International journal of medicinal mushrooms最新文献

{"title":"Hepatoprotective Effect of Floccularia luteovirens (Agaricomycetes) Polysaccharides on Alcohol-Induced Acute Liver Injury in Mice.","authors":"Huan Wang, Hu Ding, Yu Li, Xu Wang, Chang-Bao Chen, Zhu Lu, Shu-Min Wang","doi":"10.1615/IntJMedMushrooms.2025061743","DOIUrl":"10.1615/IntJMedMushrooms.2025061743","url":null,"abstract":"<p><p>Floccularia luteovirens mushroom polysaccharides (FLPs) have anti-inflammatory and antioxidant effects in many inflammatory diseases. However, its protective effect on alcoholic liver injury has not been studied. This study investigated the protective effects of FLPs on acute alcoholic liver injury in mice. After administering FLPs at doses of 200, 400, and 800 mg/kg for 14 days, it was found that FLPs could inhibit the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ-glutamyl transpeptidase (γ-GT) in the serum. FLPs also significantly reduced the levels of four inflammatory factors, interleukin (IL)-1α, IL-1β, IL-33, and tumor necrosis factor-α (TNF-α) in the serum. All dose groups of FLPs could significantly inhibit the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in liver tissues. At the same time, they could significantly increase the levels of catalase (CAT) and glutathione peroxidase (GSH-Px), enhancing the antioxidant capacity of the body, which confirmed the protective therapeutic effects of FLPs against oxidative stress and inflammation in alcoholic liver injury. The Western blot assay investigated the effect of FLPs on the NF-κB/NLRP3 signaling pathway in the liver tissues of mice with alcoholic liver injury, indicating that its mechanism of action may be to inhibit the expression of inflammatory factors such as IL-1β and suppress the NF-κB/NLRP3 inflammasome signaling pathway to achieve antioxidant and anti-inflammatory effects.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 2","pages":"63-74"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Structure and Pharmacological Effects of Polysaccharides from Sanguinoderma and Ganoderma Mushrooms (Agaricomycetes): A Mini Review.","authors":"Wen Wang, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Jingjing Li, George Pak-Heng Leung","doi":"10.1615/IntJMedMushrooms.2026063236","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2026063236","url":null,"abstract":"<p><p>The genus Sanguinoderma belongs to the Ganodermataceae family and includes both edible and medicinal mushrooms, with polysaccharides identified as their primary bioactive constituents. This review aims to consolidate recent findings on the pharmacological effects of polysaccharides isolated from various Sanguinoderma species, such as S. rugosum and S. rude, and to discuss the future challenges and directions concerning their development and utilization. Studies have shown that Sanguinoderma polysaccharides exhibit significant immunomodulatory, antioxidant, anti-cancer, neuroprotective, anti-skin aging, pro-angiogenic and anti-angiogenic properties, in addition to their potential to modulate gut microbiota. In particular, Sanguinoderma polysaccharides have demonstrated greater efficacy than Ganoderma lucidum polysaccharides, particularly in immunomodulation, antioxidant, and anti-cancer aspects, underscoring their potential as innovative dietary supplements or pharmaceutical agents with significant health benefits. The pharmacological activity of polysaccharides is generally correlated with their chemical structures. Modern analytical techniques can effectively elucidate the fundamental physicochemical properties of Sanguinoderma polysaccharides, such as monosaccharide composition, molecular weight, degree of branching, and the number of repeating units. However, the comprehensive understanding of their advanced structures remains a formidable challenge due to the complex spatial conformations. Further basic and clinical research is required to ensure the safe and effective therapeutic application of Sanguinoderma polysaccharides.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 5","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myco-Biosynthesis and Characterization of Selenium Nanoparticles Using Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) with Their Antimicrobial and Antioxidant Potential.","authors":"Prathmesh Nadarge, Shivani Sharma, Anu Kalia","doi":"10.1615/IntJMedMushrooms.2026064067","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2026064067","url":null,"abstract":"<p><p>Mushroom-mediated biosynthesis of nanoparticles is a field of growing interest due to its high yield, ease of handling, eco-friendliness, and the non-toxic nature of the process. Among these, selenium nanoparticles are gaining attention for their potential