Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology最新文献_第10页

Management of osteoarthritis: From drug molecules to nano/micromedicines 骨关节炎的治疗:从药物分子到纳米/微药物

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2022-03-06 DOI: 10.1002/wnan.1780

Martina Di Francesco, Agnese Fragassi, Martina Pannuzzo, Miguel Ferreira, Sayanti Brahmachari, P. Decuzzi

{"title":"Management of osteoarthritis: From drug molecules to nano/micromedicines","authors":"Martina Di Francesco, Agnese Fragassi, Martina Pannuzzo, Miguel Ferreira, Sayanti Brahmachari, P. Decuzzi","doi":"10.1002/wnan.1780","DOIUrl":"https://doi.org/10.1002/wnan.1780","url":null,"abstract":"Abstract With the change in lifestyle and aging of the population, osteoarthritis (OA) is emerging as a major medical burden globally. OA is a chronic inflammatory and degenerative disease initially manifesting with joint pain and eventually leading to permanent disability. To date, there are no drugs available for the definitive treatment of osteoarthritis and most therapies have been palliative in nature by alleviating symptoms rather than curing the disease. This coupled with the vague understanding of the early symptoms and methods of diagnosis so that the disease continues as a global problem and calls for concerted research efforts. A cascade of events regulates the onset and progression of osteoarthritis starting with the production of proinflammatory cytokines, including interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α; catabolic enzymes, such as matrix metalloproteinases (MMPs)‐1, ‐3, and ‐13, culminating into cartilage breakdown, loss of lubrication, pain, and inability to load the joint. Although intra‐articular injections of small and macromolecules are often prescribed to alleviate symptoms, low residence times within the synovial cavity severely impair their efficacy. This review will briefly describe the factors dictating the onset and progression of the disease, present the current clinically approved methods for its treatment and diagnosis, and finally elaborate on the main challenges and opportunities for the application of nano/micromedicines in the treatment of osteoarthritis. Thus, future treatment regimens will benefit from simultaneous consideration of the mechanobiological, the inflammatory, and tissue degradation aspects of the disease. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84655068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Bioelectricity-coupling patches for repairing impaired myocardium. 生物电偶联贴片修复受损心肌。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2022-03-01 DOI: 10.1002/wnan.1787

Yuedan Li, Xiaozhong Qiu

{"title":"Bioelectricity-coupling patches for repairing impaired myocardium.","authors":"Yuedan Li, Xiaozhong Qiu","doi":"10.1002/wnan.1787","DOIUrl":"https://doi.org/10.1002/wnan.1787","url":null,"abstract":"Cardiac abnormalities, which account for extensive burdens on public health and economy, drive necessary attempts to revolutionize the traditional therapeutic system. Advances in cardiac tissue engineering have expanded a highly efficacious platform to address cardiovascular events, especially cardiac infarction. Current efforts to overcome biocompatible limitations highlight the constructs of a conductive cardiac patch to accelerate the industrial and clinical landscape that is amenable for patient-accurate therapy, regenerative medicine, disease modeling, and drug delivery. With the notion that cardiac tissue synchronically contracts triggered by electrical pulses, the cardiac patches based on conductive materials are developed and treated on the dysfunctional heart. In this review, we systematically summarize distinct conductive materials serving as the most promising alternatives (conductive nanomaterials, conductive polymers, piezoelectric polymers, and ionic electrolytes) to achieve electric signal transmission and engineered cardiac tissues. Existing applications are discussed considering how these patches containing conductive candidates are fabricated into diverse forms with major strategies. Ultimately, we try to define a new concept as a bioelectricity-coupling patch that provides a favorable cardiac micro-environment for cardiac functional activities. Underlying challenges and prospects are presented regarding industrial processing and cardiovascular treatment of conductive patch progress. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"59 1","pages":"e1787"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88671404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Nanocarriers in photodynamic therapy-in vitro and in vivo studies. 纳米载体在光动力治疗中的体外和体内研究。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2020-05-01 DOI: 10.1002/wnan.1599

