International journal of medicinal mushrooms最新文献

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Investigation of antioxidant activity, myco-chemical content, and GC-MS based molecular docking analysis of bioactive chemicals from Amanita konajensis, a tribal myco-food from India 印度部落菌食Amanita konajensis抗氧化活性、菌化学成分研究及GC-MS分子对接分析

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/intjmedmushrooms.2023051310

Pinky Rani Biswas, Pinaki Chattopadhyay, Sudeshna Nandi, Arabinda Ghosh, Krishnendu Acharya, Arun Kumar Dutta

{"title":"Investigation of antioxidant activity, myco-chemical content, and GC-MS based molecular docking analysis of bioactive chemicals from Amanita konajensis, a tribal myco-food from India","authors":"Pinky Rani Biswas, Pinaki Chattopadhyay, Sudeshna Nandi, Arabinda Ghosh, Krishnendu Acharya, Arun Kumar Dutta","doi":"10.1615/intjmedmushrooms.2023051310","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023051310","url":null,"abstract":"In humans, a wide range of health disorders have been induced due to an imbalanced metabolism and an excess generation of reactive oxygen species (ROS).. Different biological properties found in mushrooms seem to be the reason for their customary use as a favourite delicacy. Therefore, exploration of wild edible mushrooms as a source of various biological compounds is gaining much importance today. Amanita konajensis, one of the underutilised macrofungi popularly consumed in Eastern India, demands a systematic study of its medicinal values. The study aims to explore the myco-chemical contents of A. konajensis ethanolic extract (EtAK1) and screen their antioxidant potency through various in vitro assays. GC-MS analysis identified the chemical components of EtAK1. Further, structure-based virtual screening of the identified compounds was analysed for drug-like properties and molecular docking with the human p38 MAPK protein, a potent targeting pathway for human lung cancer. The morpho-molecular features proved the authenticity of the collected mushroom. The screening assays showed that EtAK1 was abundant in flavonoids, followed by phenolics, β-carotene, and lycopene, and had strong antioxidant activity with EC50 values of 640–710 μg/ml. The GC-MS analyses of EtAK1 identified the occurrence of 19 bioactive compounds in the mushroom. In silico analysis revealed that anthraergostatetraenol p-chlorobenzoate, one of the compounds identified, displayed high binding affinity (ΔG = -10.6 kcal/mol) with human p38 MAPK. The outcome of this study will pave the way for the invention of myco-medicine using Amanita konajensis, which may lead to a novel drug for human lung cancer.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135057233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophilic Metabolite Composition of Fruiting Bodies and Mycelia of Edible Mushroom Species (Agaricomycetes). 食用菌（蘑菇门）子实体和菌丝体的亲水性代谢产物组成。

International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI: 10.1615/IntJMedMushrooms.2023050034

Rao-Chi Chien, Shin-Yu Chen, Darya O Mishchuk, Carolyn M Slupsky

{"title":"Hydrophilic Metabolite Composition of Fruiting Bodies and Mycelia of Edible Mushroom Species (Agaricomycetes).","authors":"Rao-Chi Chien, Shin-Yu Chen, Darya O Mishchuk, Carolyn M Slupsky","doi":"10.1615/IntJMedMushrooms.2023050034","DOIUrl":"10.1615/IntJMedMushrooms.2023050034","url":null,"abstract":"Mushrooms have two components, the fruiting body, which encompasses the stalk and the cap, and the mycelium, which supports the fruiting body underground. The part of the mushroom most commonly consumed is the fruiting body. Given that it is more time consuming to harvest the fruiting body versus simply the mycelia, we were interested in understanding the difference in metabolite content between the fruiting bodies and mycelia of four widely consumed mushrooms in Taiwan: Agrocybe cylindracea (AC), Coprinus comatus (CC), Hericium erinaceus (HE), and Hypsizygus marmoreus (HM). In total, we identified 54 polar metabolites using 1H NMR spectroscopy that included sugar alcohols, amino acids, organic acids, nucleosides and purine/pyrimidine derivatives, sugars, and others. Generally, the fruiting bodies of AC, CC, and HM contained higher amounts of essential amino acids than their corresponding mycelia. Among fruiting bodies, HE had the lowest essential amino acid content. Trehalose was the predominant carbohydrate in most samples except for the mycelia of AC, in which the major sugar was glucose. The amount of adenosine, uridine, and xanthine in the samples was similar, and was higher in fruiting bodies compared with mycelia, except for HM. The organic acid and sugar alcohol content between fruiting bodies and mycelia did not tend to be different. Although each mushroom had a unique metabolic profile, the metabolic profile of fruiting bodies and mycelia were most similar for CC and HE, suggesting that the mycelia of CC and HE may be good replacements for their corresponding fruiting bodies. Additionally, each mushroom species had a unique polar metabolite fingerprint, which could be utilized to identify adulteration.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 11","pages":"27-40"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice. 食入细孢Ceraceomyces tessulatus菌株BDM-X（琼脂）对小鼠非酒精性脂肪性肝炎的保护作用。

International journal of medicinal mushrooms Pub Date : 2022-01-01 DOI: 10.1615/IntJMedMushrooms.2021041928

Hiroshi Suzuki, Kenichi Watanabe, Somasundaram Arumugam, Manoj Limbraj Yellurkar, Remya Sreedhar, Rejina Afrin, Hirohito Sone

{"title":"Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice.","authors":"Hiroshi Suzuki, Kenichi Watanabe, Somasundaram Arumugam, Manoj Limbraj Yellurkar, Remya Sreedhar, Rejina Afrin, Hirohito Sone","doi":"10.1615/IntJMedMushrooms.2021041928","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2021041928","url":null,"abstract":"Nonalcoholic steatohepatitis (NASH) is becoming the most common cause of hepatocellular carcinoma (HCC) in developed countries. Oxidative stress plays a major role in the pathogenesis of NASH due to steatosis; hence, novel therapeutic approaches might include natural antioxidants. Ceraceomyces tessulatus strain Basidiomycetes-X (BDM-X), a novel edible mushroom, possesses potent antioxidant activity. This study aimed to investigate the hepato-protective effect of C. tessulatus BDM-X in a novel NASH-HCC mouse model. To prepare this animal model, 2-day-old C57BL/6J male pups were exposed to low-dose streptozotocin (STZ); at 4 weeks of age, they were randomly divided into two groups. The NASH group (NASH) received a high-fat diet (HFD32) up to 14 weeks of age; the C. tessulatus BDM-X group (BDM-X) received HFD32 up to age 10 weeks, followed by HFD32 + 20% BDM-X (percent weight per weight in the diet) up to age 14 weeks. Mice not treated with STZ and fed a normal diet served as a control group. We found that C. tessulatus BDM-X improved serum aminotransferase levels as well as histopathological features such as steatosis, inflammatory foci, and pericellular fibrosis in NASH mice. Hepatic protein expression of sterol regulatory element binding protein isoform SREBP-1 and peroxisome proliferator-activated receptor PPARα was significantly increased in NASH mice. C. tessulatus BDM-X treatment normalized the expression of both proteins. Our data suggest that C. tessulatus BDM-X may protect the liver against lipogenesis in NASH-HCC mice.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"24 1","pages":"41-52"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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