Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology最新文献

{"title":"Cerium-Based Materials for Theranostics: Building a Bridge Across the Divide From Antioxidant Therapy to Diagnostic Signals.","authors":"Liangchen Luo, Guozhu Yang, Pengli Zhang, Fengzheng Tang, Pingting Luo, Ling Ding, Xuehua Ma, Changyong Gao, Junjie Lin, Jie Lin, Aiguo Wu, Tianxiang Chen","doi":"10.1002/wnan.70055","DOIUrl":"10.1002/wnan.70055","url":null,"abstract":"<p><p>Oxidative stress (OS) serves as a fundamental pathological component in a multitude of chronic diseases, necessitating an all-round theranostic strategy for simultaneous precision intervention and real-time monitoring. Cerium-based nanomaterials (CeNMs), particularly cerium oxide nanoparticles (CeNPs), offer a disruptive theranostic platform on account of their unique Ce³⁺/Ce⁴⁺ redox cycling, intrinsic superoxide dismutase (SOD)- and Catalase (CAT)-mimetic activities, responsiveness to pathological microenvironments (e.g., high ROS and low pH), and inherent or engineerable imaging capabilities (e.g., CT contrast and fluorescence). This review not only systematically probes deep into four \"diagnosis-therapy\" bridging mechanisms of CeNMs in oxidative-stress-correlated diseases, but also digs into how these mechanisms effectively address the limitations of conventional strategies. On that account, we explore the integrated potential of CeNMs in antioxidant therapy and dynamic monitoring. These materials are poised to become a critical engine driving precision medicine in oxidative-stress-related disorders. For this reason, it facilitates interventions characterized by more individualized, dynamically regulated and safely controllable design.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 2","pages":"e70055"},"PeriodicalIF":8.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147380085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Product Development of Lipid Nanoparticle-Based mRNA Therapeutics and Vaccines.","authors":"Gideon Kersten, Eleonora Cerasoli, Bruce Kerwin, Olivia M Merkel, Andrea Hawe","doi":"10.1002/wnan.70053","DOIUrl":"10.1002/wnan.70053","url":null,"abstract":"<p><p>Lipid nanoparticles (LNP) are currently the most relevant non-viral delivery systems for mRNA and occasionally for smaller nucleic acids such as small interfering RNA. Although the manufacturing of LNP is well established and scalable equipment is available for production, LNP drug product development is not straightforward. Numerous factors influence product quality, including LNP composition, process parameters, and formulation composition. A proper understanding and control of the critical variables is essential for product development of LNP containing pharmaceuticals. This article provides an overview on the drug product development roadmap for LNP-based therapeutics and vaccines. Based on the quality target product profile and current scientific and technical knowledge, key aspects that may impact product quality will be discussed. Strategies to identify failure risks as early in the development process as possible and ways to mitigate them will be addressed. The majority of steps in the development are covered, including LNP design and LNP manufacturing process, analytical development, and formulation development to achieve a stable and safe product suitable for human application. This article is categorized under: Biology-Inspired Nanomaterials > Lipid-Based Structures.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 2","pages":"e70053"},"PeriodicalIF":8.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles-Mediated Modulation of TRP Channels: Advances and Therapeutic Potential.","authors":"Karina A Foster, Noy Midler, Ori Shine, Dekel Rosenfeld","doi":"10.1002/wnan.70058","DOIUrl":"10.1002/wnan.70058","url":null,"abstract":"<p><p>Nanoparticles have emerged as promising tools for targeting and activating ion channels that serve as transducers for external signals. Their nanoscale dimensions enable targeted activation of ion channels at the cellular or subcellular level, offering unprecedented opportunities to control biological cell signaling. Recent works have demonstrated nanoparticle-mediated stimulation based on optical, electrical, and magnetic external signals, highlighting their potential to serve as minimally invasive therapeutics. In addition, there is an increasing need to identify relevant ion channels and their physiological role in advancing emerging nanotechnologies. The transient receptor potential (TRP) family, including prominent members such as the TRPV (vanilloid), TRPM (Melastatin), and TRPA (ankyrin), plays critical roles in physiological functions, such as temperature sensation, pain perception, and mechanical stimulus detection, and can be controlled via nanoparticle signaling. This review highlights the properties and roles of dominant TRP family members in different organs and positions them as relevant targets for novel technologies. Leveraging the knowledge of nanoparticle properties with recent advances in pharmacology and disease treatments that target TRP family members will enhance the development of novel nano-biotechnologies to control cell signaling.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 2","pages":"e70058"},"PeriodicalIF":8.