K. Sztandera, M. Gorzkiewicz, B. Klajnert-Maculewicz

{"title":"Nanocarriers in photodynamic therapy-in vitro and in vivo studies.","authors":"K. Sztandera, M. Gorzkiewicz, B. Klajnert-Maculewicz","doi":"10.1002/wnan.1599","DOIUrl":"https://doi.org/10.1002/wnan.1599","url":null,"abstract":"Photodynamic therapy (PDT) is a minimally invasive technique which has proven to be successful in the treatment of several types of tumors. This relatively simple method exploits three inseparable elements: phototoxic compound (photosensitizer [PS]), light source, and oxygen. Upon irradiation by light with specified wavelength, PS generates reactive oxygen species, which starts the cascade of reactions leading to cell death. The positive therapeutic outcome of PDT may be limited due to several aspects, including low water solubility of PSs, hampering their effective administration and blood circulation, as well as low tumor specificity, inefficient cellular uptake and activation energies requiring prolonged illumination times. One of the promising approaches to overcome these obstacles involves the use of carrier systems modulating pharmacokinetics and pharmacodynamics of the PSs. In the present review, we summarized current in vitro and in vivo studies regarding the use of nanoparticles as potential delivery devices for PSs to enhance their cellular uptake and cytotoxic properties, and thus-the therapeutic outcome of PDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"7 1","pages":"e1509"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78959875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Multifluid electrospinning for the generation of complex nanostructures. 多流体静电纺丝制备复杂纳米结构。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2020-05-01 DOI: 10.1002/wnan.1601

Deng‐Guang Yu, Menglong Wang, Xiaoyan Li, Xin-kuan Liu, Li-Min Zhu, S. A. Annie Bligh

{"title":"Multifluid electrospinning for the generation of complex nanostructures.","authors":"Deng‐Guang Yu, Menglong Wang, Xiaoyan Li, Xin-kuan Liu, Li-Min Zhu, S. A. Annie Bligh","doi":"10.1002/wnan.1601","DOIUrl":"https://doi.org/10.1002/wnan.1601","url":null,"abstract":"New nanostructure means new nanotechnology and nanoscience. The need of complex nanostructure-based advanced functional nanomaterials has promoted the appearance of several kinds of multifluid electrospinning processes, such as tri-axial electrospinning, quad-fluid coaxial electrospinning, tri-fluid side-by-side electrospinning, and coaxial electrospinning with a side-by-side core. These multifluid processes can greatly expand the capability of electrospinning in generating new types of nanostructures with different organization manner of the inner parts, and from both spinnable and unspinnable working fluids. The key elements for conducting a multifluid electrospinning lie in a well-designed spinneret, compatibility of the working fluids, and special operational parameters. The complex nanostructures can be created through direct electrospinning of multiple fluids, through after-treatment of the electrospun products, and through ingenious design of the components, compositions and their spatial distributions as well. This article provides a simple review on the most recent publications about the multifluid electrospinning processes and the corresponding complex nanostructures. This article is characterized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanomaterials and Implants.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1601"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90879126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 109

Advances of functional nanomaterials for cancer immunotherapeutic applications. 功能纳米材料在癌症免疫治疗中的应用进展。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2020-03-01 DOI: 10.1002/wnan.1574

Yuhao Hao, Xingyu Zhou, Rui Li, Zechenxi Song, Yuanzeng Min

引用次数: 9

The role of sex in particle-induced inflammation and injury. 性在粒子诱导的炎症和损伤中的作用。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2020-03-01 DOI: 10.1002/wnan.1589

