Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology最新文献_第6页

Stimuli-Responsive Nanosystems for Theranostic Applications in Oral Diseases. 刺激反应纳米系统在口腔疾病治疗中的应用。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70018

Mengqing Gong, Yin Wang, Jiayong Dai, Qinrui Fu, Changqing Yuan

{"title":"Stimuli-Responsive Nanosystems for Theranostic Applications in Oral Diseases.","authors":"Mengqing Gong, Yin Wang, Jiayong Dai, Qinrui Fu, Changqing Yuan","doi":"10.1002/wnan.70018","DOIUrl":"10.1002/wnan.70018","url":null,"abstract":"Oral diseases, characterized by a high incidence rate and significant impact on patients' quality of life, have emerged as a pressing global health concern amidst escalating societal pressures. Advancements in advanced materials are crucial for the prevention, detection, and treatment of most oral diseases due to their heavy reliance on materials. Nanotechnology has facilitated the development of various nanomaterial-based preparations that have garnered considerable attention in stomatology due to their inherent advantages such as enhanced biosafety, multifunctionality, and targeted therapy capabilities. Responsive nanomaterials offer a breakthrough solution to overcome limitations associated with drug release kinetics, leading to reduced effective drug concentrations while simultaneously exhibiting antibacterial, anti-inflammatory, antioxidant, osteogenic properties along with remineralization functions within safe parameters. Substantial progress has been made towards the long-term prevention and treatment of oral diseases through these responsive nanomaterials. This review begins by elucidating the response mechanisms underlying nanomaterials, followed by an overview of their applications in treating oral diseases. Finally, we discuss the challenges faced and future directions for utilizing advanced materials in addressing treatments for oral diseases. The insights provided herein hold significant implications for both basic research endeavors and clinical translation within stomatology.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70018"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-Enhanced Raman Scattering Nanotags: Design Strategies, Biomedical Applications, and Integration of Machine Learning. 表面增强拉曼散射纳米标签：设计策略、生物医学应用和机器学习集成。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70015

Isabella Vasquez, Ruiyang Xue, Indrajit Srivastava

{"title":"Surface-Enhanced Raman Scattering Nanotags: Design Strategies, Biomedical Applications, and Integration of Machine Learning.","authors":"Isabella Vasquez, Ruiyang Xue, Indrajit Srivastava","doi":"10.1002/wnan.70015","DOIUrl":"10.1002/wnan.70015","url":null,"abstract":"Surface-enhanced Raman scattering (SERS) is a transformative technique for molecular identification, offering exceptional sensitivity, signal specificity, and resistance to photobleaching, making it invaluable for disease diagnosis, monitoring, and spectroscopy-guided surgeries. Unlike traditional Raman spectroscopy, which relies on weak scattering signals, SERS amplifies Raman signals using plasmonic nanoparticles, enabling highly sensitive molecular detection. This technological advancement has led to the development of SERS nanotags with remarkable multiplexing capabilities for biosensing applications. Recent progress has expanded the use of SERS nanotags in bioimaging, theranostics, and more recently, liquid biopsy. The distinction between SERS and conventional Raman spectroscopy is highlighted, followed by an exploration of the molecular assembly of SERS nanotags. Significant progress in bioimaging is summarized, including in vitro studies on 2D/3D cell cultures, ex vivo tissue imaging, in vivo diagnostics, spectroscopic-guided surgery for tumor margin delineation, and liquid biopsy tools for detecting cancer and SARS-CoV-2. A particular focus is the integration of machine learning (ML) and deep learning algorithms to boost SERS nanotag efficacy in liquid biopsies. Finally, it addresses the challenges in the clinical translation of SERS nanotags and offers strategies to overcome these obstacles.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70015"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Islet Transplantation: Microencapsulation, Nanoencapsulation, and Hypoimmune Engineering. 胰岛移植：微胶囊化、纳米胶囊化和低免疫工程。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70016

Kyungsene Lee, Ana Aviles Vargas, Rita Bottino, Yong Wang

引用次数: 0

Advancing Medical Applications of Cancer Nanotechnology: Highlighting Two Decades of the NCI'S Nanotechnology Characterization Laboratory Service to the Research Community. 推进癌症纳米技术的医学应用：突出二十年来NCI纳米技术表征实验室服务于研究界。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70020

Rachael M Crist, Yechezkel Barenholz, Ahuva Cern, Kate N Clark, Pieter R Cullis, Cheryl Dean, Neil Desai, Mauro Ferrari, Matthieu Germain, Carmen A Giacomantonio, Emma Grabarnik, Piotr Grodzinski, Atara Hod, Barry E Kennedy, Ruvanthi N Kularatne, Glen S Kwon, Emmanuel Loeb, Erin B Noftall, Len Pagliaro, Morteza Rasoulianboroujeni, Alexander Roth, Darren Rowles, Kulbir Singh, Nicole F Steinmetz, Zhanna Yehtina, Yao Zhang, Daniel Zilbersheid, Jeffrey D Clogston, Stephan T Stern, Marina A Dobrovolskaia

