International journal of medicinal mushrooms最新文献

{"title":"Antibacterial Effects of Polycephalomyces nipponicus (Ascomycota) Mycelial Extract on Salmonella enterica Serovar Typhi.","authors":"Winita Fowsantear, Kusavadee Sangdee, Sutthiwan Thammawat, Aphidech Sangdee","doi":"10.1615/IntJMedMushrooms.2025058095","DOIUrl":"10.1615/IntJMedMushrooms.2025058095","url":null,"abstract":"<p><p>The rise of antibiotic-resistant bacteria, particularly Salmonella enterica subsp. enterica serovar Typhi (S. Typhi), poses a significant challenge to global public health. This study investigates the antibacterial potential of mycelial extract from the medicinal fungus Polycephalomyces nipponicus strain Cod-MK1201 against S. Typhi strain DMST 16122. The extract demonstrated significant inhibitory effects, with minimum inhibitory concentration and minimum bactericidal concentration values of 3.12 mg/mL and 6.25 mg/mL, respectively. Scanning and transmission electron microscopy revealed dose-dependent severe morphological damage to S. Typhi cells, including cell wall disruption, cytoplasmic leakage, and structural deformation, indicating the extract's ability to target multiple cellular structures. Additionally, proteomic analysis showed significant alterations in the bacterial proteome, with downregulation of key proteins involved in metabolism, stress response, and virulence, and upregulation of proteins related to oxidative stress response and the stringent survival pathway. These findings demonstrate the multifaceted antimicrobial mechanisms of P. nipponicus mycelial extract, indicating its potential as a natural resource for developing novel therapeutic agents to treat S. Typhi infections. This highlights its promise as a candidate for reducing antibiotic dependency and addressing the growing challenge of antimicrobial resistance.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 6","pages":"45-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Interaction of Phellilane L with HmuY: A Promising Therapeutic Strategy against Porphyromonas gingivalis in Chronic Periodontitis.","authors":"Abhishek Mishra, Aditya Ganeshpurkar, Nazneen Dubey","doi":"10.1615/IntJMedMushrooms.2025058014","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058014","url":null,"abstract":"<p><p>This study investigates the in silico interaction between Phellilane L, a sesquiterpene metabolite from Phellinus linteus, and the Porphiromonas gingivalis HmuY protein, a key player in chronic periodontitis pathogenesis. The goal is to assess the potential of Phellilane L as a therapeutic agent against periodontal infections. Molecular docking and dynamics simulations were used to explore the interaction between Phellilane L and HmuY. Lipinski's rule of five, Wiener index, and MM/GBSA calculations were performed to assess drug-likeness, molecular connectivity, and binding affinity. Python 2.7, AutoDock 4.2, and Flare software were used to perform docking, energy calculations, and molecular dynamics simulations. Phellilane L showed favorable drug-likeness, adhering to Lipinski's rule of five. The Wiener index of 493 indicates simplicity in molecular structure, beneficial for drug absorption. Docking results revealed key interactions with HmuY, with binding energy of -7.45 μM and stable van der Waals and hydrogen bond interactions. MM/GBSA analysis indicated a favorable binding free energy of -27.45 kcal/mol, with significant contributions from van der Waals and electrostatic interactions. Phellilane L demonstrates strong binding affinity to HmuY, potentially inhibiting heme acquisition, essential for P. gingivalis survival. These findings suggest Phellilane L as a promising candidate for developing novel therapeutic approaches for treating periodontal disease.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 7","pages":"31-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxicity and Cell Death Induction on a Cervical Cancer Cell Line by Crude Extracellular Product of Omphalotus nidiformis (Agaricomycetes) Mycelium.","authors":"Isaac Tello-Salgado, Alexzandra Torres-Obando, Marisol Mir-Garcia, Vanessa Guzmán-Razón, Veronica-Nuñez Urquiza, Elizabeth Nava-García, Elizur Montiel-Arcos, María T Díaz-Hernández, Carlos Mojica-Cardoso, Carla O Contreras Ochoa","doi":"10.1615/IntJMedMushrooms.2024057069","DOIUrl":"10.1615/IntJMedMushrooms.2024057069","url":null,"abstract":"<p><p>Fungi have proved to be useful sources of compounds with antineoplastic properties. Although several metabolites isolated from species of the genus Omphalotus have shown cytotoxic effects on tumor cell lines. Few works have studied Omphalotus nidiformis. The activity of a whole crude extracellular product of a O. nidiformis micelyum strain is reported herein; this crude extract was able to reduce viability of cervical cancer HeLa cells (78% to 29%) after 24 h of exposure. Upon fractionation with dichloromethane, the fraction F1 was also capable of inhibiting cell viability, but the fraction F2 showed no effect. Both the crude extracellular product and F1 induced time- and concentration-dependent cell death by apoptosis through activation of caspase-3/7; in addition, both products induced a 3.5- to 5-fold increase in autophagy. The major components identified in both extracts by gas chromatography/mass spectrometry were 9-octadecenamide, tetradecanamide, hexadecanamide, and squalene, which could be responsible for the cytotoxic effect. Fungal metabolites with cytotoxic activity could be used in the future in combination with antineoplastic drugs for cancer treatment.