International journal of medicinal mushrooms最新文献_第2页

Phospholipid Profiles in Mushrooms: A Review of Extraction, Analysis, and Functional Applications. 蘑菇磷脂谱：提取、分析和功能应用综述。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057381

Yhiya Amen, Ahmed Othman, Kuniyoshi Shimizu

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Amino and Fatty Acids Composition, Volatile Compounds and Antioxidant Activity of Medicinal Mushroom Pholiota limonella (Agaricomycetes) from China. 中国药用蘑菇柠檬光菌的氨基酸、脂肪酸组成、挥发性化合物及抗氧化活性研究

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024056906

Jinxiu Zhang, Shengxuan Yang, Shuting Fan, Miaomiao Xiong, Xiaomin Yang, Li-An Wang, Zhuang Li, Jianhua Lv

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Exploring the Potential of Medicinal Mushroom β-Glucans as a Natural Frontier in Prostate Cancer Treatment. 探索药用蘑菇β-葡聚糖作为前列腺癌治疗天然前沿的潜力。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024056585

Rashmi Trivedi, Tarun Kumar Upadhyay

{"title":"Exploring the Potential of Medicinal Mushroom β-Glucans as a Natural Frontier in Prostate Cancer Treatment.","authors":"Rashmi Trivedi, Tarun Kumar Upadhyay","doi":"10.1615/IntJMedMushrooms.2024056585","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2024056585","url":null,"abstract":"The global increase in cancer cases, particularly prostate cancer, poses a significant health challenge worldwide. Conventional treatments such as surgery, radiation therapy, hormone therapy, chemotherapy, and immunotherapy offer valuable options but are associated with limitations and potential side effects. As a result, there is growing interest in complementary therapies, including natural compounds such as β-glucans, derived from sources such as yeast and mushrooms. In this review, we explored the potential therapeutic role of medicinal mushrooms β-glucan in prostate cancer treatment. β-glucans has demonstrated anti-cancer properties in preclinical studies, including inhibition of proliferation, induction of apoptosis, and modulation of immune responses. Studies in prostate cancer cell lines and animal models have shown promising results, with β-glucan inhibiting tumor growth, inducing DNA damage, and regulating tumor markers such as p53 and prostate specific antigen. β-glucans acts through various pathways, including stimulation of dendritic cells, modulation of cytokine secretion, suppression of myeloid-derived suppressor cells, and enhancement of immune responses. Moreover, β-glucans exhibits anti-androgenic and immune-modulatory effects, making it a promising candidate for prostate cancer treatment. In this study, we also focused on the mechanism of action of β-glucans through various pathways including tumor cell death by oxidative stress created through ROS generation and autophagy. Although preclinical studies support the potential therapeutic efficacy of medicinal mushrooms β-glucans, further research is needed to elucidate its clinical utility and safety in human trials.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 2","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dectin-1-Dependent Activation of Flt3 Ligand-Induced Dendritic Cells by the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body. 冬虫夏草子囊菌子实体Flt3配体诱导树突状细胞的检测素-1依赖性激活。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058213

Takashi Kanno, Rui Tada, Toyokazu Nakasone, Shigemi Okamatsu, Yoichiro Iwakura, Kazuhiro Tamura, Hiroaki Miyaoka, Yoshiyuki Adachi

{"title":"Dectin-1-Dependent Activation of Flt3 Ligand-Induced Dendritic Cells by the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body.","authors":"Takashi Kanno, Rui Tada, Toyokazu Nakasone, Shigemi Okamatsu, Yoichiro Iwakura, Kazuhiro Tamura, Hiroaki Miyaoka, Yoshiyuki Adachi","doi":"10.1615/IntJMedMushrooms.2025058213","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058213","url":null,"abstract":"Cordyceps militaris, an entomopathogenic fungus traditionally used in East Asian medicine, contains 1,3-β-glucans with well-known immunomodulatory properties. Our previous research has demonstrated that both fruit body powder and hot water extract of C. militaris can activate bone marrow-derived dendritic cells through dectin-1 signaling. However, the immunological effects on Fms-like tyrosine kinase 3 ligand-induced dendritic cells (fDCs), which closely resemble steady-state conventional dendritic cells in vivo, remain unexplored. In this study, we investigated the expression of dectin-1 in fDCs and its response to C. militaris fruit body powder (RK). Flow cytometric analysis revealed that conventional and plasmacytoid dendritic cells within the fDC population expressed dectin-1, with conventional dendritic cells showing particularly robust expression. Similar expression patterns were observed in freshly isolated splenic DCs. Importantly, RK induced significant tumor necrosis factor-α production in wild-type fDCs, whereas this effect was completely abolished in dectin-1-knockout fDCs. These findings demonstrate that C. militaris fruit-body powder activates fDCs through a dectin-1-dependent pathway, providing new insights into its immunomodulatory mechanisms and potential therapeutic applications.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 6","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Constituents, Nutrient Content, and In Vitro Antioxidant and Anti-Inflammatory Activity of Tricholomopsis aurea (Agaricomycetes) from Cameroon. 喀麦隆金黄色毛霉的成分、营养成分及体外抗氧化和抗炎活性

