Cancer Causes & Control最新文献

{"title":"Socioeconomic disparities: a more important risk factor for advanced-stage oral cancer in Florida than smoking?","authors":"Garrett Forman, Uche C Ezeh, Isabella Buitron, Sophia Peifer, Liana Shtern, Tonya Aaron, Abdurrahman Al-Awady, Isildinha M Reis, Erin R Kaye, Elizabeth Nicolli, David Arnold, Francisco Civantos, Ming Lee, Elizabeth Franzmann","doi":"10.1007/s10552-025-01992-7","DOIUrl":"https://doi.org/10.1007/s10552-025-01992-7","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the associations between sociodemographic factors with advanced-stage oral cavity cancer (OCC) presentation among Floridians.</p><p><strong>Methods: </strong>Demographic and cancer data on OCC patients (n = 7,826) diagnosed between 2010 and 2017 were retrieved from the Florida Cancer Data System (FCDS). Census tract median income and percentage of population with a bachelor's degree or higher were used to infer income and education. Pearson's chi-square tests of independence were used to compare sociodemographic factors between racial/ethnic groups and staging groups. Multinomial logistic regression analyzed predictors of advanced disease. Incidence and percent late-stage diagnosis versus income were mapped using ArcGIS Pro.</p><p><strong>Results: </strong>Among 5,252 cases analyzed: 5.7% were Black, 82.4% White Non-Hispanic, 61.5% male, 63.3% publicly insured, 6.5% uninsured, 58.7% current or former smokers, and 73.0% urban residents. Black patients were more likely to present with advanced disease, be single/unmarried, uninsured, and less likely to be former smokers. Male sex, Black race, non-married status, no insurance, Medicaid, VA/military insurance, and lower educational status were associated with increased risk of regional vs. early disease in multivariable analysis (MVA) (p < 0.05). These factors, in addition to Medicare, were associated with distant disease in MVA. Geospatial mapping revealed higher rates of regional and distant disease presentation in the Tampa Bay and Orlando areas.</p><p><strong>Conclusion: </strong>Black race, male sex, non-married status, lower education, Medicaid, VA/Military insurance and no insurance were associated with advanced OCC in Florida. Smoking status was not associated with advanced disease presentation after adjusting for sociodemographic variables.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive determinants of mammographic density in black women.","authors":"Zahna Bigham, Etienne X Holder, Angie Mae Rodday, Janis L Breeze, Kerrie P Nelson, Julie R Palmer, Karen M Freund, Kimberly A Bertrand","doi":"10.1007/s10552-025-01991-8","DOIUrl":"https://doi.org/10.1007/s10552-025-01991-8","url":null,"abstract":"<p><strong>Purpose: </strong>While high mammographic density has been established as one of the strongest, independent breast cancer risk factors, few studies have reported determinants of mammographic density in Black women. We aimed to identify reproductive-related characteristics associated with mammographic density in Black women.</p><p><strong>Methods: </strong>In data from a large mammography repository established in the Black Women's Health Study, we used Cumulus software to assess mammographic density from digital screening mammograms in 5,905 women ages 40-74. We used linear regression models to quantify the associations of parity, age at first birth, age at last birth, history of breastfeeding, and duration of breastfeeding with percent mammographic density. Models were adjusted for age, body mass index, and other breast cancer risk factors.</p><p><strong>Results: </strong>Among parous women age < 55 years, mean percent mammographic density was 2.0 percentage points (95% CI 0.3, 3.7) higher in women with a history of ≥ 3 births than in women with a history of only 1 birth. The magnitude of associations of number of births with mammographic density varied somewhat by age at first birth and age at mammography. We found no significant associations between other reproductive factors and mammographic density.</p><p><strong>Conclusion: </strong>In this large population of Black women, a higher number of births was modestly associated with higher percent mammographic density. This association may in part be influenced by age at first birth and age at mammography.