Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology最新文献_第4页

Emerging Advances in Nanomedicine for Targeted Cancer Photoimmunotherapy and Photo-Immunometabolic Therapy. 靶向肿瘤光免疫和光免疫代谢治疗的纳米医学新进展。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-11-01 DOI: 10.1002/wnan.70042

Alexander Chota, Paromita Sarbadhikary, Heidi Abrahamse, Blassan P George

{"title":"Emerging Advances in Nanomedicine for Targeted Cancer Photoimmunotherapy and Photo-Immunometabolic Therapy.","authors":"Alexander Chota, Paromita Sarbadhikary, Heidi Abrahamse, Blassan P George","doi":"10.1002/wnan.70042","DOIUrl":"10.1002/wnan.70042","url":null,"abstract":"Immunotherapy has advanced quickly as a promising new approach for cancer treatment, but its therapeutic efficacy and clinical translation have lagged expectations, because of its inability to directly target tumors, low response rates, and nonspecific immune reactions. Anticancer therapies like photodynamic therapy (PDT) show promise over traditional modalities, as they can induce a specific type of tumor cell death known as immunogenic cell death (ICD) to boost the immune response against solid tumors. However, successful therapeutic outcomes cannot be achieved with PDT-driven ICD-based single-modal cancer immunotherapy alone, which necessitates the combination of ICD-based PDT with other immunotherapies. Therefore, to achieve effective PDT-driven immunotherapy, it is imperative to enhance the in vivo delivery efficiency of photosensitizers and immuno agents, along with reducing the off-target side effects, to develop comprehensive therapeutic strategies like photo-immunotherapy and photo-immunometabolic therapy. Herein, this review discusses the recent advances in the field at the intersection of PDT, immunoconjugates, nanotechnology, and ICD, majorly focusing on their molecular design and nanoengineering, and their induced synergistic effects. Finally, the opportunities and current challenges encountered in this field, along with the significant advancements made in recent years, have been highlighted. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 6","pages":"e70042"},"PeriodicalIF":8.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12687716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis and Biomedical Applications of ¹⁸F Nanoprobes: A Comprehensive Review. 18F纳米探针的设计、合成及生物医学应用综述

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-11-01 DOI: 10.1002/wnan.70038

Chuqiang Que, Ying Han, Shiyao Fu, Zuxin Zhang, Pengjian Zuo, Jing Wang, Xin Yang

{"title":"Design, Synthesis and Biomedical Applications of 18F Nanoprobes: A Comprehensive Review.","authors":"Chuqiang Que, Ying Han, Shiyao Fu, Zuxin Zhang, Pengjian Zuo, Jing Wang, Xin Yang","doi":"10.1002/wnan.70038","DOIUrl":"https://doi.org/10.1002/wnan.70038","url":null,"abstract":"18F-labeled nanoprobes represent a significant advancement in molecular imaging, integrating the high sensitivity and quantitative capabilities of positron emission tomography (PET) with the versatility of nanotechnology. This review provides a comprehensive overview of the design strategies and diverse applications of 18F nanoprobes. Initially, we examine the synthesis approaches, including direct 18F radiolabeling of nanoparticles, nano-encapsulation of 18F tracers, and nanoscale self-assembly of 18F tracers, all tailored to enhance biocompatibility, targeting specificity, and imaging clarity. Subsequently, we systematically explore the in vivo behavior of 18F nanoprobes, focusing on key influencing factors such as functional precursors, physicochemical properties and surface chemistry. Furthermore, the applications of 18F nanoprobes in multimodal imaging, including PET/MR, PET/CT, and PET/MR/UCL imaging are discussed, particularly for tumor detection, therapeutic response monitoring, pharmacokinetics and biodistribution assessment in living subjects. Finally, the challenges and future perspectives of nanoprobes are addressed, highlighting their potential for utility in both clinical and research settings. This review anticipates the pivotal role of 18F nanoprobes in advancing personalized medicine, offering precise diagnostics and paving the way for next-generation targeted theranostic platforms. Detailed studies on the mechanisms of 18F nanoprobes, with an emphasis on clinical translation and potential benefits, are expected to further propel this promising field. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Diagnostic Tools > Diagnostic Nanodevices.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 6","pages":"e70038"},"PeriodicalIF":8.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide Hydrogels for Postoperative Tumor Therapy: Enhancing Immune Modulation and Local Drug Delivery. 肽水凝胶用于肿瘤术后治疗：增强免疫调节和局部药物传递。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-11-01 DOI: 10.1002/wnan.70043

