超越表面:植入式药物输送系统在现代医学中的作用。

Hammad War, Sumit Sharma, Sanchit Dhankhar, Samrat Chauhan, Supriya Khanra
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引用次数: 0

摘要

先进的给药方法的出现主要是因为口服和静脉注射等传统给药系统的局限性,以及影响治疗效果的药物浓度波动。植入式药物输送系统(IDDS)提供了一个有吸引力的替代方案:长期、连续的药物释放提高了治疗效果,同时最大限度地减少了毒副作用。IDDS于20世纪30年代首次作为皮下激素颗粒提出,近年来由于其局部和持续的药物控制释放而在给药方面受到了广泛关注。在全身治疗中,通过IDDS给药的药物逃避了胃肠道内的第一过代谢和酶降解,从而提高了药物的生物利用度。IDDS最适合的特性是它在口服制剂中与稳定性或溶解度较差的药物一起使用。尽管植入是侵入性的,但较少的给药,较高的患者依从性以及在出现副作用时能够停止治疗的好处远远大于缺点。今天,idds被用于无数的治疗领域:避孕、化疗和疼痛管理,仅举几例。这些技术的未来发展,以及对这些系统的进一步微调,将带来更好、对患者更友好、疗效更好、持续时间更长的药物,从而彻底改变药物治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beyond the Surface: The Role of Implantable Drug Delivery Systems in Modern Medicine.

Advanced drug delivery methods have emerged mainly because of the limitations of traditional drug delivery systems like oral and intravenous routes, along with fluctuating concentrations of drugs that have compromised therapeutic outcomes. An implantable drug delivery system (IDDS) presents an attractive alternative: long-term, continuous drug release improves therapeutic efficacy while minimizing toxicity and side effects. IDDS, first presented in the 1930s as subcutaneous hormone pellets, have gained much attention recently in drug delivery due to their controlled release of drugs in a localized and sustained manner. In systemic treatments, drugs administered through IDDS evade first-pass metabolism and enzymatic degradation within the gastrointestinal tract, therefore enhancing drug bioavailability. The most suitable properties of IDDS are its application with drugs that have poor stability or solubility in oral formulations. Even though implantation is invasive, the benefits of infrequent administration, higher patient compliance, and being able to discontinue therapy when side effects are present far outweigh the disadvantages. Today, IDDSs are used in a myriad of therapeutic areas: contraception, chemotherapy, and pain management, to name a few. Future developments in such technologies, fine-tuning these systems further, will revolutionize drug therapy by bringing even better and more patient-friendly drugs with both better efficacy and sustained periods of effects.

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CiteScore
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