International journal of medicinal mushrooms最新文献_第6页

Mechanism of Antihyperglycemic Activity of Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) in Type 2 Diabetic Rats. 发酵火鸡尾药菇胞外多糖对2型糖尿病大鼠降血糖作用的机制

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057058

Yi-Ying Wang, Shih-Ching Chao, Pei-Yuan Su, Hui-Chen Lo

{"title":"Mechanism of Antihyperglycemic Activity of Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) in Type 2 Diabetic Rats.","authors":"Yi-Ying Wang, Shih-Ching Chao, Pei-Yuan Su, Hui-Chen Lo","doi":"10.1615/IntJMedMushrooms.2024057058","DOIUrl":"10.1615/IntJMedMushrooms.2024057058","url":null,"abstract":"The antihyperglycemic activity of extracellular polysaccharopeptides (ePSP) obtained from Trametes versicolor (TV) strain LH-1 has been demonstrated in hepatic cells and diabetic animals. This study further investigated the mechanisms of T. versicolor-ePSP on regulating glucose metabolism, including insulin signaling molecules and glucose metabolism-associated enzymes, in the liver of rats with type 2 diabetes mellitus (T2DM). Male Wistar rats, fed with a high-fat diet followed by a streptozotocin injection to induce T2DM, were orally administered water or T. versicolor-ePSP at doses of 0.1, 0.5, or 1.0 g/kg/d. After 4 weeks of T. versicolor-ePSP administration, T2DM rats exhibited significantly lower postprandial blood glucose levels, decreased liver triglyceride and cholesterol contents, and improved serum liver function indices in a dose-dependent manner (P < 0.05, one-way ANOVA). Additionally, T2DM rats administered T. versicolor-ePSP had significantly activated insulin receptors and decreased proteins involved in insulin signaling pathway, such as insulin receptor substrates, PI3K, and total and activated Akt, and AMP-activated protein kinase in the liver. T. versicolor-ePSP administration, especially at 1.0 g/kg per day, significantly increased glucose transporters in the cell membrane and decreased glucokinase and glucose-6-phosphotase in the cytosol of the liver. In conclusion, the antihyperglycemic activities of T. versicolor-ePSP may be associated with enhanced hepatic function, alleviated gluconeogenesis, and facilitated glucose transport in an insulin- and AMPK-independent manner in the liver of T2DM rats.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 3","pages":"11-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Characterization and Anti-Obesity Activity of Exopolysaccharide Isolated from Scleroderma areolatum (Agaricomycetes). 乳状硬皮病（菌类）胞外多糖的化学特性及抗肥胖活性研究。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058054

Jiafeng Bai, Xiaoqin Peng, Yi Zhou, Zhizhong Hu, Changtong Lu, Xuewei Jia, Chunping Xu

{"title":"Chemical Characterization and Anti-Obesity Activity of Exopolysaccharide Isolated from Scleroderma areolatum (Agaricomycetes).","authors":"Jiafeng Bai, Xiaoqin Peng, Yi Zhou, Zhizhong Hu, Changtong Lu, Xuewei Jia, Chunping Xu","doi":"10.1615/IntJMedMushrooms.2025058054","DOIUrl":"10.1615/IntJMedMushrooms.2025058054","url":null,"abstract":"Two polysaccharide fractions were successfully isolated from the crude exopolysaccharide (EPS) of Scleroderma areolatum via gel filtration chromatography. Size exclusion chromatography/multi-angle laser light scattering (SEC/MALLS) analysis showed that the weight of average molecular weights (Mw) of these fractions was 3.162 ȕ 106 (Fr-I) and 2.613 ȕ 106 (Fr-II). Both EPS fractions exhibited a compact globular structure in aqueous solution. Monosaccharide composition analysis revealed that they were primarily composed of mannose and glucuronic acid. FT-IR spectral analysis identified prominent functional groups, such as hydroxyl and carboxylic, typical of heteropolysaccharides. When administered as supplements in high-fat diets to obese rats for 8 weeks, the EPS fractions reduced body weight, serum inflammatory factor levels, and significantly regulated serum lipid levels. Additionally, they increased the total concentration of short-chain fatty acids (SCFA) in colonic digesta. These results suggest a potential role for EPS in mitigating obesity and related metabolic disorders in high-fat diet-induced obese rats.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice. 香菇多糖改善h2o2诱导的Caco-2细胞和dss诱导的溃疡性结肠炎小鼠的炎症损伤