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Mass Index and subjective cognitive decline among cancer survivors in the US: a cross-sectional analysis of a nationally representative survey.","authors":"Godfred O Antwi","doi":"10.1007/s10552-025-01990-9","DOIUrl":"https://doi.org/10.1007/s10552-025-01990-9","url":null,"abstract":"<p><strong>Objective: </strong>Despite the strong evidence suggesting significant relationships between Body Mass Index (BMI) and cognitive functioning in the general population, there is a dearth of research on this potential association in the cancer survivor sub-population. Therefore, utilizing a nationally representative sample, the current study seeks to examine the cross-sectional association between BMI and subjective cognitive decline (SCD) in adult cancer survivors in the US.</p><p><strong>Methods: </strong>The 2020, 2021, and 2022 Behavioral Risk Factor Surveillance System (BRFSS) surveys were used for the analysis. Logistic regression was performed to examine the odds of SCD in a sample of 20,739 cancer survivors, controlling for age, sex, race/ethnicity, marital status, level of education, employment status, general health status, and cigarette smoking status. All analyses were weighted to account for the complex study design and to produce nationally representative population estimates.</p><p><strong>Results: </strong>The prevalence of SCD among cancer survivors in this study was approximately 15%. Significant associations between BMI and SCD were found; compared to cancer survivors with normal weight, the odds of experiencing SCD were significantly greater for those with overweight (adjusted odds ratio [AOR] 1.22, 95% confidence interval [CI] 1.01-1.49) and obesity (AOR  1.24, 95%CI 1.02-1.51).</p><p><strong>Conclusion: </strong>Among cancer survivors in this study, unhealthy weight is associated with a higher risk of subjective cognitive decline. Underscoring the need for evidence-based interventions that support the cognitive health of adult cancer survivors, with a focus on those with unhealthy weight.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging technology and standardized institutional practices to mitigate disparities in breast cancer radiation therapy.","authors":"Jacob F Oyeniyi, Bailey A Loving, Muayad F Almahariq, Maha Saada Jawad, Joshua T Dilworth","doi":"10.1007/s10552-025-01978-5","DOIUrl":"https://doi.org/10.1007/s10552-025-01978-5","url":null,"abstract":"<p><strong>Objectives: </strong>Disparities in various dimensions, including racial, in breast cancer treatment and outcomes are well established. A recent multi-institutional study reported a higher mean heart dose (MHD) in Black and minority women compared to White women who underwent left-sided breast/chest wall irradiation which translated into excess cardiac events and mortality. We evaluated the MHD of women treated in our institution and investigated whether institution-wide measures including the use of readily available but inconsistently adopted technologies can mitigate this disparity.</p><p><strong>Methods: </strong>We identified 509 female patients treated with left-sided breast/chest wall irradiation with/without regional nodal irradiation (RNI). Details regarding cardiac dosimetry, deep-inspiratory breath-hold (DIBH) such as active breathing coordinator (ABC) use, breast size, internal mammary nodal (IMN) irradiation, and whether the treatment plan met boarding pass requirements and was peer reviewed were noted. MHD differences across racial groups were analyzed using Kruskal-Wallis test, while UVA and MVA linear regression analyses assessed influence of various factors on MHD.</p><p><strong>Results: </strong>MHD(Gy) was similar across racial groups; 1.38, 1.35, and 1.39 (p = 0.6) in Black, White, and other racial groups, respectively. Utilization of hypofractionation, cavity boosts, RNI, IMN irradiation, meeting boarding pass requirements, and peer review were similar. ABC usage (%) was 83/75/62 (p = 0.005), while median breast size(cc) was 1504/1904/1331 (p = 0.001) in White/Black/other women, respectively. On UVA and MVA, MHD differed with IMN treatment, boost and ABC use but not racial groups and varying breast sizes.