International journal of medicinal mushrooms最新文献_第4页

Health Foods Made from Medicinal Mushrooms: Innovative Recipes Created by an Italian Chef. 由药用蘑菇制成的健康食品：意大利厨师创造的创新食谱。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058296

Angela Fallea, Giuseppe Venturella

引用次数: 0

Assessment of Acute Dermal Toxicity of Lignosus rhinocerus TM02Ŵ (Agaricomycetes) Sclerotium and Its Potent Cold Water Extract (xLrŴ). 犀牛木的急性皮肤毒性评价TM02Ŵ（真菌）菌核及其强效冷水提取物（xLrŴ）。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058984

Yeannie Hui-Yeng Yap, Shin Yee Fung, Szu Ting Ng, Chon Seng Tan, Soon Hao Tan

{"title":"Assessment of Acute Dermal Toxicity of Lignosus rhinocerus TM02Ŵ (Agaricomycetes) Sclerotium and Its Potent Cold Water Extract (xLrŴ).","authors":"Yeannie Hui-Yeng Yap, Shin Yee Fung, Szu Ting Ng, Chon Seng Tan, Soon Hao Tan","doi":"10.1615/IntJMedMushrooms.2025058984","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058984","url":null,"abstract":"The tiger milk mushroom (Lignosus rhinocerus), a Southeast Asian medicinal mushroom, has traditional uses for respiratory ailments, wound healing, and general health. This study evaluated the acute dermal toxicity of L. rhinocerus sclerotium (TM02Ŵ) and cold-water extract (xLrŴ) for safe topical application. Healthy female Sprague Dawley rats were topically administered TM02Ŵ or xLrŴ at 2000 mg/kg body weight, while physiological saline served as a control. Visual toxicity observations, body and organ weight measurements, food and water intake, hematological and serum biochemical analyses, and histological examinations were performed. Findings were contextualized with prior oral toxicity studies of L. rhinocerus. Both TM02Ŵ and xLrŴ demonstrated excellent dermal safety with no observed mortality, behavioural abnormalities, or significant differences in food or water intake, body weight, or organ weights compared with controls. Hematological and biochemical parameters remained within normal ranges, and histopathology of the skin and major organs revealed no adverse effects. Consistent with earlier chronic oral toxicity studies, the preparations showed no evidence of systemic toxicity or organ damage. TM02Ŵ and xLrŴ are classified as Category 5/Unclassified under the Globally Harmonized System (GHS) criteria, affirming their suitability for topical use. These findings, coupled with earlier oral toxicity studies, highlight the safety of L. rhinocerus as a versatile ingredient for therapeutic and cosmetic applications. Further research on chronic dermal exposure is recommended to reinforce its use in skincare.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 8","pages":"81-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Exploring the Potential of Medicinal Mushroom β-Glucans as a Natural Frontier in Prostate Cancer Treatment. 探索药用蘑菇β-葡聚糖作为前列腺癌治疗天然前沿的潜力。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024056585

Rashmi Trivedi, Tarun Kumar Upadhyay

{"title":"Exploring the Potential of Medicinal Mushroom β-Glucans as a Natural Frontier in Prostate Cancer Treatment.","authors":"Rashmi Trivedi, Tarun Kumar Upadhyay","doi":"10.1615/IntJMedMushrooms.2024056585","DOIUrl":"10.1615/IntJMedMushrooms.2024056585","url":null,"abstract":"The global increase in cancer cases, particularly prostate cancer, poses a significant health challenge worldwide. Conventional treatments such as surgery, radiation therapy, hormone therapy, chemotherapy, and immunotherapy offer valuable options but are associated with limitations and potential side effects. As a result, there is growing interest in complementary therapies, including natural compounds such as β-glucans, derived from sources such as yeast and mushrooms. In this review, we explored the potential therapeutic role of medicinal mushrooms β-glucan in prostate cancer treatment. β-glucans has demonstrated anti-cancer properties in preclinical studies, including inhibition of proliferation, induction of apoptosis, and modulation of immune responses. Studies in prostate cancer cell lines and animal models have shown promising results, with β-glucan inhibiting tumor growth, inducing DNA damage, and regulating tumor markers such as p53 and prostate specific antigen. β-glucans acts through various pathways, including stimulation of dendritic cells, modulation of cytokine secretion, suppression of myeloid-derived suppressor cells, and enhancement of immune responses. Moreover, β-glucans exhibits anti-androgenic and immune-modulatory effects, making it a promising candidate for prostate cancer treatment. In this study, we also focused on the mechanism of action of β-glucans through various pathways including tumor cell death by oxidative stress created through ROS generation and autophagy. Although preclinical studies support the potential therapeutic efficacy of medicinal mushrooms β-glucans, further research is needed to elucidate its clinical utility and safety in human trials.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 2","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Favorable Conditions to Improve Biomass Production and Antioxidant Activity by the Egyptian Ganoderma resinaceum EGM and Ganoderma mbrekobenum EGDA (Agaricomycetes). 提高埃及树脂灵芝（EGM）和灵芝（EGDA）生物量和抗氧化活性的有利条件评价

