黑人妇女乳房x线摄影密度的生殖决定因素。

IF 2.1 4区 医学 Q3 ONCOLOGY
Zahna Bigham, Etienne X Holder, Angie Mae Rodday, Janis L Breeze, Kerrie P Nelson, Julie R Palmer, Karen M Freund, Kimberly A Bertrand
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引用次数: 0

摘要

目的:虽然高乳房x线摄影密度已被确定为最强的独立乳腺癌危险因素之一,但很少有研究报道黑人女性乳房x线摄影密度的决定因素。我们的目的是确定与黑人妇女乳房x线摄影密度相关的生殖相关特征。方法:在黑人妇女健康研究中建立的大型乳房x线摄影资料库的数据中,我们使用Cumulus软件评估5905名40-74岁女性的数字筛查乳房x线摄影密度。我们使用线性回归模型量化胎次、第一胎年龄、最后一胎年龄、母乳喂养史和母乳喂养持续时间与乳腺x线摄影密度百分比的关系。模型根据年龄、体重指数和其他乳腺癌风险因素进行了调整。结论:在这个庞大的黑人妇女群体中,较高的出生数量与较高的乳房x线摄影密度百分比适度相关。这种关联可能部分受到初产年龄和乳房x光检查年龄的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reproductive determinants of mammographic density in black women.

Purpose: While high mammographic density has been established as one of the strongest, independent breast cancer risk factors, few studies have reported determinants of mammographic density in Black women. We aimed to identify reproductive-related characteristics associated with mammographic density in Black women.

Methods: In data from a large mammography repository established in the Black Women's Health Study, we used Cumulus software to assess mammographic density from digital screening mammograms in 5,905 women ages 40-74. We used linear regression models to quantify the associations of parity, age at first birth, age at last birth, history of breastfeeding, and duration of breastfeeding with percent mammographic density. Models were adjusted for age, body mass index, and other breast cancer risk factors.

Results: Among parous women age < 55 years, mean percent mammographic density was 2.0 percentage points (95% CI 0.3, 3.7) higher in women with a history of ≥ 3 births than in women with a history of only 1 birth. The magnitude of associations of number of births with mammographic density varied somewhat by age at first birth and age at mammography. We found no significant associations between other reproductive factors and mammographic density.

Conclusion: In this large population of Black women, a higher number of births was modestly associated with higher percent mammographic density. This association may in part be influenced by age at first birth and age at mammography.

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来源期刊
Cancer Causes & Control
Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.90
自引率
4.30%
发文量
130
审稿时长
6.6 months
期刊介绍: Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.
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