Cancer Causes & Control最新文献

{"title":"Registry versus claims-based index dates for studies of cancer diagnosis in administrative data.","authors":"Sarah E Soppe, Sharon Peacock Hinton, Jamie C Halula, Jennifer L Lund, Chris D Baggett, Sandi L Pruitt, Megan A Mullins, Ellis C Dillon, Matthew E Barclay, Matthew Thompson, Nicholas Pettit, Georgios Lyratzopoulos, Caroline A Thompson","doi":"10.1007/s10552-024-01953-6","DOIUrl":"10.1007/s10552-024-01953-6","url":null,"abstract":"<p><strong>Purpose: </strong>Studies of healthcare encounters leading to cancer diagnosis have increased over recent years. While some studies examine healthcare utilization before the cancer registry date of diagnosis, relevant pre-diagnosis interactions are not always immediately prior to this date due to date abstraction guidelines. We evaluated agreement of a registry date with a claims-based index and examined Emergency Department (ED) involvement in cancer diagnosis as an example of possible pre-diagnostic healthcare misclassification that could arise from improper date choice.</p><p><strong>Methods: </strong>We implemented an algorithm to define a claims-based index as the date of the earliest International Classification of Diseases code for the cancer in Medicare and estimated agreement with the date of diagnosis from a North Carolina registry for patients diagnosed aged 66 or older with 16 cancer types from 2008 to 2017 (n = 92,056). We then classified whether each cancer was initially diagnosed through care originating in the ED using each date.</p><p><strong>Results: </strong>The index date was identical to the cancer registry date for 47% of patients and preceded the registry date for 28%, with extent of agreement varying by cancer- and patient-specific characteristics. Agreement in ED-involved diagnosis classification using each date varied by cancer site, with sensitivity of classifications using the registry date relative to the index having a minimum of 86% for prostate and kidney cancer.</p><p><strong>Conclusion: </strong>Studies assessing healthcare utilization proximal to cancer diagnosis should carefully consider the relevant assessment window and be aware that the use of cancer registry versus claims-based dates may impact variable classification.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"539-550"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding automated breast ultrasound to mammography in women with increased breast density or at an elevated risk of breast cancer is a cost-effective screening strategy.","authors":"Ian Grady, Sean Grady, Nailya Chanisheva","doi":"10.1007/s10552-024-01958-1","DOIUrl":"10.1007/s10552-024-01958-1","url":null,"abstract":"<p><strong>Objectives: </strong>Automated breast ultrasound imaging (ABUS) results in a reduction in breast cancer stage at diagnosis beyond that seen with mammographic screening in women with increased breast density or who are at a high risk of breast cancer. It is unknown if the addition of ABUS to mammography or ABUS imaging alone, in this population, is a cost-effective screening strategy.</p><p><strong>Methods: </strong>A discrete event simulation (Monte Carlo) model was developed to assess the costs of screening, diagnostic evaluation, biopsy, and breast cancer treatment. The number of quality-adjusted life years gained through each screening method is assessed using previously published quality of life measures. Incremental cost-effectiveness ratios for screening with the combination of mammographic and ABUS imaging, and for ABUS imaging alone are calculated as compared to standard mammographic imaging.</p><p><strong>Results: </strong>Combined screening with both mammographic and ABUS imaging results in an incremental cost-effectiveness ratio of $7,071 ($6,332-$7,809) when compared to traditional mammographic imaging (p < 0.05). ABUS screening alone results in an incremental cost-effectiveness ratio of $3,559 ($- 965-$8,082) when compared to mammographic imaging (p < 0.05). ABUS screening alone is more likely to be cost-effective for a willingness-to-pay of less than $7,100.</p><p><strong>Conclusions: </strong>The addition of ABUS to mammographic imaging is a cost-effective screening strategy in women with increased breast density or who are at a high risk of developing breast cancer. ABUS imaging alone is also a cost-effective strategy in this population, particularly in resource-poor areas.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"473-481"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends and patterns for early- and late-onset adult liver cancer incidence vary by race/ethnicity, subsite, and histologic type in the United States from 2000 to 2019.","authors":"Mei-Chin Hsieh, Kendra L Ratnapradipa, Laura Rozek, Shengdi Wen, Yu-Wen Chiu, Edward S Peters","doi":"10.1007/s10552-024-01955-4","DOIUrl":"10.1007/s10552-024-01955-4","url":null,"abstract":"<p><strong>Purpose: </strong>To examine incidence trends and patterns for early- and late-onset liver cancer.