{"title":"Advancing Medical Applications of Cancer Nanotechnology: Highlighting Two Decades of the NCI'S Nanotechnology Characterization Laboratory Service to the Research Community.","authors":"Rachael M Crist, Yechezkel Barenholz, Ahuva Cern, Kate N Clark, Pieter R Cullis, Cheryl Dean, Neil Desai, Mauro Ferrari, Matthieu Germain, Carmen A Giacomantonio, Emma Grabarnik, Piotr Grodzinski, Atara Hod, Barry E Kennedy, Ruvanthi N Kularatne, Glen S Kwon, Emmanuel Loeb, Erin B Noftall, Len Pagliaro, Morteza Rasoulianboroujeni, Alexander Roth, Darren Rowles, Kulbir Singh, Nicole F Steinmetz, Zhanna Yehtina, Yao Zhang, Daniel Zilbersheid, Jeffrey D Clogston, Stephan T Stern, Marina A Dobrovolskaia","doi":"10.1002/wnan.70020","DOIUrl":"10.1002/wnan.70020","url":null,"abstract":"The Nanotechnology Characterization Laboratory (NCL) is a US federally funded resource providing characterization and expertise to the cancer nanomedicine research community. Founded as a formal partnership among the US National Cancer Institute (NCI), the US Food and Drug Administration (FDA), and the US National Institute of Standards and Technology (NIST), the NCL has spent two decades developing a one-of-a-kind service with broad multidisciplinary expertise to meet the needs of a rapidly evolving drug development field. To mark the 20th anniversary of the lab's founding, the NCL hosted a symposium to highlight the achievements of the cancer nanomedicine field, showcase novel, next-generation nanotechnology research, and discuss future priorities to enable continued growth in combating cancer and the complexities associated with treating a disease that continues to take millions of lives annually. The discussion topics from this event are summarized.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70020"},"PeriodicalIF":8.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Green" Cross-Linking of Poly(Vinyl Alcohol)-Based Nanostructured Biomaterials: From Eco-Friendly Approaches to Practical Applications. 聚乙烯醇基纳米结构生物材料的“绿色”交联：从环保方法到实际应用。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70017

Anna Zakrzewska, Paweł Nakielski, Yen Bach Truong, Chiara Gualandi, Cecilia Velino, Seyed Shahrooz Zargarian, Massimiliano Lanzi, Alicja Kosik-Kozioł, Julia Król, Filippo Pierini

{"title":"\"Green\" Cross-Linking of Poly(Vinyl Alcohol)-Based Nanostructured Biomaterials: From Eco-Friendly Approaches to Practical Applications.","authors":"Anna Zakrzewska, Paweł Nakielski, Yen Bach Truong, Chiara Gualandi, Cecilia Velino, Seyed Shahrooz Zargarian, Massimiliano Lanzi, Alicja Kosik-Kozioł, Julia Król, Filippo Pierini","doi":"10.1002/wnan.70017","DOIUrl":"10.1002/wnan.70017","url":null,"abstract":"Recently, a growing need for sustainable materials in various industries, especially biomedical, environmental, and packaging applications, has been observed. Poly(vinyl alcohol) (PVA) is a versatile and widely used polymer, valued for its biocompatibility, water solubility, and easy processing, e.g., forming nanofibers via electrospinning. As a result of cross-linking, PVA turns into a three-dimensional structure-hydrogel with unusual sorption properties and mimicry of biological tissues. However, traditional cross-linking methods often involve toxic chemicals and harsh conditions, which can limit its eco-friendly potential and raise concerns about environmental impact. \"Green\" cross-linking approaches, such as the use of natural cross-linkers, freeze-thawing, enzymatic processes, irradiation, heat treatment, or immersion in alcohol, offer an environmentally friendly alternative that aligns with global trends toward sustainability. These methods not only reduce the use of harmful substances but also enhance the biodegradability and safety of the materials. By reviewing and analyzing the latest advancements in \"green\" PVA cross-linking approaches, this review provides a comprehensive overview of current techniques, their advantages, limitations, and potential applications. The main emphasis is placed on PVA nanostructured forms and applications of PVA-based biomaterials in areas such as wound dressings, drug delivery systems, tissue engineering, biological filters, and biosensors. Moreover, this article will contribute to the broader scientific understanding of how the materials based on PVA can be optimized both in terms of \"greener\" and safer production, as well as adjusting the final platform properties.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70017"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Application of mRNA for Genetic Diseases. mRNA在遗传病治疗中的应用。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70019

