Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology最新文献

Fluorescent Nanodiamonds for Quantum Sensing in Biology. 荧光纳米金刚石用于生物学量子传感。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70012

Jia Su, Zenghao Kong, Linyu Zeng, Fei Kong, Kangwei Xia, Fazhan Shi, Jiangfeng Du

引用次数: 0

Multifunctional Nanocarriers in Bacteriophage Delivery: A Paradigm Shift in Treating Multidrug-Resistant Infections. 噬菌体递送中的多功能纳米载体：治疗多重耐药感染的范式转变。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70021

Rohit Patil, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal

{"title":"Multifunctional Nanocarriers in Bacteriophage Delivery: A Paradigm Shift in Treating Multidrug-Resistant Infections.","authors":"Rohit Patil, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal","doi":"10.1002/wnan.70021","DOIUrl":"https://doi.org/10.1002/wnan.70021","url":null,"abstract":"The rising challenge of antibiotic-resistant bacterial infections poses a severe threat to global health, highlighting the urgent need for innovative treatment strategies. Bacteriophages, viruses specifically targeting and destroying bacteria, have emerged as a promising solution. However, their therapeutic application faces significant hurdles, including sensitivity to the immune system, limited stability, and challenges in effectively reaching infection sites. Multifunctional nanocarriers offer a cutting-edge approach to address these limitations. These nanoscale delivery systems protect bacteriophages from degradation, enhance their stability, and enable precise release at the infection site. Certain nanocarriers are engineered to respond to specific physiological conditions, such as pH or temperature, and can be combined with additional therapies, like antibiotics, for synergistic effects. Moreover, they hold the potential for real-time infection tracking and treatment monitoring, aligning with the goals of personalized medicine. This review highlights the synergistic potential of nanotechnology and bacteriophage therapy in combating antibiotic-resistant bacteria. By overcoming critical barriers to bacteriophage application, multifunctional nanocarriers represent a transformative advancement in the fight against drug-resistant infections. Furthermore, their ability to enhance treatment efficacy and outcomes establishes them as an essential innovation in advancing global health solutions.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70021"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metallic Nanoparticles and Cosmetics: The Role of Mitochondria and Premature Aging. 金属纳米粒子和化妆品：线粒体和早衰的作用。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70014

Veronica Montesinos-Cruz, Justin Olmason

{"title":"Metallic Nanoparticles and Cosmetics: The Role of Mitochondria and Premature Aging.","authors":"Veronica Montesinos-Cruz, Justin Olmason","doi":"10.1002/wnan.70014","DOIUrl":"https://doi.org/10.1002/wnan.70014","url":null,"abstract":"The cosmetic industry has developed and commercialized numerous products using new technologies, making them increasingly appealing to the public. The use of metallic nanoparticles (MtNPs) as key ingredients in cosmetics has become more widespread due to their demonstrated benefits. However, the use of these products remains controversial, as some studies have shown that MtNPs can penetrate the deeper layers of the skin and disrupt homeostatic balance. It has also been demonstrated that the interaction between MtNPs and keratinocytes increases the generation of reactive oxygen species (ROS), which can lead to oxidative stress, a condition associated with premature aging. Mitochondria, as the main organelles responsible for energy production, also provide and maintain the regulatory mechanisms necessary for keratinocytes to sustain a strong protective barrier against environmental threats including MtNPs. To date, the relationship between redox imbalance, premature aging, and the central role of mitochondria remains under investigation due to the fact that mitochondrial metabolism, linked to increased oxidative stress, is associated with the development of various defense mechanisms, including antioxidant enzymes. In this review, we focus on the role of oxidative stress generated in mitochondria and the function of antioxidant enzymes in detoxifying metal ions from MtNPs contained in cosmetics. We examine their effects on keratinocytes and the potential for premature aging.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70014"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimuli-Responsive Nanosystems for Theranostic Applications in Oral Diseases. 刺激反应纳米系统在口腔疾病治疗中的应用。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70018