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058082

Jun Lin, Meng Yuan, Hong-Yu Shi, Qiang Liu, Shuai Du, Mei-Xia Zhang, Qu-Quan Li, Zhen-Bang Yang, Pei Lin

{"title":"Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice.","authors":"Jun Lin, Meng Yuan, Hong-Yu Shi, Qiang Liu, Shuai Du, Mei-Xia Zhang, Qu-Quan Li, Zhen-Bang Yang, Pei Lin","doi":"10.1615/IntJMedMushrooms.2025058082","DOIUrl":"10.1615/IntJMedMushrooms.2025058082","url":null,"abstract":"Phellinus linteus (Agaricomycetes) is a valuable medicinal mushroom traditionally used as a food supplement and medicinal ingredient. Polysaccharides of Ph. linteus (PLP) possess strong anti-inflammatory effects and gut microbiota modulating properties. However, the mechanism of its efficacy in ulcerative colitis (UC) remains unclear. This study utilized 1mM H2O2 to induce an in vitro model of UC in Caco-2 cells. Additionally, a 3% solution of dextran sulfate sodium salt (DSS) was employed to establish an in vivo UC model in mice. After treating the cells with PLP at various concentrations, there was a significant reduction in the mRNA expression of TNF-α and IL-6, and the nuclear factor-κB (NF-κB) signaling pathway was also inhibited. Concurrently, symptoms such as colon shortening, weight loss, and a decrease in disease activity index (DAI) scores were significantly improved in UC mice. Additionally, the treatment led to downregulated expression of TNF-α and IFN-γ mRNA in colon tissues. PLP had shown potential in reducing inflammation and oxidative stress in Caco-2 cells, demonstrating therapeutic effects in treating UC-like inflammation by inhibiting the NF-κ signaling pathway and activating the nuclear factor erythroid derived 2-like 2(Nrf2)/heme oxygenase-1(HO-1) signaling pathway. These findings suggest that PLP has great potential for further investigation and development in UC treatment.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 5","pages":"17-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valorization of Morchella esculenta (Ascomycota) Using a Healthy Extraction Method: Investigation of Bioavailability, Anti-Acetylcholinesterase, and Antioxidant Potentials. 健康提取法对羊肚菌（子囊菌）的增殖作用：生物利用度、抗乙酰胆碱酯酶和抗氧化能力的研究。

IF 1.4

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025059268

Arij Khemiri, Mohamed Mendili, Chedia Aouadhi, Chahrazed Jaffali, Ayda Khadhri

{"title":"Valorization of Morchella esculenta (Ascomycota) Using a Healthy Extraction Method: Investigation of Bioavailability, Anti-Acetylcholinesterase, and Antioxidant Potentials.","authors":"Arij Khemiri, Mohamed Mendili, Chedia Aouadhi, Chahrazed Jaffali, Ayda Khadhri","doi":"10.1615/IntJMedMushrooms.2025059268","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025059268","url":null,"abstract":"Edible fungi are unexploited natural sources of high added value biomolecules, such as phenolic compounds. This study used an innovative and green extraction method based on the quick, easy, new, cheap, reproducible (QUENCHER) process of Morchella esculenta. The QUENCHER extract had a much higher concentration of total polyphenols [(125 mg gallic acid equivalents (GAE)/g dry weight (DW)], flavonoids [38 mg catechin equivalents (CE)/g DW], flavanols [22 mg quercetin equivalents (QE)/g DW], and proanthocyanidins [44 mg CE/g DW] than the traditional aqueous extraction. In addition, antioxidant activities were evaluated by the in vitro scavenging capacity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and iron reducing power. In the DPPH test, this phenolic richness clearly improved antioxidant activity, with an IC50 (inhibition concentration at 50%) of 0.097 mg/mL. It has also shown encouraging antibacterial qualities against resistant Gram-positive bacteria like Staphylococcus aureus (minimum inhibitory concentration varied between 6.25 and 25 μg/mL). For the acetylcholinesterase (AChE) inhibition, QUENCHER extract demonstrated strong AChE inhibition (IC50 = 0.002 mg/mL), a characteristic of significant interest in neurodegenerative disorders. These results open possibilities for using this extract as a natural antimicrobial agent, against resistant bacterial infections. Furthermore, in vitro digestion data indicates that the bioactive compounds in these extracts maintain relative stability during transit through the gastrointestinal tract, allowing for favorable bioavailability and, consequently, potential therapeutic efficacy. After 4 h of simulated digestion, over 66% of the antioxidant and anti-AChE activity was still present, indicating a degree of stability in the bioactive chemicals and an intriguing potential for bioavailability, according to in vitro digestibility experiments.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 9","pages":"61-74"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal Fungi and Soil: Interactions, Plant Interactions, and Ecological Restoration for Sustainable Use: A Review. 药用真菌与土壤：相互作用、植物相互作用和可持续利用的生态恢复综述。

