Cancer Causes & Control最新文献

{"title":"Registry versus claims-based index dates for studies of cancer diagnosis in administrative data.","authors":"Sarah E Soppe, Sharon Peacock Hinton, Jamie C Halula, Jennifer L Lund, Chris D Baggett, Sandi L Pruitt, Megan A Mullins, Ellis C Dillon, Matthew E Barclay, Matthew Thompson, Nicholas Pettit, Georgios Lyratzopoulos, Caroline A Thompson","doi":"10.1007/s10552-024-01953-6","DOIUrl":"10.1007/s10552-024-01953-6","url":null,"abstract":"<p><strong>Purpose: </strong>Studies of healthcare encounters leading to cancer diagnosis have increased over recent years. While some studies examine healthcare utilization before the cancer registry date of diagnosis, relevant pre-diagnosis interactions are not always immediately prior to this date due to date abstraction guidelines. We evaluated agreement of a registry date with a claims-based index and examined Emergency Department (ED) involvement in cancer diagnosis as an example of possible pre-diagnostic healthcare misclassification that could arise from improper date choice.</p><p><strong>Methods: </strong>We implemented an algorithm to define a claims-based index as the date of the earliest International Classification of Diseases code for the cancer in Medicare and estimated agreement with the date of diagnosis from a North Carolina registry for patients diagnosed aged 66 or older with 16 cancer types from 2008 to 2017 (n = 92,056). We then classified whether each cancer was initially diagnosed through care originating in the ED using each date.</p><p><strong>Results: </strong>The index date was identical to the cancer registry date for 47% of patients and preceded the registry date for 28%, with extent of agreement varying by cancer- and patient-specific characteristics. Agreement in ED-involved diagnosis classification using each date varied by cancer site, with sensitivity of classifications using the registry date relative to the index having a minimum of 86% for prostate and kidney cancer.</p><p><strong>Conclusion: </strong>Studies assessing healthcare utilization proximal to cancer diagnosis should carefully consider the relevant assessment window and be aware that the use of cancer registry versus claims-based dates may impact variable classification.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"539-550"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding automated breast ultrasound to mammography in women with increased breast density or at an elevated risk of breast cancer is a cost-effective screening strategy.","authors":"Ian Grady, Sean Grady, Nailya Chanisheva","doi":"10.1007/s10552-024-01958-1","DOIUrl":"10.1007/s10552-024-01958-1","url":null,"abstract":"<p><strong>Objectives: </strong>Automated breast ultrasound imaging (ABUS) results in a reduction in breast cancer stage at diagnosis beyond that seen with mammographic screening in women with increased breast density or who are at a high risk of breast cancer. It is unknown if the addition of ABUS to mammography or ABUS imaging alone, in this population, is a cost-effective screening strategy.</p><p><strong>Methods: </strong>A discrete event simulation (Monte Carlo) model was developed to assess the costs of screening, diagnostic evaluation, biopsy, and breast cancer treatment. The number of quality-adjusted life years gained through each screening method is assessed using previously published quality of life measures. Incremental cost-effectiveness ratios for screening with the combination of mammographic and ABUS imaging, and for ABUS imaging alone are calculated as compared to standard mammographic imaging.</p><p><strong>Results: </strong>Combined screening with both mammographic and ABUS imaging results in an incremental cost-effectiveness ratio of $7,071 ($6,332-$7,809) when compared to traditional mammographic imaging (p < 0.05). ABUS screening alone results in an incremental cost-effectiveness ratio of $3,559 ($- 965-$8,082) when compared to mammographic imaging (p < 0.05). ABUS screening alone is more likely to be cost-effective for a willingness-to-pay of less than $7,100.</p><p><strong>Conclusions: </strong>The addition of ABUS to mammographic imaging is a cost-effective screening strategy in women with increased breast density or who are at a high risk of developing breast cancer. ABUS imaging alone is also a cost-effective strategy in this population, particularly in resource-poor areas.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"473-481"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends and patterns for early- and late-onset adult liver cancer incidence vary by race/ethnicity, subsite, and histologic type in the United States from 2000 to 2019.","authors":"Mei-Chin Hsieh, Kendra L Ratnapradipa, Laura Rozek, Shengdi Wen, Yu-Wen Chiu, Edward S Peters","doi":"10.1007/s10552-024-01955-4","DOIUrl":"10.1007/s10552-024-01955-4","url":null,"abstract":"<p><strong>Purpose: </strong>To examine incidence trends and patterns for early- and late-onset liver cancer.