Mengqing Gong, Yin Wang, Jiayong Dai, Qinrui Fu, Changqing Yuan

{"title":"Stimuli-Responsive Nanosystems for Theranostic Applications in Oral Diseases.","authors":"Mengqing Gong, Yin Wang, Jiayong Dai, Qinrui Fu, Changqing Yuan","doi":"10.1002/wnan.70018","DOIUrl":"https://doi.org/10.1002/wnan.70018","url":null,"abstract":"Oral diseases, characterized by a high incidence rate and significant impact on patients' quality of life, have emerged as a pressing global health concern amidst escalating societal pressures. Advancements in advanced materials are crucial for the prevention, detection, and treatment of most oral diseases due to their heavy reliance on materials. Nanotechnology has facilitated the development of various nanomaterial-based preparations that have garnered considerable attention in stomatology due to their inherent advantages such as enhanced biosafety, multifunctionality, and targeted therapy capabilities. Responsive nanomaterials offer a breakthrough solution to overcome limitations associated with drug release kinetics, leading to reduced effective drug concentrations while simultaneously exhibiting antibacterial, anti-inflammatory, antioxidant, osteogenic properties along with remineralization functions within safe parameters. Substantial progress has been made towards the long-term prevention and treatment of oral diseases through these responsive nanomaterials. This review begins by elucidating the response mechanisms underlying nanomaterials, followed by an overview of their applications in treating oral diseases. Finally, we discuss the challenges faced and future directions for utilizing advanced materials in addressing treatments for oral diseases. The insights provided herein hold significant implications for both basic research endeavors and clinical translation within stomatology.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70018"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-Enhanced Raman Scattering Nanotags: Design Strategies, Biomedical Applications, and Integration of Machine Learning. 表面增强拉曼散射纳米标签：设计策略、生物医学应用和机器学习集成。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70015

Isabella Vasquez, Ruiyang Xue, Indrajit Srivastava

{"title":"Surface-Enhanced Raman Scattering Nanotags: Design Strategies, Biomedical Applications, and Integration of Machine Learning.","authors":"Isabella Vasquez, Ruiyang Xue, Indrajit Srivastava","doi":"10.1002/wnan.70015","DOIUrl":"https://doi.org/10.1002/wnan.70015","url":null,"abstract":"Surface-enhanced Raman scattering (SERS) is a transformative technique for molecular identification, offering exceptional sensitivity, signal specificity, and resistance to photobleaching, making it invaluable for disease diagnosis, monitoring, and spectroscopy-guided surgeries. Unlike traditional Raman spectroscopy, which relies on weak scattering signals, SERS amplifies Raman signals using plasmonic nanoparticles, enabling highly sensitive molecular detection. This technological advancement has led to the development of SERS nanotags with remarkable multiplexing capabilities for biosensing applications. Recent progress has expanded the use of SERS nanotags in bioimaging, theranostics, and more recently, liquid biopsy. The distinction between SERS and conventional Raman spectroscopy is highlighted, followed by an exploration of the molecular assembly of SERS nanotags. Significant progress in bioimaging is summarized, including in vitro studies on 2D/3D cell cultures, ex vivo tissue imaging, in vivo diagnostics, spectroscopic-guided surgery for tumor margin delineation, and liquid biopsy tools for detecting cancer and SARS-CoV-2. A particular focus is the integration of machine learning (ML) and deep learning algorithms to boost SERS nanotag efficacy in liquid biopsies. Finally, it addresses the challenges in the clinical translation of SERS nanotags and offers strategies to overcome these obstacles.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70015"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Islet Transplantation: Microencapsulation, Nanoencapsulation, and Hypoimmune Engineering. 胰岛移植：微胶囊化、纳米胶囊化和低免疫工程。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70016

Kyungsene Lee, Ana Aviles Vargas, Rita Bottino, Yong Wang

引用次数: 0

Advancing Medical Applications of Cancer Nanotechnology: Highlighting Two Decades of the NCI'S Nanotechnology Characterization Laboratory Service to the Research Community. 推进癌症纳米技术的医学应用：突出二十年来NCI纳米技术表征实验室服务于研究界。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70020

Rachael M Crist, Yechezkel Barenholz, Ahuva Cern, Kate N Clark, Pieter R Cullis, Cheryl Dean, Neil Desai, Mauro Ferrari, Matthieu Germain, Carmen A Giacomantonio, Emma Grabarnik, Piotr Grodzinski, Atara Hod, Barry E Kennedy, Ruvanthi N Kularatne, Glen S Kwon, Emmanuel Loeb, Erin B Noftall, Len Pagliaro, Morteza Rasoulianboroujeni, Alexander Roth, Darren Rowles, Kulbir Singh, Nicole F Steinmetz, Zhanna Yehtina, Yao Zhang, Daniel Zilbersheid, Jeffrey D Clogston, Stephan T Stern, Marina A Dobrovolskaia

