Plant signaling & behavior最新文献

{"title":"Antifungal and enzymatic activities of endophytic fungi associated with <i>Tamarix nilotica</i>.","authors":"Helal F Al-Harthi","doi":"10.1080/15592324.2024.2439250","DOIUrl":"https://doi.org/10.1080/15592324.2024.2439250","url":null,"abstract":"<p><p>Fungal endophytes were recovered from <i>Tamarix nilotica</i> (Tamaricaceae) roots and stems collected in Taif, Saudi Arabia. A total of 49 different taxa were identified. The overall colonization rate of root and stem segments was 30.6%. A total of 49 isolates were collected and categorized into 21 operational taxonomic units using the rRNA gene's internal transcribed spacer region. The most prevalent species were <i>Penicillium chrysogenum</i> (16 isolates), Fungal sp. (12), and <i>Alternaria alternata</i> (10). Forty-nine isolates were investigated for antifungal activity against <i>Fusarium solani</i> and <i>Rhizoctonia solani</i>; all tested isolates showed antifungal activity against <i>Fusarium solani</i>, while 43 isolates showed antifungal activity against <i>Rhizoctonia solani</i>. The most potent antifungal agents against <i>Fusarium solani</i> and <i>Rhizoctonia solani</i> are <i>Aspergillus ochraceus</i> (2 isolates) and <i>Penicillium chrysogenum</i> (16 isolates). Endophytic isolates collected during this experiment were evaluated to produce amylase, cellulase, lipase, and protease enzymes. Among the strains examined for enzymatic potentials (4 enzymes), 26 strains (53% of the total strains) produce only one enzyme. <i>Penicillium chrysogenum</i> (TUPc2, 3, and 4) produced the highest amount of the four enzymes that were examined.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2439250"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide identification and analysis of the NF-Y transcription factor family reveal its potential roles in tobacco (<i>Nicotiana tabacum</i> L.).","authors":"Zhen Tian, Luyao Xue, Jincun Fu, Wenting Song, Baojian Wang, Jinhao Sun, Xiujiang Yue, Fanrui Cheng, Jingjing Mao, Jiangtao Chao, Dawei Wang, Shaopeng Li","doi":"10.1080/15592324.2025.2451700","DOIUrl":"10.1080/15592324.2025.2451700","url":null,"abstract":"<p><p>Nuclear Factor Y (NF-Y) represents a group of transcription factors commonly present in higher eukaryotes, typically consisting of three subunits: NF-YA, NF-YB, and NF-YC. They play crucial roles in the embryonic development, photosynthesis, flowering, abiotic stress responses, and other essential processes in plants. To better understand the genome-wide NF-Y domain-containing proteins, the protein physicochemical properties, chromosomal localization, synteny, phylogenetic relationships, genomic structure, promoter <i>cis</i>-elements, and protein interaction network of NtNF-Ys in tobacco (<i>Nicotiana tabacum</i> L.) were systematically analyzed. In this study, we identified 58 NtNF-Ys in tobacco, respectively, and divided into three subfamilies corresponding to their phylogenetic relationships. Their tissue specificity and expression pattern analyses for leaf development, drought and saline-alkali stress, and ABA response were carried out using RNA-seq or qRT-PCR. These findings illuminate the role of NtNF-Ys in regulating plant leaf development, drought and saline-alkali stress tolerance, and ABA response. This study offers new insights to enhance our understanding of the roles of NtNF-Ys and identify potential genes involved in leaf development, as well as drought and saline-alkali stress tolerance of plants.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2451700"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants.","authors":"Ugwu Okechukwu Paul-Chima, Anyanwu Chinyere Nkemjika, Ugwu Melvin Nnaemeka, Hope Onohuean","doi":"10.1080/15592324.2025.2486076","DOIUrl":"https://doi.org/10.1080/15592324.2025.2486076","url":null,"abstract":"<p><p>The exploration of plant signaling pathways is transforming the way diabetes is managed, providing new, multi-target strategies for controlling this complex metabolic disorder. Medicinal plants are rich in bioactive compounds like phytohormones, flavonoids and polyphenols, which regulate key pathways including oxidative stress, inflammation, insulin resistance, and gut microbiota modulation. Research is emerging on the therapeutic potential of Momordica charantia, Cinnamomum verum and Trigonella foenum-graecum, which enhance insulin secretion, sensitivity and glucose homeostasis. These plant derived compounds, resveratrol and plant based insulin mimetics, not only address metabolic dysfunction but also offer holistic treatment for long term complications such as neuropathy and retinopathy. The development of precision medicine advances the tailoring of plant based therapies to individual metabolic responses, increasing efficacy and decreasing reliance on synthetic drugs with adverse side effects. Despite challenges of standardization, regulatory barriers, and limited clinical trials, incorporating medicinal plants into national diabetes management guidelines represents a cost effective and accessible option, particularly in resource limited settings. In this review, we highlight the importance of collaborative work across disciplines and the use of technologies such as artificial intelligence to speed research and optimize patient specific applications. The therapeutic power of plant signaling pathways is harnessed to develop sustainable, inclusive, and effective diabetes management strategies.