International journal of medicinal mushrooms最新文献_第3页

Substrate Influence on Yield and Biometabolite Production in the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes). 底物对冬虫夏草药用蘑菇（子囊菌）产量和生物代谢物产量的影响。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025057939

Pavleen Kour, Moni Gupta, Sachin Gupta, Priti Sharma, Meh-Run-Nisa, Kamlesh Bali, Manmohan Sharma

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Identification and Quantification of α-D-Glucopyranosyl-Isomaltol, α-D-Maltosyl-Isomaltol, and α-Glucan in AHCCŴ Cultured Mushroom Mycelia Extract. AHCCŴ培养蘑菇菌丝体提取物中α- d -葡萄糖酰异麦芽糖醇、α- d -麦芽糖酰异麦芽糖醇和α-葡聚糖的鉴定与定量

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058247

Brian V Hong, Yousef A Al-Dashti, Prae Charoenwoodhipong, Angela M Zivkovic, Robert M Hackman

{"title":"Identification and Quantification of α-D-Glucopyranosyl-Isomaltol, α-D-Maltosyl-Isomaltol, and α-Glucan in AHCCŴ Cultured Mushroom Mycelia Extract.","authors":"Brian V Hong, Yousef A Al-Dashti, Prae Charoenwoodhipong, Angela M Zivkovic, Robert M Hackman","doi":"10.1615/IntJMedMushrooms.2025058247","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058247","url":null,"abstract":"Consumer demand and use of mushrooms and their extracts for health promotion is increasing in the United States and worldwide. In order to further advance the science and quality assurance of mushroom products and ingredients, analytical data is needed to identify and standardize biochemical markers. This information is also needed to help prevent fraudulent products from entering the market. Three carbohydrate compounds, two of which have not yet been noted in mushrooms, have been identified and quantified in a standardized extract of cultured Lentinula edodes mycelia (AHCCŴ, Amino Up Co. Ltd., Sapporo, Japan). α-D-glucopyranosyl-isomaltol and α-D-maltosyl-isomaltol, collectively referred to as \"active hexose correlated compound,\" were quantified with pure standards using ultra high-performance liquid chromatography-mass spectrometry. α-Glucan content was quantified using a glucose autokit. Samples from three separate lots were analyzed. The mean concentration of α-D-glucopyranosyl-isomaltol was 990.2 + 330.1 μg/g and 184.2 + 86.8 μg/g for α-D-maltosyl-isomaltol. α-Glucan was present at 26.2 ± 0.5% of dry matter. To help prevent low-quality or counterfeit mushroom items from being sold, especially via websites, precise identification and quantification of marker compounds in medicinal mushroom extracts will support the differentiation of products, enhance research efforts and aid in consumer acceptance.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 6","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Fermentation Conditions in Ergothioneine Biosynthesis from Ganoderma resinaceum (Agaricomycetes) and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase. 灵芝合成麦角硫因发酵条件的优化及其对黄嘌呤氧化酶抑制活性的评价

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057485

Ying-Hao Yu, Zhi-Wei Ye, Ying-Min Huang, Na Wang, Qian-Wang Zheng, Jing-Ru Zhong, Bai-Xiong Chen, Jun-Fang Lin, Li-Qiong Guo

{"title":"Optimization of Fermentation Conditions in Ergothioneine Biosynthesis from Ganoderma resinaceum (Agaricomycetes) and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase.","authors":"Ying-Hao Yu, Zhi-Wei Ye, Ying-Min Huang, Na Wang, Qian-Wang Zheng, Jing-Ru Zhong, Bai-Xiong Chen, Jun-Fang Lin, Li-Qiong Guo","doi":"10.1615/IntJMedMushrooms.2024057485","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2024057485","url":null,"abstract":"Ganoderma resinaceum is a traditional mushroom that contains natural products, including ergothioneine (EGT), which has powerful antioxidant properties in the human body. To increase EGT yield from G. resinaceum, the optimal carbon and nitrogen sources in the culture medium were determined as 20 g/L sucrose and 4 g/L NH4Cl, respectively. The fermentation conditions were then optimized using response surface methodology, with the highest EGT yield of approximately 4.10 mg/L achieved at an initial pH of 5.19, a culture medium volume of 118 mL, and a fermentation temperature of 26.90°C. After extraction, EGT was purified using Sephadex G-10, resulting in a purity of 43.72%. Both the crude and purified EGT extracts were evaluated for their inhibitory activity against xanthine oxidase in vitro, with positive results. These findings suggest the potential for developing edible fungi-derived medicines to treat gout, which could alleviate the side effects of traditional medicines.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 3","pages":"71-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 12th International Medicinal Mushrooms Conference (IMMC12), September 24-27, 2024, Bari, Italy. 第十二届国际药用蘑菇会议（IMMC12）， 2024年9月24-27日，意大利巴里。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057063