Paul J L Schürmann, Stijn P E van Breda Vriesman, Jose A Castro-Alpízar, Sander A A Kooijmans, Edward E S Nieuwenhuis, Raymond M Schiffelers, Sabine A Fuchs

{"title":"Therapeutic Application of mRNA for Genetic Diseases.","authors":"Paul J L Schürmann, Stijn P E van Breda Vriesman, Jose A Castro-Alpízar, Sander A A Kooijmans, Edward E S Nieuwenhuis, Raymond M Schiffelers, Sabine A Fuchs","doi":"10.1002/wnan.70019","DOIUrl":"10.1002/wnan.70019","url":null,"abstract":"While gene therapy has been at the center of an active research field for decades, messenger RNA (mRNA) has long been considered unsuited for therapeutic application due to challenges with stability, immunogenicity, and delivery. Where gene therapy focuses on providing the desired genetic code, mRNA can directly provide the instructions encoded in the corresponding gene. This review aims to explore recent advances in mRNA therapies, building on the success of mRNA COVID-19 vaccines, and extend these insights to the potential treatment of rare genetic diseases. We follow the \"outside-in\" trajectory of mRNA therapies from administration to intracellular function, focusing on carrier systems such as lipid nanoparticles and virus-like particles, mRNA modifications, and the potential and challenges for clinical applications. To treat rare diseases, different approaches can be envisioned, including chronic or acute delivery of mRNAs encoding functional enzymes for enzyme deficiencies and delivery of CRISPR/Cas9-based gene-editing tools for gene correction. These different approaches determine safety and immunological considerations. By exploring genetic, technical, and therapeutic aspects, this review highlights the potential and current challenges of mRNA therapies to address the large unmet needs in rare genetic disorders.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70019"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-24: A Multidimensional Therapeutic for Treatment of Human Diseases. 白介素-24：治疗人类疾病的多维疗法。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-05-01 DOI: 10.1002/wnan.70013

Rajeswari Raguraman, Anupama Munshi, Rajagopal Ramesh

{"title":"Interleukin-24: A Multidimensional Therapeutic for Treatment of Human Diseases.","authors":"Rajeswari Raguraman, Anupama Munshi, Rajagopal Ramesh","doi":"10.1002/wnan.70013","DOIUrl":"10.1002/wnan.70013","url":null,"abstract":"The field of targeted therapy exploits the selective expression of therapeutic genes or proteins in diseased cells. While this area is gaining attraction in the context of cardiovascular diseases, diabetes, and other major health disorders, it has been most extensively explored in the realm of cancer. Targeted therapy has gained significance in the cancer field for its potential to address the limitations of conventional treatments and enhance patient survival. Interleukin-24 (IL-24), a versatile cytokine, has been evaluated as a cancer therapeutic in various preclinical cancer models and clinical trials, and has yielded promising results. Consequently, multiple studies highlight IL-24 as a viable \"anti-cancer\" therapeutic, with successful outcomes observed in combination therapies involving small molecule inhibitors, chemotherapeutic drugs, and radiation. Despite the evidence validating the tumor-suppressing properties of IL-24 in cancer models, there is a dearth of information regarding its role in other human diseases. The objective of this review is to offer a synopsis of the potential role of IL-24 in diverse human diseases. Additionally, it provides a comprehensive review of the progress in cancer therapy utilizing IL-24. Finally, from the author's standpoint, the review also addresses some of the limitations that impede the translational potential of IL-24-based therapy in clinical settings. It offers arguments in favor of incorporating IL-24-based targeted therapy as an effective and safer alternative for current treatment modalities, thereby highlighting its potential to revolutionize the field of therapeutics.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 3","pages":"e70013"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial Autonomous Intelligent Microrobots for Biomedical Applications. 生物医学应用的细菌自主智能微型机器人。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-03-01 DOI: 10.1002/wnan.70011

Haotian Chen, Yingze Li, Zhenguang Li, Yuantai Sun, Weicheng Gu, Chang Chen, Yu Cheng

