Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology最新文献

{"title":"Emerging Biomimetic Drug Delivery Nanoparticles Inspired by Extracellular Vesicles.","authors":"Viswanathan Sundaram, Santosh Aryal","doi":"10.1002/wnan.70025","DOIUrl":"10.1002/wnan.70025","url":null,"abstract":"<p><p>Nanoparticles (NPs) made up of cellular components such as extracellular vesicles (EVs) with a biomimetic outlook have emerged as a revolutionary approach in nanomedicine, providing significant benefits for targeted drug administration, immunotherapy, monitoring therapeutic response, and diagnostic applications. Utilizing the distinctive characteristics of natural cell membranes, membrane proteins, and cellular contents, these biomimetic NPs acquire essential biological functions from their source and biogenesis, including immune evasion, extended circulation, and target recognition, rendering them optimal candidates for therapeutic applications. This review offers a comprehensive examination of the methodologies of EVs infused with synthetic NP systems with the goal of overcoming their respective shortcomings. For instance, EVs are biogenic with cellular targeting features, but their isolation yield is limited, and their structural and colloidal stability are weak. Whereas, we have decades of experience in the mass production of highly stable synthetic NPs, they lack cellular targeting features. Therefore, the integration of these two systems as a single entity in the field of nanomedicine has gained significant attention. In this review, we emphasized the variety of EVs sources, such as erythrocytes, leukocytes, cancer cells, and stem cells, each providing unique biological benefits. Critical procedures encompassing EV's separation, coating processes, and material integration were examined while addressing the issues, including scalability, membrane stability, and preservation of functionality. Additionally, their promise in customized medicine is analyzed, highlighting their immediate medical applications. This review seeks to elucidate the existing methodologies, their constraints, and prospective advancements in the creation of EV-derived biomimetic NPs for clinical use. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 4","pages":"e70025"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning and Artificial Intelligence in Nanomedicine.","authors":"Wei-Chun Chou, Alexa Canchola, Fan Zhang, Zhoumeng Lin","doi":"10.1002/wnan.70027","DOIUrl":"10.1002/wnan.70027","url":null,"abstract":"<p><p>Nanomedicine harnesses nanoscale materials, such as lipid, polymeric, and inorganic nanoparticles, to deliver diagnostic or therapeutic agents for cancer, infectious disease, and neurological disorders, among others. However, translating promising nanoparticle designs into clinically approved products remains a challenge. Factors such as particle size, surface chemistry, and payload interactions must be optimized, and preclinical results often fail to predict human efficacy. In recent years, artificial intelligence (AI) and machine learning (ML) have emerged as transformative tools to address these hurdles at every stage of nanomedicine development. By rapidly screening extensive libraries and extracting structure-function relationships, AI-driven models can rationalize nanoparticle formulation, predict biodistribution, and guide optimal design. Techniques like high-throughput DNA barcoding and automated liquid handling facilitate robust, large-scale data collection, feeding into computational pipelines that expedite discovery while reducing reliance on resource-intensive trial-and-error experiments. AI-based platforms also enable improved modeling of protein corona formation, which profoundly affects nanoparticle immunogenicity and cellular uptake. Despite these advances, challenges persist in data standardization, model generalizability, and establishing a clear regulatory framework since no dedicated U.S. Food and Drug Administration (FDA) guidance addresses the intersection of AI and nanomedicine. Overcoming these limitations requires harmonized data sharing, rigorous in vivo validation, and clear ethical and regulatory guidelines. This review summarizes the rapidly evolving landscape of AI in nanomedicine, highlighting key successes in design and preclinical prediction, as well as persistent obstacles to full-scale clinical integration. By illuminating these dynamics, we aim to chart a more efficient path forward in developing next-generation nanomedicine.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 4","pages":"e70027"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Pathogen Detection: From Traditional Methods to Nanotechnology, Biosensing and AI Integration.","authors":"Jing Xu, Muhammad Akhtar, Wei Meng, Jinming Bai, Sharon Prince, Rongqin Huang","doi":"10.1002/wnan.70022","DOIUrl":"10.1002/wnan.70022","url":null,"abstract":"<p><p>The rapid and precise detection of pathogenic microbes plays a critical role in the successful diagnosis, management, and containment of infectious diseases. In this review article, we systematically examine the latest technological progress in methodologies for identifying disease-causing microorganisms. These methods are categorized into six major approaches: traditional culture-based techniques, immunological assays, molecular biological methods, metabolic profiling, spectroscopic technologies, and emerging nanotechnology-driven innovations. Moreover, this review offers a comparative assessment of these techniques, shedding light on their underlying mechanisms, strengths, weaknesses, and practical applications in real-world scenarios. This review also discusses the integration of artificial intelligence (AI)-based techniques, paving the way for next-generation pathogen surveillance. In light of the preceding analysis, this review highlights cutting-edge technological developments that could facilitate more efficient, precise, and widely available methods for identifying pathogenic microorganisms. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 4","pages":"e70022"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-Agents for NIR-II Photoacoustic Imaging.","authors":"Qian Wang, Shuxin Lyu, Xiaoyu Zhang, Ruiping Zhang","doi":"10.1002/wnan.70026","DOIUrl":"10.1002/wnan.70026","url":null,"abstract":"<p><p>Photoacoustic imaging (PAI), an intriguing imaging technology, is increasingly being utilized in both basic and clinical medical research. PAI in the second near-infrared window (NIR-II) offers a series of notable advantages, enhanced depth penetration, diminished tissue autofluorescence, elevated maximum allowable exposure, and reduced background noise, which are not available in the first near-infrared window (NIR-I). These attributes underscore the considerable potential of NIR-II window for PAI in the realm of biomedical applications. This review centers on elucidating the significance of the NIR-II window for PAI, presenting an overview of NIR-II PAI contrast agents, and spotlighting the latest advancements in NIR-II PAI with an emphasis on their biomedical uses. Furthermore, prospective problems and opportunities for NIR-II PA contrast agents are highlighted. This article is categorized under: Diagnostic Tools > In Vitro Nanoparticle-Based Sensing.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 4","pages":"e70026"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Cancer Nanotechnology Data Analysis and User Experience. Part I: Current Challenges and Solutions Provided by caNanoLab.","authors":"Weina Ke, Rui He, Mark A Jensen, Marina A Dobrovolskaia","doi":"10.1002/wnan.70030","DOIUrl":"10.1002/wnan.70030","url":null,"abstract":"<p><p>Cancer nanotechnologies have the potential to revolutionize cancer diagnosis and treatment; however, their complexity poses challenges to data analysis and knowledge sharing. caNanoLab, a dedicated cancer nanotechnology data-sharing portal, has emerged as a valuable resource for researchers in this field. However, to fully utilize the wealth of data available in caNanoLab, there is a need for real-time descriptive statistical presentation and an optimized user experience. Herein, we provide an overview of cancer nanotechnologies and federally funded efforts to create data repositories, aiming to improve information flow and data sharing among researchers in the cancer nanotechnology field. We use caNanoLab as a case study to analyze the challenges in this area and highlight how caNanoLab addresses them. We also identify gaps and explore the potential of Large Language Models (LLMs) to improve user experience. A more detailed analysis of LLM and their applications to caNanoLab is provided in the second part of this review. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 4","pages":"e70030"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered Extracellular Vesicles in Arthritic Diseases: Therapeutic Applications & Challenges.","authors":"Seif Ehab, Ola A Gaser, Atif Abdulwahab A Oyouni, Nader Kameli, Faisal Alzahrani, Ahmed Abdal Dayem","doi":"10.1002/wnan.70031","DOIUrl":"10.1002/wnan.70031","url":null,"abstract":"<p><p>Arthritic diseases are a significant global health challenge, highlighting the urgent need for innovative therapeutic strategies. Extracellular vesicles (EVs) have emerged as promising candidates for treating various intractable diseases. This review explores the therapeutic potential of engineered EVs in joint diseases, particularly in comparison to their parental stem cells. Recent research underscores the efficacy of EVs in treating joint diseases, especially Osteoarthritis (OA). We discuss EV engineering strategies aimed at overcoming the limitations of natural EVs. Data from preclinical trials, clinical studies, and in vitro and in vivo reports are analyzed to evaluate the effectiveness of EVs in treating joint conditions. In addition to their role in intercellular communication, EVs influence various biological processes crucial for bone remodeling, cartilage regeneration, immunomodulation, and inflammation control. EVs are rich in vital biomolecules such as proteins, microRNAs (miRNA), lipids, and nucleic acids, which enhance their therapeutic potential compared to parental stem cells. This understanding is key to developing targeted and effective engineered EVs for OA and other joint diseases. A comprehensive grasp of EV engineering and underlying mechanisms will pave the way for novel and efficient therapies for arthritic diseases and related conditions. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Nanotechnology Approaches to Biology > Cells at the Nanoscale Biology-Inspired Nanomaterials > Peptide-Based Structures.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 4","pages":"e70031"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent Nanodiamonds for Quantum Sensing in Biology.","authors":"Jia Su, Zenghao Kong, Linyu Zeng, Fei Kong, Kangwei Xia, Fazhan Shi, Jiangfeng Du","doi":"10.1002/wnan.70012","DOIUrl":"10.1002/wnan.70012","url":null,"abstract":"<p><p>Fluorescent nanodiamonds exhibiting outstanding optical and biocompatible properties are the subject of increased studies and attention in physics and biology. The nitrogen-vacancy center in diamonds with unique quantum properties at room temperature is sensitive to physical properties such as magnetic field, electric field, temperature, and pressure. By taking advantage of the NV center and high sensitivity that arises from the intrinsic quantum properties of spins in nanodiamonds, which are extensively employed in quantum sensing, bio-imaging, and bio-sensing. In this review, the selected topic mainly focuses on the surface functionalization of nanodiamonds and the recent progress in applying nanodiamonds as quantum sensors for intracellular orientation tracking, temperature sensing, and notably nuclear magnetic resonance and electron spin resonance applications.