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Targeting of Hepatic Stellate Cells: Nanotherapeutic Strategies for Liver Fibrosis Regression.","authors":"Xinying Ma, Dawei Chen, Ming Zhao, Haiyang Hu","doi":"10.1002/wnan.70046","DOIUrl":"https://doi.org/10.1002/wnan.70046","url":null,"abstract":"<p><p>Liver fibrosis (LF), a major global health burden causing over two million deaths annually, arises from chronic injury leading to hepatic stellate cell (HSC) activation and pathological extracellular matrix (ECM) deposition. Current therapies are limited by nonspecific biodistribution and inadequate drug delivery to HSCs. Nanosystems engineered for active HSC targeting offer a promising approach to overcome fibrotic barriers-including capillarized sinusoids and dense ECM-through strategies such as receptor-specific ligand modification, RNA-based gene silencing, and multifunctional combinatorial therapies. These platforms enable precise modulation of HSC activation and ECM remodeling, promoting fibrosis regression while sparing healthy tissue. Despite promising preclinical outcomes, key challenges remain in biosafety, scalable fabrication, and clinical validation. Advancements in HSC-specific nanotherapeutics hold transformative potential for reversing liver fibrosis and restoring hepatic function. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 1","pages":"e70046"},"PeriodicalIF":8.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living Organs as Micro-Factories: Material-Producing Organoids.","authors":"Quentin M Perrin, Ali Miserez","doi":"10.1002/wnan.70049","DOIUrl":"10.1002/wnan.70049","url":null,"abstract":"<p><p>Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing process, where the material (e.g., spider silk) and its production unit are self-organized (e.g., silk glands). Biological systems orchestrate the emergence of hierarchical materials with superior mechanical properties and biodegradability, using abundant and renewable resources. Tissue engineering enables the creation of biological systems that surpass current synthetic designs in complexity. We highlight application opportunities, focusing on spider silk as a model to demonstrate how organs synthesize and assemble next-generation materials. The concept of growing both a material and its organ production units is exemplified by hair-bearing organoids, self-organized from induced pluripotent stem cells (iPSCs). Key challenges in expanding organoid research to new model species and scaling-up production are discussed alongside potential solutions. We propose a simplified description of these complex systems to help address key challenges. Furthermore, synthetic and hybrid approaches are explored, considering the ethical, societal, and technological impacts. Though still in their infancy, material-producing organoids present a promising avenue for sustainable, high-value products, fostering new interdisciplinary collaborations among bioengineers, developmental biologists, and material scientists. This work aims to inspire further exploration into the applications of self-organized biological systems in addressing global challenges. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Nanotechnology Approaches to Biology > Cells at the Nanoscale.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 1","pages":"e70049"},"PeriodicalIF":8.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Peptide-Based Cancer Vaccines: Materials, Targeting, and Delivery Strategies.","authors":"Shea Garland, Jacques Lux","doi":"10.1002/wnan.70044","DOIUrl":"https://doi.org/10.1002/wnan.70044","url":null,"abstract":"<p><p>Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has transformed cancer treatment by achieving durable responses in a subset of patients. However, the effectiveness of ICIs is often limited by factors such as low tumor expression of PD-L1 and low tumor mutational burden, which contribute to immune evasion in \"cold\" tumors. Cancer vaccination through the delivery of tumor antigens offers a promising strategy to enhance antigen-specific immune priming and improve the responses to ICIs. Despite this potential, peptide-based cancer vaccines face several challenges, including immune tolerance, insufficient antigen delivery and presentation, and the immunosuppressive tumor microenvironment. To overcome these barriers, novel platforms are being developed to codeliver antigens with immunostimulatory agents. In this review, we highlight recent advances in peptide-based cancer vaccine design, including innovative materials, adjuvants, targeting strategies, and controlled release mechanisms. We also discuss their translation and how these approaches may ultimately expand the benefit of immunotherapy to patients with treatment-refractory cancers. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials > Peptide-Based Structures Biology-Inspired Nanomaterials > Lipid-Based Structures.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 1","pages":"e70044"},"PeriodicalIF":8.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Plasmon-Assisted Optical Sensing of Inflammatory Biomarkers.","authors":"Daria Stoia, Alexandru-Milentie Hada, Sorina Suarasan, Monica Potara, Simion Astilean","doi":"10.1002/wnan.70048","DOIUrl":"10.1002/wnan.70048","url":null,"abstract":"<p><p>The precise monitoring of specific inflammatory biomarkers is crucial for the accurate diagnosis and management of inflammation and infections, as well as for determining the most effective treatment. Recently, there has been a growing interest in innovative methods employing optical biosensors based on plasmonic nanoparticles (PNPs) for the detection of specific biomarkers. PNPs enable the translation of molecular recognition into results that are simple, fast, reliable, real-time, and easy to interpret. This review explores the studies published in recent years that focus on the development of apta- or immuno-sensors for the detection of inflammatory biomarkers. Focusing on diverse analysis techniques, including colorimetry, localized surface plasmon resonance, surface-enhanced Raman spectroscopy, fluorescence, chemiluminescence, and electrochemiluminescence, this review provides a comprehensive investigation of their applications in the detection of inflammatory biomarkers such as interleukins, procalcitonin, and C-reactive protein. For each method, advancements in sensor design, sensitivity, and specificity are reported. This article is categorized under: Diagnostic Tools > Biosensing.