Temporal trends and patterns for early- and late-onset adult liver cancer incidence vary by race/ethnicity, subsite, and histologic type in the United States from 2000 to 2019.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Causes & Control Pub Date : 2025-01-09 DOI:10.1007/s10552-024-01955-4

Mei-Chin Hsieh, Kendra L Ratnapradipa, Laura Rozek, Shengdi Wen, Yu-Wen Chiu, Edward S Peters

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引用次数: 0

Abstract

Purpose: To examine incidence trends and patterns for early- and late-onset liver cancer.

Methods: Liver and intrahepatic bile duct (IBD) cancers diagnosed between 2000 and 2019 were acquired from 22 SEER registries. Variables included early-onset (20-49) vs. late-onset (50+), anatomic subsite, histologic type (hepatocellular carcinoma [HCC] and IBD cholangiocarcinoma [ICC]), sex, and race/ethnicity. Age-standardized incidence rates were calculated using SEER*Stat. Jointpoint regression analysis was employed to estimate the annual percent change (APC) and the average APC (AAPC) with pairwise comparisons for trend by sex and by race/ethnicity stratified by age and subsite.

Results: Liver cancer incidence decreased among early-onset (AAPC [95% CI] - 2.39 [- 2.74, - 2.07]) but increased among late-onset patients (2.85 [2.71, 3.01]), primarily driven by HCC (3.60 [3.50, 3.71]). IBD incidence increased for both ages with ICC incidence annually increasing 7.92% (6.84, 9.26) for early-onset and 6.32% (5.46, 8.86) for late-onset patients. Early-onset liver cancer displayed comparable trends across racial/ethnic groups; however, late-onset liver cancer showed more variation, particularly among American Indian/Alaska Native/Asian Pacific Islander (AI/AN/API) populations, which experienced a significant decrease in incidence, thereby narrowing the gap with other racial/ethnic groups. For IBD, an identical pattern of early-onset IBD among non-Hispanic Blacks (NHBs) compared to Hispanics was showed with coincidence test p = 0.1522, and a parallel pattern was observed among late-onset patients for both sexes (p = 0.5087).

Conclusion: Late-onset HCC continues to rise, except for NHB and AI/AN/API, where incidence rates have started to decrease over the past 4-5 years. Early and late-onset ICC incidence continues to increase across all racial/ethnic groups.

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从2000年到2019年，美国早发性和晚发性成人肝癌发病率的时间趋势和模式因种族/民族、亚位点和组织学类型而异。

目的：探讨早发性和晚发性肝癌的发病率趋势和模式。方法：从22个SEER登记处获得2000年至2019年间诊断出的肝脏和肝内胆管（IBD）癌症。变量包括早发（20-49岁）与晚发（50岁以上）、解剖亚位点、组织学类型（肝细胞癌[HCC]和IBD胆管癌[ICC]）、性别和种族/民族。使用SEER*Stat计算年龄标准化发病率。采用联合点回归分析估计年变化百分比（APC）和平均APC (AAPC)，并两两比较按性别和按年龄和子地点分层的种族/民族的趋势。结果：早发患者的肝癌发病率下降（AAPC [95% CI] - 2.39[- 2.74, - 2.07]），但晚发患者的肝癌发病率上升（2.85[2.71,3.01]），主要由HCC驱动（3.60[3.50,3.71]）。两个年龄段的IBD发病率均呈上升趋势，其中早发型IBD发病率年增长7.92%(6.84,9.26)，晚发型IBD发病率年增长6.32%（5.46,8.86）。早发性肝癌在种族/民族群体中显示出可比的趋势；然而，晚发性肝癌表现出更多的差异，特别是在美国印第安人/阿拉斯加原住民/亚太岛民（AI/AN/API）人群中，其发病率显著下降，从而缩小了与其他种族/族裔群体的差距。对于IBD，非西班牙裔黑人（NHBs）与西班牙裔相比，早发性IBD的模式相同，符合检验p = 0.1522，并且在两性晚发性患者中观察到平行模式（p = 0.5087）。结论：迟发性HCC持续上升，除了NHB和AI/AN/API，其发病率在过去4-5年开始下降。早发性和晚发性ICC发病率在所有种族/族裔群体中持续增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.90

自引率

4.30%

发文量

130

审稿时长

6.6 months

期刊介绍： Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.