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 3","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential of Spent Pleurotus eryngii (Agaricomycetes) Substrate to Cultivate Pleurotus florida with Enhanced Productivity, Nutritional Profile, and Therapeutic Potential.","authors":"Preeti Thakur, Savita Jandaik, Shikha Guleria, Annu Sharma, Ranjana Sharma, Rajender Singh","doi":"10.1615/IntJMedMushrooms.2024056896","DOIUrl":"10.1615/IntJMedMushrooms.2024056896","url":null,"abstract":"<p><p>Every year, several mushroom farms create a significant volume of discarded mushroom substrate. To make use of spent mushroom substrate, Pleurotus florida was grown on wheat straw that had been supplemented in varying amounts with one year old spent substrate of Pleurotus eryngii, wheat bran, and CaCo3. Physico-chemical parameters of the substrates (pH, C, and N) were higher prior to cultivation and reduced following cultivation except electrical conductivity, that displayed the opposite trend. The wheat straw used as the control showed the highest yield, approximate composition, myco-chemicals, and antioxidant activity of P. florida sporophores. According to the data, the optimal ratio for P florida production following control, was for a combination of P. eryngii spent substrate (PESS) + wheat straw + wheat bran + CaCO3 (50:40:9.5:0.5). The results imply that adding a suitable quantity of wheat straw, wheat bran and CaCo3 to discarded mushroom substrate can enable its reuse, offering a practical method for preserving the environment, cutting expenses, and producing high-quality mushrooms.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 2","pages":"47-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiger Milk Medicinal Mushroom Lignosus rhinocerus (Agaricomycetes) Polysaccharides Mediates Airway Smooth Muscle Relaxation via Muscarinic and Histamine Receptors.","authors":"Abubakar Bishir Daku, Bushra Solehah Mohd Rosdan, Nurul Iffah Kamaruddin, Wan Amir Nizam Wan Ahmad, Asma Abdullah Nurul","doi":"10.1615/IntJMedMushrooms.2025058606","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058606","url":null,"abstract":"<p><p>The medicinal and nutritional benefits of mushrooms have long been explored, with polysaccharides among the major bioactive constituents. Among these, Lignosus rhinocerus (tiger milk mushroom) is well documented for the traditional treatment of ailments, including respiratory illness, and has been shown to express several bioactivities, including anti-asthmatic effects. In this study, the polysaccharide constituents of L. rhinocerus mushroom were successfully extracted and fractionated using Soxhlet extraction, column chromatographic methods followed by cytotoxicity analysis. To test for its airway relaxation potential, an isolated guinea pig trachea (GPT) ring was used in a functional multichannel myograph study to evaluate the relaxation effects of L. rhinocerus polysaccharides (LRP) on muscarinic, histamine, and β2 airway receptor agonist-antagonist responses. The mushroom polysaccharides were found to be a neutral, water-soluble polysaccharide-protein complex, and the LR crude extract and its polysaccharides fraction showed no cytotoxic effect against the Vero cell line. LRP induced concentration-dependent relaxation in contracted airway smooth muscle, which was pre-contracted with EC40 carbachol and EC50 histamine. The airway relaxation effect of LRP is mediated via muscarinic and histamine receptors which supports the therapeutic potential of LRP as a natural alternative for the management of asthma.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 8","pages":"37-50"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Activity of Different Collections of Medicinal Polypore Fungus Fomitopsis pinicola (Agaricomycetes).","authors":"Susanna M Badalyan, Alla V Shnyreva, Anush Barkhudaryan","doi":"10.1615/IntJMedMushrooms.2024055590","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2024055590","url":null,"abstract":"<p><p>The study of antimicrobial activity (AMA) of 14 genetically identified dikaryotic strains of red belted medicinal polypore Fomitopsis pinicola isolated from Betula sp. and other deciduous trees, as well as conifers Picea sp. and Abies alba in Russia, France and Italy against test fungi and bacteria is discussed. The