International journal of medicinal mushrooms最新文献

{"title":"Hepatoprotective Effect of Floccularia luteovirens (Agaricomycetes) Polysaccharides on Alcohol-Induced Acute Liver Injury in Mice.","authors":"Huan Wang, Hu Ding, Yu Li, Xu Wang, Chang-Bao Chen, Zhu Lu, Shu-Min Wang","doi":"10.1615/IntJMedMushrooms.2025061743","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025061743","url":null,"abstract":"<p><p>Floccularia luteovirens mushroom polysaccharides (FLPs) have anti-inflammatory and antioxidant effects in many inflammatory diseases. However, its protective effect on alcoholic liver injury has not been studied. This study investigated the protective effects of FLPs on acute alcoholic liver injury in mice. After administering FLPs at doses of 200, 400, and 800 mg/kg for 14 days, it was found that FLPs could inhibit the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ-glutamyl transpeptidase (γ-GT) in the serum. FLPs also significantly reduced the levels of four inflammatory factors, interleukin (IL)-1α, IL-1β, IL-33, and tumor necrosis factor-α (TNF-α) in the serum. All dose groups of FLPs could significantly inhibit the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in liver tissues. At the same time, they could significantly increase the levels of catalase (CAT) and glutathione peroxidase (GSH-Px), enhancing the antioxidant capacity of the body, which confirmed the protective therapeutic effects of FLPs against oxidative stress and inflammation in alcoholic liver injury. The Western blot assay investigated the effect of FLPs on the NF-κB/NLRP3 signaling pathway in the liver tissues of mice with alcoholic liver injury, indicating that its mechanism of action may be to inhibit the expression of inflammatory factors such as IL-1β and suppress the NF-κB/NLRP3 inflammasome signaling pathway to achieve antioxidant and anti-inflammatory effects.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 2","pages":"63-74"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-Assisted Extraction Optimization, Solubility, and Bioactivity Evaluation of Polysaccharides from Broken Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Spore Powder.","authors":"Yuhang Liu, Lingli Guo Guo, Xinyue Dong, Sisi Wang, Hao Xu, Hongli Zhou","doi":"10.1615/IntJMedMushrooms.2025061994","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025061994","url":null,"abstract":"<p><p>One of the main active components of broken Ganoderma lucidum spore powder was polysaccharide (BGSPP), but the extraction time was long, and the yield was low at present. Therefore, the extraction and activity of BGSPP were studied in this paper. Microwave-assisted extraction of BGSPP was designed by single factor experiment combined with a response surface methodology. Scanning electron microscopy and the 2020 edition of the Pharmacopoeia of the People's Republic of China method were used to examine the morphological characteristics and solubility of BGSPP, respectively. The monosaccharide composition of BGSPP was analyzed by high-performance liquid chromatography (HPLC). Its activities were antioxidant and hypouricemic in vitro. The results of the optimum conditions of BGSPP were temperature of 90°C, power of 400 W, time of 16 min, liquid-solid ratio of 20:1 mL/g, and extracted twice. The extraction yield, purity, and solubility were 2.57 ± 0.03%, 59.63 ± 0.11%, and 37.13 ± 0.20 mg/mL, respectively. The BGSPP extracted by the two methods had the same composition, but the molar percentages of its composition differed. The IC50 values of DPPH, ABTS+ and hydroxyl radicals were 1.31 ± 0.02 mg/mL, 0.75 ± 0.01 mg/mL and 5.30 ± 0.08 mg/mL, respectively. The IC50 value of hypouricemic activity was 14.05 ± 0.11 mg/mL. The extraction yield, solubility and activities were better than those of hot reflux extraction. In conclusion, the extraction process is stable and efficient has been found to have a hypouricemic activity, which provides a scientific basis for the development and utilization of BGSPP.