NPs were evaluated for particle size, zeta potential (ZP), polydispersity index (PDI), morphology, encapsulation efficiency (EE), in vitro drug release, and cytotoxicity.</p><p><strong>Results: </strong>The optimized formulation containing PCL, PVA, and Volume of organic solvent as 43.7 mg, 6.2 mg, and 10.0 ml, respectively was chosen because it showed EE (%) of 94.0%, average particle size of 150 nm, PDI of 0.10, ZP of -28.0 and exhibited sustained release of GEN for around four days. The antiproliferative activities of GEN PCL NPs were confirmed by the MTT test <i>in vitro</i> on malignant prostate carcinoma cell lines (PC3). Flow cytometric analysis showed that the inhibition of cell proliferation of more potent GEN PCL NPs is comparable with the effects of free GEN.</p><p><strong>Conclusion: </strong>The findings indicate that genistein-loaded PCL nanoparticles have the potential to augment the anticancer efficacy of genistein, both <i>in vitro</i> and <i>in vivo</i>. This suggests their promise as a viable candidate for prostate cancer treatment.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"19 1","pages":"53-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Kenaf Nanocrystalline Cellulose-based Hydrogel Containing Platelet Lysate for Full-thickness Wound Healing.","authors":"Payal Bhatnagar, Jia-Xian Law, Shiow-Fern Ng","doi":"10.2174/0126673878323868240924154455","DOIUrl":"https://doi.org/10.2174/0126673878323868240924154455","url":null,"abstract":"<p><strong>Introduction: </strong>Healing full-thickness wounds is often challenging and time-consuming, with complications such as scarring and infections. The standard treatment, split skin grafting, has limitations due to the availability of healthy donors and suitability for immunocompromised patients.</p><p><strong>Methods: </strong>Autologous platelet lysate (PL) has been popular for tissue regenerative potential because it contains growth factors (GF) and is a safer option for bedridden patients with weak immune systems. However, PL has inconsistent clinical efficacy, high costs, and a short half-life. To address these issues, this study explores a novel delivery system by fabricating a chitosan/nanocrystalline cellulose (CS/NCC) hydrogel to sustainably deliver autologous PL to the wound site. Notably, NCC was prepared from kenaf bast fibers using acid hydrolysis and integrated into the CS matrix through physical entrapment without any chemical crosslinkers. The composite hydrogel was then enriched with autologous PL and further characterized for its physicochemical properties, <i>in vitro</i> GF release, and compatibility with skin cells. At the molecular level, gene expression of wound healing genes was facilitated using qPCR, revealing that the PL-supplemented hydrogel upregulated the expression of extracellular matrix genes. An <i>in vivo</i> study using a full-thickness wound model demonstrated that the CS-NCC-PL hydrogel dressing achieved 81.8% wound closure within 14 days, compared to the control groups.</p><p><strong>Results: </strong>Histological analysis indicated enhanced re-epithelialization, angiogenesis, and collagen deposition. Particularly, the CS-NCC-PL hydrogel group showed a significantly higher hydroxyproline content (60.62 ± 11.46 μg/100 mg) by day 14. Immunohistochemistry results revealed elevated levels of α-SMA and CD31, markers of myofibroblast presence and angiogenesis, peaking at day 7.</p><p><strong>Conclusion: </strong>These findings suggest that the CS-NCC-PL hydrogel is a promising personalized wound dressing for bedridden patients, offering improved healing outcomes in hospital settings.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":"19 1","pages":"72-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Nanostructured Lipid Carriers: Innovations and Applications in Breast Cancer Treatment.","authors":"Prathamesh Mirajkar, Priyanka Ahlawat, Asha Patel, Shruti Patel, Drishti Panjwani","doi":"10.2174/0126673878313086241031154146","DOIUrl":"10.2174/0126673878313086241031154146","url":null,"abstract":"<p><p>Nanostructured Lipid Carriers (NLCs) represent a promising advancement in the treatment of breast cancer, addressing the significant challenges posed by conventional chemotherapy, such as poor drug solubility, short half-lives, and high toxicity. This review delves into the potential of NLCs to overcome these limitations, highlighting their unique structure comprising a solid and lipid liquid core stabilized by surfactants. By examining diverse lipid blends used in the preparation of NLCs, the article emphasizes their suitability for targeted drug delivery. Various facets of NLC configuration, categorization, composition, and formulation approaches are systematically explored to provide a comprehensive understanding of their attributes. The findings reveal that NLCs possess a high capacity for lipophilic drugs and offer advantages over traditional lipid-based nanocarriers. The review underscores the pivotal role of NLCs in enhancing drug delivery efficiency for breast cancer therapy while minimizing systemic toxicity. Conclusively, this review positions NLCs as a key player in the evolution of drug delivery systems for breast cancer treatment, providing a detailed outlook on their transformative potential and contributing to a nuanced understanding of their significance in advancing the field of breast cancer treatment.</p>","PeriodicalId":94352,"journal":{"name":"Recent advances in drug delivery and formulation","volume":" ","pages":"25-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}