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2486076"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: plant-microbial symbiosis toward sustainable food security.","authors":"Ixchel Campos-Avelar, Amelia C Montoya-Martínez, Fannie I Parra-Cota, Sergio de Los Santos-Villalobos","doi":"10.1080/15592324.2023.2298054","DOIUrl":"10.1080/15592324.2023.2298054","url":null,"abstract":"<p><p>The use of plant-associated microorganisms is increasingly being investigated as a key tool for mitigating the impact of biotic and abiotic threats to crops and facilitating migration to sustainable agricultural practices. The microbiome is responsible for several functions in agroecosystems, such as the transformation of organic matter, nutrient cycling, and plant/pathogen growth regulation. As climate change and global warming are altering the dynamics of plant-microbial interactions in the ecosystem, it has become essential to perform comprehensive studies to decipher current and future microbial interactions, as their useful symbiotic mechanisms could be better exploited to achieve sustainable agriculture. This will allow for the development of effective microbial inoculants that facilitate nutrient supply for the plant at its minimal energy expense, thus increasing its resilience to biotic and abiotic stresses. This article collection aims to compile state-of-the-art research focused on the elucidation and optimization of symbiotic relationships between crops and their associated microbes. The information presented here will contribute to the development of next-generation microbial inoculants for achieving a more sustainable agriculture.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"19 1","pages":"2298054"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139107022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of flowering period on floral traits, pollinator behavior and seed production of David's mountain laurel (<i>Sophora davidii</i>).","authors":"Chengtao Pan, Zhimin Chen, Mao Zhang, Xiangsheng Chen, Guy Smagghe, Mingyu Fan, Zhimin Chang, Lili Zhao, Jiankun Long","doi":"10.1080/15592324.2024.2383823","DOIUrl":"10.1080/15592324.2024.2383823","url":null,"abstract":"<p><p><i>Sophora davidii</i> is a cross-pollinated plant with important ecological protection and medicinal value in China, but its seed yield is low due to backward and nonstandard production technology. Therefore, we divide the flowering period of <i>Sophora davidii</i> into initial, full and final flowering period, measuring the floral morphology, pollen viability, stigma receptivity, nectar volume and nectar concentration, foraging behavior of pollinators, fertilization physiology, seed yield and quality through field observation and indoor testing to explore whether the flowering period affects the floral traits, pollinator behavior and seed production of plants. Our results revealed that the nectar volume, nectar concentration, pollen viability and stigma receptivity at full flowering period were the highest. The single visit time and visit time per flower of Chinese honey bees were the longest in the full flowering period, while the number of transfer, visit frequency and number of touching stigma were the least. The visiting number of the bees was the most and the most active in the full flowering period. The bees pollination not only improved the pollen amount, germination rate, pollen tube length and the ovule number of <i>S. davidii</i>, but also their effect was the most obvious in full flowering period. The principal component analysis showed that pollination by Chinese honey bees during the whole flowering period of <i>S. davidii</i> was the best way to produce seeds. We can conclude that flowering period affects flower traits, foraging behavior of pollinators, seed yield and quality of <i>S. davidii</i>.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"19 1","pages":"2383823"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric oxide and cytokinin cross-talk and their role in plant hypoxia response.","authors":"Felix Lutter, Wolfram Brenner, Franziska Krajinski-Barth, Vajiheh Safavi-Rizi","doi":"10.1080/15592324.2024.2329841","DOIUrl":"10.1080/15592324.2024.2329841","url":null,"abstract":"<p><p>Nitric oxide (NO) and cytokinins (CKs) are known for their crucial contributions to plant development, growth, senescence, and stress response. Despite the importance of both signals in stress responses, their interaction remains largely unexplored. The interplay between NO and CKs emerges as particularly significant not only regarding plant growth and development but also in addressing plant stress response, particularly in the context of extreme weather events leading to yield loss. In this review, we summarize NO and CKs metabolism and signaling. Additionally, we emphasize the crosstalk between NO and CKs, underscoring its potential impact on stress response, with a focus on hypoxia tolerance. Finally, we address the most urgent questions that demand answers and offer recommendations for future research endeavors.