International journal of medicinal mushrooms最新文献_第3页

Advances in Mechanism and Application of Molecular Breeding of Medicinal Mushrooms: A Review. 药用蘑菇分子育种机理及应用研究进展。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023050122

Wenming Jiang, Jing Wang, Hongyu Pan, Rui Yang, Feifei Ma, Jiahao Luo, Chunchao Han

引用次数: 0

Interactive Effects of Selenium, Zinc, and Iron on the Uptake of Selenium in Mycelia of the Culinary-Medicinal Winter Mushroom Flammulina velutipes (Agaricomycetes). 硒、锌、铁对冬菇菌丝体硒吸收的交互作用。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023050153

Rezvan Ramezannejad, Hamid R Pourianfar, Sharareh Rezaeian

{"title":"Interactive Effects of Selenium, Zinc, and Iron on the Uptake of Selenium in Mycelia of the Culinary-Medicinal Winter Mushroom Flammulina velutipes (Agaricomycetes).","authors":"Rezvan Ramezannejad, Hamid R Pourianfar, Sharareh Rezaeian","doi":"10.1615/IntJMedMushrooms.2023050153","DOIUrl":"10.1615/IntJMedMushrooms.2023050153","url":null,"abstract":"The present study for the first time addressed whether the simultaneous presence of selenium, zinc and iron may have effects on the selenium uptake in the mycelia of the winter mushroom (also known as enoki), Flammulina velutipes. Response surface methodology was used to optimize concentrations of selenium, zinc and iron in the range of 0 to 120 mg L-1. The findings showed that application of selenium, zinc and iron (singly, in pairs, or triads) significantly enhanced the selenium accumulation in the mycelia. The highest amount of the selenium accumulation was observed when selenium (60 mg L-1) and zinc (120 mg L-1) were applied into submerged culture media, concurrently, leading to an 85-fold and 88-fold increase in the selenium content of the mycelia compared to that of the mycelia treated with selenium only and untreated mycelia, respectively. In addition, accumulation of selenium into the mycelia had no deteriorative effects on the mycelial biomass. The findings presented in this study may have implications for daily nutrition and industrial bioproduction of mushroom mycelia enriched with selenium.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 11","pages":"75-87"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal Value, Biological Characteristics, and Domestication of the Wild Mushroom Pholiota adiposa (Agaricomycetes). 野生蘑菇黄腹菇的药用价值、生物学特性及驯化研究。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023049499

Tianxu Cao, Shanshan Luo, Ping Du, Hui Tu, Qian Zhang

{"title":"Medicinal Value, Biological Characteristics, and Domestication of the Wild Mushroom Pholiota adiposa (Agaricomycetes).","authors":"Tianxu Cao, Shanshan Luo, Ping Du, Hui Tu, Qian Zhang","doi":"10.1615/IntJMedMushrooms.2023049499","DOIUrl":"10.1615/IntJMedMushrooms.2023049499","url":null,"abstract":"Pholiota adiposa is an important edible and medicinal mushroom with high nutritional and medicinal effects. The fruiting body of wild fungi collected from Mudanjiang City, Heilongjiang Province, was identified by morphological description and molecular identification, the biological characteristics and domestication of the fungus was determined by single factor and orthogonal tests. The wild strain isolated was determined to be Ph. adiposa based on morphological characteristics, sequence alignment between ITS and nLSU, and phylogenetic relationship analysis. The single factor results revealed that the optimal carbon source, nitrogen source, culture temperature, and pH for the mycelia growth of Ph. adiposa were glucose, yeast paste, 25°C, and pH 6.5-7.0, respectively. Orthogonal test showed that the optimal formula for mycelia culture was fructose 20 g/L, yeast extract 6 g/L, KH2PO4 1 g/L and MgSO4 2.5 g/L. The highest single bag yield of the fruiting body of Ph. adiposa was 24.96 g in the culture medium formula of sawdust (20%), wheat bran (10%), soybean powder (1%), and quicklime powder (1%). The results will provide basic information for the protection, utilization and domestication of the resources of Ph. adiposa.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 10","pages":"77-90"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiparasitic Activity of Compounds Isolated from Ganoderma tuberculosum (Agaricomycetes) from Mexico. 从墨西哥结核灵芝中分离的化合物的抗寄生虫活性。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023049446