{"title":"Advancing Medical Applications of Cancer Nanotechnology: Highlighting Two Decades of the NCI'S Nanotechnology Characterization Laboratory Service to the Research Community.","authors":"Rachael M Crist, Yechezkel Barenholz, Ahuva Cern, Kate N Clark, Pieter R Cullis, Cheryl Dean, Neil Desai, Mauro Ferrari, Matthieu Germain, Carmen A Giacomantonio, Emma Grabarnik, Piotr Grodzinski, Atara Hod, Barry E Kennedy, Ruvanthi N Kularatne, Glen S Kwon, Emmanuel Loeb, Erin B Noftall, Len Pagliaro, Morteza Rasoulianboroujeni, Alexander Roth, Darren Rowles, Kulbir Singh, Nicole F Steinmetz, Zhanna Yehtina, Yao Zhang, Daniel Zilbersheid, Jeffrey D Clogston, Stephan T Stern, Marina A Dobrovolskaia","doi":"10.1002/wnan.70020","DOIUrl":"10.1002/wnan.70020","url":null,"abstract":"The Nanotechnology Characterization Laboratory (NCL) is a US federally funded resource providing characterization and expertise to the cancer nanomedicine research community. Founded as a formal partnership among the US National Cancer Institute (NCI), the US Food and Drug Administration (FDA), and the US National Institute of Standards and Technology (NIST), the NCL has spent two decades developing a one-of-a-kind service with broad multidisciplinary expertise to meet the needs of a rapidly evolving drug development field. To mark the 20th anniversary of the lab's founding, the NCL hosted a symposium to highlight the achievements of the cancer nanomedicine field, showcase novel, next-generation nanotechnology research, and discuss future priorities to enable continued growth in combating cancer and the complexities associated with treating a disease that continues to take millions of lives annually. The discussion topics from this event are summarized.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70020"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-24: A Multidimensional Therapeutic for Treatment of Human Diseases. 白介素-24：治疗人类疾病的多维疗法。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70013

Rajeswari Raguraman, Anupama Munshi, Rajagopal Ramesh

{"title":"Interleukin-24: A Multidimensional Therapeutic for Treatment of Human Diseases.","authors":"Rajeswari Raguraman, Anupama Munshi, Rajagopal Ramesh","doi":"10.1002/wnan.70013","DOIUrl":"https://doi.org/10.1002/wnan.70013","url":null,"abstract":"The field of targeted therapy exploits the selective expression of therapeutic genes or proteins in diseased cells. While this area is gaining attraction in the context of cardiovascular diseases, diabetes, and other major health disorders, it has been most extensively explored in the realm of cancer. Targeted therapy has gained significance in the cancer field for its potential to address the limitations of conventional treatments and enhance patient survival. Interleukin-24 (IL-24), a versatile cytokine, has been evaluated as a cancer therapeutic in various preclinical cancer models and clinical trials, and has yielded promising results. Consequently, multiple studies highlight IL-24 as a viable \"anti-cancer\" therapeutic, with successful outcomes observed in combination therapies involving small molecule inhibitors, chemotherapeutic drugs, and radiation. Despite the evidence validating the tumor-suppressing properties of IL-24 in cancer models, there is a dearth of information regarding its role in other human diseases. The objective of this review is to offer a synopsis of the potential role of IL-24 in diverse human diseases. Additionally, it provides a comprehensive review of the progress in cancer therapy utilizing IL-24. Finally, from the author's standpoint, the review also addresses some of the limitations that impede the translational potential of IL-24-based therapy in clinical settings. It offers arguments in favor of incorporating IL-24-based targeted therapy as an effective and safer alternative for current treatment modalities, thereby highlighting its potential to revolutionize the field of therapeutics.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70013"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Green" Cross-Linking of Poly(Vinyl Alcohol)-Based Nanostructured Biomaterials: From Eco-Friendly Approaches to Practical Applications. 聚乙烯醇基纳米结构生物材料的“绿色”交联：从环保方法到实际应用。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70017