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 3","pages":"31-47"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LED Light Spectra Modulate Growth, Morphogenesis, and Bioactive Compound Production in Cordyceps militaris (Ascomycota).","authors":"Gam Thi Do, Dong Thi Ta, Nhung Hong Nguyen, Huyen Thi Tran, Linh Khanh Chu, Ngoc Thu Le, Cong Quang Tong, Tien Quoc Tran, Son Viet Ha, Trung Khuat Huu, Phat Tien Do, Phuong Van Nguyen","doi":"10.1615/IntJMedMushrooms.2025062343","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025062343","url":null,"abstract":"<p><p>Light is a crucial environmental factor influencing fungal development and secondary metabolite biosynthesis. In this study, we investigated the effects of nine different LED light spectra on the growth, morphogenesis, and production of bioactive compounds in Cordyceps militaris strain DT22. Mycelial cultures and stromata were cultivated under controlled LED conditions, and their morphological characteristics, carotenoid, adenosine, and cordycepin contents were evaluated. Additionally, the expression levels of genes related to stromata development (CmHYD1), carotenoid biosynthesis (CmFHP), and cordycepin biosynthesis (CmCNS3) were analyzed by qRT-PCR. The results demonstrated that LED light treatments significantly influenced mycelial color, colony diameter, stromata formation, and biomass accumulation. Particularly, light formulas RW23 (2 Red:3 White) and wW (Warm White) promoted larger colony diameters and higher fresh and dry weights of stromata. Total carotenoid content peaked at the orange mycelial stage under RB (5 Red:1 Blue) and nW (Neutral White) treatments, but declined during primordia and mature stages. Cordycepin accumulation was highest under RBW (3 Red:2 Blue:1 White) treatment, whereas adenosine content showed no significant variation across light conditions. Gene expression analysis revealed that CmHYD1 and CmFHP were upregulated under most LED treatments, while CmCNS3 exhibited variable expression patterns. The mating-type gene MAT1.1.1 remained stable across treatments, whereas MAT1.1.2 showed a notable decrease under certain spectral conditions. Overall, our findings highlight the potential of tailored LED light combinations to optimize stromata production and bioactive metabolite synthesis in C. militaris, offering insights into environmental modulation strategies for industrial-scale cultivation.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 4","pages":"41-56"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Polysaccharides for Improved In Vitro Probiotic Growth, Adhesion, Antioxidant Activity, and Cryoprotective Properties.","authors":"Worrapot Pengpa, Tanes Sangsri, Prissana Wiriyajitsomboon, Patcharaporn Siwayaprahm","doi":"10.1615/IntJMedMushrooms.2025061287","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025061287","url":null,"abstract":"<p><p>Hericium erinaceus, commonly known as lion's mane mushroom, is a rare edible and medicinal fungus that is highly valued in both the culinary and medical fields. Its primary bioactive component, polysaccharides, holds significant therapeutic potential, particularly in healthcare. This study investigates the prebiotic effects of crude polysaccharides extracted from H. erinaceus on various probiotic strains. Three distinct fractions of crude polysaccharides, HEP-30, HEP-50, and HEP-80 were obtained through fractional precipitation using 30%, 50%, and 80% (v/v) ethanol concentrations from hot water-soluble extracts. The effects of the polysaccharide extracts on probiotic growth, adhesion, antioxidant activity, and cryoprotective properties were evaluated in vitro. Of the HEP fractions, HEP-80 contains the highest amounts of protein, total sugars, and reducing sugars. Galactose is the predominant monosaccharide in all HEP fractions. The polysaccharide extract exhibited antioxidant activity by inhibiting DPPH free radicals across all three tested concentrations, with an average IC50 value of 10.189 mg/mL. HEP-80 significantly enhanced the growth of all three probiotic strains compared with an unsupplemented control group. HEP-80 at a concentration of 50 μg/mL increased the adhesion of Lactiplantibacillus plantarum strain L47-2 by up to 30%. Furthermore, HEP compounds demonstrated cryoprotective properties, resulting in over 70% survival of L. plantarum strain L47-2 after 90 days of storage at -20°C following freeze-drying. H. erinaceus-derived crude polysaccharides hold promise as both prebiotics and cryoprotectants, making them a potentially valuable functional ingredient for use in food products.