The association between increases in nitrate in drinking water and colorectal cancer incidence rates in California, USA.

IF 2.2 4区 医学 Q3 ONCOLOGY
Ricardo Cisneros, Marzieh Amiri, Hamed Gharibi
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引用次数: 0

Abstract

Purpose: The water resources in California are polluted with nitrate (NO3) due to the ever-increasing application of nitrogen-based fertilizers. Considering the potential connection between NO3 in drinking water and the incidence rate of colorectal cancer, this study aims to investigate the association between long-term exposure to NO3 via drinking water and the incidence of colorectal cancer from 2010 to 2015 in California.

Methods: A total of 56,631 diagnoses of colorectal cancer were recorded from 2010 to 2015. A generalized linear model was used to obtain the risk ratio (RR) and 95% confidence interval associated with a 1 mg/l-NO3 increase in NO3 concentration across five latency periods. The potential effect modification by sex, race/ethnicity, and age (> 40, 41-64, 65-90, and > 90) was explored through stratification.

Results: The association between increases in the concentration of NO3 at lag 0-1, lag 0-5, lag 0-10, lag 0-15, and lag 0-20 (RRs: 1.056 [1.055, 1.058]; 1.066 [1.063, 1.069]; 1.030 [1.028, 1.031]; 1.017 [1.016, 1.018]; 1.035 [1.034, 1.037], respectively) was positively associated with the RR of colorectal cancer. Sex was not found to be a significant modifier. The RRs for Hispanics, Blacks, and other races were greater than those for Whites; the RRs across different age categories were all significantly positive.

Conclusion: This study confirms an association between long-term NO3 exposure in drinking water and the incidence of colorectal cancer in California, emphasizing the need for stringent water quality control and public health strategies to address this risk, particularly in vulnerable populations.

美国加利福尼亚州饮用水中硝酸盐含量的增加与结直肠癌发病率的关系。
目的:由于氮肥使用量的不断增加,加州水资源受到硝酸盐(NO3)的污染。考虑到饮用水中NO3与结直肠癌发病率之间的潜在联系,本研究旨在调查2010 - 2015年加州长期通过饮用水接触NO3与结直肠癌发病率之间的关系。方法:收集2010 - 2015年结直肠癌确诊病例56631例。采用广义线性模型计算5个潜伏期NO3浓度每增加1 mg/l时的风险比(RR)和95%置信区间。通过分层探讨性别、种族/民族和年龄(> 40、41-64、65-90和> 90)对潜在影响的改变。结果:NO3浓度在滞后0-1、滞后0-5、滞后0-10、滞后0-15、滞后0-20时升高的相关性(rr: 1.056 [1.055, 1.058];1.066 [1.063, 1.069];1.030 [1.028, 1.031];[1.016, 1.018];(1.035[1.034, 1.037])与结直肠癌RR呈正相关。性别并不是一个重要的修饰因素。西班牙裔、黑人和其他种族的风险比大于白人;不同年龄段的rrr均为显著正相关。结论:本研究证实了加利福尼亚州长期暴露于饮用水中的NO3与结直肠癌发病率之间的关联,强调需要严格的水质控制和公共卫生策略来解决这一风险,特别是在弱势群体中。
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来源期刊
Cancer Causes & Control
Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.90
自引率
4.30%
发文量
130
审稿时长
6.6 months
期刊介绍: Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.
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