International journal of medicinal mushrooms最新文献_第4页

The 12th International Medicinal Mushrooms Conference (IMMC12), September 24-27, 2024, Bari, Italy. 第十二届国际药用蘑菇会议（IMMC12）， 2024年9月24-27日，意大利巴里。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057063

Maria Letizia Gargano, Giuseppe Venturella

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Antihyperlipidemic Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract in Rats with Postnatal Sucrose Consumption Whose Mothers Also Consumed Sucrose. 生蚝食药菇平菇提取物对食糖大鼠的降血脂作用。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057783

Itzel Daysi Gutiérrez-Hernández, Jorge Rodríguez-Antolín, Margarita Cervantes-Rodríguez, Rubén Díaz, Gerardo Díaz-Godínez

{"title":"Antihyperlipidemic Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract in Rats with Postnatal Sucrose Consumption Whose Mothers Also Consumed Sucrose.","authors":"Itzel Daysi Gutiérrez-Hernández, Jorge Rodríguez-Antolín, Margarita Cervantes-Rodríguez, Rubén Díaz, Gerardo Díaz-Godínez","doi":"10.1615/IntJMedMushrooms.2024057783","DOIUrl":"10.1615/IntJMedMushrooms.2024057783","url":null,"abstract":"Male offspring of rats whose mothers consumed sucrose (5% solution) during gestation and lactation were also given the sucrose solution instead of drinking water for 3 months, and subsequently, for 1 month, they were given an aqueous extract obtained from dehydrated fruiting bodies of Pleurotus ostreatus. The offspring that consumed sucrose (experimental group) did not show differences in body weight compared with those that did not consume sucrose (control group), however, total adiposity was higher in the experimental group. In rats that consumed the aqueous extract, a decrease in the amount of cholesterol and triglycerides in blood plasma was observed, total adiposity also decreased and the average size of adipocytes in the visceral area was reduced. Consumption of the aqueous extract of P. ostreatus showed an antihyperlipidemic effect when triglyceride, cholesterol and adipose tissue levels were increased by the consumption of sucrose in rats descended from mothers who also consumed sucrose.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 4","pages":"39-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Taxonomy and Biopharmaceutical Properties of a Newly Discovered Variety of Lentinus squarrosulus (Agaricomycetes) from West Bengal, India. 印度西孟加拉邦一新发现的香菇属（香菇菌）的分类及生物制药特性。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058024

Arghya Naskar, Pinaki Chattopadhyay, Arun Kumar Dutta, Krishnendu Acharya

{"title":"Taxonomy and Biopharmaceutical Properties of a Newly Discovered Variety of Lentinus squarrosulus (Agaricomycetes) from West Bengal, India.","authors":"Arghya Naskar, Pinaki Chattopadhyay, Arun Kumar Dutta, Krishnendu Acharya","doi":"10.1615/IntJMedMushrooms.2025058024","DOIUrl":"10.1615/IntJMedMushrooms.2025058024","url":null,"abstract":"In the present study, a unique mushroom belonging to the genus Lentinus was collected from the Lateritic region of West Bengal, India. The purpose of our investigation is to determine its taxonomic identity and evaluate its therapeutic properties, with a particular emphasis on its antioxidant and antimicrobial properties. A thorough morpho-molecular investigation revealed that the collected mushroom is a novel variety that has been named Lentinus squarrosulus var. odoratus in recognition of its potent, rotting banana-like aroma. The methanolic extract of the desiccated basidiocarps exhibits potent antioxidant properties, as evidenced by the EC50 values that range from 314.201 ± 3.12 to 933.48 ± 3.58 μg/mL, contingent upon the type of free radicals employed. The extracted fraction was also discovered to be effective in inhibiting the growth of human-pathogenic bacterial strains in a dose-responsive manner, as evidenced by the low MIC50 values, which varied from 281.61 ± 1.64 to 680.31 ± 4.12 μg/mL depending on the strains under investigation. The inhibitory effect was shown to be potentially caused by an increase in membrane porosity and damage to the cell wall, resulting in the leaking of intracellular components. The findings of this research indicate that there is a significant therapeutic potential encased in this mushroom, necessitating further comprehensive investigation.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Optimization of Fermentation Conditions in Ergothioneine Biosynthesis from Ganoderma resinaceum (Agaricomycetes) and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase. 灵芝合成麦角硫因发酵条件的优化及其对黄嘌呤氧化酶抑制活性的评价

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057485

Ying-Hao Yu, Zhi-Wei Ye, Ying-Min Huang, Na Wang, Qian-Wang Zheng, Jing-Ru Zhong, Bai-Xiong Chen, Jun-Fang Lin, Li-Qiong Guo