Sangshuang Li, Huaimin Wang

{"title":"Peptide Hydrogels for Postoperative Tumor Therapy: Enhancing Immune Modulation and Local Drug Delivery.","authors":"Sangshuang Li, Huaimin Wang","doi":"10.1002/wnan.70043","DOIUrl":"https://doi.org/10.1002/wnan.70043","url":null,"abstract":"Postoperative tumor cavities provide a transient but targetable immune niche where local biomaterials can suppress residual disease and complement systemic therapy. Self-assembling peptidic hydrogels are uniquely suited for this setting because their molecular programmability, supramolecular order, and tissue-conforming mechanics enable both precision drug delivery and immune modulation. In this review, we organize recent advances into three emerging strategies: (i) immunoactive carriers that remain immunologically inert while delivering innate agonists, nucleic acids, or antibodies with spatial and temporal precision; (ii) intrinsically immunomodulatory matrices whose chirality, supramolecular order, and mechanics regulate dendritic-cell activation, macrophage polarization, and memory formation; and (iii) drug-as-hydrogelator formats that integrate cytotoxic debulking and myeloid reprogramming within a single filament network. We highlight design elements such as sequence-encoded motifs, stimulus-responsive linkers, chemokine programming, and logic-gated release systems, and we discuss translational considerations including cavity geometry, surgical workflow, and safety liabilities. Together, these strategies reframe the resection cavity as a programmable immune interface rather than a passive drug reservoir, pointing toward material-centric frameworks that could transform postoperative oncology. This article is categorized under: Biology-Inspired Nanomaterials > Peptide-Based Structures Therapeutic Approaches and Drug Discovery > Emerging Technologies.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 6","pages":"e70043"},"PeriodicalIF":8.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational Design of Zwitterionic Nanosystems to Overcome Biological Barriers for Drug Delivery by Various Administration Routes. 合理设计两性离子纳米系统以克服不同给药途径给药的生物障碍。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-09-01 DOI: 10.1002/wnan.70037

Jiahui Ma, Dongyue Ding, Rui Xu, Shuxian Ma, Yinan Zhong, Wei Liu, Liqing Gao, Wei Chen

{"title":"Rational Design of Zwitterionic Nanosystems to Overcome Biological Barriers for Drug Delivery by Various Administration Routes.","authors":"Jiahui Ma, Dongyue Ding, Rui Xu, Shuxian Ma, Yinan Zhong, Wei Liu, Liqing Gao, Wei Chen","doi":"10.1002/wnan.70037","DOIUrl":"https://doi.org/10.1002/wnan.70037","url":null,"abstract":"The drug delivery nanosystems (DDNS) have demonstrated excellent potential in numerous drug modifications reliant on the physical and chemical properties. However, the main challenge in the clinical application transformation of DDNS lies in the biological barriers between the administration site and the target site, which hinders efficient drug transport. The polyethylene glycol (PEG)-modified stealth strategies that have been clinically approved have also been questioned due to inherent defects such as accelerated blood clearance and specific immune responses. As an alternative to PEG, zwitterion polymers with characteristics including forming a strong hydration layer, extremely low immunogenicity, and ultra-delayed blood circulation time have stood out in the surface modification of DDNS for various administration routes. This review introduces the biological barriers faced by drugs in various administration routes, elaborates on the advantages of the inherent properties of zwitterions in overcoming these barriers, and focuses on the latest progress in how zwitterions can flexibly modify DDNS to achieve superior delivery efficiency and efficacy in various administration routes. Finally, the rational design of zwitterion-modified DDNS for future disease treatment is envisioned. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 5","pages":"e70037"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Galleria mellonella as a Simple Yet Reliable In Vivo Model for Nanotoxicology: Techniques and Applications. 一种简单而可靠的体内纳米毒理学模型：技术与应用。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-09-01 DOI: 10.1002/wnan.70033