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057418

Ache Roland Ndifor, Ngnintedo Dominique, Mossebo Dominique Claude, Kemzeu Raoul, Ferdinand Lanvin Edoun Ebouel, Yanick Kevin Melogmo Dongmo, Ambassa Pantaléon, Céline Henoumont, Njinga Ngaitad Stanislaus, Sophie Laurent, Sonchieu Jean, Ngameni Bathelemy, Fotso Wabo Ghislain

{"title":"Constituents, Nutrient Content, and In Vitro Antioxidant and Anti-Inflammatory Activity of Tricholomopsis aurea (Agaricomycetes) from Cameroon.","authors":"Ache Roland Ndifor, Ngnintedo Dominique, Mossebo Dominique Claude, Kemzeu Raoul, Ferdinand Lanvin Edoun Ebouel, Yanick Kevin Melogmo Dongmo, Ambassa Pantaléon, Céline Henoumont, Njinga Ngaitad Stanislaus, Sophie Laurent, Sonchieu Jean, Ngameni Bathelemy, Fotso Wabo Ghislain","doi":"10.1615/IntJMedMushrooms.2024057418","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2024057418","url":null,"abstract":"Tricholomopsis aurea is used as food in different parts of the world, but has not been investigated for its nutrients, metabolites, and biological potentials like other edible mushrooms. This work aimed to quantify the metabolic and nutrient content of T. aurea and evaluate the antioxidant and anti-inflammatory activities of the extract and isolated compounds. The method employed involves chromatographic, spectroscopic, bovine serum albumin microplate, analytical and standard assays. Oleic, elaidic, petroselinic acids, ergosterol, ergosterol peroxide, 22E724R)-24-ethylcholesta-5,7,22-trien-3β-ol, and adenosine were isolated and identified using 1D and 2D-NMR spectroscopy and spectrometric data. The metabolic content revealed high phenolics (799.62 μgGaE/g of dry matter (DM)), low flavonoids (24.54 μgQE/g DM), alkaloids (32.92 μgQiE/g DM), and saponins (88.00 μgQSE/g DM). The nutrients content was made up of proteins (4.79%), lipids (10.43%), fibers (16.01%), ashes (15.96%), carbohydrates (8.74%), dry matter (85.93%), and moisture (14.07%) with energy value of 362.89 kcal. In mg/100 g, the minerals were phosphorus (283.97%), calcium (817.25%), potassium (67.10%), magnesium (94.42%), iron (57.27%), and sodium (74.4%). The extract displayed the antioxidant activity against TAC and FRAP (100-1000 μg/mL), DPPH (SC50 of 248.95 μg/mL) and ABTS (SC50 of 180.7 μg/mL), while the test compounds were not active. The extract, adenosine, ergosterol peroxide, and ergosterol showed anti-inflammatory activity with IC50 of 49.19 μg/mL, 4.91 μg/mL, 6.85 μg/mL, and 29.51 μg/mL, respectively. Conclusively, this study will help to promote the application of T. aurea in traditional dishes and functional or nutraceutical foods.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 4","pages":"71-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Evaluation of Favorable Conditions to Improve Biomass Production and Antioxidant Activity by the Egyptian Ganoderma resinaceum EGM and Ganoderma mbrekobenum EGDA (Agaricomycetes). 提高埃及树脂灵芝（EGM）和灵芝（EGDA）生物量和抗氧化活性的有利条件评价

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057141

Shimaa R El-Esseily, Amira A El-Fallal, Mahmoud M Nour El-Dein, Ahmed K A El-Sayed