IF 1.4

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025059592

Linqiu Liu, Liming He, Ling Cai, Xin Xie, Yi Wang, Xia Luo

{"title":"Medicinal Fungi and Soil: Interactions, Plant Interactions, and Ecological Restoration for Sustainable Use: A Review.","authors":"Linqiu Liu, Liming He, Ling Cai, Xin Xie, Yi Wang, Xia Luo","doi":"10.1615/IntJMedMushrooms.2025059592","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025059592","url":null,"abstract":"Medicinal fungi are widely used in Chinese traditional medicine for their various medicinal effects. Soil has an irreplaceable effect on most medicinal fungi. The purpose of this study is to sum up the relationship between medicinal fungi and soil. We obtained high-quality literatures of last two decades from PubMed, ScienceDirect, Web of Science and Springer with keywords including \"medicinal fungi,\" \"fungi,\" \"medicinal mushroom,\" and \"soil,\" and Latin names of some common medicinal fungi. Different medicinal fungi are adapted to different soil environments, and different soil environments affect medicinal fungi. In addition, medicinal fungi could have a positive or negative effect on the nearby plants via soil. Furthermore, medicinal fungi played a role in soil ecological restoration. Finally, future directions are proposed: firstly, researchers are supposed to use advanced methods including high-resolution sequencing methods and the confirmatory factor analysis method; secondly, researchers should include more research content to improve the integrity of the study, such as the micro-foodwebs in soil; thirdly, medicinal fungi can be used as multi-purpose soil amendments.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 10","pages":"61-74"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Tiger Milk Medicinal Mushroom Lignosus rhinocerus (Agaricomycetes) Mitigates Oxidative Damage in a Cellular Model Mimicking Friedreich's Ataxia. 虎乳药用蘑菇Lignosus rhinocerus（木链菌）在模拟弗里德赖希共济失调的细胞模型中减轻氧化损伤。

IF 1.4

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025059734

Michael Weng Lok Phang, Nur Shahirah Mohd Hisam, Farahaniza Supandi, Poh Guat Cheng, Siew Huah Lim, Lee Wei Lim, Kah Hui Wong

{"title":"The Tiger Milk Medicinal Mushroom Lignosus rhinocerus (Agaricomycetes) Mitigates Oxidative Damage in a Cellular Model Mimicking Friedreich's Ataxia.","authors":"Michael Weng Lok Phang, Nur Shahirah Mohd Hisam, Farahaniza Supandi, Poh Guat Cheng, Siew Huah Lim, Lee Wei Lim, Kah Hui Wong","doi":"10.1615/IntJMedMushrooms.2025059734","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025059734","url":null,"abstract":"Lignosus rhinocerus is a medicinal mushroom that is well recognized for its diverse pharmacological properties. We evaluated the protective effects of L. rhinocerus ethanol fraction (LREF) in Friedreich's ataxia (FRDA) by using fibroblasts treated with L-buthionine sulfoximine (L-BSO) to induce oxidative damage to mimic the pathogenesis of the disease. Liquid chromatography-mass spectrometry (LC-MS) of LREF revealed a total of eight compounds. The compound-target gene-disease network analysis also identified that phthalic acid, citric acid, oleic acid, methyl palmitate and tryptophan, were associated with gene subunits related to potassium, sodium, and calcium ion channels. In FRDA, dysregulation of ion channels leads to mitochondrial iron accumulation and decreased activity of iron-sulfur cluster enzymes. The FRDA fibroblasts were administered LREF for 4 h, followed by 12 mM L-BSO for 24 h to induce oxidative damage. Fibroblasts treated with 2.50 µM idebenone were used as positive control. Administration of LREF (15.63 to 62.50 µg/mL) enhanced cell viability, superoxide dismutase (SOD) activity, and mitochondrial function and biogenesis; attenuated lactate dehydrogenase (LDH) release, excessive intracellular ROS generation and apoptosis; and modulated the expression of key metabolic genes, namely peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A), nuclear respiratory factor 1 (NRF1), and transcription factor A, mitochondrial (TFAM). The protective effects of LREF were associated with its antioxidant properties and compounds that regulate mitochondrial function and biogenesis. Our study showed that LREF can mitigate oxidative damage induced by L-BSO in a cellular model of FRDA, which could be developed into mitochondria-targeted antioxidants.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 11","pages":"63-87"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Examination of Cholinergic Symptoms Produced by the Fly Agaric Mushroom Amanita muscaria (Agaricomycetes): Revisiting the Role of Muscarine. 蝇类黑木耳菌（黑木耳菌）产生的胆碱能症状的检查：重新审视蘑菇碱的作用。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058603