Maria Letizia Gargano, Giuseppe Venturella

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Taxonomy and Biopharmaceutical Properties of a Newly Discovered Variety of Lentinus squarrosulus (Agaricomycetes) from West Bengal, India. 印度西孟加拉邦一新发现的香菇属（香菇菌）的分类及生物制药特性。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058024

Arghya Naskar, Pinaki Chattopadhyay, Arun Kumar Dutta, Krishnendu Acharya

{"title":"Taxonomy and Biopharmaceutical Properties of a Newly Discovered Variety of Lentinus squarrosulus (Agaricomycetes) from West Bengal, India.","authors":"Arghya Naskar, Pinaki Chattopadhyay, Arun Kumar Dutta, Krishnendu Acharya","doi":"10.1615/IntJMedMushrooms.2025058024","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058024","url":null,"abstract":"In the present study, a unique mushroom belonging to the genus Lentinus was collected from the Lateritic region of West Bengal, India. The purpose of our investigation is to determine its taxonomic identity and evaluate its therapeutic properties, with a particular emphasis on its antioxidant and antimicrobial properties. A thorough morpho-molecular investigation revealed that the collected mushroom is a novel variety that has been named Lentinus squarrosulus var. odoratus in recognition of its potent, rotting banana-like aroma. The methanolic extract of the desiccated basidiocarps exhibits potent antioxidant properties, as evidenced by the EC50 values that range from 314.201 ± 3.12 to 933.48 ± 3.58 μg/mL, contingent upon the type of free radicals employed. The extracted fraction was also discovered to be effective in inhibiting the growth of human-pathogenic bacterial strains in a dose-responsive manner, as evidenced by the low MIC50 values, which varied from 281.61 ± 1.64 to 680.31 ± 4.12 μg/mL depending on the strains under investigation. The inhibitory effect was shown to be potentially caused by an increase in membrane porosity and damage to the cell wall, resulting in the leaking of intracellular components. The findings of this research indicate that there is a significant therapeutic potential encased in this mushroom, necessitating further comprehensive investigation.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antihyperlipidemic Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract in Rats with Postnatal Sucrose Consumption Whose Mothers Also Consumed Sucrose. 生蚝食药菇平菇提取物对食糖大鼠的降血脂作用。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057783

Itzel Daysi Gutiérrez-Hernández, Jorge Rodríguez-Antolín, Margarita Cervantes-Rodríguez, Rubén Díaz, Gerardo Díaz-Godínez

{"title":"Antihyperlipidemic Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract in Rats with Postnatal Sucrose Consumption Whose Mothers Also Consumed Sucrose.","authors":"Itzel Daysi Gutiérrez-Hernández, Jorge Rodríguez-Antolín, Margarita Cervantes-Rodríguez, Rubén Díaz, Gerardo Díaz-Godínez","doi":"10.1615/IntJMedMushrooms.2024057783","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2024057783","url":null,"abstract":"Male offspring of rats whose mothers consumed sucrose (5% solution) during gestation and lactation were also given the sucrose solution instead of drinking water for 3 months, and subsequently, for 1 month, they were given an aqueous extract obtained from dehydrated fruiting bodies of Pleurotus ostreatus. The offspring that consumed sucrose (experimental group) did not show differences in body weight compared with those that did not consume sucrose (control group), however, total adiposity was higher in the experimental group. In rats that consumed the aqueous extract, a decrease in the amount of cholesterol and triglycerides in blood plasma was observed, total adiposity also decreased and the average size of adipocytes in the visceral area was reduced. Consumption of the aqueous extract of P. ostreatus showed an antihyperlipidemic effect when triglyceride, cholesterol and adipose tissue levels were increased by the consumption of sucrose in rats descended from mothers who also consumed sucrose.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 4","pages":"39-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Characterization and Anti-Obesity Activity of Exopolysaccharide Isolated from Scleroderma areolatum (Agaricomycetes). 乳状硬皮病（菌类）胞外多糖的化学特性及抗肥胖活性研究。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058054