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057141

Shimaa R El-Esseily, Amira A El-Fallal, Mahmoud M Nour El-Dein, Ahmed K A El-Sayed

{"title":"Evaluation of Favorable Conditions to Improve Biomass Production and Antioxidant Activity by the Egyptian Ganoderma resinaceum EGM and Ganoderma mbrekobenum EGDA (Agaricomycetes).","authors":"Shimaa R El-Esseily, Amira A El-Fallal, Mahmoud M Nour El-Dein, Ahmed K A El-Sayed","doi":"10.1615/IntJMedMushrooms.2024057141","DOIUrl":"10.1615/IntJMedMushrooms.2024057141","url":null,"abstract":"Physiological studies were performed to investigate the optimal mycelial growth parameters for Ganoderma resinaceum EGM (AC: LN774970) and G. mbrekobenum EGDA (previously identified as Ganoderma sp. EGDA, AC: LN774971). The study found that the highest growth of mycelia was at 11 d for Ganoderma species. The nutritional studies were carried out to know the best growth conditions including temperature, culture media, pH, carbon source, and nitrogen source. The most appropriate temperature for the highest growth for Ganoderma species was at 30°C; this benefit enables the cultivation of these species in the spring. The most favorable media for their growth was potato dextrose broth as semi-synthetic followed by Saburaoud broth as synthetic media. They also could grow at pH ranges from 3.0-9.0, with the highest mycelial growth at pH 5.0. This study confirmed that both Ganoderma species prefer glucose as a carbon source and peptone as an organic nitrogen source. Decolorization of poly R associated with peptone was 21.37% and 18.66% for both EGM and EGDA strains, respectively. The highest cellulase production was achieved after 11 d of incubation with activity reached 0.305 μmole/mL/min and 0.236 μmole/mL/min for G. mbrekobenum EGDA and G. resinaceum EGM, respectively. The highest laccase activity was obtained after 8, 12 d of incubation with a value of 5.53 μmole/mL/min and 31.32 μmole/mL/min, for EGM and EGDA strains, respectively. Moreover, the highest peroxidase activity for both EGM and EGDA strains was recorded after 26 and 20 d of incubation with a value of 0.333 μmole/mL/min and 0.230 μmole/mL/min, respectively. G. mbrekobenum EGDA possessed higher flavonoids and phenolic compounds (4.098 mg/g and 6.298 mg/g dry weight, respectively) than G. resinaceum EGM (1.137 mg/g and 2.420 mg/g dry weight, respectively).","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 4","pages":"53-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Investigation of Ganoderic Acid A Targeting Amyloid-Beta and Tau Protein Aggregation in Alzheimer's Disease. 在阿尔茨海默病中靶向淀粉样蛋白- β和Tau蛋白聚集的灵芝酸A的计算机研究。