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 2","pages":"47-61"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactives of Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Targeting PPAR Signaling Pathway: An Experimental and In Silico Investigation.","authors":"S Mahema, Jency Roshni, V Janakiraman, Sheikh F Ahmad, Sabry M Attia, Shiek S S J Ahmed","doi":"10.1615/IntJMedMushrooms.2025062333","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025062333","url":null,"abstract":"<p><p>Hericium erinaceus is a widely consumed edible mushroom with significant ethnopharmacological value. Nevertheless, the pharmacological understanding of H. erinaceus presenting crucial bioactive compounds, their therapeutic targets, and its benefits across diseases in the form of bioactive-target-disease connectivity is yet to be explored. This study evaluates the antioxidant activity and cytoprotective effects of H. erinaceus extract on V79 fibroblast cells in vitro, to profile its bioactive compounds, and to conduct a network pharmacological analysis to identify key bioactives linked to therapeutic target proteins and diseases. A qualitative analysis identified the existence of tannins, alkaloids, steroids, terpenoids, polysaccharides, and phytosterols. Vibrational infrared spectroscopy confirmed the existence of alkanes, alkenes, alkynes, aromatics, aldehydes, esters, alcohols, aliphatics, and primary amines. Cytoprotective investigation demonstrated that the concentrations (10-25 μg/mL) of the extract preserve 95% cell viability and significant antioxidant properties. Gas chromatography-mass spectrometry analysis of the H. erinaceus extract yielded 49 components. The absorption, distribution, metabolism, excretion, and toxicity (ADMET)-filtered compounds were subjected to target prediction and pathway analysis, which revealed PPARG protein and its signaling pathways were the most significant targets. Further, disease association analysis identified PPARG's links to various diseases, which could benefit from using H. erinaceus. Molecular docking (-6.804 kcal/mol), binding free energy (-42.05 kcal/mol), and dynamic simulations confirmed a strong interaction between PPARG and 2-methyl hexadecanoic acid. These findings underscore the antioxidant and cytoprotective capabilities of H. erinaceus phytochemicals, as well as their potential therapeutic safety and efficacy for further investigation.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 4","pages":"21-39"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detrimental, Essential, and Nutritionally Nonessential Elements in Fruiting Bodies of Auricularia auricula-judae (Agaricomycetes) Collected in Localities with Different Environmental Burdens.","authors":"Jan Šíma, Martin Křížek, Jiří Krejsa, Martin Šeda, Barbora Vyhlídková, Lukáš Rokos, Lubomír Svoboda","doi":"10.1615/IntJMedMushrooms.2025061255","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025061255","url":null,"abstract":"<p><p>Selected detrimental, essential, and nutritionally nonessential elements (total of 26 elements) were determined in fruiting bodies of Auricularia auricula-judae taken from three localities with different environmental burdens: a sampling site with no direct sources of contamination, a site located near a heavily trafficked road, and a site located near an amphibolite quarry. The analysis revealed that proximity of the road led to increased contents (mg/kg of dry matter; compared with the site without any direct contamination) of Al (140 vs. 40), As (0.14 vs. 0.06), Ba (17 vs. 11), Ca (5600 vs. 2600), Co (0.17 vs. 0.07), Cr (0.51 vs. 0.28), Cu (4.6 vs. 3.4), Fe (200 vs. 120), Mn (32 vs. 21), Mo (0.31 vs. 0.15), Na (420 vs. 170), Ni (1.4 vs. 0.72), Pb (0.14 vs. 0.08), Sr (15 vs. 9.7), and V (0.33 vs. 0.12). Similarly, the amphibolite quarrying led to increased contents of Al (590 vs. 40), As (0.15 vs. 0.06), Ca (9300 vs. 2600), Co (0.27 vs. 0.07), Cr (2.8 vs. 0.28), Cu (6.2 vs. 3.4), Fe (400 vs. 120), Mg (2400 vs. 1800), Mo (0.60 vs. 0.15), Na (370 vs. 170), Ni (1.6 vs. 0.72), Pb (0.18 vs. 0.08), Sr (17 vs. 9.7), and V (0.80 vs. 0.12) in comparison with the site without direct contamination. The studied sources of contamination may substantially affect the element levels in A. auricula-judae fruiting bodies, and this must be considered if this mushroom is collected for culinary or alternative medicine purposes.