Victoria Espinosa-García, Jose J Fernandez, Desirée San Nicolás-Hernández, Iñigo Arberas-Jiménez, Rubén L Rodríguez-Expósito, María L Souto, José E Piñero, Guillermo Mendoza, Jacob Lorenzo-Morales, Ángel Trigos

{"title":"Antiparasitic Activity of Compounds Isolated from Ganoderma tuberculosum (Agaricomycetes) from Mexico.","authors":"Victoria Espinosa-García, Jose J Fernandez, Desirée San Nicolás-Hernández, Iñigo Arberas-Jiménez, Rubén L Rodríguez-Expósito, María L Souto, José E Piñero, Guillermo Mendoza, Jacob Lorenzo-Morales, Ángel Trigos","doi":"10.1615/IntJMedMushrooms.2023049446","DOIUrl":"10.1615/IntJMedMushrooms.2023049446","url":null,"abstract":"The genus Ganoderma has a long history of use in traditional Asiatic medicine due to its different nutritional and medicinal properties. In Mexico, the species G. tuberculosum is used in indigenous communities, for example, the Wixaritari and mestizos of Villa Guerrero Jalisco for the treatment of diseases that may be related to parasitic infections; however, few chemical studies corroborate its traditional medicinal potential. Thereby, the objective of this study was to isolate and identify anti-parasitic activity compounds from a strain of G. tuberculosum native to Mexico. From the fruiting bodies of G. tuberculosum (GVL-21) a hexane extract was obtained which was subjected to guided fractioning to isolate pure compounds. The in vitro anti-parasitic activity of the pure compound (IC50) was assayed against Leishmania amazonensis, Trypanosoma cruzi, Acanthamoeba castellanii Neff, and Naegleria fowleri. Furthermore, the cytotoxicity (CC50) of the isolated compounds was determined against murine macrophages. The guided fractioning produced 5 compounds: ergosterol (1), ergosta-4,6,8(14),22-tetraen-3-one (2), ergosta-7,22-dien-3β-ol (3), 3,5-dihydroxy-ergosta-7,22-dien-6-one (4), and ganoderic acid DM (5). Compounds 2 and 5 showed the best anti-parasitic activity in an IC50 range of 54.34 ± 8.02 to 12.38 ± 2.72 µM against all the parasites assayed and low cytotoxicity against murine macrophages. The present study showed for the first time the in vitro anti-parasitic activity of compounds 1-5 against L. amazonensis, T. cruzi, A. castellanii Neff, and N. fowleri, corroborating the medicinal potential of Ganoderma and its traditional applications.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 9","pages":"63-72"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food and Antioxidant Supplements with Therapeutic Properties of Morchella esculenta (Ascomycetes): A Review. 具有治疗特性的羊肚菌（子囊菌门）食品和抗氧化剂补充剂：综述。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023049147