results of this study have shown that F. pinicola strains possess significant antimicrobial potential against dermatophytes (Chrysosporium keratinophilum, Microsporum gypseum, Trichophyton terrestre) and Penicillium species (P. griseofulvum, P. sp.) isolated from soil samples in Armenia, as well as Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium) and Gram-positive (Staphylococcus aureus) bacteria received from different culture collections. In dual culture experiments, F. pinicola showed high antagonistic/antifungal activity toward test fungi by suppressing their average growth rate (GRavr) and sporulation causing morphological changes of colonies. The cultural broth (CB) samples obtained from 21-d static culture of F. pinicola demonstrated higher antifungal activity (AFA) with fungicidic (FC) and fungistatic (FS) effects against dermatophytes and more than 50% GRavr inhibitory effect for Penicillium spp. compared with mycelial extracts (ME) samples. Tested CB and ME samples of F. pinicola showed also antibacterial activity (ABA) against test bacteria. The AMA of CB samples was higher than the activity of ME samples. The mycelium of F. pinicola may be considered a potential source of extra- and intracellular antimicrobial compounds. Further studies to elucidate the mechanism of antimicrobial effect of F. pinicola for developing mushroom-derived biotech products are warranted.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"26 12","pages":"33-48"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Button Mushroom Agaricus bisporus (Agaricomycetes) and Soybean Oil on Storage Characteristics of Chicken Sausage.","authors":"Haijuan Nan,&nbsp;Tetiana Stepanova,&nbsp;Bo Li","doi":"10.1615/IntJMedMushrooms.2023049470","DOIUrl":"10.1615/IntJMedMushrooms.2023049470","url":null,"abstract":"<p><p>To investigate the effect of Agaricus bisporus and soybean oil as complex fat substitutes on the storage characteristics of chicken sausages, a pre-mixture of A. bisporus and soybean oil (1:2) was used to replace 0% (CK), 30% (T30), 60% (T60), and 90% (T90) of pork back fat in chicken sausages. The changes in color (brightness value, L*; redness value, a*; and yellowness value, b*), texture, pH, and total viable count of the sausages were examined at 1, 5, 10, 15, 20, 25, 30 and 35 d of storage at 4°C, respectively. The results showed that A. bisporus and soybean oil altered the color of the sausages. At the same storage time, compared with CK, L* values of fat-reduced chicken sausages decreased significantly, while a* values increased significantly (P < 0.05), b* values increased significantly (P < 0.05) at the 10 d of storage. During storage, L* and a* values of CK gradually decreased and b* values gradually increased, fat-reduced sausages exhibited opposite trends in a* values and b* values compared with CK. The hardness and chewiness of fat-reduced sausages increased significantly (P < 0.05) compared with CK at the same storage time. During storage, the overall hardness of fat-reduced sausages increased, and the springiness and chewiness fluctuated. T60 did not change significantly in cohesiveness throughout the storage period (P < 0.05). The pH of fat-reduced sausage was relatively stable during storage. The higher the amount of A. bisporus added, the greater the pH. The pH of T60 did not change throughout the storage period. A. bisporus and soybean oil showed some antibacterial effect on sausage and the minimum shelf life of chicken sausage with A. bisporus was 25 d. In conclusion, A. bisporus and soybean oil increased the redness and hardness of the sausages during storage, but the pH and total viable bacteria count remained relatively stable. T60 displayed the most stable storage properties among them, making it the optimum method for the manufacturing of fat-reduced chicken sausages.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 9","pages":"73-83"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoptosis-Mediated Anticancer Activity of Ganoderma colossus (Agaricomycetes) Extracts in Breast Cancer Cells.","authors":"Riji E,&nbsp;Prashantha Naik,&nbsp;Katheeja Muhseena N,&nbsp;Suparna Laha","doi":"10.1615/IntJMedMushrooms.2023049907","DOIUrl":"10.1615/IntJMedMushrooms.2023049907","url":null,"abstract":"<p><p>Cancer is a leading cause of death worldwide. The current cancer treatments including chemo-, radio- and immuno-therapies pose various side effects, and chances of recurrence that demand for new therapeutics to overcome the issues with existing ones. Mushrooms are considered a potential source of novel therapeutic agents. Ganoderma colossus, a non-edible wood-inhabiting mushroom, is known for certain medical properties. The present study aimed to investigate the possible anticancer activity of methanolic, ethyl acetate, and chloroform extracts of G. colossus, against MCF-7 cells and the mechanism of action(s). MTT assay and gene expression studies were carried out