</p><p><strong>Methods: </strong>Liver and intrahepatic bile duct (IBD) cancers diagnosed between 2000 and 2019 were acquired from 22 SEER registries. Variables included early-onset (20-49) vs. late-onset (50+), anatomic subsite, histologic type (hepatocellular carcinoma [HCC] and IBD cholangiocarcinoma [ICC]), sex, and race/ethnicity. Age-standardized incidence rates were calculated using SEER*Stat. Jointpoint regression analysis was employed to estimate the annual percent change (APC) and the average APC (AAPC) with pairwise comparisons for trend by sex and by race/ethnicity stratified by age and subsite.</p><p><strong>Results: </strong>Liver cancer incidence decreased among early-onset (AAPC [95% CI] - 2.39 [- 2.74, - 2.07]) but increased among late-onset patients (2.85 [2.71, 3.01]), primarily driven by HCC (3.60 [3.50, 3.71]). IBD incidence increased for both ages with ICC incidence annually increasing 7.92% (6.84, 9.26) for early-onset and 6.32% (5.46, 8.86) for late-onset patients. Early-onset liver cancer displayed comparable trends across racial/ethnic groups; however, late-onset liver cancer showed more variation, particularly among American Indian/Alaska Native/Asian Pacific Islander (AI/AN/API) populations, which experienced a significant decrease in incidence, thereby narrowing the gap with other racial/ethnic groups. For IBD, an identical pattern of early-onset IBD among non-Hispanic Blacks (NHBs) compared to Hispanics was showed with coincidence test p = 0.1522, and a parallel pattern was observed among late-onset patients for both sexes (p = 0.5087).</p><p><strong>Conclusion: </strong>Late-onset HCC continues to rise, except for NHB and AI/AN/API, where incidence rates have started to decrease over the past 4-5 years. Early and late-onset ICC incidence continues to increase across all racial/ethnic groups.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"551-560"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historical redlining and clustering of present-day breast cancer factors.","authors":"Sarah M Lima, Tia M Palermo, Jared Aldstadt, Lili Tian, Helen C S Meier, Henry Taylor Louis, Heather M Ochs-Balcom","doi":"10.1007/s10552-024-01950-9","DOIUrl":"10.1007/s10552-024-01950-9","url":null,"abstract":"<p><strong>Purpose: </strong>Historical redlining, a 1930s-era form of residential segregation and proxy of structural racism, has been associated with breast cancer risk, stage, and survival, but research is lacking on how known present-day breast cancer risk factors are related to historical redlining. We aimed to describe the clustering of present-day neighborhood-level breast cancer risk factors with historical redlining and evaluate geographic patterning across the US.</p><p><strong>Methods: </strong>This ecologic study included US neighborhoods (census tracts) with Home Owners' Loan Corporation (HOLC) grades, defined as having a score in the Historic Redlining Score dataset; 2019 Population Level Analysis and Community EStimates (PLACES) data; and 2014-2016 Environmental Justice Index (EJI) data. Neighborhoods were defined as redlined if score ≥ 2.5. Prevalence quintiles of established adverse and protective breast cancer factors relating to behavior, environment, and socioeconomic status (SES) were used to classify neighborhoods as high-risk or not. Factor analysis grouped factors into domains. Overall and domain-specific scores were calculated for each neighborhood according to historical redlining status. Percent difference in score by historical redlining was used to assess differences in average scores, with Wilcoxon-Mann-Whitney test used to estimate significance. Kappa statistic was used to estimate concordance between historical redlining status and high-risk status. Heatmaps of scores were created to compare spatial clustering of high-risk factors to historical redlining.</p><p><strong>Results: </strong>We identified two domains: (1) behavior + SES; (2) healthcare. Across the US, redlined neighborhoods had significantly more breast cancer factors than non-redlined (redlined neighborhoods = 5.41 average high-risk factors vs. non-redlined = 3.55 average high-risk factors; p < 0.0001). Domain-specific results were similar (percent difference for redlined vs. non-redlined: 39.1% higher for behavior + SES scale; 23.1% higher for healthcare scale). High-scoring neighborhoods tended to spatially overlap with D-grades, with heterogeneity by scale and region.</p><p><strong>Conclusion: </strong>Breast cancer risk factors clustered together more in historically redlined neighborhoods compared to non-redlined neighborhoods. Our findings suggest there are regional differences for which breast cancer factors cluster by historical redlining, therefore interventions aimed at redlining-based cancer disparities need to be tailored to the community.