as therapeutic agents, owing to their diverse biological and clinical applications. This study aimed to synthesize Hericium erinaceus-derived selenium nanoparticles using an extracellular extract from the mushroom's fruiting body and various concentrations of sodium selenite. The successful biosynthesis was indicated by a visual color change in the reaction mixture from light yellow to orangish-red. The myco-synthesized nanoparticles were found to have shapes ranging from irregular to spherical, with an average particle size of 75 nm. Dynamic light scattering analysis revealed a mean hydrodynamic size of 186.10 nm, indicating the homogeneity and stability of the nanoparticle suspension. The formation of selenium nanoparticles was further confirmed by ultraviolet absorption peaks in the 290-295 nm range. Fourier transform infrared spectroscopy was used to identify the functional groups involved in the biosynthesis and stabilization of the nanoparticles. In terms of biological activity, the myco-synthesized selenium nanoparticles demonstrated significant antibacterial efficacy against several human pathogenic bacteria, including Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella enterica serovar Typhi. Furthermore, the synthesized nanoparticles exhibited significant antioxidant potential. These results highlight the potential of H. erinaceus as a sustainable source for the biosynthesis of selenium nanoparticles, which could be developed as effective therapeutic agents.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 7","pages":"33-45"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic Biology Approaches for Representative Bioactive Metabolites of Medicinal Mushrooms.","authors":"Yan Li, Xianlei Wang, Mengtao Cheng, Xin Zhao, Chunchao Han","doi":"10.1615/IntJMedMushrooms.2026064068","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2026064068","url":null,"abstract":"<p><p>Medicinal mushrooms represent valuable sources of high-value bioactive molecules. However, these valuable active ingredients exhibit low yield in their natural sources, and their structural complexity presents significant challenges for their extraction and isolation. Synthetic biology addresses these limitations by enabling the green and efficient synthesis of bioactive molecules through engineered microbial cell factories, offering a sustainable approach to utilizing rare mushroom-derived compounds. This review summarizes recent advances in the biosynthesis and heterologous microbial production of key bioactive constituents, including cordycepin, ganoderic acid, ergothioneine, pachymic acid, blazeispirols, erinacines and Sanghuang polysaccharide. Furthermore, it provides methodological strategies based on synthetic biology to produce other rare bioactive constituents from medicinal mushrooms.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 7","pages":"1-20"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Bioactivity of the Golden Oyster Culinary-Medicinal Mushroom Pleurotus citrinopileatus (Agaricomycetes) Infusion and Decoction: A Journey from Farm to Healthy Beverage.","authors":"Priti Yadav, Somanjana Khatua","doi":"10.1615/IntJMedMushrooms.2026066503","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2026066503","url":null,"abstract":"<p><p>Noncommunicable diseases such as cardiovascular disorders, diabetes, cancer, and obesity pose a leading threat to human health largely driven by unhealthy diet. To mitigate the problem, intake of edible mushrooms has garnered attention worldwide owing to their beneficial health effects. Among them, Pleurotus citrinopileatus is widely cultivated in several countries such as China, Japan and Russia, due to taste, lucrative color and easy cultivation process. The present study aimed to evaluate mycochemical composition and antioxidant capacity of water-based preparations isolated from the yellow oyster mushroom. Qualitative tests for bioactive compounds revealed presence of flavonoids, phenols, alkaloids, saponins, cardiac glycosides, polysterols, terpenoids and tannins in both the aqueous extracts. Whereas quantitative analysis demonstrated that the infusion contained significantly higher levels of total phenolics (21.37 μg of GAE/mg of dry extract); while the decoction exhibited slightly elevated contents of flavanoid (8.8 μg of quercetin equivalents/mg of dry extract), β-carotene (0.032 μg/mg dry extract), lycopene (0.02 μg/mg dry extract) and ascorbic acid (0.89 μg/mg extract). Antioxidant evaluations revealed that infusion outperformed the decoction in all experiments, exhibiting remarkable 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino bis (3-ethylbenzothi-azoline-6-sulfonic acid) (ABTS) radical scavenging activity, as reflected by low half-maximal effective concentration (EC50) values of 303.6 and 70.69 μg/mL, respectively. In addition, the infusion also displayed notable Fe2+-chelating ability, total antioxidant capacity and reducing power portraying better bioactivity. Pearson's correlation analysis confirmed a strong positive relationship between phenolic and flavonoid contents and antioxidative activities of both the extracts. Overall, these findings suggest consideration of infusion extract from P. citrinopileatus as an antioxidant rich functional beverage for industrial application supporting Sustainable Development Goals 3, 12, and 17.