Jiafeng Bai, Xiaoqin Peng, Yi Zhou, Zhizhong Hu, Changtong Lu, Xuewei Jia, Chunping Xu

{"title":"Chemical Characterization and Anti-Obesity Activity of Exopolysaccharide Isolated from Scleroderma areolatum (Agaricomycetes).","authors":"Jiafeng Bai, Xiaoqin Peng, Yi Zhou, Zhizhong Hu, Changtong Lu, Xuewei Jia, Chunping Xu","doi":"10.1615/IntJMedMushrooms.2025058054","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058054","url":null,"abstract":"Two polysaccharide fractions were successfully isolated from the crude exopolysaccharide (EPS) of Scleroderma areolatum via gel filtration chromatography. Size exclusion chromatography/multi-angle laser light scattering (SEC/MALLS) analysis showed that the weight of average molecular weights (Mw) of these fractions was 3.162 ȕ 106 (Fr-I) and 2.613 ȕ 106 (Fr-II). Both EPS fractions exhibited a compact globular structure in aqueous solution. Monosaccharide composition analysis revealed that they were primarily composed of mannose and glucuronic acid. FT-IR spectral analysis identified prominent functional groups, such as hydroxyl and carboxylic, typical of heteropolysaccharides. When administered as supplements in high-fat diets to obese rats for 8 weeks, the EPS fractions reduced body weight, serum inflammatory factor levels, and significantly regulated serum lipid levels. Additionally, they increased the total concentration of short-chain fatty acids (SCFA) in colonic digesta. These results suggest a potential role for EPS in mitigating obesity and related metabolic disorders in high-fat diet-induced obese rats.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice. 香菇多糖改善h2o2诱导的Caco-2细胞和dss诱导的溃疡性结肠炎小鼠的炎症损伤

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058082

Jun Lin, Meng Yuan, Hong-Yu Shi, Qiang Liu, Shuai Du, Mei-Xia Zhang, Qu-Quan Li, Zhen-Bang Yang, Pei Lin

{"title":"Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice.","authors":"Jun Lin, Meng Yuan, Hong-Yu Shi, Qiang Liu, Shuai Du, Mei-Xia Zhang, Qu-Quan Li, Zhen-Bang Yang, Pei Lin","doi":"10.1615/IntJMedMushrooms.2025058082","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058082","url":null,"abstract":"Phellinus linteus (Agaricomycetes) is a valuable medicinal mushroom traditionally used as a food supplement and medicinal ingredient. Polysaccharides of Ph. linteus (PLP) possess strong anti-inflammatory effects and gut microbiota modulating properties. However, the mechanism of its efficacy in ulcerative colitis (UC) remains unclear. This study utilized 1mM H2O2 to induce an in vitro model of UC in Caco-2 cells. Additionally, a 3% solution of dextran sulfate sodium salt (DSS) was employed to establish an in vivo UC model in mice. After treating the cells with PLP at various concentrations, there was a significant reduction in the mRNA expression of TNF-α and IL-6, and the nuclear factor-κB (NF-κB) signaling pathway was also inhibited. Concurrently, symptoms such as colon shortening, weight loss, and a decrease in disease activity index (DAI) scores were significantly improved in UC mice. Additionally, the treatment led to downregulated expression of TNF-α and IFN-γ mRNA in colon tissues. PLP had shown potential in reducing inflammation and oxidative stress in Caco-2 cells, demonstrating therapeutic effects in treating UC-like inflammation by inhibiting the NF-κ signaling pathway and activating the nuclear factor erythroid derived 2-like 2(Nrf2)/heme oxygenase-1(HO-1) signaling pathway. These findings suggest that PLP has great potential for further investigation and development in UC treatment.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"17-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Effects of Polycephalomyces nipponicus (Ascomycota) Mycelial Extract on Salmonella enterica Serovar Typhi. 日本多头菌（子囊菌）菌丝提取物对伤寒沙门氏菌血清型的抑菌作用。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058095