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"483-495"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral cavity and oropharyngeal cancers in Texas: examining incidence rates in dental health professional shortage areas.","authors":"Stacey B Griner, Biai Digbeu, Alexandra N Farris, Blair Williams, Malinee Neelamegam, Erika L Thompson, Yong-Fang Kuo","doi":"10.1007/s10552-024-01954-5","DOIUrl":"10.1007/s10552-024-01954-5","url":null,"abstract":"<p><strong>Purpose: </strong>Oral cavity (OC) and oropharyngeal (OP) cancer rates have increased annually rising in the U.S. and Texas. Dental providers could play a key role in lowering OC/OP cancer rates through prevention and screening, but Texas faces a significant shortage of dental health professionals, affecting access to dental care, including OC/OP cancer prevention and early detection. This study aims to explore the link between OC/OP cancer rates and these dental shortage areas in Texas.</p><p><strong>Methods: </strong>We analyzed OC/OP cancer incidence in Texas using SEER-Medicare data for patients aged 65 and over from 2012 to 2017. Rates per 100,000 were stratified by age, gender, and dental health provider shortage area (DHPSA) status (yes/no). Zero-Inflated Poisson Regression models were used to adjust for patient characteristics in studying cancer incidence, Late-stage diagnoses were assessed using logistic regression.</p><p><strong>Results: </strong>The incidence rate was 27.3 per 100,000 people in Texas. DHPSA counties had lower incidence rates (24.3 per 100,000) compared to non-DHPSA counties (29.8 per 100,000; p = 0.0423). Among patients with OC/OP diagnoses, those living in a DHPSA county had lower odds of advanced stage diagnoses (aOR: 0.79; CI: 0.64-0.96) than those in non-DHPSA counties.</p><p><strong>Conclusion: </strong>The findings highlight the complex link between dental providers and OC/OP cancer diagnoses, noting differences in indicators of need based on DHPSA location. Limited local dental services may lead to underreported cancer cases. Further research on dental service usage could improve OC/OP outcomes by prioritizing interventions from dental professionals.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":"509-520"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between increases in nitrate in drinking water and colorectal cancer incidence rates in California, USA.","authors":"Ricardo Cisneros, Marzieh Amiri, Hamed Gharibi","doi":"10.1007/s10552-025-02003-5","DOIUrl":"https://doi.org/10.1007/s10552-025-02003-5","url":null,"abstract":"<p><strong>Purpose: </strong>The water resources in California are polluted with nitrate (NO₃) due to the ever-increasing application of nitrogen-based fertilizers. Considering the potential connection between NO₃ in drinking water and the incidence rate of colorectal cancer, this study aims to investigate the association between long-term exposure to NO₃ via drinking water and the incidence of colorectal cancer from 2010 to 2015 in California.</p><p><strong>Methods: </strong>A total of 56,631 diagnoses of colorectal cancer were recorded from 2010 to 2015. A generalized linear model was used to obtain the risk ratio (RR) and 95% confidence interval associated with a 1 mg/l-NO₃ increase in NO₃ concentration across five latency periods. The potential effect modification by sex, race/ethnicity, and age (> 40, 41-64, 65-90, and > 90) was explored through stratification.</p><p><strong>Results: </strong>The association between increases in the concentration of NO₃ at lag 0-1, lag 0-5, lag 0-10, lag 0-15, and lag 0-20 (RRs: 1.056 [1.055, 1.058]; 1.066 [1.063, 1.069]; 1.030 [1.028, 1.031]; 1.017 [1.016, 1.018]; 1.035 [1.034, 1.037], respectively) was positively associated with the RR of colorectal cancer. Sex was not found to be a significant modifier. The RRs for Hispanics, Blacks, and other races were greater than those for Whites; the RRs across different age categories were all significantly positive.</p><p><strong>Conclusion: </strong>This study confirms an association between long-term NO₃ exposure in drinking water and the incidence of colorectal cancer in California, emphasizing the need for stringent water quality control and public health strategies to address this risk, particularly in vulnerable populations.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic, medical, health behavior, and psychosocial factors associated with COVID-19 diagnoses in the New Jersey cancer survivor cohort.","authors":"Sharon Manne, Adana A M Llanos, Hari S Iyer, Lisa E Paddock, Katie Devine, Shawna V Hudson, Denalee O'Malley, Elisa V Bandera, Sara Frederick, Jacintha Peram, Justin Solleder, Shengguo Li, Hao Liu, Andrew M Evens","doi":"10.1007/s10552-025-01997-2","DOIUrl":"https://doi.org/10.1007/s10552-025-01997-2","url":null,"abstract":"<p><strong>Background: </strong>Cancer survivors are more susceptible to contracting COVID-19. However, beyond race, age, and sex, less is known about other neighborhood and psychosocial factors contribute to this increased risk.