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 10","pages":"45-60"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149303517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-Assisted Extraction Optimization, Solubility, and Bioactivity Evaluation of Polysaccharides from Broken Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Spore Powder.","authors":"Yuhang Liu, Lingli Guo Guo, Xinyue Dong, Sisi Wang, Hao Xu, Hongli Zhou","doi":"10.1615/IntJMedMushrooms.2025061994","DOIUrl":"10.1615/IntJMedMushrooms.2025061994","url":null,"abstract":"<p><p>One of the main active components of broken Ganoderma lucidum spore powder was polysaccharide (BGSPP), but the extraction time was long, and the yield was low at present. Therefore, the extraction and activity of BGSPP were studied in this paper. Microwave-assisted extraction of BGSPP was designed by single factor experiment combined with a response surface methodology. Scanning electron microscopy and the 2020 edition of the Pharmacopoeia of the People's Republic of China method were used to examine the morphological characteristics and solubility of BGSPP, respectively. The monosaccharide composition of BGSPP was analyzed by high-performance liquid chromatography (HPLC). Its activities were antioxidant and hypouricemic in vitro. The results of the optimum conditions of BGSPP were temperature of 90°C, power of 400 W, time of 16 min, liquid-solid ratio of 20:1 mL/g, and extracted twice. The extraction yield, purity, and solubility were 2.57 ± 0.03%, 59.63 ± 0.11%, and 37.13 ± 0.20 mg/mL, respectively. The BGSPP extracted by the two methods had the same composition, but the molar percentages of its composition differed. The IC50 values of DPPH, ABTS+ and hydroxyl radicals were 1.31 ± 0.02 mg/mL, 0.75 ± 0.01 mg/mL and 5.30 ± 0.08 mg/mL, respectively. The IC50 value of hypouricemic activity was 14.05 ± 0.11 mg/mL. The extraction yield, solubility and activities were better than those of hot reflux extraction. In conclusion, the extraction process is stable and efficient has been found to have a hypouricemic activity, which provides a scientific basis for the development and utilization of BGSPP.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 3","pages":"31-47"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LED Light Spectra Modulate Growth, Morphogenesis, and Bioactive Compound Production in Cordyceps militaris (Ascomycota).","authors":"Gam Thi Do, Dong Thi Ta, Nhung Hong Nguyen, Huyen Thi Tran, Linh Khanh Chu, Ngoc Thu Le, Cong Quang Tong, Tien Quoc Tran, Son Viet Ha, Trung Khuat Huu, Phat Tien Do, Phuong Van Nguyen","doi":"10.1615/IntJMedMushrooms.2025062343","DOIUrl":"10.1615/IntJMedMushrooms.2025062343","url":null,"abstract":"<p><p>Light is a crucial environmental factor influencing fungal development and secondary metabolite biosynthesis. In this study, we investigated the effects of nine different LED light spectra on the growth, morphogenesis, and production of bioactive compounds in Cordyceps militaris strain DT22. Mycelial cultures and stromata were cultivated under controlled LED conditions, and their morphological characteristics, carotenoid, adenosine, and cordycepin contents were evaluated. Additionally, the expression levels of genes related to stromata development (CmHYD1), carotenoid biosynthesis (CmFHP), and cordycepin biosynthesis (CmCNS3) were analyzed by qRT-PCR. The results demonstrated that LED light treatments significantly influenced mycelial color, colony diameter, stromata formation, and biomass accumulation. Particularly, light formulas RW23 (2 Red:3 White) and wW (Warm White) promoted larger colony diameters and higher fresh and dry weights of stromata. Total carotenoid content peaked at the orange mycelial stage under RB (5 Red:1 Blue) and nW (Neutral White) treatments, but declined during primordia and mature stages. Cordycepin accumulation was highest under RBW (3 Red:2 Blue:1 White) treatment, whereas adenosine content showed no significant variation across light conditions. Gene expression analysis revealed that CmHYD1 and CmFHP were upregulated under most LED treatments, while CmCNS3 exhibited variable expression patterns. The mating-type gene MAT1.1.1 remained stable across treatments, whereas MAT1.1.2 showed a notable decrease under certain spectral conditions. Overall, our findings highlight the potential of tailored LED light combinations to optimize stromata production and bioactive metabolite synthesis in C. militaris, offering insights into environmental modulation strategies for industrial-scale cultivation.