{"title":"Bacterial Autonomous Intelligent Microrobots for Biomedical Applications.","authors":"Haotian Chen, Yingze Li, Zhenguang Li, Yuantai Sun, Weicheng Gu, Chang Chen, Yu Cheng","doi":"10.1002/wnan.70011","DOIUrl":"10.1002/wnan.70011","url":null,"abstract":"Micro/nanorobots are being increasingly utilized as new diagnostic and therapeutic platforms in the biomedical field, enabling remote navigation to hard-to-reach tissues and the execution of various medical procedures. Although significant progress has been made in the development of biomedical micro/nanorobots, how to achieve closed-loop control of them from sensing, memory, and precise trajectory planning to feedback to carry out biomedical tasks remains a challenge. Bacteria with self-propulsion and autonomous intelligence properties are well suited to be engineered as microrobots to achieve closed-loop control for biomedical applications. By virtue of synthetic biology, bacterial microrobots possess an expanded genetic toolbox, allowing them to load input sensors to respond or remember external signals. To achieve accurate control in the complex physiological environment, the development of bacterial microrobots should be matched with the corresponding control system design. In this review, a detailed summary of the sensing and control mechanisms of bacterial microrobots is presented. The engineering and applications of bacterial microrobots in the biomedical field are highlighted. Their future directions of bacterial autonomous intelligent microrobots for precision medicine are forecasted.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 2","pages":"e70011"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microscale Delivery Systems for Hydrophilic Active Ingredients in Functional Consumer Goods. 功能性消费品中亲水活性成分的微型输送系统。

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-03-01 DOI: 10.1002/wnan.70009

Zhirui Guan, Daniele Baiocco, Andre Barros, Zhibing Zhang

{"title":"Microscale Delivery Systems for Hydrophilic Active Ingredients in Functional Consumer Goods.","authors":"Zhirui Guan, Daniele Baiocco, Andre Barros, Zhibing Zhang","doi":"10.1002/wnan.70009","DOIUrl":"10.1002/wnan.70009","url":null,"abstract":"Hydrophilic active ingredients play a crucial role in formulated consumer products, encompassing antioxidants, flavoring substances, and pharmaceuticals. Yet, their susceptibility to environmental factors, such as light, pH, temperature, and humidity, poses challenges to their stability and sustained release. Microencapsulation offers a promising avenue to address these challenges, facilitating stabilization, targeted delivery, and enhanced efficacy of hydrophilic actives. However, despite significant advancements in the field, microencapsulation of hydrophilic actives remains at the forefront of innovation. This is primarily due to the intrinsic characteristics of hydrophilic actives, including small molecular weight and thus high permeability through many microcarriers (e.g., shells), which often necessitate complex and costly technologies to be developed. Moreover, in light of escalating regulatory frameworks, the pursuit of biodegradable and other compliant materials suitable for the entrapment of hydrophilic ingredients is gaining momentum. These advancements aim to provide alternatives to currently used non-degradable synthetic polymer materials. Research is currently pushing towards meeting these regulatory constraints via cutting-edge technologies to engineer novel microscale delivery systems for hydrophilic active ingredients, including microcapsules, microspheres, microneedles, and micropatches. Although still in its infancy, this approach holds true potential for revolutionizing the future of formulated consumer goods.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 2","pages":"e70009"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Nanomedicine in Transforming Pharmacotherapy for Substance Use Disorder (SUD). 纳米医学在改变药物使用障碍 (SUD) 的药物疗法中的作用。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-03-01 DOI: 10.1002/wnan.70008

Akshata Y Patne, Subhra Mohapatra, Shyam S Mohapatra

{"title":"Role of Nanomedicine in Transforming Pharmacotherapy for Substance Use Disorder (SUD).","authors":"Akshata Y Patne, Subhra Mohapatra, Shyam S Mohapatra","doi":"10.1002/wnan.70008","DOIUrl":"10.1002/wnan.70008","url":null,"abstract":"The field of nanomedicine offers revolutionary potential to reshape the discovery and development of therapeutics for diverse human diseases. However, its application has been limited in improving Substance Use Disorders (SUDs), which represent a profound public health crisis, including major types such as opioid, alcohol, stimulant, and cannabis use disorders. Pharmacotherapy, a cornerstone of SUD management, has reduced morbidity, mortality, and the societal impact of addiction, though its efficacy has ranged from none to moderate. Thus, there is a major unmet need to transform SUD pharmacotherapy to curb the epidemic of addiction. This article explores the potential roles of nanomedicine-inspired precision-targeted drug delivery, sustained release, and combination therapies to increase therapeutic efficacy and minimize side effects. Additionally, it discusses innovative mechanisms that align with the neurobiological complexities of addiction and synergistic approaches that integrate nanomedicine with behavioral interventions, device-based therapies, and emerging modalities such as immunotherapy and neurostimulation. Despite these advancements, barriers such as treatment accessibility, adherence challenges, and inequitable resource distribution persist, particularly in underserved populations. By harnessing the transformative capabilities of nanomedicine and integrating it into holistic, equitable, and personalized care frameworks, this review highlights a path forward to revolutionize the SUD pharmacotherapy landscape. The article underscores the need for continued nano-SUD pharmacotherapy research and the development of strategies to alleviate the substantial burden of addiction on individuals, families, and society.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 2","pages":"e70008"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0