Anna Zakrzewska, Paweł Nakielski, Yen Bach Truong, Chiara Gualandi, Cecilia Velino, Seyed Shahrooz Zargarian, Massimiliano Lanzi, Alicja Kosik-Kozioł, Julia Król, Filippo Pierini

{"title":"\"Green\" Cross-Linking of Poly(Vinyl Alcohol)-Based Nanostructured Biomaterials: From Eco-Friendly Approaches to Practical Applications.","authors":"Anna Zakrzewska, Paweł Nakielski, Yen Bach Truong, Chiara Gualandi, Cecilia Velino, Seyed Shahrooz Zargarian, Massimiliano Lanzi, Alicja Kosik-Kozioł, Julia Król, Filippo Pierini","doi":"10.1002/wnan.70017","DOIUrl":"https://doi.org/10.1002/wnan.70017","url":null,"abstract":"Recently, a growing need for sustainable materials in various industries, especially biomedical, environmental, and packaging applications, has been observed. Poly(vinyl alcohol) (PVA) is a versatile and widely used polymer, valued for its biocompatibility, water solubility, and easy processing, e.g., forming nanofibers via electrospinning. As a result of cross-linking, PVA turns into a three-dimensional structure-hydrogel with unusual sorption properties and mimicry of biological tissues. However, traditional cross-linking methods often involve toxic chemicals and harsh conditions, which can limit its eco-friendly potential and raise concerns about environmental impact. \"Green\" cross-linking approaches, such as the use of natural cross-linkers, freeze-thawing, enzymatic processes, irradiation, heat treatment, or immersion in alcohol, offer an environmentally friendly alternative that aligns with global trends toward sustainability. These methods not only reduce the use of harmful substances but also enhance the biodegradability and safety of the materials. By reviewing and analyzing the latest advancements in \"green\" PVA cross-linking approaches, this review provides a comprehensive overview of current techniques, their advantages, limitations, and potential applications. The main emphasis is placed on PVA nanostructured forms and applications of PVA-based biomaterials in areas such as wound dressings, drug delivery systems, tissue engineering, biological filters, and biosensors. Moreover, this article will contribute to the broader scientific understanding of how the materials based on PVA can be optimized both in terms of \"greener\" and safer production, as well as adjusting the final platform properties.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70017"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Application of mRNA for Genetic Diseases. mRNA在遗传病治疗中的应用。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70019

Paul J L Schürmann, Stijn P E van Breda Vriesman, Jose A Castro-Alpízar, Sander A A Kooijmans, Edward E S Nieuwenhuis, Raymond M Schiffelers, Sabine A Fuchs

{"title":"Therapeutic Application of mRNA for Genetic Diseases.","authors":"Paul J L Schürmann, Stijn P E van Breda Vriesman, Jose A Castro-Alpízar, Sander A A Kooijmans, Edward E S Nieuwenhuis, Raymond M Schiffelers, Sabine A Fuchs","doi":"10.1002/wnan.70019","DOIUrl":"10.1002/wnan.70019","url":null,"abstract":"While gene therapy has been at the center of an active research field for decades, messenger RNA (mRNA) has long been considered unsuited for therapeutic application due to challenges with stability, immunogenicity, and delivery. Where gene therapy focuses on providing the desired genetic code, mRNA can directly provide the instructions encoded in the corresponding gene. This review aims to explore recent advances in mRNA therapies, building on the success of mRNA COVID-19 vaccines, and extend these insights to the potential treatment of rare genetic diseases. We follow the \"outside-in\" trajectory of mRNA therapies from administration to intracellular function, focusing on carrier systems such as lipid nanoparticles and virus-like particles, mRNA modifications, and the potential and challenges for clinical applications. To treat rare diseases, different approaches can be envisioned, including chronic or acute delivery of mRNAs encoding functional enzymes for enzyme deficiencies and delivery of CRISPR/Cas9-based gene-editing tools for gene correction. These different approaches determine safety and immunological considerations. By exploring genetic, technical, and therapeutic aspects, this review highlights the potential and current challenges of mRNA therapies to address the large unmet needs in rare genetic disorders.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70019"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0