by following the standard protocols. The results demonstrated that among the three solvents, the ethyl acetate crude extract of the mushroom exhibited potential cytotoxic activity on MCF-7 (IC50, 17.2 ± 2.7). The DNA damage induced by the solvent extracts of G. colossus was observed by H2AX foci formation. The TP53 over-expression and flow cytometry analysis indicated that checkpoint activation followed by cell cycle arrest occurred at G1/G0 phase in response to the extract treatment. The dual acridine orange/ethidium bromide (AO/EB) staining revealed apoptosis-associated changes in the cells. Analysis of caspase 3 activations by immunophenotyping confirmed the apoptotic process in the extract-treated cells. Bcl-2 and TP53 mRNA expression data by RT-PCR disclosed the apoptosis pathway. The GC- MS spectral data of the ethyl acetate crude extract of the mushroom indicated the presence of molecules capable of inducing apoptosis. The present study warrants further studies to isolate the molecule(s) from G. colossus which may be a potential drug candidate for breast cancers.</p>","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 10","pages":"23-37"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Biological Studies of the Terpenoids from Ganoderma resinaceum and Serpula similis (Agaricomycetes).","authors":"Tejal N Rikame, Preeti S Ranawade, Smriti P K Mittal, Vitthal T Barvkar, Mahesh Y Borde, Rajesh D Tak","doi":"10.1615/IntJMedMushrooms.2023050771","DOIUrl":"10.1615/IntJMedMushrooms.2023050771","url":null,"abstract":"Mycochemical properties and bioactivities of Ganoderma resinaceum and Serpula similis remain unexplored. The present study assessed antioxidant, cytotoxicity, and cell migration abilities of Ganoderma and Serpula extracts, followed by their phytochemical analyses. The MTT assay was conducted to determine the cytotoxicity along with the cell migration studies in human cancer cell lines. The antioxidant profiles were evaluated through DPPH and FRAP assays. Furthermore, LC-MS/MS analysis was performed to elucidate the phytochemicals responsible for anticancer and antioxidant activities. Significant concentration-dependent cytotoxicities of 12.7% and 13.7% were observed against HCT 116 cell lines at 1% and 5% concentrations of the G. resinaceum extract, respectively. Similarly, significant concentration-dependent cytotoxicities of 6.7% and 25.5% were observed at 1% and 5% concentrations of the S. similis extract, respectively. The extracts of G. resinaceum and S. similis both shows better anti-migration potential in lung cancer cells. Both extracts demonstrated good scavenging activity on DPPH and ferric ion free radicals. LC-MS analysis revealed 11 compounds from S. similis and 15 compounds from G. resinaceum fruiting bodies. Compounds such as terpenoids, alkaloids, cytotoxic peptides, and other metabolites were identified as major components in both extracts. These extracts exhibited cytotoxic activity against HCT 116 cancer cells, along with moderate antioxidant activity. This implies that the extracts might be used as bioactive natural sources in the pharmaceutical and food industries.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 12","pages":"15-31"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPLORING THE ANTIOXIDANT POTENTIAL OF METHANOLIC EXTRACTS OF WILD EDIBLE MUSHROOMS FROM DARMA VALLEY, PITHORAGARH, KUMAUN HIMALAYA, INDIA","authors":"Priya Bisht, Basant Singh, Pardeep Sharma, Narendra Lotani, Chandra Negi, Indra Bhatt","doi":"10.1615/intjmedmushrooms.2023051350","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023051350","url":null,"abstract":"This study presents a comprehensive analysis of the methanolic extracts of nine species of wild edible mushrooms (WEM) native to the Darma Valley in the Kumaun Himalaya region. The investigation encompasses the assessment of various biochemical attributes, including Total Phenolics (TP), Total Flavonoids (TF), Total Tannins (TT) contents, the ABTS assay, and the DPPH radical scavenging assay. Among the nine WEM species examined, C. craniiformis stands out for displaying the highest antioxidant capacities, indicated by exceptional TP (54.94 ± 0.54 mg GAE/g dw) and TT (4.23 ± 0.17 mg TAE/g dw) contents, along with noteworthy ABTS (10.44 ± 0.34 mg AAE/g dw) and DPPH activity (0.335 ± 0.001 mg AAE/g dw). Subsequent in antioxidant potential are R. fennica, G. clavatus, R. sanguinea, R. flava, C. zollingeri, P. ostreatus, R. botrytis, and K. mutabilis. Variations in antioxidant capacities align with distinct phenolic content. This study underscores Clavatia craniiformis as a remarkable source of antioxidants, suggesting its potential suitability for nutraceutical applications. The findings contribute to a deeper understanding of the antioxidant properties inherent in wild edible mushrooms, particularly emphasizing the prominence of C. craniiformis.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}