</p><p><strong>Methods: </strong>Liver and intrahepatic bile duct (IBD) cancers diagnosed between 2000 and 2019 were acquired from 22 SEER registries. Variables included early-onset (20-49) vs. late-onset (50+), anatomic subsite, histologic type (hepatocellular carcinoma [HCC] and IBD cholangiocarcinoma [ICC]), sex, and race/ethnicity. Age-standardized incidence rates were calculated using SEER*Stat. Jointpoint regression analysis was employed to estimate the annual percent change (APC) and the average APC (AAPC) with pairwise comparisons for trend by sex and by race/ethnicity stratified by age and subsite.</p><p><strong>Results: </strong>Liver cancer incidence decreased among early-onset (AAPC [95% CI] - 2.39 [- 2.74, - 2.07]) but increased among late-onset patients (2.85 [2.71, 3.01]), primarily driven by HCC (3.60 [3.50, 3.71]). IBD incidence increased for both ages with ICC incidence annually increasing 7.92% (6.84, 9.26) for early-onset and 6.32% (5.46, 8.86) for late-onset patients. Early-onset liver cancer displayed comparable trends across racial/ethnic groups; however, late-onset liver cancer showed more variation, particularly among American Indian/Alaska Native/Asian Pacific Islander (AI/AN/API) populations, which experienced a significant decrease in incidence, thereby narrowing the gap with other racial/ethnic groups. For IBD, an identical pattern of early-onset IBD among non-Hispanic Blacks (NHBs) compared to Hispanics was showed with coincidence test p = 0.1522, and a parallel pattern was observed among late-onset patients for both sexes (p = 0.5087).</p><p><strong>Conclusion: </strong>Late-onset HCC continues to rise, except for NHB and AI/AN/API, where incidence rates have started to decrease over the past 4-5 years. Early and late-onset ICC incidence continues to increase across all racial/ethnic groups.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"551-560"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historical redlining and clustering of present-day breast cancer factors.","authors":"Sarah M Lima, Tia M Palermo, Jared Aldstadt, Lili Tian, Helen C S Meier, Henry Taylor Louis, Heather M Ochs-Balcom","doi":"10.1007/s10552-024-01950-9","DOIUrl":"10.1007/s10552-024-01950-9","url":null,"abstract":"<p><strong>Purpose: </strong>Historical redlining, a 1930s-era form of residential segregation and proxy of structural racism, has been associated with breast cancer risk, stage, and survival, but research is lacking on how known present-day breast cancer risk factors are related to historical redlining. We aimed to describe the clustering of present-day neighborhood-level breast cancer risk factors with historical redlining and evaluate geographic patterning across the US.</p><p><strong>Methods: </strong>This ecologic study included US neighborhoods (census tracts) with Home Owners' Loan Corporation (HOLC) grades, defined as having a score in the Historic Redlining Score dataset; 2019 Population Level Analysis and Community EStimates (PLACES) data; and 2014-2016 Environmental Justice Index (EJI) data. Neighborhoods were defined as redlined if score ≥ 2.5. Prevalence quintiles of established adverse and protective breast cancer factors relating to behavior, environment, and socioeconomic status (SES) were used to classify neighborhoods as high-risk or not. Factor analysis grouped factors into domains. Overall and domain-specific scores were calculated for each neighborhood according to historical redlining status. Percent difference in score by historical redlining was used to assess differences in average scores, with Wilcoxon-Mann-Whitney test used to estimate significance. Kappa statistic was used to estimate concordance between historical redlining status and high-risk status. Heatmaps of scores were created to compare spatial clustering of high-risk factors to historical redlining.</p><p><strong>Results: </strong>We identified two domains: (1) behavior + SES; (2) healthcare. Across the US, redlined neighborhoods had significantly more breast cancer factors than non-redlined (redlined neighborhoods = 5.41 average high-risk factors vs. non-redlined = 3.55 average high-risk factors; p < 0.0001). Domain-specific results were similar (percent difference for redlined vs. non-redlined: 39.1% higher for behavior + SES scale; 23.1% higher for healthcare scale). High-scoring neighborhoods tended to spatially overlap with D-grades, with heterogeneity by scale and region.</p><p><strong>Conclusion: </strong>Breast cancer risk factors clustered together more in historically redlined neighborhoods compared to non-redlined neighborhoods. Our findings suggest there are regional differences for which breast cancer factors cluster by historical redlining, therefore interventions aimed at redlining-based cancer disparities need to be tailored to the community.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"483-495"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral cavity and oropharyngeal cancers in Texas: examining incidence rates in dental health professional shortage areas.","authors":"Stacey B Griner, Biai Digbeu, Alexandra N Farris, Blair Williams, Malinee Neelamegam, Erika L Thompson, Yong-Fang Kuo","doi":"10.1007/s10552-024-01954-5","DOIUrl":"10.1007/s10552-024-01954-5","url":null,"abstract":"<p><strong>Purpose: </strong>Oral cavity (OC) and oropharyngeal (OP) cancer rates have increased annually rising in the U.S. and Texas. Dental providers could play a key role in lowering OC/OP cancer rates through prevention and screening, but Texas faces a significant shortage of dental health professionals, affecting access to dental care, including OC/OP cancer prevention and early detection. This study aims to explore the link between OC/OP cancer rates and these dental shortage areas in Texas.