Pushpa Kewlani, Deepti Tiwari, Laxman Singh, Shivani Balodi, Indra D Bhatt

{"title":"Food and Antioxidant Supplements with Therapeutic Properties of Morchella esculenta (Ascomycetes): A Review.","authors":"Pushpa Kewlani, Deepti Tiwari, Laxman Singh, Shivani Balodi, Indra D Bhatt","doi":"10.1615/IntJMedMushrooms.2023049147","DOIUrl":"10.1615/IntJMedMushrooms.2023049147","url":null,"abstract":"Morchella esculenta, commonly known as yellow morels, is an edible and medicinal mushroom popular worldwide for its unique flavor and culinary purposes. The traditional medical system effectively uses morels against infertility, fatigue, cancer, muscular pain, cough, and cold. The M. esculenta possesses many health-promoting nutritional components such as mono and polyunsaturated fatty acids, polyphenols, protein hydrolysates, vitamins, amino acids and minerals. The potential medicinal properties of morels is due to polysaccharides (galactomannan, chitin, β-glucans, and β-1,3-1,6-glucan) present that has high economic importance worldwide. Polysaccharides present possess a broad spectrum of biological activities such as anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, and antioxidant. However, the toxicity and clinical trials to prove its safety and efficacy for medicinal uses are yet to be evaluated. Moreover, the separation, purification, identification, and structural elucidation of active compounds responsible for the unique flavors and biological activities are still lacking in M. esculenta. The available information provides a new base for future perspectives. It highlights the need for further studies of this potent medicinal mushroom species as a source of beneficial therapeutic drugs and nutraceutical supplements.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 9","pages":"11-29"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychoactive Isoxazoles, Muscimol, and Isoxazole Derivatives from the Amanita (Agaricomycetes) Species: Review of New Trends in Synthesis, Dosage, and Biological Properties. 鹅膏菌属的精神活性异恶唑、麝香醇和异恶唑衍生物：合成、剂量和生物特性的新趋势综述。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023049458

Alex Okhovat, Westley Cruces, Maite L Docampo-Palacios, Kyle P Ray, Giovanni A Ramirez

{"title":"Psychoactive Isoxazoles, Muscimol, and Isoxazole Derivatives from the Amanita (Agaricomycetes) Species: Review of New Trends in Synthesis, Dosage, and Biological Properties.","authors":"Alex Okhovat, Westley Cruces, Maite L Docampo-Palacios, Kyle P Ray, Giovanni A Ramirez","doi":"10.1615/IntJMedMushrooms.2023049458","DOIUrl":"10.1615/IntJMedMushrooms.2023049458","url":null,"abstract":"Herbal products found in nature can serve as great systems of study for drug design. The Amanita muscaria mushroom is native to many parts of the Northern Hemisphere and has a very distinctive appearance with its red cap and white spotted warts. The mushroom comprises several pharmacologically active alkaloids, including muscazone, muscarine, ibotenic acid, and muscimol, the latter two compounds being potent GABA agonists. Muscimol has served as a backbone in the design of GABA agonists devoid of effects on the GABA-metabolizing enzyme, GABA transaminase, and GABA uptake systems. In this sense, several analogs of muscimol have been synthesized and studied including THIP, THPO, iso-THIP, iso-THAZ and 4-PIOL which all interact with the GABA receptors much differently. The growing pharmacological and toxicological interest based on many conflicting opinions on the use of the neuroprotective role of muscimol analogs against some neurodegenerative diseases, its potent role in the treatment of cerebral ischemia and other socially significant health conditions provided the basis for this review.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 9","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticancer Activity of the Bioactive Extract of the Morel Mushroom (Morchella elata, Ascomycetes) from Kashmir Himalaya (India) and Identification of Major Bioactive Compounds. 克什米尔喜马拉雅山羊肚菌（Morchella elata，子囊菌门）生物活性提取物的抗癌活性和主要生物活性化合物的鉴定。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023050169

Haridas Ramya, Korattuvalappil S Ravikumar, Thekkuttparambil A Ajith, Zuhara Fathimathu, Kainoor Krishnankutty Janardhanan