J. Ray, P. Fletcher, R. Burmeister, A. Holian

{"title":"The role of sex in particle-induced inflammation and injury.","authors":"J. Ray, P. Fletcher, R. Burmeister, A. Holian","doi":"10.1002/wnan.1589","DOIUrl":"https://doi.org/10.1002/wnan.1589","url":null,"abstract":"The use of engineered nanomaterials within various applications such as medicine, electronics, and cosmetics has been steadily increasing; therefore, the rate of occupational and environmental exposures has also increased. Inhalation is an important route of exposure to nanomaterials and has been shown to cause various respiratory diseases in animal models. Human lung disease frequently presents with a sex/gender-bias in prevalence or severity, but investigation of potential sex-differences in the adverse health outcomes associated with nanoparticle inhalation is greatly lacking. Only ~20% of basic research in the general sciences use both male and female animals and a substantial percentage of these do not address differences between sexes within their analyses. This has prevented researchers from fully understanding the impact of sex-based variables on health and disease, particularly the pathologies resulting from the inhalation of particles. The mechanisms responsible for sex-differences in respiratory disease remain unclear, but could be related to a number of variables including sex-differences in hormone signaling, lung physiology, or respiratory immune function. By incorporating sex-based analysis into respiratory nanotoxicology and utilizing human data from other relevant particles (e.g., asbestos, silica, particulate matter), we can improve our understanding of sex as a biological variable in nanoparticle exposures. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"29 1","pages":"e1589"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90160142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Polymer-based activatable optical probes for tumor fluorescence and photoacoustic imaging. 用于肿瘤荧光和光声成像的聚合物可活化光学探针。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2020-03-01 DOI: 10.1002/wnan.1593

Xu Zhen, Xiqun Jiang

{"title":"Polymer-based activatable optical probes for tumor fluorescence and photoacoustic imaging.","authors":"Xu Zhen, Xiqun Jiang","doi":"10.1002/wnan.1593","DOIUrl":"https://doi.org/10.1002/wnan.1593","url":null,"abstract":"Optical imaging including fluorescence imaging and photoacoustic imaging have been widely employed in early and accurate diagnosis of cancer. Compared to the \"always on\" optical probes, the molecular probes that could emit their signal in response to the tumor microenvironment exhibit the low background noise and high signal-to-background ratio, allowing sensitive and accurate cancer diagnosis. Polymer-based activatable optical probes display the advantages of improved water solubility, good photostability, extended blood circulation time, and easy functionalization, which enable them to accumulate in tumor for early and accurate diagnosis. This review focuses on recent advances in the development of polymer-based activatable optical probes for tumor fluorescence and PA imaging. The designs of polymer-based optical probes are first discussed. Then the applications for tumor fluorescence and PA imaging using pH, hypoxia, reactive oxygen and nitrogen species, and enzymes responsive polymer-based optical probes are discussed in details. At last, the present challenges and perspectives of polymer-based activatable optical probes to further advance them into the clinical application are also suggested. This article is categorized under: Diagnostic Tools > In vivo Nanodiagnostics and Imaging Diagnostic Tools > Biosensing.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"10 1","pages":"e1593"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83212314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

From stars to stripes: RNA-directed shaping of plant viral protein templates-structural synthetic virology for smart biohybrid nanostructures. 从星形到条纹:植物病毒蛋白模板的rna定向塑造——智能生物杂交纳米结构的结构合成病毒学。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2020-03-01 DOI: 10.1002/wnan.1591

C. Wege, Claudia Koch

{"title":"From stars to stripes: RNA-directed shaping of plant viral protein templates-structural synthetic virology for smart biohybrid nanostructures.","authors":"C. Wege, Claudia Koch","doi":"10.1002/wnan.1591","DOIUrl":"https://doi.org/10.1002/wnan.1591","url":null,"abstract":"The self-assembly of viral building blocks bears exciting prospects for fabricating new types of bionanoparticles with multivalent protein shells. These enable a spatially controlled immobilization of functionalities at highest surface densities-an increasing demand worldwide for applications from vaccination to tissue engineering, biocatalysis, and sensing. Certain plant viruses hold particular promise because they are sustainably available, biodegradable, nonpathogenic for mammals, and amenable to in vitro self-organization of virus-like particles. This offers great opportunities for their redesign into novel \"green\" carrier systems by spatial and structural synthetic biology approaches, as worked out here for the robust nanotubular tobacco mosaic virus (TMV) as prime example. Natural TMV of 300 x 18 nm is built from more than 2,100 identical coat proteins (CPs) helically arranged around a 6,395 nucleotides ssRNA. In vitro, TMV-like particles (TLPs) may self-assemble also from modified CPs and RNAs if the latter contain an Origin of Assembly structure, which initiates a bidirectional encapsidation. By way of tailored RNA, the process can be reprogrammed to yield uncommon shapes such as branched nanoobjects. The nonsymmetric mechanism also proceeds on 3'-terminally immobilized RNA and can integrate distinct CP types in blends or serially. Other emerging plant virus-deduced systems include the usually isometric cowpea chlorotic mottle virus (CCMV) with further strikingly altered structures up to \"cherrybombs\" with protruding nucleic acids. Cartoon strips and pictorial descriptions of major RNA-based strategies induct the reader into a rare field of nanoconstruction that can give rise to utile soft-matter architectures for complex tasks. This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"30 1","pages":"e1591"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83416256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Plant molecular farming of virus-like nanoparticles as vaccines and reagents. 植物分子农业的病毒样纳米颗粒作为疫苗和试剂。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2020-03-01 DOI: 10.1002/wnan.1587