</p><p><strong>Methods: </strong>We analyzed OC/OP cancer incidence in Texas using SEER-Medicare data for patients aged 65 and over from 2012 to 2017. Rates per 100,000 were stratified by age, gender, and dental health provider shortage area (DHPSA) status (yes/no). Zero-Inflated Poisson Regression models were used to adjust for patient characteristics in studying cancer incidence, Late-stage diagnoses were assessed using logistic regression.</p><p><strong>Results: </strong>The incidence rate was 27.3 per 100,000 people in Texas. DHPSA counties had lower incidence rates (24.3 per 100,000) compared to non-DHPSA counties (29.8 per 100,000; p = 0.0423). Among patients with OC/OP diagnoses, those living in a DHPSA county had lower odds of advanced stage diagnoses (aOR: 0.79; CI: 0.64-0.96) than those in non-DHPSA counties.</p><p><strong>Conclusion: </strong>The findings highlight the complex link between dental providers and OC/OP cancer diagnoses, noting differences in indicators of need based on DHPSA location. Limited local dental services may lead to underreported cancer cases. Further research on dental service usage could improve OC/OP outcomes by prioritizing interventions from dental professionals.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"509-520"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between increases in nitrate in drinking water and colorectal cancer incidence rates in California, USA.","authors":"Ricardo Cisneros, Marzieh Amiri, Hamed Gharibi","doi":"10.1007/s10552-025-02003-5","DOIUrl":"https://doi.org/10.1007/s10552-025-02003-5","url":null,"abstract":"<p><strong>Purpose: </strong>The water resources in California are polluted with nitrate (NO₃) due to the ever-increasing application of nitrogen-based fertilizers. Considering the potential connection between NO₃ in drinking water and the incidence rate of colorectal cancer, this study aims to investigate the association between long-term exposure to NO₃ via drinking water and the incidence of colorectal cancer from 2010 to 2015 in California.</p><p><strong>Methods: </strong>A total of 56,631 diagnoses of colorectal cancer were recorded from 2010 to 2015. A generalized linear model was used to obtain the risk ratio (RR) and 95% confidence interval associated with a 1 mg/l-NO₃ increase in NO₃ concentration across five latency periods. The potential effect modification by sex, race/ethnicity, and age (> 40, 41-64, 65-90, and > 90) was explored through stratification.</p><p><strong>Results: </strong>The association between increases in the concentration of NO₃ at lag 0-1, lag 0-5, lag 0-10, lag 0-15, and lag 0-20 (RRs: 1.056 [1.055, 1.058]; 1.066 [1.063, 1.069]; 1.030 [1.028, 1.031]; 1.017 [1.016, 1.018]; 1.035 [1.034, 1.037], respectively) was positively associated with the RR of colorectal cancer. Sex was not found to be a significant modifier. The RRs for Hispanics, Blacks, and other races were greater than those for Whites; the RRs across different age categories were all significantly positive.</p><p><strong>Conclusion: </strong>This study confirms an association between long-term NO₃ exposure in drinking water and the incidence of colorectal cancer in California, emphasizing the need for stringent water quality control and public health strategies to address this risk, particularly in vulnerable populations.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Climate Change on Cancer Surgery and Healthcare Delivery: A Review of Environmental and Surgical Challenges.","authors":"Shaneeta Johnson, Timia' Sims, Evangeline Obichere, Jacqueline McWhorter, Jennifer Edwards, Ashley Lewis, Hadiyah-Nicole Green","doi":"10.1007/s10552-025-01999-0","DOIUrl":"https://doi.org/10.1007/s10552-025-01999-0","url":null,"abstract":"<p><strong>Purpose: </strong>More than 10 million annual global cancer deaths are exacerbated by the impact of climate change and environmental determinants of health. This brief report provides a summary of and mitigating recommendations for the complex intersection between climate change and surgical cancer care.</p><p><strong>Methods: </strong>A review of scientific literature from the last 10 years was conducted to assess the current impact of climate change on cancer care with a focus on surgical interventions. Studies with an impact score of 6 or higher and the keywords of climate change, extreme weather, cancer care, and surgery were reviewed. After removing duplicates and excluded studies, 30 studies remained and were reviewed by two reviewers.</p><p><strong>Results: </strong>Climate-related factors impacting surgical care result in a myriad of healthcare impacts, including disruption of services, impact on patient outcomes and survival, as well as an overburdening of hospital and surgical services.</p><p><strong>Conclusion: </strong>Climate change, including extreme weather events, threatens cancer surgical care and delivery by exacerbating comorbidities, disrupting healthcare systems, and increasing disparities in cancer care. Climate change is a burgeoning threat to global health, cancer care, patients, and communities.