{"title":"Evaluation of Favorable Conditions to Improve Biomass Production and Antioxidant Activity by the Egyptian Ganoderma resinaceum EGM and Ganoderma mbrekobenum EGDA (Agaricomycetes).","authors":"Shimaa R El-Esseily, Amira A El-Fallal, Mahmoud M Nour El-Dein, Ahmed K A El-Sayed","doi":"10.1615/IntJMedMushrooms.2024057141","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2024057141","url":null,"abstract":"Physiological studies were performed to investigate the optimal mycelial growth parameters for Ganoderma resinaceum EGM (AC: LN774970) and G. mbrekobenum EGDA (previously identified as Ganoderma sp. EGDA, AC: LN774971). The study found that the highest growth of mycelia was at 11 d for Ganoderma species. The nutritional studies were carried out to know the best growth conditions including temperature, culture media, pH, carbon source, and nitrogen source. The most appropriate temperature for the highest growth for Ganoderma species was at 30°C; this benefit enables the cultivation of these species in the spring. The most favorable media for their growth was potato dextrose broth as semi-synthetic followed by Saburaoud broth as synthetic media. They also could grow at pH ranges from 3.0-9.0, with the highest mycelial growth at pH 5.0. This study confirmed that both Ganoderma species prefer glucose as a carbon source and peptone as an organic nitrogen source. Decolorization of poly R associated with peptone was 21.37% and 18.66% for both EGM and EGDA strains, respectively. The highest cellulase production was achieved after 11 d of incubation with activity reached 0.305 μmole/mL/min and 0.236 μmole/mL/min for G. mbrekobenum EGDA and G. resinaceum EGM, respectively. The highest laccase activity was obtained after 8, 12 d of incubation with a value of 5.53 μmole/mL/min and 31.32 μmole/mL/min, for EGM and EGDA strains, respectively. Moreover, the highest peroxidase activity for both EGM and EGDA strains was recorded after 26 and 20 d of incubation with a value of 0.333 μmole/mL/min and 0.230 μmole/mL/min, respectively. G. mbrekobenum EGDA possessed higher flavonoids and phenolic compounds (4.098 mg/g and 6.298 mg/g dry weight, respectively) than G. resinaceum EGM (1.137 mg/g and 2.420 mg/g dry weight, respectively).","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 4","pages":"53-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Biological Efficiency, Nutritional Composition, and Bioactive Compound Contents of the Lung Oyster Mushroom Pleurotus pulmonarius (Agaricomycetes) Cultivated on Spent Mushroom Substrates. 废菌基质培养肺平菇的生物效率、营养成分及活性化合物含量

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058216

Chih-Hung Liang, Chiu-Yeh Wu, Po-Hsien Li, Zeng-Chin Liang

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Health Foods Made from Medicinal Mushrooms: Innovative Recipes Created by an Italian Chef. 由药用蘑菇制成的健康食品：意大利厨师创造的创新食谱。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058296

Angela Fallea, Giuseppe Venturella

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Anti-Aging Effects of Polysaccharides Derived from Amauroderma rugosum (Agaricomycetes) Aqueous Extract on Keratinocytes. 黑皮菌多糖对角质形成细胞的抗衰老作用。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025057696

Polly Ho-Ting Shiu, Wen Wang, Panthakarn Rangsinth, Chengwen Zheng, Jingjing Li, George Pak-Heng Leung

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Protective Effect of Polycephalomyces nipponicus (Ascomycota) Against Alcohol-Induced Liver Injury and Alcohol Intoxication in ICR Mice. 日本多头菌（子囊菌）对ICR小鼠酒精性肝损伤和酒精中毒的保护作用

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057762

Araya Supawat, Jintana Sattayasai, Sirinapa Rungruang, Jirayut Kaewmor, Kusavadee Sangdee, Aphidech Sangdee

{"title":"Protective Effect of Polycephalomyces nipponicus (Ascomycota) Against Alcohol-Induced Liver Injury and Alcohol Intoxication in ICR Mice.","authors":"Araya Supawat, Jintana Sattayasai, Sirinapa Rungruang, Jirayut Kaewmor, Kusavadee Sangdee, Aphidech Sangdee","doi":"10.1615/IntJMedMushrooms.2024057762","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2024057762","url":null,"abstract":"Polycephalomyces nipponicus, a traditional East Asian medicinal fungus, is recognized for its anticancer and antimicrobial properties, but its protective effects against alcohol-induced liver injury are less understood. This study investigated the activity of P. nipponicus strain MK1201 on motor coordination, alcohol metabolism, and hepatoprotection in mice after 14 d of ethanol exposure. Mice were assigned to five groups with nine treatments: (I) normal control (treatment 1), (II) ethanol administration (2 or 6 g/kg; treatments 2 and 3), (III) P. nipponicus (PN) extract alone (200 or 600 mg/kg; treatments 4 and 5), and (IV, V) PN-pretreated groups (200 or 600 mg/kg) followed by ethanol (2 or 6 g/ kg; treatments 6-9). Prior to ethanol administration, mice received either water or PN extract (200 or 600 mg/kg) by oral gavage. One h later, mice were given either water or ethanol (2 or 6 g/kg). Liver enzyme activities-alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP)-and blood triglyceride and cholesterol levels were measured, with motor coordination assessed post-ethanol. Pretreatment with PN extract (600 mg/kg) significantly enhanced ADH and ALDH activities and maintained normal motor coordination following ethanol exposure. Fourteen days of PN pretreatment (200 or 600 mg/ kg) significantly reduced AST, ALP, triglyceride, and total cholesterol levels, with 600 mg/kg also lowering ALT. These findings suggest PN extract as a promising therapeutic candidate to mitigate ethanol-induced motor, hepatic, and metabolic dysfunctions, presenting a potential natural intervention for alcohol-related health issues.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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