{"title":"Anticancer Activity of the Bioactive Extract of the Morel Mushroom (Morchella elata, Ascomycetes) from Kashmir Himalaya (India) and Identification of Major Bioactive Compounds.","authors":"Haridas Ramya, Korattuvalappil S Ravikumar, Thekkuttparambil A Ajith, Zuhara Fathimathu, Kainoor Krishnankutty Janardhanan","doi":"10.1615/IntJMedMushrooms.2023050169","DOIUrl":"10.1615/IntJMedMushrooms.2023050169","url":null,"abstract":"Morel mushrooms, Morchella species are highly nutritional, excellently edible and medicinal. Anticancer activity of M. elata, growing in forests of Kashmir Himalaya was studied. Ethyl acetate extract of fruiting bodies of M. elata (MEAE) was evaluated for cytotoxicity by MTT assay using Daltons lymphoma ascites (DLA), human colon cancer (HCT-116) and normal cell lines. Anti-carcinogenic and antiangiogenic activities of MEAE were tested using mouse models. Proapoptotic activity was detected by double staining of acridine orange-ethidium bromide assay. MEAE was partially purified by column chromatography and the bioactive compounds were identified by LC-MS analysis. The bioactive extract of M. elata showed significant cytotoxicic activity against DLA (P < 0.05), HCT-116 cell lines (P < 0.05) and did not possess appreciable adverse effect on the viability of normal cells. At a concentration of 100 µg/mL, 60% cell death was observed in HCT-116 cell line while 80% cell death was found in DLA cell line. The extract also possessed profound anticarcinogenic, antiangiogenic and proapoptotic activities. LC-MS analysis showed celastrol (RT 9.504, C29H38O4, MW 450.27), convallatoxin (RT 9.60, C29H42O10, MW 550.27), cucurbitacin A (RT 11.97, C32H46O9, MW 574.71) and madecassic acid (RT 14.35, C30H48O6, MW 504.70) as the major bioactive components. Current experimental studies indicated that bioactive extract of M. elata possessed significant anticancer activity. Being an excellently edible mushroom, the potential therapeutic use of M. elata and its bioactive extract in complementary therapy of cancer is envisaged.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 11","pages":"41-52"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Mitogenic and Genotoxic Effects of the Turkey Tail Medicinal Mushroom (Trametes versicolor, Agaricomycetes) Extracts from Mexico on Human Lymphocyte Cultures. 墨西哥土耳其尾药用蘑菇提取物对人淋巴细胞培养的有丝分裂和基因毒性作用的检测。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023050464

Letzi de Jesus Salinas-Solis, Juan Carlos Gaytan-Oyarzun, Pablo Octavio-Aguilar

{"title":"Detection of Mitogenic and Genotoxic Effects of the Turkey Tail Medicinal Mushroom (Trametes versicolor, Agaricomycetes) Extracts from Mexico on Human Lymphocyte Cultures.","authors":"Letzi de Jesus Salinas-Solis, Juan Carlos Gaytan-Oyarzun, Pablo Octavio-Aguilar","doi":"10.1615/IntJMedMushrooms.2023050464","DOIUrl":"10.1615/IntJMedMushrooms.2023050464","url":null,"abstract":"Diseases caused by a compromised immune system, characterized by decreased production and diversification of T lymphocytes, such as immunodeficiencies or chronic infections, are becoming increasingly prominent. These diseases lead to increased vulnerability to infections caused by parasites, viruses, bacteria, fungi, and other microorganisms. According to various articles, Trametes versicolor has been used as immunotherapy and cancer treatment due to its polysaccharides, which have shown their value in traditional medicine. However, most of the studies have been done with Asian samples. For this reason, the aim of this study was to evaluate the effect of samples of Mexican T. versicolor on human lymphoid cells. Of various extracts, the one with the best T cell proliferative response was the extract produced by maceration in water at room temperature, but all treatments in aqueous and ethanolic extracts increased the lymphocyte count, showing that extracts of Mexican T. versicolor also have compounds that stimulate T cells. Unfortunately, genetic damage expressed as an increment in micronuclei count was identified, so using these fungus extracts in traditional medicine would require careful control of recommended doses.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 12","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound Intensify the Flavonoid Production of the Willow Bracket Mushroom, Phellinus igniarius (Agaricomycetes), Fermentation Mycelia. 超声波强化柳支架蘑菇、桑黄、发酵菌丝体中黄酮类化合物的产生。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023050198