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"19 1","pages":"2329841"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly efficient CRISPR/Cas9-RNP mediated <i>CaPAD1</i> editing in protoplasts of three pepper (<i>Capsicum annuum</i> L.) cultivars.","authors":"Hanyi Choi, Hyunjae Shin, Chan Yong Kim, Jeongbin Park, Hyeran Kim","doi":"10.1080/15592324.2024.2383822","DOIUrl":"10.1080/15592324.2024.2383822","url":null,"abstract":"<p><p>Parthenocarpy, characterized by seedless fruit development without pollination or fertilization, offers the advantage of consistent fruit formation, even under challenging conditions such as high temperatures. It can be induced by regulating auxin homeostasis; <i>PAD1</i> (<i>PARENTAL ADVICE-1</i>) is an inducer of parthenocarpy in <i>Solanaceae</i> plants. However, precise editing of <i>PAD1</i> is not well studied in peppers. Here, we report a highly efficient clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) ribonucleoprotein (RNP) for <i>CaPAD1</i> editing in three valuable cultivars of pepper (<i>Capsicum annuum</i> L.): Dempsey, a gene-editable bell pepper; C15, a transformable commercial inbred line; and Younggo 4, a Korean landrace. To achieve the seedless pepper trait under high temperatures caused by unstable climate change, we designed five single guide RNAs (sgRNAs) targeting the <i>CaPAD1</i> gene. We evaluated <i>the in vitro</i> on-target activity of the RNP complexes in three cultivars. Subsequently, we introduced five CRISPR/Cas9-RNP complexes into protoplasts isolated from three pepper leaves and compared indel frequencies and patterns through targeted deep sequencing analyses. We selected two sgRNAs, sgRNA2 and sgRNA5, which had high <i>in vivo</i> target efficiencies for the <i>CaPAD1</i> gene across the three cultivars and were validated as potential off-targets in their genomes. These findings are expected to be valuable tools for developing new seedless pepper cultivars through precise molecular breeding of recalcitrant crops in response to climate change.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"19 1","pages":"2383822"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11275519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cloning and functional validation of <i>DsWRKY6</i> gene from <i>Desmodium styracifolium</i>.","authors":"Qilin Yang, Jinheng Huang, Xiaofeng Nie, XiaoMin Tang, Peiran Liao, Quan Yang","doi":"10.1080/15592324.2024.2349868","DOIUrl":"10.1080/15592324.2024.2349868","url":null,"abstract":"<p><p>The purpose of this study was to analyze the role of transcription factor in <i>Desmodium styracifolium</i>, proving that the <i>DsWRKY6</i> transcription factor was related to the plant phenotypes of <i>Desmodium styracifolium</i> - cv. 'GuangYaoDa1' and it could be used in molecular-assisted breeding. 'GuangYaoDa1' was used as the material and its DNA was the template to clone DsWRKY6, the transgenic <i>Arabidopsis thaliana</i> line was constructed by agrobacterium tumefaciens‑mediated transformation. Transgenic <i>Arabidopsis thaliana</i> was cultivated to study phenotype and physiological and biochemical indexes. Phenotypic observation showed that <i>DsWRKY6</i> transgenic <i>Arabidopsis thaliana</i> had a faster growth rate while compared with the control group, they had longer lengths of main stem, lateral branches of cauline leaves, and root, but a lower number of cauline leaves and lateral branches of cauline leaves. And it also showed that their flowering and fruiting periods were advanced. The results of physiological and biochemical indexes showed that the relative expressions of <i>DsWRKY6</i> increased and the abscisic acid content significantly increased in <i>DsWRKY6</i> transgenic <i>Arabidopsis thaliana</i> compared with the control group. According to the above results, <i>DsWRKY6</i> could regulate the advancing of flowering and fruiting periods caused by the improvement of abscisic acid content, and expression of the <i>DsWRKY6</i> transcription factor might be the cause of the upright growth of 'GuangYaoDa1'.