</p><p><strong>Objective: </strong>The goal of this study was to examine the associations of individual and area-level social determinants of health (SDOH) measures, medical, lifestyle, and psychosocial factors and COVID-19 infection in a statewide cohort of cancer survivors in New Jersey.</p><p><strong>Methods: </strong>Survey data from 864 cancer survivors in New Jersey were collected from 2018 to 2022, which were merged with study participant data from the state of New Jersey on COVID-19 diagnoses in 2020, 2021, and 2022. We estimated adjusted odds ratios (aOR) for associations of COVID-19 diagnosis with individual-level factors (cancer type and stage, health behaviors, and psychosocial factors) and area-level SDOH [Social Vulnerability Index, Area Deprivation Index, and Index of Concentration at the Extremes (ICE) to quantify racialized deprivation vs. privilege based on income].</p><p><strong>Results: </strong>Cancer survivors born outside the US were more than twice as likely to contract COVID-19 compared to US-born survivors (aOR 2.29, 95% CI 1.01, 4.92). Compared to Quartile 4, residence in an area in Quartile 1 of racialized income ICE (i.e., predominantly Black, low income) was associated with higher odds of COVID-19 (aOR 2.15, 95% CI 0.98, 4.87). Retired survivors had lower odds of COVID-19 (aOR 0.39, 95% CI 0.19, 0.80) compared to those who were employed. Higher social well-being was associated with higher COVID-19 (aOR 1.07, 95% CI 1.02, 1.13). Type of cancer and cancer treatments received were not associated with the risk of COVID-19.</p><p><strong>Conclusions: </strong>Immigrant status and increased racialized deprivation as measured by ICE for income were associated with COVID-19. These findings support evidence that individual and area-level SDOH measures contribute to increased risk of COVID-19 among cancer survivors.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilevel socioecological determinants of colorectal cancer screening among American Indian communities in New Mexico.","authors":"Prajakta Adsul, Nidhi Kanabar, Joseph Rodman, Kevin English, Cheyenne Jim, Vernon Shane Pankratz, Nicholas Edwardson, Jimmie Charlie, John Pagett, Jonathan Trujillo, Jillian Grisel-Cambridge, Steven Mora, Kaitlyn L Yepa, Shiraz I Mishra","doi":"10.1007/s10552-025-01993-6","DOIUrl":"https://doi.org/10.1007/s10552-025-01993-6","url":null,"abstract":"<p><strong>Purpose: </strong>Low rates of colorectal cancer (CRC) screening and persistent racial disparities in CRC incidence and mortality among American Indian communities present an urgent public health concern in the United States. Although several evidence-based interventions exist for CRC screening, a gap remains in understanding how these interventions could be effectively implemented in American Indian communities given local contextual factors and preferences.</p><p><strong>Methods: </strong>Using a community-based participatory research approach, we worked with two American Indian communities and their tribally operated healthcare facilities in New Mexico. To better understand the implementation context within each community, we conducted focus group discussions with two groups of stakeholders: (1) community members and (2) staff, providers, and physicians (collectively referred to as \"healthcare professionals\") who worked in the tribally operated healthcare facilities. We conducted our analysis of transcripts and notes from these discussions using a grounded theory approach to examine factors according to the multilevel influences on cancer care delivery.</p><p><strong>Results: </strong>We convened six focus groups and listening sessions with healthcare professionals (n = 15) and community members (n = 65) from the two tribal communities in New Mexico. Participants described key factors likely to influence the implementation and uptake of CRC screening interventions in their communities across three ecological levels. From an individual perspective, several participants mentioned understanding the importance of screening as a cancer prevention intervention, even when individuals perceived themselves to be healthy. Interpersonally, participants highlighted the crucial role of provider recommendations around screening and indicated that listening to individuals share their personal healthcare experiences motivated the community members to get screened. Finally, from a healthcare system perspective, many providers mentioned the need for improved technology and care coordination to support the healthcare delivery within clinical settings to improve CRC screening rates.