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 2","pages":"83-97"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic Profile and Biological Activities of Stropharia inuncta (Agaricomycetes) Extracts: Insights into Antioxidant, Enzyme Inhibition, and Cytotoxic Effects.","authors":"İskender Karaltı, Celal Bal, Emre Cem Eraslan, Ilgaz Akata, Mustafa Sevindik","doi":"10.1615/IntJMedMushrooms.2025061853","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025061853","url":null,"abstract":"<p><p>The phenolic compound profile of ethanolic extract of Stropharia inuncta (Fr.) Quél., a natural macrofungus species, and the effects of this chemical structure on antioxidant, anticholinesterase and antiproliferative activities were evaluated. Antioxidant capacity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and Rel Assay Diagnostics kits; DPPH: 72.653 ± 1.857 mg Trolox equivalents (TE)/g, FRAP: 86.873 ± 1.125 mg TE/g, otal antioxidant status (TAS): 4.049 ± 0.057 mmol/L, total oxidant status (TOS): 9.642 ± 0.038 μmol/L, oxidative stress index (OSI): 0.238 ± 0.002, respectively. Within the scope of anticholinesterase activity, IC50 values of the extract on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were determined as 55.007 ± 1.411 μg/mL and 82.993 ± 1.501 μg/mL, respectively. Antiproliferative effect was evaluated on A549 human lung adenocarcinoma cell line after 24 h of incubation; significant decrease in cell viability was observed especially at concentrations of 100 and 200 μg/mL. Phenolic content was analyzed by LC-MS/MS method and the highest levels of gallic acid (3713.45 ± 12.26 mg/kg), quercetin (2911.40 ± 6.19 mg/kg), and 4-hydroxybenzoic acid (2167.69 ± 4.71 mg/kg) were detected. Also compounds such as vanillic acid, catechinhydrate and acetohydroxamic acid were found at significant levels. The findings show that S. inuncta is a rich natural source of phenolic compounds and this chemical structure contributes to versatile biological activities. The limited information in the literature on the biological activities and phenolic compound profile of this species positions the study as a contribution to the field.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 4","pages":"87-96"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mushrooms and Their Bioactive Ingredients as Natural Resources for Development of Innovative Skin Care Formulations and Products.","authors":"Kainoor Krishnankutty Janardhanan, Sneha Das, Ravindran Kalathil Veena","doi":"10.1615/IntJMedMushrooms.2025061274","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025061274","url":null,"abstract":"<p><p>Glowing skin is the aspiration of individuals especially women for enhancing the beauty and charm. Modern lifestyle attaches significant importance to skin care. Hence the cosmetic industry is paying immense attention to cosmetic product development. Cosmetic industry is one of the fastest growing industries in the world in recent years. Majority of cosmetics contain synthetics as well as natural compounds. The risk associated with synthetic chemicals in cosmetics was realized by consumers and this awareness led to the demand for natural products-based cosmetics. As a result, cosmetic industries are compelled to pay adequate attention to raw materials from natural sources. Traditionally plants have been exploited for cosmetic product formulations. One of the natural resources that has caught the attention of cosmetic industry in recent years is the mushrooms. They are known to have strong antioxidant, antibacterial, anti-inflammatory, and tyrosinase, hyaluronidase, collagenase, and elastase inhibitory properties. Because of these attributes they are considered as multifunctional cosmetic bioactive ingredients. They have excellent antioxidant, antiaging, skin whitening, antiwrinkle and moisturizing properties. Common mushrooms frequently used in cosmetic formulation are Lentinula edodes, Grifola frondosa, Ganoderma lucidum, Cordyceps sinensis, Tremella fuciformis, Agaricus bisporus, Pleurotus ostreatus, Inonotus obliquus, and Hericium erinaceus. Mushroom based cosmetic products have substantial world market especially in USA, China, UK, Korea and Japan. Mushroom cosmetic market presents promising opportunities for expansion because of the growing demands of aging solutions. Global demand is predicted to reach nearly 3.9 billion USD by 2032. This review outlines the importance of mushrooms and their bioactive ingredients for development of skin care formulations and products in the multibillion-dollar cosmetic industry.