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70012"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Nanocarriers in Bacteriophage Delivery: A Paradigm Shift in Treating Multidrug-Resistant Infections.","authors":"Rohit Patil, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal","doi":"10.1002/wnan.70021","DOIUrl":"10.1002/wnan.70021","url":null,"abstract":"<p><p>The rising challenge of antibiotic-resistant bacterial infections poses a severe threat to global health, highlighting the urgent need for innovative treatment strategies. Bacteriophages, viruses specifically targeting and destroying bacteria, have emerged as a promising solution. However, their therapeutic application faces significant hurdles, including sensitivity to the immune system, limited stability, and challenges in effectively reaching infection sites. Multifunctional nanocarriers offer a cutting-edge approach to address these limitations. These nanoscale delivery systems protect bacteriophages from degradation, enhance their stability, and enable precise release at the infection site. Certain nanocarriers are engineered to respond to specific physiological conditions, such as pH or temperature, and can be combined with additional therapies, like antibiotics, for synergistic effects. Moreover, they hold the potential for real-time infection tracking and treatment monitoring, aligning with the goals of personalized medicine. This review highlights the synergistic potential of nanotechnology and bacteriophage therapy in combating antibiotic-resistant bacteria. By overcoming critical barriers to bacteriophage application, multifunctional nanocarriers represent a transformative advancement in the fight against drug-resistant infections. Furthermore, their ability to enhance treatment efficacy and outcomes establishes them as an essential innovation in advancing global health solutions.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70021"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-Revolution: Harnessing Silica Nanoparticles for Next-Generation Cancer Therapeutics.","authors":"Yashaswi Dutta Gupta, Suman Bhandary","doi":"10.1002/wnan.70023","DOIUrl":"10.1002/wnan.70023","url":null,"abstract":"<p><p>Silica nanoparticles (SiNPs) emerge as a promising material in the realm of nanotechnology, boasting a unique combination of compatibility with living tissues, adaptable characteristics, and easily customizable surfaces, making them an attractive foundation for innovative cancer therapies. SiNPs permit the efficient loading of therapeutic agents, nucleic acids, and imaging agents, leveraging their structural design for enhanced payload capacity. The ability to precisely tune their dimensions, morphology, and surface properties allows controlled regulation of drug release timing and localization, thereby improving therapeutic precision and reducing unintended impacts on healthy tissues. Surface functionalization with ligands, antibodies, or peptides facilitates active targeting of cancer cells, boosting tumor-specific drug accumulation and reducing systemic toxicity. Beyond drug delivery, SiNPs excel in photothermal and photodynamic therapies. The light-responsive nature of these nanoparticles facilitates efficient photon-to-energy conversion, generating localized hyperthermia or cytotoxic reactive species for selective tumor ablation. Additionally, their dual role as contrast enhancers in imaging techniques like MRI and fluorescence enables real-time visualization of therapeutic response and tumor dynamics. Despite their promise, challenges like durable biological compatibility, immune system reactions, and scalable production need further development for clinical use. Ongoing studies prioritize optimizing nanostructure architecture, surface functionalization, and formulation methodologies to overcome existing challenges. In summary, SiNPs signify pioneering advancements in precision oncology, offering tailored therapeutic strategies. Their versatility enables multimodal therapies and image-guided treatments and minimizes adverse effects. Collaborative interdisciplinary efforts and continuous innovation are essential to unlocking their full capabilities, driving the development of next-generation precision oncology tailored to improve patient prognosis.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70023"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metallic Nanoparticles and Cosmetics: The Role of Mitochondria and Premature Aging.","authors":"Veronica Montesinos-Cruz, Justin Olmason","doi":"10.1002/wnan.70014","DOIUrl":"10.1002/wnan.70014","url":null,"abstract":"<p><p>The cosmetic industry has developed and commercialized numerous products using new technologies, making them increasingly appealing to the public. The use of metallic nanoparticles (MtNPs) as key ingredients in cosmetics has become more widespread due to their demonstrated benefits. However, the use of these products remains controversial, as some studies have shown that MtNPs can penetrate the deeper layers of the skin and disrupt homeostatic balance. It has also been demonstrated that the interaction between MtNPs and keratinocytes increases the generation of reactive oxygen species (ROS), which can lead to oxidative stress, a condition associated with premature aging. Mitochondria, as the main organelles responsible for energy production, also provide and maintain the regulatory mechanisms necessary for keratinocytes to sustain a strong protective barrier against environmental threats including MtNPs. To date, the relationship between redox imbalance, premature aging, and the central role of mitochondria remains under investigation due to the fact that mitochondrial metabolism, linked to increased oxidative stress, is associated with the development of various defense mechanisms, including antioxidant enzymes. In this review, we focus on the role of oxidative stress generated in mitochondria and the function of antioxidant enzymes in detoxifying metal ions from MtNPs contained in cosmetics. We examine their effects on keratinocytes and the potential for premature aging.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70014"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}