{"title":"Optimization of Fermentation Conditions in Ergothioneine Biosynthesis from Ganoderma resinaceum (Agaricomycetes) and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase.","authors":"Ying-Hao Yu, Zhi-Wei Ye, Ying-Min Huang, Na Wang, Qian-Wang Zheng, Jing-Ru Zhong, Bai-Xiong Chen, Jun-Fang Lin, Li-Qiong Guo","doi":"10.1615/IntJMedMushrooms.2024057485","DOIUrl":"10.1615/IntJMedMushrooms.2024057485","url":null,"abstract":"Ganoderma resinaceum is a traditional mushroom that contains natural products, including ergothioneine (EGT), which has powerful antioxidant properties in the human body. To increase EGT yield from G. resinaceum, the optimal carbon and nitrogen sources in the culture medium were determined as 20 g/L sucrose and 4 g/L NH4Cl, respectively. The fermentation conditions were then optimized using response surface methodology, with the highest EGT yield of approximately 4.10 mg/L achieved at an initial pH of 5.19, a culture medium volume of 118 mL, and a fermentation temperature of 26.90°C. After extraction, EGT was purified using Sephadex G-10, resulting in a purity of 43.72%. Both the crude and purified EGT extracts were evaluated for their inhibitory activity against xanthine oxidase in vitro, with positive results. These findings suggest the potential for developing edible fungi-derived medicines to treat gout, which could alleviate the side effects of traditional medicines.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 3","pages":"71-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Structure Characterization and Antioxidant Properties of a Triple Helix Galactoglucomannan from the Fruiting Bodies of Russula virescens (Agaricomycetes). 一种三螺旋半乳糖葡甘露聚糖的结构表征及抗氧化性能。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057484

Guofeng Yu, Yuanshang Liu, Yuan Gao, Xuewei Jia, Rong Ma, Tianxiao Li, Wenning Feng, Chunping Xu

{"title":"Structure Characterization and Antioxidant Properties of a Triple Helix Galactoglucomannan from the Fruiting Bodies of Russula virescens (Agaricomycetes).","authors":"Guofeng Yu, Yuanshang Liu, Yuan Gao, Xuewei Jia, Rong Ma, Tianxiao Li, Wenning Feng, Chunping Xu","doi":"10.1615/IntJMedMushrooms.2024057484","DOIUrl":"10.1615/IntJMedMushrooms.2024057484","url":null,"abstract":"RVP, a water-soluble triple-helix galactoglucomannan, was successfully extracted from the fruiting body of Russula virescens using an alkali extraction method. Physicochemical properties analysis showed that the protein content of RVP was low (0.95%). The main chain was mainly composed of 1,3,6-linked D-mannose and 1,6-linked glucose residues, and contained terminal glucose units and a small amount of 1,4-linked glucose and 1,6-linked galactose. The average molecular weight of RVP is approximately 8.91 ȕ 105, and it adopts a semi-rigid triple helix conformation. The antioxidant potential of RVP was initially assessed in vitro using H2O2 to induce oxidative stress in a cellular model, leading to cell damage and decreased survival rates. In comparison to the H2O2 model group, RVP exhibited substantial antioxidant activity, demonstrating a capacity to enhance cell viability in a concentration-dependent manner and notably reduce the level of malondialdehyde (MDA) in the cell supernatant, thus indicating its effectiveness in reducing lipid peroxidation. Furthermore, RVP was found to boost the activity of crucial antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the cells. Thus, RVP with antioxidant properties has broad application prospects in health and wellness.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 3","pages":"45-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of Antihyperglycemic Activity of Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) in Type 2 Diabetic Rats. 发酵火鸡尾药菇胞外多糖对2型糖尿病大鼠降血糖作用的机制