Kevin Feeney, James Kababick, Stacy Wise

{"title":"An Examination of Cholinergic Symptoms Produced by the Fly Agaric Mushroom Amanita muscaria (Agaricomycetes): Revisiting the Role of Muscarine.","authors":"Kevin Feeney, James Kababick, Stacy Wise","doi":"10.1615/IntJMedMushrooms.2025058603","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025058603","url":null,"abstract":"The English mycological and toxicological literature has, for decades, asserted that muscarine concentrations in Amanita muscaria are insignificant based on a study from the 1950s that demonstrated muscarine levels in fresh A. muscaria mushrooms at a meager 0.0003%. This position has been maintained despite frequent reports of cholinergic symptoms following consumption of this mushroom and despite the dated study upon which this position is based. To update the literature on A. muscaria's pharmacology and to address disparities between the current scientific consensus on the role of muscarine, a cholinergic compound, in A. muscaria poisonings and the frequent reports of cholinergic symptoms following its ingestion, four steps were taken: (1) surveys were collected from 53 individuals who experienced cholinergic symptoms following ingestion of A. muscaria; (2) mushroom samples were procured for HPLC-MS/MS analysis from three survey participants; (3) mushrooms were collected independently for HPLC-MS/MS analysis; and (4) commercial analyses of Amanita muscaria were compiled to illustrate a range of muscarine concentrations. Survey results demonstrated that mild-to-moderate cholinergic symptoms were experienced at doses that reflect common use of the mushroom for recreational, therapeutic, and spiritual purposes (1-20 g dried). Results of HPLC-MS/MS analyses demonstrated muscarine concentrations ranging from 0.004% up to 0.043%, significantly exceeding the consensus value. Study findings demonstrate that current understandings of muscarine concentrations in A. muscaria are inaccurate, and that the occurrence of muscarine in A. muscaria must be understood as a broad range, one that ranges from the insignificant up to physiologically significant levels.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 7","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Effects of Polycephalomyces nipponicus (Ascomycota) Mycelial Extract on Salmonella enterica Serovar Typhi. 日本多头菌（子囊菌）菌丝提取物对伤寒沙门氏菌血清型的抑菌作用。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025058095

Winita Fowsantear, Kusavadee Sangdee, Sutthiwan Thammawat, Aphidech Sangdee

{"title":"Antibacterial Effects of Polycephalomyces nipponicus (Ascomycota) Mycelial Extract on Salmonella enterica Serovar Typhi.","authors":"Winita Fowsantear, Kusavadee Sangdee, Sutthiwan Thammawat, Aphidech Sangdee","doi":"10.1615/IntJMedMushrooms.2025058095","DOIUrl":"10.1615/IntJMedMushrooms.2025058095","url":null,"abstract":"The rise of antibiotic-resistant bacteria, particularly Salmonella enterica subsp. enterica serovar Typhi (S. Typhi), poses a significant challenge to global public health. This study investigates the antibacterial potential of mycelial extract from the medicinal fungus Polycephalomyces nipponicus strain Cod-MK1201 against S. Typhi strain DMST 16122. The extract demonstrated significant inhibitory effects, with minimum inhibitory concentration and minimum bactericidal concentration values of 3.12 mg/mL and 6.25 mg/mL, respectively. Scanning and transmission electron microscopy revealed dose-dependent severe morphological damage to S. Typhi cells, including cell wall disruption, cytoplasmic leakage, and structural deformation, indicating the extract's ability to target multiple cellular structures. Additionally, proteomic analysis showed significant alterations in the bacterial proteome, with downregulation of key proteins involved in metabolism, stress response, and virulence, and upregulation of proteins related to oxidative stress response and the stringent survival pathway. These findings demonstrate the multifaceted antimicrobial mechanisms of P. nipponicus mycelial extract, indicating its potential as a natural resource for developing novel therapeutic agents to treat S. Typhi infections. This highlights its promise as a candidate for reducing antibiotic dependency and addressing the growing challenge of antimicrobial resistance.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 6","pages":"45-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The King Tuber Medicinal Mushroom Pleurotus tuberregium (Agaricomycetes): A Review on Nutritional Composition, Phytochemistry, Pharmacological Activities, and Toxicity Profile. 块茎王药用蘑菇平菇：营养成分、植物化学、药理活性和毒性研究进展。