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 2","pages":"17-32"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Knowledge and Study of Medicinal Properties of the Weeping Milk Cap Mushroom Lactarius volemus (Agaricomycetes) in México.","authors":"Isaac Tello-Salgado, Daniel Martínez-Carrera, Quetzalli Hernandez-Villegas, Elizur Montiel-Arcos, Elizabeth Nava-García, Veronica-Nuñez Urquiza, José Blancas, Beatriz Petlacalco","doi":"10.1615/IntJMedMushrooms.2025062397","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025062397","url":null,"abstract":"<p><p>Gathering and consumption of wild edible mushrooms are traditional practices in Mexico, influenced by the local culture of indigenous communities. In the Mestiza community of El Salto, municipality of Puente de Ixtla, Morelos, Mexico, traditional knowledge promotes the use and management of natural resources for meeting nutritional, economic, social, cultural, and environmental needs. Main mushroom species are gathered in the community for consumptions or marketing, involving women and men in the processes of collecting, consuming, cleaning, and selling. The traditional consumption of mushrooms supported healthy eating patterns, and Lactarius volemus was found to be a species of the most cultural importance (i.e., the highest frequency of mentioning in the interviews). Antioxidant and antibacterial properties of L. volemus extracts were analyzed and described. L. volemus showed significant DPPH free radical scavenging activity of 355.63 μg/mL, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) scavenging activity of 742.13 μg/mL, as well as bacteriostatic and bactericidal effects. Analyses of the minimal inhibitory concentration showed a high degree of susceptibility; the most potent minimal bactericidal concentration was 28.94 mg/mL recorded against Escherichia coli and Streptococcus agalactiae. Strategies for promoting mushroom consumption in indigenous and peasant communities, based on local cultural traditions, are discussed.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 4","pages":"97-105"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Medicinal Fungi Cryptoporus (Agaricomycetes): An Integrated Review of Taxonomic Advances, Chemodiversity Profiling, and Multidimensional Pharmacological Exploration.","authors":"Jia-Yao Li, Yu-Ying Liu, Ming Zhang, Zhen-Xin Wang, Khassanov Vadim, Minglei Li, Jianzhao Qi","doi":"10.1615/IntJMedMushrooms.2025061285","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025061285","url":null,"abstract":"<p><p>The genus Cryptoporus (Polyporaceae) has attracted significant attention in the fields of ethnopharmacology and drug discovery, owing to its distinctive chemodiversity and therapeutic potential. This comprehensive review synthesizes current knowledge on the taxonomy, bioactive metabolites, and pharmacological properties of Cryptoporus species. Taxonomically, molecular phylogenetic analyses have validated Cryptoporus as a monophyletic clade, with three recognized species, C. volvatus, C. sinensis, and C. qinlingensis, exhibiting transcontinental distribution and specific host preferences. From a chemical perspective, these fungi are responsible for the production of structurally unique drimane sesquiterpenoids (44 characterized compounds) and immunomodulatory polysaccharides, in addition to ergosterol derivatives. Pharmacological investigations have revealed multifaceted bioactivities, including antitumor effects via cell cycle disruption and apoptosis induction, anti-inflammatory actions through TNF-α/IL-1β suppression, and antioxidant capacity demonstrated by ABTS radical scavenging. It is noteworthy that the species-specific drimane sesquiterpenoid profile places these compounds as potential quality markers (Q-markers) for phytopharmaceutical standardization. Whilst in vitro and animal studies have validated traditional uses in treating respiratory disorders and inflammatory conditions, clinical evidence remains lacking. This review aims to facilitate the utilization of Cryptoporus in modern precision medicine, thereby integrating traditional knowledge with contemporary pharmaceutical development.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"28 2","pages":"33-45"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}