Winita Fowsantear, Kusavadee Sangdee, Sutthiwan Thammawat, Aphidech Sangdee

{"title":"Antibacterial Effects of Polycephalomyces nipponicus (Ascomycota) Mycelial Extract on Salmonella enterica Serovar Typhi.","authors":"Winita Fowsantear, Kusavadee Sangdee, Sutthiwan Thammawat, Aphidech Sangdee","doi":"10.1615/IntJMedMushrooms.2025058095","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058095","url":null,"abstract":"The rise of antibiotic-resistant bacteria, particularly Salmonella enterica subsp. enterica serovar Typhi (S. Typhi), poses a significant challenge to global public health. This study investigates the antibacterial potential of mycelial extract from the medicinal fungus Polycephalomyces nipponicus strain Cod-MK1201 against S. Typhi strain DMST 16122. The extract demonstrated significant inhibitory effects, with minimum inhibitory concentration and minimum bactericidal concentration values of 3.12 mg/mL and 6.25 mg/mL, respectively. Scanning and transmission electron microscopy revealed dose-dependent severe morphological damage to S. Typhi cells, including cell wall disruption, cytoplasmic leakage, and structural deformation, indicating the extract's ability to target multiple cellular structures. Additionally, proteomic analysis showed significant alterations in the bacterial proteome, with downregulation of key proteins involved in metabolism, stress response, and virulence, and upregulation of proteins related to oxidative stress response and the stringent survival pathway. These findings demonstrate the multifaceted antimicrobial mechanisms of P. nipponicus mycelial extract, indicating its potential as a natural resource for developing novel therapeutic agents to treat S. Typhi infections. This highlights its promise as a candidate for reducing antibiotic dependency and addressing the growing challenge of antimicrobial resistance.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 6","pages":"45-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure Characterization and Antioxidant Properties of a Triple Helix Galactoglucomannan from the Fruiting Bodies of Russula virescens (Agaricomycetes). 一种三螺旋半乳糖葡甘露聚糖的结构表征及抗氧化性能。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057484

Guofeng Yu, Yuanshang Liu, Yuan Gao, Xuewei Jia, Rong Ma, Tianxiao Li, Wenning Feng, Chunping Xu

{"title":"Structure Characterization and Antioxidant Properties of a Triple Helix Galactoglucomannan from the Fruiting Bodies of Russula virescens (Agaricomycetes).","authors":"Guofeng Yu, Yuanshang Liu, Yuan Gao, Xuewei Jia, Rong Ma, Tianxiao Li, Wenning Feng, Chunping Xu","doi":"10.1615/IntJMedMushrooms.2024057484","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2024057484","url":null,"abstract":"RVP, a water-soluble triple-helix galactoglucomannan, was successfully extracted from the fruiting body of Russula virescens using an alkali extraction method. Physicochemical properties analysis showed that the protein content of RVP was low (0.95%). The main chain was mainly composed of 1,3,6-linked D-mannose and 1,6-linked glucose residues, and contained terminal glucose units and a small amount of 1,4-linked glucose and 1,6-linked galactose. The average molecular weight of RVP is approximately 8.91 ȕ 105, and it adopts a semi-rigid triple helix conformation. The antioxidant potential of RVP was initially assessed in vitro using H2O2 to induce oxidative stress in a cellular model, leading to cell damage and decreased survival rates. In comparison to the H2O2 model group, RVP exhibited substantial antioxidant activity, demonstrating a capacity to enhance cell viability in a concentration-dependent manner and notably reduce the level of malondialdehyde (MDA) in the cell supernatant, thus indicating its effectiveness in reducing lipid peroxidation. Furthermore, RVP was found to boost the activity of crucial antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the cells. Thus, RVP with antioxidant properties has broad application prospects in health and wellness.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 3","pages":"45-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0