</p><p><strong>Conclusion: </strong>Despite anatomical differences such as breast size, achieving similar cardiac dose is feasible across racial groups by uniformly utilizing appropriate technology such as ABC, with standardized boarding pass constraints, and peer review of all cases. Further studies to identify factors that may cause varied cardiac morbidity rates despite similar cardiac dosimetry among racial groups are warranted.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung cancer screening completion among patients using decision aids: a systematic review and meta-analysis.","authors":"Alexander Antigua-Made, Sabrina Nguyen, Ali Rashidi, Wen-Pin Chen, Argyrios Ziogas, Gelareh Sadigh","doi":"10.1007/s10552-025-01987-4","DOIUrl":"10.1007/s10552-025-01987-4","url":null,"abstract":"<p><strong>Purpose: </strong>Utilization of lung cancer screening (LCS) among eligible patients remains low at 16% in 2022. In this systematic review and meta-analysis we assessed the (a) LCS completion rate, and (b) intention to complete LCS, among patients who receive patient decision aids (PDAs).</p><p><strong>Methods: </strong>PubMed, Cochrane, Scopus, CINAHL, and Web of Science were searched for articles published in English between 1 January 2011, and 28 February 2023. Two independent reviewers selected randomized controlled trials and prospective cohort studies that reported PDA interventions targeting either LCS completion rate or intention to complete LCS. Quality appraisal and data extraction were performed independently by 2 reviewers using the National Heart, Lung, and Blood Institute quality assessment tool. A random-effects model meta-analysis was performed. Reporting followed the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines.</p><p><strong>Results: </strong>Thirteen studies with 2,277 total participants (51.5% male) were included. The pooled LCS completion rate across all follow-up periods (range, 1-6 months) was 40% (95% confidence interval [CI], 15-65%) with an I² of 97% for heterogeneity. Pooled intention to complete LCS among patients who received PDA across all follow-up periods (same day to 3 months) was 57% (95% CI, 34% to 80%) with significant heterogeneity (I²) of 96% (p < 0.0001). No publication bias was identified.</p><p><strong>Conclusions: </strong>LCS completion and intention to complete LCS among patients who use PDAs is high. Our findings support the need to implement PDAs in clinical practice which could further facilitate shared decision-making and improve LCS uptake among eligible patients.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social media use and the relationship with colorectal cancer screening among foreign-born populations in the United States.","authors":"Joseph Atarere, Eugene Annor, Mariah Malak Bilalaga, Olachi Egbo, Greeshma N Gaddipati, Ramya Vasireddy, Boniface Mensah, Lewis Roberts","doi":"10.1007/s10552-025-01985-6","DOIUrl":"https://doi.org/10.1007/s10552-025-01985-6","url":null,"abstract":"<p><strong>Background: </strong>Social media (SM) has emerged as a tool for health-related usage among US adults, including cancer screening promotion. Here, we aimed to assess the differences in health-related SM use between US and foreign-born adults and the relationship between health-related SM use and colorectal (CRC) screening practices.</p><p><strong>Methods: </strong>Using data from the fifth edition of the National Cancer Institute's Health Information National Trends Survey (HINTS 5), cycle 2, we compared the differences in health-related SM use between US and foreign-born adults and the effects of SM use on CRC screening by country of birth. We included adults aged 50-75 and excluded participants with a history of CRC. The primary endpoint was CRC screening, which was determined by self-reported CRC screening using colonoscopy, sigmoidoscopy, or stool occult blood testing.</p><p><strong>Results: </strong>Our study included 1,812 adults, of whom 236 (13.0%) were foreign-born. Most participants (72.1%) reported undergoing CRC screening. Interestingly, we found no discernible difference in health-related SM use [odds ratio [OR] 0.91; 95% CI (0.49, 1.69)] between US and foreign-born adults. Furthermore, our analysis revealed that SM use did not influence CRC screening practices among either group (US-born: 0.88 [95% CI: 0.50, 1.52], foreign-born 0.52 [0.10, 2.51]).</p><p><strong>Conclusion: </strong>Contrary to previous studies, which showed a positive relationship between SM use and satisfactory health-related practices, we found that although foreign-born adults use SM as much as US-born adults, there was no significant relationship between SM use and CRC screening.