基于材料的传染病疫苗

Yang Bo, Hua Wang
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引用次数: 1

摘要

由病原体感染引起的传染病是导致人类死亡的主要原因之一,人类免疫缺陷病毒、疟疾、流感和持续存在的SARS - COV - 2病毒等病原体不断威胁着全球人口。虽然各种传染病背后的机制尚不完全清楚,因而阻碍了有效治疗方法的发展,但疫苗已成为控制传染病的普遍方法。然而,仅由抗原组成或简单混合抗原和佐剂的传统疫苗未能控制各种高传染性或致命的病原体。基于生物材料的疫苗提供了一个很有前途的解决方案,因为它们能够协同抗原和佐剂的功能,解决递送问题,在原位安置和操纵免疫细胞。在这篇综述中,我们将总结不同类型的材料基疫苗对病原体产生细胞和体液反应,并讨论扩大材料基疫苗对传染病的效力的设计标准。本文分类为:治疗方法与药物发现>传染病纳米医学
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Materials‐based vaccines for infectious diseases
Abstract Infectious diseases that result from pathogen infection are among the leading causes of human death, with pathogens such as human immunodeficiency virus, malaria, influenza, and ongoing SARS‐COV‐2 viruses constantly threatening the global population. While the mechanisms behind various infectious diseases are not entirely clear and thus retard the development of effective therapeutics, vaccines have served as a universal approach to containing infectious diseases. However, conventional vaccines that solely consist of antigens or simply mix antigens and adjuvants have failed to control various highly infective or deadly pathogens. Biomaterials‐based vaccines have provided a promising solution due to their ability to synergize the function of antigens and adjuvants, troubleshoot delivery issues, home and manipulate immune cells in situ. In this review, we will summarize different types of materials‐based vaccines for generating cellular and humoral responses against pathogens and discuss the design criteria for amplifying the efficacy of materials‐based vaccines against infectious diseases. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease
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CiteScore
17.60
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