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A recipe for a disaster: food, climate change, and cancer.","authors":"Leticia M Nogueira, Rand Sakka, Christine Jovanovic","doi":"10.1007/s10552-025-01996-3","DOIUrl":"https://doi.org/10.1007/s10552-025-01996-3","url":null,"abstract":"<p><p>Climate change impacts each step of the cancer control continuum, from prevention to survivorship. Importantly, several human activities driving greenhouse gas emissions also impact cancer risk and outcomes. Therefore, there is significant overlap between climate and cancer control solutions. This article describes the connection between the current food system, climate change, and cancer; one realm of human activities with enormous potential for modifications and implementation of win-win solutions.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin use after cancer diagnosis and survival among patients with cancer.","authors":"Hanbing Guo, Kathleen E Malone, Susan R Heckbert, Christopher I Li","doi":"10.1007/s10552-024-01939-4","DOIUrl":"10.1007/s10552-024-01939-4","url":null,"abstract":"<p><strong>Purpose: </strong>The association between statin use and cancer survival has been investigated in previous studies with conflicting findings. This study aimed to assess the association between statin use following cancer diagnosis and survival in six common cancers using the Surveillance, Epidemiology, and End Results (SEER)-Medicare database.</p><p><strong>Methods: </strong>Individuals aged ≥ 66 years diagnosed with prostate cancer, colorectal cancer, lung cancer, bladder cancer, pancreatic cancer, or non-Hodgkin lymphoma (NHL) from 2008 through 2017 were identified. Statin use was defined as two or more statin prescription fills after cancer diagnosis. Time-dependent Cox proportional hazard regression models were used to estimate the association between statin use and cancer-specific mortality for each cancer.</p><p><strong>Results: </strong>This study included 34,618 patients with prostate cancer (median follow-up 4.0 years), 20,579 with colorectal cancer (2.9 years), 20,133 with lung cancer (1.7 years), 6,163 with bladder cancer (2.1 years), 4,538 with pancreatic cancer (0.8 years), and 3,270 with NHL (2.9 years). Statin use post-diagnosis was associated with a reduced risk of cancer-specific mortality in lung cancer (hazard ratio [HR], 0.81; 95% confidence interval [CI], 0.74-0.88) and pancreatic cancer (HR, 0.72; 95% CI, 0.59-0.87). The association was not statistically significant for prostate cancer, colorectal cancer, bladder cancer, or NHL. A dose-response relationship by duration of statin use was observed in lung cancer and pancreatic cancer.</p><p><strong>Conclusion: </strong>Statin use after cancer diagnosis appears associated with improved survival in lung cancer and pancreatic cancer. Clinical trials of statin therapy in lung and pancreatic cancer patients are warranted to confirm these findings.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"443-455"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer history and accelerated aging: findings from a nationally representative sample in the US.","authors":"Xuesong Han, Margaret Katana Ogongo, Feng Tian, Jingxuan Zhao, Zhiyuan Zheng, Zuyun Liu, K Robin Yabroff","doi":"10.1007/s10552-024-01941-w","DOIUrl":"10.1007/s10552-024-01941-w","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer and its treatments may accelerate the aging process. However, accelerated aging among cancer survivors is not well understood. This study examines accelerated aging among adults with and without a cancer history in a nationally representative sample and identifies health-related social needs and behavioral factors associated with accelerated aging.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 11,432 adults aged 20-84 years from the 1999 to 2010 National Health and Nutrition Examination Survey, including 728 cancer survivors. Accelerated aging was measured by validated Phenotypic Age Acceleration (PhenoAgeAccel) based on clinical chemistry biomarkers. We described accelerated aging by cancer history, demographics, health-related social needs, and health behaviors, and utilized weighted linear regression to assess their associations with accelerated aging.</p><p><strong>Results: </strong>Majority of the sample were < 65 years old (n = 8,800, weighted percentage = 84.8%), female (n = 5,856, 50.8%), and non-Hispanic White (n = 5,709, 71.7%). Cancer survivors experienced an average of 0.14 (95% CI 0.03, 0.24) years of accelerated aging measured by PhenoAgeAccel. Individuals who were male, unmarried, less educated, with lower-income, or with 3 or more medical conditions also had accelerated aging regardless of cancer history. Moreover, health-related social needs in food insecurity, unemployment, health insurance and coverage continuity as well as obesity and smoking were associated with accelerated aging in both cancer survivors and individuals without a cancer history.</p><p><strong>Conclusions: </strong> Cancer survivors experience accelerated aging in the US. Addressing health-related social needs and promoting healthy behaviors in care delivery may advance healthy aging.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"379-388"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}