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057058

Yi-Ying Wang, Shih-Ching Chao, Pei-Yuan Su, Hui-Chen Lo

{"title":"Mechanism of Antihyperglycemic Activity of Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) in Type 2 Diabetic Rats.","authors":"Yi-Ying Wang, Shih-Ching Chao, Pei-Yuan Su, Hui-Chen Lo","doi":"10.1615/IntJMedMushrooms.2024057058","DOIUrl":"10.1615/IntJMedMushrooms.2024057058","url":null,"abstract":"The antihyperglycemic activity of extracellular polysaccharopeptides (ePSP) obtained from Trametes versicolor (TV) strain LH-1 has been demonstrated in hepatic cells and diabetic animals. This study further investigated the mechanisms of T. versicolor-ePSP on regulating glucose metabolism, including insulin signaling molecules and glucose metabolism-associated enzymes, in the liver of rats with type 2 diabetes mellitus (T2DM). Male Wistar rats, fed with a high-fat diet followed by a streptozotocin injection to induce T2DM, were orally administered water or T. versicolor-ePSP at doses of 0.1, 0.5, or 1.0 g/kg/d. After 4 weeks of T. versicolor-ePSP administration, T2DM rats exhibited significantly lower postprandial blood glucose levels, decreased liver triglyceride and cholesterol contents, and improved serum liver function indices in a dose-dependent manner (P < 0.05, one-way ANOVA). Additionally, T2DM rats administered T. versicolor-ePSP had significantly activated insulin receptors and decreased proteins involved in insulin signaling pathway, such as insulin receptor substrates, PI3K, and total and activated Akt, and AMP-activated protein kinase in the liver. T. versicolor-ePSP administration, especially at 1.0 g/kg per day, significantly increased glucose transporters in the cell membrane and decreased glucokinase and glucose-6-phosphotase in the cytosol of the liver. In conclusion, the antihyperglycemic activities of T. versicolor-ePSP may be associated with enhanced hepatic function, alleviated gluconeogenesis, and facilitated glucose transport in an insulin- and AMPK-independent manner in the liver of T2DM rats.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 3","pages":"11-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice. 香菇多糖改善h2o2诱导的Caco-2细胞和dss诱导的溃疡性结肠炎小鼠的炎症损伤

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058082

Jun Lin, Meng Yuan, Hong-Yu Shi, Qiang Liu, Shuai Du, Mei-Xia Zhang, Qu-Quan Li, Zhen-Bang Yang, Pei Lin

{"title":"Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice.","authors":"Jun Lin, Meng Yuan, Hong-Yu Shi, Qiang Liu, Shuai Du, Mei-Xia Zhang, Qu-Quan Li, Zhen-Bang Yang, Pei Lin","doi":"10.1615/IntJMedMushrooms.2025058082","DOIUrl":"10.1615/IntJMedMushrooms.2025058082","url":null,"abstract":"Phellinus linteus (Agaricomycetes) is a valuable medicinal mushroom traditionally used as a food supplement and medicinal ingredient. Polysaccharides of Ph. linteus (PLP) possess strong anti-inflammatory effects and gut microbiota modulating properties. However, the mechanism of its efficacy in ulcerative colitis (UC) remains unclear. This study utilized 1mM H2O2 to induce an in vitro model of UC in Caco-2 cells. Additionally, a 3% solution of dextran sulfate sodium salt (DSS) was employed to establish an in vivo UC model in mice. After treating the cells with PLP at various concentrations, there was a significant reduction in the mRNA expression of TNF-α and IL-6, and the nuclear factor-κB (NF-κB) signaling pathway was also inhibited. Concurrently, symptoms such as colon shortening, weight loss, and a decrease in disease activity index (DAI) scores were significantly improved in UC mice. Additionally, the treatment led to downregulated expression of TNF-α and IFN-γ mRNA in colon tissues. PLP had shown potential in reducing inflammation and oxidative stress in Caco-2 cells, demonstrating therapeutic effects in treating UC-like inflammation by inhibiting the NF-κ signaling pathway and activating the nuclear factor erythroid derived 2-like 2(Nrf2)/heme oxygenase-1(HO-1) signaling pathway. These findings suggest that PLP has great potential for further investigation and development in UC treatment.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"17-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Characterization and Anti-Obesity Activity of Exopolysaccharide Isolated from Scleroderma areolatum (Agaricomycetes). 乳状硬皮病（菌类）胞外多糖的化学特性及抗肥胖活性研究。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058054

Jiafeng Bai, Xiaoqin Peng, Yi Zhou, Zhizhong Hu, Changtong Lu, Xuewei Jia, Chunping Xu

{"title":"Chemical Characterization and Anti-Obesity Activity of Exopolysaccharide Isolated from Scleroderma areolatum (Agaricomycetes).","authors":"Jiafeng Bai, Xiaoqin Peng, Yi Zhou, Zhizhong Hu, Changtong Lu, Xuewei Jia, Chunping Xu","doi":"10.1615/IntJMedMushrooms.2025058054","DOIUrl":"10.1615/IntJMedMushrooms.2025058054","url":null,"abstract":"Two polysaccharide fractions were successfully isolated from the crude exopolysaccharide (EPS) of Scleroderma areolatum via gel filtration chromatography. Size exclusion chromatography/multi-angle laser light scattering (SEC/MALLS) analysis showed that the weight of average molecular weights (Mw) of these fractions was 3.162 ȕ 106 (Fr-I) and 2.613 ȕ 106 (Fr-II). Both EPS fractions exhibited a compact globular structure in aqueous solution. Monosaccharide composition analysis revealed that they were primarily composed of mannose and glucuronic acid. FT-IR spectral analysis identified prominent functional groups, such as hydroxyl and carboxylic, typical of heteropolysaccharides. When administered as supplements in high-fat diets to obese rats for 8 weeks, the EPS fractions reduced body weight, serum inflammatory factor levels, and significantly regulated serum lipid levels. Additionally, they increased the total concentration of short-chain fatty acids (SCFA) in colonic digesta. These results suggest a potential role for EPS in mitigating obesity and related metabolic disorders in high-fat diet-induced obese rats.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Examination of Cholinergic Symptoms Produced by the Fly Agaric Mushroom Amanita muscaria (Agaricomycetes): Revisiting the Role of Muscarine. 蝇类黑木耳菌（黑木耳菌）产生的胆碱能症状的检查：重新审视蘑菇碱的作用。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058603

