纳米颗粒介导高温联合放化疗治疗癌症的未来机遇和剩余挑战。

Sakine Shirvalilou, Zahed Tavangari, Mohammad Hossein Parsaei, Saman Sargazi, Roghayeh Sheervalilou, Milad Shirvaliloo, Habib Ghaznavi, Samideh Khoei
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引用次数: 0

摘要

癌症是现代世界死亡的主要原因,是一种潜伏的病理,应该在早期诊断才能成功治疗。开发具有最小侵袭性和高效性的治疗干预措施,区分肿瘤细胞和正常细胞,是临床科学特别感兴趣的,因为它们可以提高患者的生存率。纳米颗粒是一种宝贵的资产,可用于开发此类诊断和治疗模式,因为它们具有非常小的尺寸和可改变的表面,高度安全和稳定,并且可以以可控的方式合成。迄今为止,不同的纳米颗粒已被纳入多种模式,如肿瘤靶向治疗、热疗、化疗和放疗。本文旨在简要介绍纳米颗粒在高温癌症治疗中的研究和应用的最新进展。总结了最新的研究,以突出联合热化疗发展的最新进展,以及与纳米颗粒在癌症治疗中的应用相关的挑战。这篇文章分类在:治疗方法和药物发现>肿瘤疾病的纳米医学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The future opportunities and remaining challenges in the application of nanoparticle-mediated hyperthermia combined with chemo-radiotherapy in cancer.

The future opportunities and remaining challenges in the application of nanoparticle-mediated hyperthermia combined with chemo-radiotherapy in cancer.

A pivotal cause of death in the modern world, cancer is an insidious pathology that should be diagnosed at an early stage for successful treatment. Development of therapeutic interventions with minimal invasiveness and high efficacy that can discriminate between tumor and normal cells is of particular interest to the clinical science, as they can enhance patient survival. Nanoparticles are an invaluable asset that can be adopted for development of such diagnostic and therapeutic modalities, since they come in very small sizes with modifiable surface, are highly safe and stable, and can be synthesized in a controlled fashion. To date, different nanoparticles have been incorporated into numerous modalities such as tumor-targeted therapy, thermal therapy, chemotherapy, and radiotherapy. This review article seeks to deliver a brief account of recent advances in research and application of nanoparticles in hyperthermia-based cancer therapies. The most recent investigations are summarized to highlight the latest advances in the development of combined thermo-chemo-radiotherapy, along with the challenges associated with the application of nanoparticles in cancer therapy. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

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