Núria Blanco-Cabra, Joana Admella, Eduard Torrents

{"title":"Galleria mellonella as a Simple Yet Reliable In Vivo Model for Nanotoxicology: Techniques and Applications.","authors":"Núria Blanco-Cabra, Joana Admella, Eduard Torrents","doi":"10.1002/wnan.70033","DOIUrl":"10.1002/wnan.70033","url":null,"abstract":"Nanomaterials are a rapidly advancing tool with applications across various scientific fields. However, their interactions with living organisms have raised numerous safety concerns, making it crucial to develop reliable models to predict and evaluate associated toxicity effects. Traditional in vitro assays fail to mimic the true physiological responses of living organisms to nanomaterials, whereas murine and other in vivo models are time-consuming, costly, and ethically controversial. The greater wax moth, Galleria mellonella, has emerged as a promising in vivo model for nanotoxicology, serving as an effective bridge between in vitro and in vivo mammalian testing. This model combines simplicity and ethical viability with a human-conserved innate immune system, making it ideal for immunotoxicity testing. While it cannot fully replace more complex animal models, G. mellonella represents a valuable alternative for early-stage nanotoxicology screening and deserves greater recognition and integration into toxicological research. In this review, we examine all the methodologies and applications of G. mellonella in nanotoxicological studies, highlighting its potential as a reliable and ethical model for assessing nanomaterial safety. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 5","pages":"e70033"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An End-to-End Differentiable, Graph Neural Network-Embedded Pore Network Model for Permeability Prediction 渗透率预测的端到端可微图神经网络嵌入孔隙网络模型

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-09-01 DOI: 10.22541/essoar.175674593.36296351/v1

Qingqi Zhao, Heng Xiao

引用次数: 0

Sex and Gender Dimensions in Hazard and Risk Assessment of Engineered Nanomaterials. 工程纳米材料危害和风险评估中的性别和性别维度。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-09-01 DOI: 10.1002/wnan.70034

Lucija Božičević, Karolina Jagiello, Anita Sosnowska, Maciej Stepnik, Maria Dusinska, Iseult Lynch, Nikolina Peranić, Ivona Capjak, Valérie Fessard, Mihaela R Cimpan, Arno C Gutleb, Elise Runden Pran, Tomasz Puzyn, Ivana Vinković Vrček

{"title":"Sex and Gender Dimensions in Hazard and Risk Assessment of Engineered Nanomaterials.","authors":"Lucija Božičević, Karolina Jagiello, Anita Sosnowska, Maciej Stepnik, Maria Dusinska, Iseult Lynch, Nikolina Peranić, Ivona Capjak, Valérie Fessard, Mihaela R Cimpan, Arno C Gutleb, Elise Runden Pran, Tomasz Puzyn, Ivana Vinković Vrček","doi":"10.1002/wnan.70034","DOIUrl":"10.1002/wnan.70034","url":null,"abstract":"The knowledge on hazards and risks connected to human exposure to engineered nanomaterials (ENMs) is still very limited, despite several decades of research and regulatory efforts at the international level. In particular, sex/gender-related responses to such exposure have not been clearly articulated so far in any of the existing guidance documents or regulatory relevant opinions provided to the parties involved in the risk assessment and risk management of ENMs. We aimed to demonstrate the relevance of the sex/gender dimension for the characterization of the risks and hazards associated with ENMs by analyzing existing scientific data on sex-related differences in response to ENMs exposure. This was achieved by performing an extensive review of in vivo mammalian toxicity studies published in PubMed and Web of Science databases. Further analysis was performed only for data reported in publications that satisfied scientific quality criteria assessed using the GUIDEnano approach. Finally, we demonstrated the importance of the sex/gender dimension for safety testing of ENMs in the future and provided recommendations on how to include the sex/gender dimension in toxicity testing of ENMs to ensure precise, transparent, and reliable conclusions in the process of hazard and risk assessments. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials Toxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 5","pages":"e70034"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Tumor Radiosensitization: A Perspective of Nano-Radiotherapy. 肿瘤放射增敏机制：纳米放射治疗的视角。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-09-01 DOI: 10.1002/wnan.70035

Jiangwei Zhou, Yongcheng Zhang, Fushi Dong, Kotone Matsuyama, Yosuke Tanaka, Lina Wu

