抗菌和抗癌应用聚合体的智能设计。

Tao Wang, Jinlong Qin, Jia-jing Cheng, Chang Li, Jianzhong Du
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引用次数: 9

摘要

近年来,聚合物小体(或聚合物囊泡)在生物医学领域的应用受到了广泛的关注,因为它们的管腔可以用于药物传递,它们的冠状和膜可以被各种功能基团修饰。因此,聚合体非常适合用于改善抗菌和抗癌治疗。本文综述了智能抗菌和抗癌聚合体的合成方案和设计原理的最新进展。抗菌聚合体分为三大类:作为抗生素纳米载体的聚合体,内在抗菌聚合体,以及光热、光动力等辅助手段的抗菌聚合体。同样,抗癌聚合体也分为两类:基于聚合体的传递系统和抗癌聚合体的辅助手段。此外,还讨论了细菌与癌症的双边关系,因为越来越多的证据表明细菌可能导致癌症或促进癌症进展。最后,对新一代抗菌和抗癌聚合体的研究前景进行了展望。本文分类如下:治疗方法和药物发现>感染性疾病的纳米药物治疗方法和药物发现>肿瘤疾病的纳米药物-生物学启发的纳米材料>基于脂质结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intelligent design of polymersomes for antibacterial and anticancer applications.
Polymersomes (or polymer vesicles) have attracted much attention for biomedical applications in recent years because their lumen can be used for drug delivery and their coronas and membrane can be modified with a variety of functional groups. Thus, polymersomes are very suitable for improved antibacterial and anticancer therapy. This review mainly highlighted recent advances in the synthetic protocols and design principles of intelligent antibacterial and anticancer polymersomes. Antibacterial polymersomes are divided into three categories: polymersomes as antibiotic nanocarriers, intrinsically antibacterial polymersomes, and antibacterial polymersomes with supplementary means including photothermal and photodynamic therapy. Similarly, the anticancer polymersomes are divided into two categories: polymersomes-based delivery systems and anticancer polymersomes with supplementary means. In addition, the bilateral relationship between bacteria and cancer is addressed, since more and more evidences show that bacteria may cause cancer or promote cancer progression. Finally, prospective on next-generation antibacterial and anticancer polymersomes are discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Biology-Inspired Nanomaterials > Lipid-Based Structures.
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CiteScore
17.60
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