</p><p><strong>Conclusions: </strong>Engaging community members and providers through a community-based participatory research approach allowed us to identify key determinants for the successful implementation of CRC screening interventions in tribal communities. Future research will examine the effectiveness and implementation of the multicomponent, multilevel interventions and strategies for improving CRC screening rates in tribal communities in New Mexico.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clustering of childhood acute leukemia in Finland: a nationwide register-based study.","authors":"Julia Ventelä, Mia Korja, Anssi Auvinen, Olli Lohi, Atte Nikkilä","doi":"10.1007/s10552-025-01998-1","DOIUrl":"https://doi.org/10.1007/s10552-025-01998-1","url":null,"abstract":"<p><strong>Purpose: </strong>Acute leukemia is the most common childhood malignancy, with suspected contributions from environmental factors and immune responses to common pathogens. A recent meta-analysis indicated possible spatiotemporal clustering, though the findings were hindered by data quality limitations. We investigated spatial and spatiotemporal clustering of childhood leukemia using advanced methods and complete residential histories.</p><p><strong>Methods: </strong>We included patients aged 0-17 years diagnosed in 1990-2019, using data from the Finnish Cancer Registry. A 1:3 age- and sex-matched case-control design was employed and residential history data with exact coordinates was collected. Clustering was evaluated using the Cuzick-Edwards test, Knox test, Kulldorff's scan statistic, and Jacquez's Q statistic.</p><p><strong>Results: </strong>The dataset included 1,626 childhood leukemia cases (median age 5.0 years, 54% male). The Knox test revealed no evidence of spatiotemporal clustering. However, the Cuzick-Edwards test revealed spatial clustering at diagnosis addresses for children under 1 year (OR 1.35, 95% CI 1.14-1.57). Further analysis with Jacquez's Q test using complete residential histories identified significant spatiotemporal clustering in young children (ages 1.5-5.99 years) with acute lymphoblastic leukemia (ALL, p = 0.037). We also tested for co-incidence between leukemia and type 1 diabetes but found no clustering.</p><p><strong>Conclusion: </strong>Overall, we found limited evidence for clustering. In the subgroup analyses, significant spatiotemporal clustering in acute lymphoblastic leukemia cases among children aged 1.5-5.99 years was observed, coinciding with the peak incidence in early childhood. Previous research has shown that this age group has distinct genetic characteristics and may possess a unique etiology.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method of detection, determinants and subsequent treatments for breast, cervical and prostate cancers in Edo-Benin, Nigeria.","authors":"Gregrey Agbonvihele Oko-Oboh, Anssi Auvinen, Darlington Ewaen Obaseki, Janne Pitkäniemi","doi":"10.1007/s10552-025-02001-7","DOIUrl":"https://doi.org/10.1007/s10552-025-02001-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study sought to describe the methods of detection (MOD), their determinants and association with type of treatments received for breast, cervical and prostate cancers using a population-based cancer registry in Nigeria.</p><p><strong>Methods: </strong>The study analyzed incident breast (n = 205), cervical (n = 147), and prostate (n = 250) cancers from the Edo-Benin Cancer Registry (EBCR) from 2016 to 2018. The MOD was assigned as health check-up detected or clinically detected. Case proportion ratios (CPR) were used to compare MOD across determinant levels. Statistical association between demographic determinants and MOD were assessed using binomial regression.</p><p><strong>Results: </strong>Among the cancers recorded by the EBCR, 46% of breast (n = 205), 43% of cervical (n = 146), and 50% of prostate (n = 250) cases were identified through health check-ups. MOD was not significantly linked to age or marital status. Health check-ups were less common in those with less than tertiary education [breast, CPR 0.61 (95% CI 0.46-0.80), cervical, CPR 0.73 (95% CI 0.49-1.08), prostate, CPR 0.64 (95% CI 0.50-0.82)]. Significantly, more cancers detected via health check-ups were assigned to palliative care compared to clinical detection (breast: 76% vs. 58%, cervical: 80% vs. 59%, prostate: 83% vs. 64%).</p><p><strong>Conclusion: </strong>Health check-up campaigns are a key source of new cases in EBCR, but cancers detected through them are more often assigned to palliative care than those detected clinically. The findings suggest that efforts at early detection are not expressed in treatments assignment. Pre-symptomatic individuals should be encouraged to participate in health check-ups and proper treatment made available to improve these programmes.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}