Kevin Feeney, James Kababick, Stacy Wise

{"title":"An Examination of Cholinergic Symptoms Produced by the Fly Agaric Mushroom Amanita muscaria (Agaricomycetes): Revisiting the Role of Muscarine.","authors":"Kevin Feeney, James Kababick, Stacy Wise","doi":"10.1615/IntJMedMushrooms.2025058603","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058603","url":null,"abstract":"The English mycological and toxicological literature has, for decades, asserted that muscarine concentrations in Amanita muscaria are insignificant based on a study from the 1950s that demonstrated muscarine levels in fresh A. muscaria mushrooms at a meager 0.0003%. This position has been maintained despite frequent reports of cholinergic symptoms following consumption of this mushroom and despite the dated study upon which this position is based. To update the literature on A. muscaria's pharmacology and to address disparities between the current scientific consensus on the role of muscarine, a cholinergic compound, in A. muscaria poisonings and the frequent reports of cholinergic symptoms following its ingestion, four steps were taken: (1) surveys were collected from 53 individuals who experienced cholinergic symptoms following ingestion of A. muscaria; (2) mushroom samples were procured for HPLC-MS/MS analysis from three survey participants; (3) mushrooms were collected independently for HPLC-MS/MS analysis; and (4) commercial analyses of Amanita muscaria were compiled to illustrate a range of muscarine concentrations. Survey results demonstrated that mild-to-moderate cholinergic symptoms were experienced at doses that reflect common use of the mushroom for recreational, therapeutic, and spiritual purposes (1-20 g dried). Results of HPLC-MS/MS analyses demonstrated muscarine concentrations ranging from 0.004% up to 0.043%, significantly exceeding the consensus value. Study findings demonstrate that current understandings of muscarine concentrations in A. muscaria are inaccurate, and that the occurrence of muscarine in A. muscaria must be understood as a broad range, one that ranges from the insignificant up to physiologically significant levels.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 7","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Aqueous Extract Reverses Hypoxia Induced Redox Imbalance and Inflammatory Response in Rat Thymocytes. 灵芝或灵芝灵芝水提物逆转缺氧诱导的大鼠胸腺细胞氧化还原失衡和炎症反应。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025059009

Rekha Maithani, Rajkumar Tulsawani

{"title":"Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Aqueous Extract Reverses Hypoxia Induced Redox Imbalance and Inflammatory Response in Rat Thymocytes.","authors":"Rekha Maithani, Rajkumar Tulsawani","doi":"10.1615/IntJMedMushrooms.2025059009","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025059009","url":null,"abstract":"Inflammatory diseases are associated with immune imbalances and the linkage between immune system and inflammatory mechanisms, particularly under hypoxia, is still incomprehensive. Furthermore, development of a natural agent necessitates, in lack of therapeutics, to prevent thymus receding under hypoxia-induced inflammation. Rat primary thymocytes were exposed to hypoxia (0.5% O2) in the absence or presence of aqueous extract of Ganoderma lucidum. After exposure, redox status and bioenergetic and biochemical variables were evaluated. Hypoxia exposure to thymocytes results in cell growth arreast and death with concurrent surge in reactive oxygen species and decrease in total antioxidant status. Moreover, these hypoxic cells had imbalanced redox homeostasis and bioenergetics with decreased NAD/NADH and increased ADP/ATP ratio. The cells treated with an aqueous extract of G. lucidum rescue cells from death, reverse redox imbalance and changes in bioenergetic markers. Hypoxia exposure enhance pro-inflammatory cytokines; IL6, TNFα, and NFκB in thymocytes which normalizes with the extract treatment. Hypoxic cells displayed higher expression of Nrf2, HIF1α, VEGF in rat thymocytes but downplayed role of erythropeotin. The extract treatment overtakes adverse hypoxia-induced changes on hypoxic markers. Thus, G. lucidum reverses redox imbalance, changes in bio-energetic markers, and displayed strong anti-stress and anti-inflammatory effect.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 8","pages":"51-63"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0