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 4","pages":"41-56"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Inhibitory Effect of Naematelia aurantialba (Basidiomycota) Polysaccharides on Zebrafish Ulcerative Colitis","authors":"Jinheng Fu, Hongyou Liu, Yu ZHOU","doi":"10.1615/intjmedmushrooms.2026065085","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2026065085","url":null,"abstract":"","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cordyceps militaris (Ascomycetes) Intracellular Polysaccharide Nanoemulsion for Improving Antimicrobial Activities.","authors":"Zhenxing Li, Mengtao Cheng, Bin Liu, Chunchao Han","doi":"10.1615/IntJMedMushrooms.v28.i7.80","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.v28.i7.80","url":null,"abstract":"<p><p>This study aimed to develop a Cordyceps militaris intracellular polysaccharides nanoemulsion (CMIPS-NE) to improve its antimicrobial properties. Based on the results of pseudoternary phase diagram, the formulation of nanoemulsion was optimized as Tween 80-Span 80/anhydrous ethanol/Olive oil/polysaccharide = 40/10/38/12 (w/w/w/w), were used as the surfactant, co-surfactant, oil, and aqueous phase, respectively. Under these conditions, the particle size of water-in-oil CMIPS-NE is 83.61 ± 3.52 nm, with the polydispersity index is 0.252 ± 0.025, the pH is 6.12 ± 0.09, and the viscosity is 168.34 ± 1.95 mPa·s. The prepared CMIPS-NE exhibited excellent stability and a sustained release. Moreover, the antimicrobial activity of C. militaris intracellular polysaccharide was notably improved after nanoemulsification, an effect demonstrated to be driven by the polysaccharide itself and not the nanoemulsion vehicle. The results showed that CMIPS-NE might be valuable and antimicrobial and show potential for application in health and medicine as well as in the food industry.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 7","pages":"91-102"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Measuring the Biodegradability of a Hybrid Material Resulting from the Transformation of Plastic and Organic Waste with the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes).","authors":"Carmenza Jaramillo-Lã Pez, Marà A F Ocampo-Barrero, Ivà N F Macà As-Quiroga, Camila Giraldo-Loaiza, Erwin U Landazury-Rosero, Nancy R Sanabria-Gonzà Lez","doi":"10.1615/IntJMedMushrooms.2026064182","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2026064182","url":null,"abstract":"<p><p>Fungi are recognized as among the most effective microbial agents for plastic degradation due to their production of extracellular enzymes, including lipases, cutinases, esterases, proteases, dehydrogenases, hydrolases, laccases, peroxidases, and oxidoreductases. These enzymes target ester and carbon-carbon bonds in plastics, breaking them down into smaller molecules that fungi can metabolize as carbon sources. In 2014, a process was patented in Colombia and the United States that utilizes macromycetes to transform various cafeteria wastes, including polyethylene, polypropylene, and polystyrene cups; cardboard cups; napkins; solid waste such as bread and cake scraps; and liquid residues from coffee, sodas, chocolate, and milk into a biodegradable hybrid material. This study employed a mixture of polystyrene and coffee grounds as the waste substrate, inoculated with an oyster mushroom, Pleurotus ostreatus, to convert the plastic-organic blend into a more environmentally benign material. Throughout incubation, changes in coloration, biofilm formation on the surface, and other physical transformations were systematically monitored. Biodegradation progress was documented via photographic records and stereomicroscopy. To quantify chemical alterations, Fourier-transform infrared spectroscopy (FT-IR) was employed, demonstrating its effectiveness in confirming modifications to the hybrid material's chemical composition and enabling critical evaluation of the mycelium's impact on expanded polystyrene. The findings indicate significant degradation of polystyrene, suggesting complex biochemical interactions that yield a novel material that continues to degrade over time, akin to that of organic compounds.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 7","pages":"85-90"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}