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 1","pages":"e70048"},"PeriodicalIF":8.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoengineered Niclosamide as a Microenvironment Modulator for Spinal Cord Regeneration: A Hypothetical Roadmap Toward Brain/Head Transplant Feasibility.","authors":"N Sanoj Rejinold, Geun-Woo Jin, Jin-Ho Choy","doi":"10.1002/wnan.70054","DOIUrl":"10.1002/wnan.70054","url":null,"abstract":"<p><p>Restoring long-distance spinal cord connectivity remains a major challenge in regenerative medicine. Despite advances in stem cell therapy, biomaterial scaffolds, and neuromodulation, recovery after spinal cord injury (SCI) is limited by a hostile post-injury microenvironment marked by chronic inflammation, glial scarring, and extracellular matrix (ECM) stiffening. This Perspective proposes nanoengineered niclosamide, a repurposable multi-pathway modulator, as a strategy to reprogram this niche. By attenuating NF-κB/STAT3-driven inflammation, suppressing fibrotic signaling, and reducing ECM rigidity, nanoengineered niclosamide may synergize with scaffold- and stimulation-based approaches, highlighting microenvironmental modulation as a realistic path forward for SCI repair.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 1","pages":"e70054"},"PeriodicalIF":8.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12926724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Microbial Diagnostics: Machine Learning and Nanotechnology for Zoonotic Disease Control.","authors":"Narges Lotfalizadeh, Cinzia Santucciu, Valentina Chisu, Helia Sepahvand, Abbas Rahdar, Razieh Behzadmehr, Octavio Luiz Franco, Guettari Moez, Luiz Fernando Romanholo Ferreira","doi":"10.1002/wnan.70050","DOIUrl":"10.1002/wnan.70050","url":null,"abstract":"<p><p>Zoonotic diseases pose significant global health threats, with microbial pathogens, including bacteria, viruses, fungi, and protozoa, responsible for severe outbreaks. The rapid identification and control of zoonotic pathogens remain a major challenge due to their complex transmission dynamics and environmental persistence. Recent advances in molecular microbiology, nanotechnology, and artificial intelligence (AI) have revolutionized diagnostic and therapeutic strategies, enhancing the detection, monitoring, and prevention of diseases caused by pathogens. In machine learning (ML), it is possible to predict outbreaks and classify pathogens with high precision using genomic, proteomics, and epidemiological data, which can be analyzed with machine learning methods. Molecular-level detection is possible with nanotechnology-based biosensors, enabling rapid diagnosis even in areas with limited resources. Machine learning-driven computational models and nanotechnology-based detection tools can drive further advancements in microbial diagnostics, zoonotic disease surveillance, and host-pathogen interactions. Bioinformatics will be discussed along with new trends in microbial resistance and molecular mechanisms underlying pathogen identification in relation to zoonotic spillover events. By combining artificial intelligence with nanoscale biosensors, microbiology can develop more effective diagnostic platforms, real-time surveillance tools, and targeted antimicrobials. The standardization of data, the elimination of biosafety concerns, and the development of regulatory frameworks are all essential steps in advancing this cutting-edge approach to controlling zoonotic disease. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"18 1","pages":"e70050"},"PeriodicalIF":8.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the Power of D-Alpha-Tocopheryl Polyethylene Glycol Succinate-Based Nanoparticles for Targeted Breast Cancer Therapy.","authors":"Zrien Naz, Mohammad Fareed, Niher Tabassum Snigdha, Ameeduzzafar Zafar, Omar Awad Alsaidan, Mohammed Aslam, Karthik Mangu, Kaushik Neogi, Shahnawaz Ahmad, Md Rizwanullah","doi":"10.1002/wnan.70040","DOIUrl":"https://doi.org/10.1002/wnan.70040","url":null,"abstract":"<p><p>Breast cancer (BC) continues to be the most common cancer affecting women globally, posing significant therapeutic challenges due to limited therapeutic efficacy, non-specific drug targeting, systemic toxicity, and the emergence of chemoresistance. These hurdles emphasize the critical need for novel and effective treatment strategies. Nanomedicine has revolutionized cancer therapy, especially D-alpha-tocopheryl polyethylene glycol succinate (TPGS)-based nanoparticles (TPGS-NPs), which have emerged as a promising strategy due to their enhanced therapeutic potential. TPGS, an amphiphilic derivative of Vitamin E, not only enhances the solubility, stability, and bioavailability of lipophilic drugs but also exhibits intrinsic anti-BC properties. The incorporation of TPGS into NPs significantly enhances their physicochemical properties. Further, the engineering of TPGS-NPs with targeting ligands significantly improves their specificity towards cancer cells. Also, TPGS-NPs show great potential to improve photothermal and photodynamic therapies due to their excellent physicochemical properties. Moreover, TPGS-NPs demonstrate an excellent ability for gene (plasmid DNA, siRNA, and miRNA) delivery by enhancing stability and transfection efficiency. This review explores the multifaceted role of TPGS and the role of different TPGS-NPs in circumventing the limitations of conventional chemotherapy in BC treatment. Overall, developing TPGS-NPs offers a versatile and multifaceted approach to achieve better therapeutic outcomes against BC. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.</p>","PeriodicalId":94267,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"17 6","pages":"e70040"},"PeriodicalIF":8.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145461191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}