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of middle aged and older cancer survivors in the US Health and Retirement Study (HRS) and the Surveillance, Epidemiology, and End Results (SEER).","authors":"Peiyao Zhu, Lindsay C Kobayashi, Ashly C Westrick","doi":"10.1007/s10552-025-01986-5","DOIUrl":"https://doi.org/10.1007/s10552-025-01986-5","url":null,"abstract":"<p><strong>Introduction: </strong>We evaluated the effectiveness of the US Health and Retirement Study (HRS) in representing middle-aged and older cancer survivors by comparing individual- and county-level characteristics with those of a comparable cohort in Surveillance, Epidemiology, and End Results (SEER).</p><p><strong>Methods: </strong>We identified incident cancer survivors aged ≥ 50 years in the HRS and SEER biennially from 2000 to 2020. We calculated proportions of individual- level and county-level sociodemographic attributes for the sampling-weighted HRS and SEER. We calculated the standardized differences (SD) between the HRS and SEER, with an SD of ≥ 0.1 indicating a meaningful difference.</p><p><strong>Results: </strong>Cancer survivors in the HRS and SEER had similar sociodemographic characteristics, with some exceptions. Across most years, the HRS had a lower proportion of cancer survivors in the younger baseline age group (e.g., in 2020, 1.3% in HRS vs. 7.4% in SEER for ages 50-54), but a higher proportion of non-Hispanic White (e.g., in 2020, 75.7% in HRS, 68.3% in SEER), and married (e.g., in 2020, 59.5% in HRS, 53.2% in SEER), all with SD ≥ 0.1. The general populations of their data collection areas were similar, while the HRS over-represented counties with a higher proportion of Hispanic residents.</p><p><strong>Conclusions: </strong>The sociodemographic profiles of middle-aged and older cancer survivors in the HRS and SEER were similar, with some minor exceptions, reflecting their distinct objectives and data collection methodologies. Understanding the comparability between HRS and SEER is crucial for ensuring that HRS data can reliably inform cancer survivorship research across the US population while providing additional longitudinal aging and covariates data.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus and prostate cancer in Mexican men: a systematic review and meta-analysis.","authors":"Diego Arriaga-Izabal, Francisco Morales-Lazcano, Adrián Canizalez-Román","doi":"10.1007/s10552-025-01989-2","DOIUrl":"https://doi.org/10.1007/s10552-025-01989-2","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically evaluate the association between a history of Condyloma acuminatum, human papillomavirus (HPV) infection in prostate tissue, and prostate cancer in Mexican men, as well as to assess the prevalence of high- and low-risk HPV genotypes in prostate tissue.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted on studies that investigated the presence of HPV in prostate tissue or a history of condyloma and their association with prostate cancer. Data were extracted from PubMed and Web of Science, and the Newcastle-Ottawa Scale was used to assess study quality. Pooled odds ratios (OR) and the prevalence of HPV genotypes were calculated using a random effects model.</p><p><strong>Results: </strong>Eight case-control studies were included, comprising 1,059 cases and 1,768 controls. A significant association was found between the presence of HPV in prostate tumour tissue and prostate cancer (OR 2.34, 95% CI 1.52-3.60). Meanwhile, a borderline statistically significant relationship was observed between a history of Condyloma acuminatum and prostate cancer (2.26, 95% CI 1.00-5.11). The prevalence of high-risk HPV was 77% (95% CI 69-84%), while the prevalence of low-risk HPV was 23% (95% CI 16-31%). No significant publication bias or heterogeneity was detected.</p><p><strong>Conclusions: </strong>The presence of HPV in prostate tissue is significantly associated with increased odds of prostate cancer in Mexican men. These findings suggest that HPV may play a role in the development of prostate cancer and underscore the importance of further investigation into HPV screening and vaccination as potential preventive measures.