IF 1.4

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2025060085

Eziuche Amadike Ugbogu, Chollom Longs Israel, Emmanuel Iroha Akubugwo, Uche Okuu Arunsi, Ezeibe Chidi Nwaru, Solomon Owumi, Victor Nwankwo

{"title":"The King Tuber Medicinal Mushroom Pleurotus tuberregium (Agaricomycetes): A Review on Nutritional Composition, Phytochemistry, Pharmacological Activities, and Toxicity Profile.","authors":"Eziuche Amadike Ugbogu, Chollom Longs Israel, Emmanuel Iroha Akubugwo, Uche Okuu Arunsi, Ezeibe Chidi Nwaru, Solomon Owumi, Victor Nwankwo","doi":"10.1615/IntJMedMushrooms.2025060085","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2025060085","url":null,"abstract":"Pleurotus tuberregium is an important economic edible mushroom with remarkable nutritional values and medicinal properties. This present review study aims to provide a broad and up-to-date literature on the nutritional composition, bioactive compounds and health-promoting properties of P. tuberregium. P. tuberregium contains a reasonable number of proteins, carbohydrates, fats, dietary fiber, minerals and vitamins. The bioactive phytochemicals in P. tuberregium include kaempferol, quercetin, epicatechin, apigenin, quercitrin, naringin, rutin, isoquercetin, luteolin, caffeic acid, chlorogenic acid, p-coumaric acid, catechin and ellagic acid. Biochemical studies by various authors show that the extract of P. tuberregium has antioxidant, anticancer, antidiabetic, anti-inflammatory, antimicrobial and hepatorenal protective effects. This review revealed that P. tuberregium could be used for therapeutic purposes against diseases and as a new material to produce functional foods. However, further studies should be conducted to explore the effective and quality-controlled dosages for the use of this mushroom and to investigate the mechanism of action of the identified bioactive compounds for the treatment of various diseases.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 11","pages":"1-19"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure Characterization and Antioxidant Properties of a Triple Helix Galactoglucomannan from the Fruiting Bodies of Russula virescens (Agaricomycetes). 一种三螺旋半乳糖葡甘露聚糖的结构表征及抗氧化性能。

International journal of medicinal mushrooms Pub Date : 2025-01-01 DOI: 10.1615/IntJMedMushrooms.2024057484

Guofeng Yu, Yuanshang Liu, Yuan Gao, Xuewei Jia, Rong Ma, Tianxiao Li, Wenning Feng, Chunping Xu

{"title":"Structure Characterization and Antioxidant Properties of a Triple Helix Galactoglucomannan from the Fruiting Bodies of Russula virescens (Agaricomycetes).","authors":"Guofeng Yu, Yuanshang Liu, Yuan Gao, Xuewei Jia, Rong Ma, Tianxiao Li, Wenning Feng, Chunping Xu","doi":"10.1615/IntJMedMushrooms.2024057484","DOIUrl":"10.1615/IntJMedMushrooms.2024057484","url":null,"abstract":"RVP, a water-soluble triple-helix galactoglucomannan, was successfully extracted from the fruiting body of Russula virescens using an alkali extraction method. Physicochemical properties analysis showed that the protein content of RVP was low (0.95%). The main chain was mainly composed of 1,3,6-linked D-mannose and 1,6-linked glucose residues, and contained terminal glucose units and a small amount of 1,4-linked glucose and 1,6-linked galactose. The average molecular weight of RVP is approximately 8.91 ȕ 105, and it adopts a semi-rigid triple helix conformation. The antioxidant potential of RVP was initially assessed in vitro using H2O2 to induce oxidative stress in a cellular model, leading to cell damage and decreased survival rates. In comparison to the H2O2 model group, RVP exhibited substantial antioxidant activity, demonstrating a capacity to enhance cell viability in a concentration-dependent manner and notably reduce the level of malondialdehyde (MDA) in the cell supernatant, thus indicating its effectiveness in reducing lipid peroxidation. Furthermore, RVP was found to boost the activity of crucial antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the cells. Thus, RVP with antioxidant properties has broad application prospects in health and wellness.","PeriodicalId":94323,"journal":{"name":"International journal of medicinal mushrooms","volume":"27 3","pages":"45-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0