{"title":"Mechanisms of Tumor Radiosensitization: A Perspective of Nano-Radiotherapy.","authors":"Jiangwei Zhou, Yongcheng Zhang, Fushi Dong, Kotone Matsuyama, Yosuke Tanaka, Lina Wu","doi":"10.1002/wnan.70035","DOIUrl":"https://doi.org/10.1002/wnan.70035","url":null,"abstract":"Radiotherapy (RT) is one of the cornerstones in cancer treatment, with approximately 50% of patients receiving radiation regimens annually. However, its clinical efficacy is constrained by two persistent challenges: tumor radioresistance and radiation-induced damage to healthy tissues. Recent advances in nanomedicine have yielded innovative nano-radiosensitizers capable of enhancing tumor-specific radiation dose deposition while sparing normal tissues, thereby addressing both limitations simultaneously. Previous advanced reviews have extensively covered intrinsic nanomaterial properties and physicochemical mechanisms of radiosensitization; this review systematically elucidates radiosensitization mechanisms through the lens of RT subprocesses, offering a novel framework to evaluate how specific mechanisms modulate discrete stages of radiation response. It includes increasing radiation dose deposition; lowering antioxidant system level to promote ROS production; collaborating with other ways to promote ROS production; collaborating with the production of exogenous cytotoxic substances; augmenting intrinsic radiosensitivity of cancer cells; stabilizing radiation-induced DNA lesions to suppress repair machinery; and enhancing radiogenic immunogenic cell death to strengthen antitumor immunity. Furthermore, we discuss emerging trends in nanotechnology-driven combination therapies. This systematic perspective advances the rational design of next-generation nano-radiosensitizers and informs personalized radiotherapy protocols. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 5","pages":"e70035"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Prodrug-Loaded Nanoparticles for Enhanced Immunotherapy Efficacy. 前体载药纳米颗粒增强免疫治疗效果的研究进展。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-07-01 DOI: 10.1002/wnan.70028

Yajun Xu, Jincheng Du, Ya Liu, Chuwen Luo, Zhaohui Tang, Xuesi Chen

{"title":"Recent Advances in Prodrug-Loaded Nanoparticles for Enhanced Immunotherapy Efficacy.","authors":"Yajun Xu, Jincheng Du, Ya Liu, Chuwen Luo, Zhaohui Tang, Xuesi Chen","doi":"10.1002/wnan.70028","DOIUrl":"10.1002/wnan.70028","url":null,"abstract":"Immunotherapy has emerged as an important approach for cancer treatment. However, most drugs for activating the cancer-immunity cycle have serious side effects from systemic off-target action, endangering patients' safety. Prodrug-loaded nanoparticles integrate prodrug activation strategies based on passive or active targeted delivery, which is expected to improve the enrichment of drugs in tumors, reduce the activation of drugs in normal tissues, and enhance the drugs' tumor selectivity. For example, adjuvants represented by Toll-like receptor 7/8 (TLR7/8) agonists and stimulator of interferon genes (STING) agonists are promising for the de novo priming of antitumor immunity. However, these drugs face pressing challenges in achieving tumor-specific immune activation to enhance the therapeutic effect and minimize systemic toxicity. This review systematically analyzes recent advances in these prodrug-loaded nanoparticles for precise controlled release adjuvants in tumors, focusing on TLR7/8 and STING agonists. We discuss the tumor microenvironment-driven prodrug activation, externally triggered prodrug activation, and explore the generalized design principles and mechanisms applicable to prodrug-loaded nanoparticles. Furthermore, we explore these adjuvants' current status, challenges, and future development direction in the clinical translation. This article aims to inspire the further development of these agonists. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 4","pages":"e70028"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming Cancer Nanotechnology Data Analysis and User Experience. Part II: Providing Future Solutions Using Large Language Models. 转化癌症纳米技术数据分析和用户体验。第二部分：使用大型语言模型提供未来的解决方案。

IF 8.2

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2025-07-01 DOI: 10.1002/wnan.70029

Weina Ke, Rui He, Mark A Jensen, Marina A Dobrovolskaia

{"title":"Transforming Cancer Nanotechnology Data Analysis and User Experience. Part II: Providing Future Solutions Using Large Language Models.","authors":"Weina Ke, Rui He, Mark A Jensen, Marina A Dobrovolskaia","doi":"10.1002/wnan.70029","DOIUrl":"https://doi.org/10.1002/wnan.70029","url":null,"abstract":"The advances in cancer nanotechnologies and current efforts focused on data sharing, along with the associated challenges, have been summarized in the first part of this review. Herein, we explore the potential of Large Language Models (LLMs) to enhance user experience, using the federally funded data repository caNanoLab as a case study. By training the LLM on caNanoLab data, we demonstrate its ability to provide more comprehensive search results, well-guided data entry, and a personalized, assisted search experience. We also discuss how integrating LLMs would optimize user experience, making it easier for researchers to navigate complex data and find relevant information. Our findings suggest that LLMs have significant potential to transform cancer nanotechnology data analysis and user experience, potentially paving the way for more efficient and effective advancements in cancer research. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies.","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 4","pages":"e70029"},"PeriodicalIF":8.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0