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inclusion of tribes and American Indian and Alaska Native People in State comprehensive cancer control plans.","authors":"Dornell Pete, Paige E Farris, Prajakta Adsul, Jennifer W Bea, Dylan Decker, Jalisa Ingram, Jason Semprini, Hailey Baker, Monica Yellowhair, Cecily Blackwater, Craig Dee, Katherine J Briant, Myra Parker, Whitney E Zahnd, Sarah H Nash","doi":"10.1007/s10552-025-01981-w","DOIUrl":"https://doi.org/10.1007/s10552-025-01981-w","url":null,"abstract":"<p><strong>Purpose: </strong>State and District Comprehensive Cancer Control (CCC) plans often do not include priorities for all individuals within their state or district borders. In particular, American Indian and Alaska Native (AI/AN) people experience persistent cancer disparities, yet their inclusion in CCC plans has not been examined. Our study systematically reviewed state and district CCC plans for the inclusion of Tribal-specific cancer control strategies and priorities.</p><p><strong>Methods: </strong>A collaborative team of researchers from Tribal serving organizations, cancer centers, and academic institutions conducted a content analysis of state CCC plans to assess terms, concepts, context, and goals related to Tribal populations across twelve domains.</p><p><strong>Results: </strong>Seventy-three percent (n = 37) of state CCC plans addressed at least one of twelve domain criteria, while 14 states (27%) did not mention Tribal data or priorities. Specifically, the terms \"Indigenous or Native\" (n = 29) or \"American Indian, Indian Country, Reservations, or Indian Health Service\" (n = 27) were referenced most often. Three states met the highest domain criteria (New Mexico, California, Montana). Six states with federally recognized tribes within their borders did not meet any domains (Alabama, Florida, Massachusetts, Missouri, Texas, Virginia).</p><p><strong>Conclusion: </strong>By highlighting state and Tribal CCC plans' best practices and incorporating Tribal priorities within state and district CCC plans and programs, we underscore the importance of addressing cancer in Tribal populations across the U.S. and offer examples of inclusive CCC plan development and implementation.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet needs among long-term breast cancer survivors.","authors":"Rina A Yarosh, Hazel B Nichols, Rachel Hirschey, Erin E Kent, Deborah K Mayer, Melissa A Troester, Eboneé N Butler","doi":"10.1007/s10552-025-01984-7","DOIUrl":"https://doi.org/10.1007/s10552-025-01984-7","url":null,"abstract":"<p><strong>Purpose: </strong>Breast cancer survivors experience unmet needs throughout survivorship. We described the burden of unmet needs among ≥ 10-year survivors.</p><p><strong>Methods: </strong>We used the Cancer Survivors Unmet Needs Assessment (CaSun) to characterize unmet needs (information, quality of life, emotional and relationships, life perspective) among participants in Phase 3 of the Carolina Breast Cancer Study, a population-based study of breast cancer survivors diagnosed from 2008 to 2013. We calculated the prevalence of having ≥ 5 unmet needs (%) and estimated prevalence differences (PD) and 95% confidence intervals (CI) using generalized linear models with a binomial distribution to describe the burden of unmet needs across patient, clinical, and treatment characteristics.</p><p><strong>Results: </strong>We included 1445 women who completed the CaSun an average of 11.2 (SD = 0.6) years post-diagnosis. The sample was roughly balanced between Black (46.2%) and White (53.8%) participants. Overall, 27.1% of participants reported ≥ 5 unmet needs. We observed a higher burden of unmet needs among Black women compared to White women (PD: 14.2; 95% CI 9.6, 18.7) and among women < 50 years of age compared to women ≥ 50 (PD: 9.5; 95% CI 5.0, 13.9). Notably, women characterized as having \"more barriers to care\" had the highest prevalence of unmet needs in our study, with 28.6 percentage points higher prevalence compared to women with \"fewer barriers to care\" (95% CI 18.7, 38.5).</p><p><strong>Conclusions: </strong>Black, younger, and socioeconomically disadvantaged women had a higher burden of long-term unmet needs ≥ 10 years post-diagnosis. Identifying patient characteristics that predict long-term unmet needs may help to identify targeted interventions.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}