IF 1.4

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025059137

Abuzer Ali, Ankit Ganeshpurkar, Aditya Ganeshpurkar, Nazneen Dubey

{"title":"In Silico Investigation of Ganoderic Acid A Targeting Amyloid-Beta and Tau Protein Aggregation in Alzheimer's Disease.","authors":"Abuzer Ali, Ankit Ganeshpurkar, Aditya Ganeshpurkar, Nazneen Dubey","doi":"10.1615/IntJMedMushrooms.2025059137","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025059137","url":null,"abstract":"Alzheimer's disease (AD) represents a significant challenge in neurodegenerative disorders, characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein tangles in the brain. Current treatments provide symptomatic relief but do not halt disease progression. ganoderic acid A, derived from Ganoderma lucidum, has shown to act as a dual inhibitor of Aβ and tau protein aggregation through in vitro and animal model studies. This study aims to explore the therapeutic potential of ganoderic acid A using in silico methods to predict its binding affinity and mode of interaction with Aβ and tau proteins. Analysis included molecular docking simulations using computational models to evaluate the binding of ganoderic acid A to Aβ and tau proteins. Various tools were employed to predict the binding energy, interaction sites (Autodock), and MD (CABSflex 2.0) of these complexes. Ganoderic acid A demonstrated favorable binding energies and interactions with both Aβ and tau proteins. The compound exhibited potential dual inhibition capabilities by forming stable complexes with critical residues involved in Aβ aggregation and tau protein hyperphosphorylation. The findings suggest that ganoderic acid A holds promise as a dual inhibitor of Aβ and tau protein aggregation in AD. By targeting these key pathological processes, ganoderic acid A may offer therapeutic benefits in halting or slowing disease progression. Confirming these predictions and advancing ganoderic acid A as a possible AD treatment will require additional experimental validation, including in vitro and in vivo research.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 9","pages":"85-92"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Aging Effects of Polysaccharides Derived from Amauroderma rugosum (Agaricomycetes) Aqueous Extract on Keratinocytes. 黑皮菌多糖对角质形成细胞的抗衰老作用。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025057696

Polly Ho-Ting Shiu, Wen Wang, Panthakarn Rangsinth, Chengwen Zheng, Jingjing Li, George Pak-Heng Leung

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Protective Effect of Polycephalomyces nipponicus (Ascomycota) Against Alcohol-Induced Liver Injury and Alcohol Intoxication in ICR Mice. 日本多头菌（子囊菌）对ICR小鼠酒精性肝损伤和酒精中毒的保护作用

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057762

Araya Supawat, Jintana Sattayasai, Sirinapa Rungruang, Jirayut Kaewmor, Kusavadee Sangdee, Aphidech Sangdee

{"title":"Protective Effect of Polycephalomyces nipponicus (Ascomycota) Against Alcohol-Induced Liver Injury and Alcohol Intoxication in ICR Mice.","authors":"Araya Supawat, Jintana Sattayasai, Sirinapa Rungruang, Jirayut Kaewmor, Kusavadee Sangdee, Aphidech Sangdee","doi":"10.1615/IntJMedMushrooms.2024057762","DOIUrl":"10.1615/IntJMedMushrooms.2024057762","url":null,"abstract":"Polycephalomyces nipponicus, a traditional East Asian medicinal fungus, is recognized for its anticancer and antimicrobial properties, but its protective effects against alcohol-induced liver injury are less understood. This study investigated the activity of P. nipponicus strain MK1201 on motor coordination, alcohol metabolism, and hepatoprotection in mice after 14 d of ethanol exposure. Mice were assigned to five groups with nine treatments: (I) normal control (treatment 1), (II) ethanol administration (2 or 6 g/kg; treatments 2 and 3), (III) P. nipponicus (PN) extract alone (200 or 600 mg/kg; treatments 4 and 5), and (IV, V) PN-pretreated groups (200 or 600 mg/kg) followed by ethanol (2 or 6 g/ kg; treatments 6-9). Prior to ethanol administration, mice received either water or PN extract (200 or 600 mg/kg) by oral gavage. One h later, mice were given either water or ethanol (2 or 6 g/kg). Liver enzyme activities-alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP)-and blood triglyceride and cholesterol levels were measured, with motor coordination assessed post-ethanol. Pretreatment with PN extract (600 mg/kg) significantly enhanced ADH and ALDH activities and maintained normal motor coordination following ethanol exposure. Fourteen days of PN pretreatment (200 or 600 mg/ kg) significantly reduced AST, ALP, triglyceride, and total cholesterol levels, with 600 mg/kg also lowering ALT. These findings suggest PN extract as a promising therapeutic candidate to mitigate ethanol-induced motor, hepatic, and metabolic dysfunctions, presenting a potential natural intervention for alcohol-related health issues.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substrate Influence on Yield and Biometabolite Production in the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes). 底物对冬虫夏草药用蘑菇（子囊菌）产量和生物代谢物产量的影响。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025057939

Pavleen Kour, Moni Gupta, Sachin Gupta, Priti Sharma, Meh-Run-Nisa, Kamlesh Bali, Manmohan Sharma

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Identification and Quantification of α-D-Glucopyranosyl-Isomaltol, α-D-Maltosyl-Isomaltol, and α-Glucan in AHCCŴ Cultured Mushroom Mycelia Extract. AHCCŴ培养蘑菇菌丝体提取物中α- d -葡萄糖酰异麦芽糖醇、α- d -麦芽糖酰异麦芽糖醇和α-葡聚糖的鉴定与定量