E. Rybicki

{"title":"Plant molecular farming of virus-like nanoparticles as vaccines and reagents.","authors":"E. Rybicki","doi":"10.1002/wnan.1587","DOIUrl":"https://doi.org/10.1002/wnan.1587","url":null,"abstract":"The use of plants for the production of virus-like nanoparticles (VNPs) dates back to separating natural empty capsids of plant viruses from whole virions nearly 70 years ago, through to the present use of transgenic plants or recombinant Agrobacterium tumefaciens and/or plant virus-derived vectors for the transient expression of engineered viral or other structural proteins in plants-a production system also known as molecular farming. Plant production of heterologous proteins has major advantages in terms of convenience-whole plants are generally used, and processes do not need to be sterile-and cost, as bulk biomass production is significantly cheaper than by any other method. Plant-made VNPs in current use for nanotechnology include whole virions and naturally occurring empty capsids of plant viruses, and particles made by reassembly of coat protein (CP) purified from virions or by recombinant expression. Engineered VNP-forming animal or human virus CPs expressed in plants include L1 protein from human papillomaviruses, human norovirus CP, hepatitis B surface and core antigens, influenza virus HA protein and HIV Gag polyprotein forming large enveloped particles by budding, orbi- and rotavirus particles that require assembly of four co-expressed proteins, and polio- and foot and mouth disease viruses which require proteolytic processing of a polyprotein precursor to form 4-component VNPs. Both plant and animal virus-derived plant-made VNPs can be used for surface and internal display of heterologous peptides or even whole proteins. A significant recent development has been the production of pseudovirions in plants, comprising plant or animal virus CPs and RNA or DNA pseudogenomes that can be used to deliver nucleic acid payloads into cultured cells or specific tissues or tumors in whole animals. This article is characterized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > in vivo Nanodiagnostics and Imaging.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"7 1","pages":"e1587"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82538846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 74

Recent advancements in two-dimensional nanomaterials for drug delivery. 用于药物传递的二维纳米材料的最新进展。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2020-03-01 DOI: 10.1002/wnan.1596

X. Mei, Tingting Hu, Yingjie Wang, X. Weng, Ruizheng Liang, Min Wei

{"title":"Recent advancements in two-dimensional nanomaterials for drug delivery.","authors":"X. Mei, Tingting Hu, Yingjie Wang, X. Weng, Ruizheng Liang, Min Wei","doi":"10.1002/wnan.1596","DOIUrl":"https://doi.org/10.1002/wnan.1596","url":null,"abstract":"Different from conventional zero-dimensional (0D) and one-dimensional (1D) counterparts, two-dimensional (2D) nanomaterials show unique properties resulting from their specific structure and morphology. In recent years, broad interest has been focused on the exploration of 2D nanomaterials for drug delivery, which benefits greatly to various disease treatments due to the superior properties of 2D nanomaterials. The fast development of 2D-based drug delivery systems provides great potential for biomedical studies. In this review, a case-by-case analysis was carried out on the state-of-the-art 2D nanomaterials-based drug delivery systems, which possesses great significance to the further biomedical development of 2D nanomaterials. For the purpose of discussing the special advantages of these novel drug delivery systems, this review is organized according to the different types of the latest 2D nanomaterials and their loading capacity towards various cargos. Special emphasis will be located on the application of these 2D nanomaterials-based drug delivery systems in chemotherapy, gene therapy, and immunotherapy. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"220 3 1","pages":"e1596"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86177400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28