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"19 1","pages":"2349868"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140924162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drought-induced molecular changes in crown of various barley phytohormone mutants.","authors":"Anetta Kuczyńska, Martyna Michałek, Piotr Ogrodowicz, Michał Kempa, Natalia Witaszak, Michał Dziurka, Damian Gruszka, Agata Daszkowska-Golec, Iwona Szarejko, Paweł Krajewski, Krzysztof Mikołajczak","doi":"10.1080/15592324.2024.2371693","DOIUrl":"10.1080/15592324.2024.2371693","url":null,"abstract":"<p><p>One of the main signal transduction pathways that modulate plant growth and stress responses, including drought, is the action of phytohormones. Recent advances in omics approaches have facilitated the exploration of plant genomes. However, the molecular mechanisms underlying the response in the crown of barley, which plays an essential role in plant performance under stress conditions and regeneration after stress treatment, remain largely unclear. The objective of the present study was the elucidation of drought-induced molecular reactions in the crowns of different barley phytohormone mutants. We verified the hypothesis that defects of gibberellins, brassinosteroids, and strigolactones action affect the transcriptomic, proteomic, and hormonal response of barley crown to the transitory drought influencing plant development under stress. Moreover, we assumed that due to the strong connection between strigolactones and branching the <i>hvdwarf14.d</i> mutant, with dysfunctional receptor of strigolactones, manifests the most abundant alternations in crowns and phenotype under drought. Finally, we expected to identify components underlying the core response to drought which are independent of the genetic background. Large-scale analyses were conducted using gibberellins-biosynthesis, brassinosteroids-signaling, and strigolactones-signaling mutants, as well as reference genotypes. Detailed phenotypic evaluation was also conducted. The obtained results clearly demonstrated that hormonal disorders caused by mutations in the <i>HvGA20ox2</i>, <i>HvBRI1</i>, and <i>HvD14</i> genes affected the multifaceted reaction of crowns to drought, although the expression of these genes was not induced by stress. The study further detected not only genes and proteins that were involved in the drought response and reacted specifically in mutants compared to the reaction of reference genotypes and <i>vice versa</i>, but also the candidates that may underlie the genotype-universal stress response. Furthermore, candidate genes involved in phytohormonal interactions during the drought response were identified. We also found that the interplay between hormones, especially gibberellins and auxins, as well as strigolactones and cytokinins may be associated with the regulation of branching in crowns exposed to drought. Overall, the present study provides novel insights into the molecular drought-induced responses that occur in barley crowns.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"19 1","pages":"2371693"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide identification of <i>YABBY</i> gene family and its expression pattern analysis in <i>Astragalus mongholicus</i>.","authors":"Jiamei Wang, Zhen Wang, Panpan Wang, Jianhao Wu, Lingyang Kong, Lengleng Ma, Shan Jiang, Weichao Ren, Weili Liu, Yanli Guo, Wei Ma, Xiubo Liu","doi":"10.1080/15592324.2024.2355740","DOIUrl":"10.1080/15592324.2024.2355740","url":null,"abstract":"<p><p>During plant growth and development, the <i>YABBY</i> gene plays a crucial role in the morphological structure, hormone signaling, stress resistance, crop breeding, and agricultural production of plant lateral organs, leaves, flowers, and fruits. <i>Astragalus mongholicus</i> is a perennial herbaceous plant in the legume family, widely used worldwide due to its high medicinal and edible value. However, there have been no reports of the <i>YABBY</i> gene family in <i>A. mongholicus</i>. This study used bioinformatics methods, combined with databases and analysis websites, to systematically analyze the <i>AmYABBY</i> gene family in the entire genome of <i>A. mongholicus</i> and verified its expression patterns in different tissues of <i>A. mongholicus</i> through transcriptome data and qRT-PCR experiments. A total of seven <i>AmYABBY</i> genes were identified, which can be divided into five subfamilies and distributed on three chromosomes. Two pairs of <i>AmYABBY</i> genes may be involved in fragment duplication on three chromosomes. All AmYABBY proteins have a zinc finger YABBY domain, and members of the same group have similar motif composition and intron - exon structure. In the promoter region of the genes, light-responsive and MeJa-response <i>cis</i>-elements are dominant. <i>AmYABBY</i> is highly expressed in stems and leaves, especially <i>AmYABBY1</i>, <i>AmYABBY2</i>, and <i>AmYABBY3</i>, which play important roles in the growth and development of stems and leaves. The <i>AmYABBY</i> gene family regulates the growth and development of <i>A. mongholicus</i>. In summary, this study provides a theoretical basis for in-depth research on the function of the <i>AmYABBY</i> gene and new insights into the molecular response mechanism of the growth and development of the traditional Chinese medicine <i>A. mongholicus</i>.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"19 1","pages":"2355740"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11123558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}