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058247

Brian V Hong, Yousef A Al-Dashti, Prae Charoenwoodhipong, Angela M Zivkovic, Robert M Hackman

{"title":"Identification and Quantification of α-D-Glucopyranosyl-Isomaltol, α-D-Maltosyl-Isomaltol, and α-Glucan in AHCCŴ Cultured Mushroom Mycelia Extract.","authors":"Brian V Hong, Yousef A Al-Dashti, Prae Charoenwoodhipong, Angela M Zivkovic, Robert M Hackman","doi":"10.1615/IntJMedMushrooms.2025058247","DOIUrl":"10.1615/IntJMedMushrooms.2025058247","url":null,"abstract":"Consumer demand and use of mushrooms and their extracts for health promotion is increasing in the United States and worldwide. In order to further advance the science and quality assurance of mushroom products and ingredients, analytical data is needed to identify and standardize biochemical markers. This information is also needed to help prevent fraudulent products from entering the market. Three carbohydrate compounds, two of which have not yet been noted in mushrooms, have been identified and quantified in a standardized extract of cultured Lentinula edodes mycelia (AHCCŴ, Amino Up Co. Ltd., Sapporo, Japan). α-D-glucopyranosyl-isomaltol and α-D-maltosyl-isomaltol, collectively referred to as \"active hexose correlated compound,\" were quantified with pure standards using ultra high-performance liquid chromatography-mass spectrometry. α-Glucan content was quantified using a glucose autokit. Samples from three separate lots were analyzed. The mean concentration of α-D-glucopyranosyl-isomaltol was 990.2 + 330.1 μg/g and 184.2 + 86.8 μg/g for α-D-maltosyl-isomaltol. α-Glucan was present at 26.2 ± 0.5% of dry matter. To help prevent low-quality or counterfeit mushroom items from being sold, especially via websites, precise identification and quantification of marker compounds in medicinal mushroom extracts will support the differentiation of products, enhance research efforts and aid in consumer acceptance.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 6","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The In Vitro and In Vivo Antioxidant Capacities of Auricularia auricula-judae (Agaricomycetes) Polysaccharides Prepared via Free Radical-Mediated Methods. 自由基介导法制备黑木耳多糖体外和体内抗氧化能力的研究

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058618

Hailiang Ge, Yingxuan Gu, Jiale Liang, Xuyang Liu, Mingyu Wei, Han Shu, Qianwen Shi, Liyun Zhu, Yongjun Zhang

{"title":"The In Vitro and In Vivo Antioxidant Capacities of Auricularia auricula-judae (Agaricomycetes) Polysaccharides Prepared via Free Radical-Mediated Methods.","authors":"Hailiang Ge, Yingxuan Gu, Jiale Liang, Xuyang Liu, Mingyu Wei, Han Shu, Qianwen Shi, Liyun Zhu, Yongjun Zhang","doi":"10.1615/IntJMedMushrooms.2025058618","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058618","url":null,"abstract":"As a basidiomycete fungus, the cell wall of the Auricularia auricula-judae fruiting body is extremely tough and complex, making it difficult to extract the polysaccharides. In this study, A. auricula-judae crude polysaccharides were extracted by breaking the cell wall with free radicals generated by H2O2-Vc, followed by alcohol precipitation and deproteinization using the Sevag method. The in vitro free radical scavenging capacities against active nitrogen (ABTS and DPPH) and active oxygen (hydroxyl and PTIO) were first studied. Subsequently, a high-fat diet (HFD)-induced obesity model in C57BL/6 mice was established to investigate the effects of A. auricula-judae polysaccharides on the antioxidant capacity of obese mice. The results showed that the A. auricula-judae polysaccharides exhibit concentration-dependent scavenging capacities against active nitrogen (ABTS and DPPH) and active oxygen (hydroxyl and PTIO) radicals, with IC50 values of 0.378 and 0.037 mg/mL for ABTS and DPPH radicals, respectively, and an IC50 value of 0.986 mg/mL for hydroxyl radicals. After being fed a HFD, the mice exhibited significant weight gain and symptoms of oxidative stress injury. A. auricula-judae polysaccharides intervention significantly enhanced the activity of SOD and the level of GSH, reduced MDA content in the liver of the mice (P < 0.05), and alleviated mitochondrial structural damage in the liver. These findings indicate that A. auricula-judae polysaccharides prepared using H2O2-Vc as a solvent can improve the body's antioxidant defense system.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 8","pages":"65-80"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0