Yating Dong, Haile Ma, Muhammad Tayyab Rashid, Jamila Akter Tuly, Yiting Guo, Xiaofei Ye, Ling Sun, Bengang Wu, Cunshan Zhou, Ronghai He, Bingcheng Gan, Tao Wang, Mengxing Chen, Dan Wu

{"title":"Ultrasound Intensify the Flavonoid Production of the Willow Bracket Mushroom, Phellinus igniarius (Agaricomycetes), Fermentation Mycelia.","authors":"Yating Dong, Haile Ma, Muhammad Tayyab Rashid, Jamila Akter Tuly, Yiting Guo, Xiaofei Ye, Ling Sun, Bengang Wu, Cunshan Zhou, Ronghai He, Bingcheng Gan, Tao Wang, Mengxing Chen, Dan Wu","doi":"10.1615/IntJMedMushrooms.2023050198","DOIUrl":"10.1615/IntJMedMushrooms.2023050198","url":null,"abstract":"This research aimed to use a novel and effective ultrasound (US) approach for obtaining high bio-compound production, hence proposing strategies for boosting active ingredient biosynthesis. Furthermore, the US promotes several physiological effects on the relevant organelles in the cell, morphological effects on the structure of Phellinus igniarius mycelium, and increases the transfer of nutrients and metabolites. One suitable US condition for flavonoid fermentation was determined as once per day for 7-9 days at a frequency 22 + 40 kHz, power density 120 W/L, treated 10 min, treatment off time 7 s. The flavonoid content and production increased about 47.51% and 101.81%, respectively, compared with the untreated fermentation (P < 0.05). SEM showed that sonication changes the morphology and structure of Ph. igniarius mycelium; TEM reveals the ultrasonic treatment causes organelle aggregation. The ultrasound could affect the metabolism of the biosynthesis of the active ingredients.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 12","pages":"55-64"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crude Polysaccharides from Mushrooms Elicit Anti-allergic Effect Against Type 1 Allergy in vitro 蘑菇粗多糖对1型过敏的体外抗过敏作用

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/intjmedmushrooms.2023051549

Omoanghe Isikhuemhen, Felicia N. Anike, Judith O. Enemudo, Masashi Mizuno, Chidube A. Alagbaoso

{"title":"Crude Polysaccharides from Mushrooms Elicit Anti-allergic Effect Against Type 1 Allergy in vitro","authors":"Omoanghe Isikhuemhen, Felicia N. Anike, Judith O. Enemudo, Masashi Mizuno, Chidube A. Alagbaoso","doi":"10.1615/intjmedmushrooms.2023051549","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023051549","url":null,"abstract":"Type 1 allergic disease is a global challenge, hence the search for alternative therapies. Mushrooms have several medicinal and health benefits. However, scant data exist on the anti-allergic properties of polysaccharides from fruiting bodies (FB) and mycelia of mushrooms. We used an in vitro co-culture system comprising Caco-2 cells (intestinal epithelial colorectal carcinoma cell line) and RBL-2H3 cells (cell line from rat basophilic leukemia cells). Reduction in degranulation of mast cells indicated anti-allergy properties. The inhibitory effect of crude polysaccharides from different mushroom FB and mycelia on β-hexosaminidase release from RBL-2H3 cells was measured. Results showed that crude polysaccharides from the FB of Inonotus obliquus exhibited a significant inhibitory effect on β-hexosaminidase release and lowered it by 16%. Polysaccharides from the FB of Lentinus squarrosulus, and Pleurotus ostreatus did not exhibit a significant reduction in β-hexosaminidase. However, crude polysaccharides from their mycelia had a significant inhibitory effect, resulting in up to a 23% reduction in β-hexosaminidase activity. Among fungi showing degranulation properties, crude polysaccharides from their mycelia showed more potent action against degranulation than their corresponding FB. Polysaccharides extracted from FB and or mycelia, of selected mushrooms, possess anti-allergic properties that could be harnessed for use in alternative allergy therapies.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135500924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0