Photobiomodulation, photomedicine, and laser surgery最新文献

{"title":"A Combinatorial Strategy for Peripheral Nerve Repair Utilizing 3D-Printed Collagen Nerve Guidance Conduits and Photobiomodulation Therapy: A Pilot Study in a Rat Sciatic Nerve Transection Model.","authors":"Christopher R Fellin, Richard C Steiner, Jack T Buchen, Juanita J Anders, Xiaoning Yuan, Shailly H Jariwala","doi":"10.1177/25785478251414510","DOIUrl":"10.1177/25785478251414510","url":null,"abstract":"<p><strong>Background: </strong>Nerve guidance conduits (NGCs) are a clinically approved option for peripheral nerve repair but remain ineffective compared with autograft \"gold standard\" treatment options. A combinatorial approach to conduit-based peripheral nerve repair could improve repair outcomes. Photobiomodulation therapy (PBMT) has shown potential to enhance axonal regeneration, but its efficacy in combination with NGCs requires further evaluation.</p><p><strong>Objective: </strong>This pilot study investigated the therapeutic potential of a novel 3D-printed, collagen-based NGC combined with PBMT for peripheral nerve regeneration in a 10 mm rat sciatic nerve injury model.</p><p><strong>Materials and methods: </strong>A total of 36 male, 3-month-old, Sprague-Dawley rats were used in a pre-clinical rat model of peripheral neurotmesis and randomly assigned to one of three groups (<i>N</i> = 12 each): Autograft (control), NGC-PBMT (experimental), and NGC + PBMT (experimental). All groups were further subdivided (<i>N</i> = 6) by recovery period (3 or 6 weeks). Collagen-based NGCs were fabricated via DLP 3D printing and implanted into rats with 10 mm sciatic nerve transections. PBMT treatment was applied transcutaneously every other day at 980 nm for 30 s at 1 W. Gross examination, immunohistochemistry, and immunofluorescence were used to assess biocompatibility, vascularization, and nerve regeneration at 3- and 6-weeks post-surgery.</p><p><strong>Results: </strong>Gross examination revealed no sign of inflammation or immune rejection, with significant neovascularization observed throughout the NGCs. Immunostaining demonstrated nerve regeneration in all groups, with progressive axonal growth from week 3 to 6 in the NGC-PBMT group. However, neither experimental group achieved regeneration comparable to the autograft control. PBMT did not yield significant improvement in regenerative outcomes under the tested parameters.</p><p><strong>Conclusions: </strong>Altogether, this study provides encouraging preliminary evidence that these novel, 3D-printed NGCs are biocompatible and promote early nerve regeneration after peripheral neurotmesis. While PBMT did not enhance outcomes in this study, further work is needed to optimize light delivery parameters and improve conduit design for enhanced neuroregeneration.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"168-176"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Erbium-Doped Yttrium Aluminum Garnet Laser Irradiation on the Proliferation and Alteration of Gene Expression in MLO-Y4 Osteocyte-like Cells.","authors":"Peiya Lin, Yosuke Tsuchiya, Sayaka Katagiri, Yujin Ohsugi, Keita Toyoshima, Tomomitsu Hirota, Hiromi Niimi, Tsuyoshi Shimohira, Takanori Iwata, Akira Aoki","doi":"10.1177/25785478251389400","DOIUrl":"10.1177/25785478251389400","url":null,"abstract":"<p><strong>Objective: </strong>To determine how Erbium-doped yttrium aluminum garnet (Er:YAG) laser irradiation affects the proliferation and transcriptional programs of MLO-Y4 osteocyte-like cells.</p><p><strong>Background: </strong>Although Er:YAG lasers are widely used in periodontal hard tissue therapy, how they affect osteocytes remain elusive.</p><p><strong>Materials and methods: </strong>MLO-Y4 cells were seeded before 72 h Er:YAG laser irradiation at energy fluences of 3.1, 6.0, and 8.9 J/cm². Cell surface temperature and <i>Hspa1a</i> expression were measured to evaluate thermal effects. Cell proliferation and cytotoxicity were assessed by the Cell Counting Kit-8 (CCK-8) and lactate dehydrogenase (LDH) assays. RNA sequencing (RNA-seq) was performed 6 h after 6.0 J/cm² laser irradiation versus nonirradiated controls.</p><p><strong>Results: </strong>According to surface temperature and <i>Hspa1a</i> expression, no major thermal effects were observed at 6.0 J/cm². The CCK-8 assay revealed significantly increased proliferative activity, although LDH levels were slightly but significantly increased at 6.0 J/cm² laser irradiation. RNA-seq identified 337 differentially expressed genes (DEGs). Expression of mechanical stimulation-associated genes, including <i>Epha2</i>, <i>Itga5</i>, and <i>Tcf7</i>, was highly upregulated in the laser-irradiated cells. Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed upregulation of the PI3K-Akt signaling pathway in the laser-irradiated cells. Upregulated DEGs belonged to the \"euchromatin\" cellular component Gene Ontology term in the laser-irradiated cells. Gene set enrichment analysis showed enrichment of the Transforming Growth Factor Beta (TGF-β) signaling gene set and downregulation of mechanistic target of rapamycin (mTORC1) signaling gene set in the laser-irradiated cells.</p><p><strong>Conclusion: </strong>Er:YAG laser irradiation at 6.0 J/cm² promotes MLO-Y4 osteocyte-like cell proliferation via altering gene expression, possibly by activating PI3K-Akt and TGF-β signaling while suppressing mTORC1 signaling.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"119-130"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Photobiomodulation Therapy on the Acupuncture Points on Pain, Maximum Mouth Opening, and Quality of Life in Patients with Temporomandibular Joint Disorders: A Double-Blinded Randomized Clinical Trial.","authors":"Maryam Shirnasab, Nahid Karbasi, Mohaddeseh Davari, Rasool Bagheri, Raheb Ghorbani, Parisa Sabbaghian, Fatemeh Sohrabpoor","doi":"10.1177/25785478251385389","DOIUrl":"10.1177/25785478251385389","url":null,"abstract":"<p><strong>Objective: </strong>Temporomandibular joint disorders (TMDs) are multi-factorial conditions with a chronic progression that affects individual's quality of life (QOL).</p><p><strong>Background: </strong>Currently, there is no definitive treatment for TMDs. Few clinical trials have investigated the potential effects of Photobiomodulation therapy on the acupuncture points on these disorders.</p><p><strong>Methods: </strong>Twenty patients with TMD, referred to the facial pain clinic at Semnan Faculty of Dentistry, were randomly assigned into two groups: treatment (<i>n</i> = 10) and placebo (<i>n</i> = 10). Treatment group received low-power Photobiomodulation therapy for 3 min at each of 10 acupuncture points, including GB20, SI19, ST6, ST7, and LI4. The placebo group received only the guiding light of the device on the same points. Treatment consisted of 10 sessions (twice a week). QOL was assessed using the OHIP-14 and SF-36 questionnaires at the beginning and end of treatment.</p><p><strong>Result: </strong>Significant differences were observed between the treatment and placebo groups according to pain relief and maximum mouth opening (<i>p</i> < 0.05; Mann-Whitney). However, no significant difference was observed between the groups for the QOL using OHIP-14. In contrast, the SF-36 showed significant improvements in the physical health subscale in the treatment group.</p><p><strong>Conclusions: </strong>Photobiomodulation therapy on the acupuncture is a complementary, noninvasive therapy that may benefit patients with TMDs.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"88-93"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy of 308 nm Excimer Light and Red Light for Refractory Vitiligo: A Case Report.","authors":"Wenting Hu, Miaoni Zhou, Anqi Sheng, Rong Jin, Qimin Fan, Ai-E Xu","doi":"10.1177/25785478251405610","DOIUrl":"10.1177/25785478251405610","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is a chronic autoimmune skin disorder characterized by depigmented macules and patches due to melanocyte destruction. Traditional therapies include topical corticosteroids, calcineurin inhibitors, phototherapy, and systemic immunomodulators.</p><p><strong>Objective: </strong>There is growing interest in alternative and adjunctive light-based therapies, such as 308 nm excimer light and red light, for promoting repigmentation and modulating the immune response.</p><p><strong>Methods: </strong>We report the case of a 37-year-old male patient with non-segmental vitiligo, affecting the arm and hands, who demonstrated significant repigmentation following treatment with 308 nm excimer light and 635 nm red light therapy.</p><p><strong>Results: </strong>The patient had a 3-year history of vitiligo and had previously been unresponsive to topical treatment and 308 nm excimer light monotherapy. However, with the combination of 308 nm excimer light and red light, gradual repigmentation was observed over 3 months. The patient tolerated the therapy well with no adverse effects.</p><p><strong>Conclusion: </strong>This case suggests that the combination of 308 nm excimer light and red light therapy may offer a promising treatment option for vitiligo.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"131-133"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swept-Source OCT and OCT Angiography Biomarkers in Dry AMD Treated with Photobiomodulation: A Prospective Study.","authors":"Marcussi Palata Rezende, Fernanda Atoui Faria, Julia Polido, Rubens Belfort, Thiago Cabral","doi":"10.1177/25785478251385768","DOIUrl":"10.1177/25785478251385768","url":null,"abstract":"<p><strong>Background: </strong>Photobiomodulation Valeda (PBM-Valeda) is a novel therapeutic approach for dry age-related macular degeneration (AMD). The primary objective of this short-term study was to conduct an analysis of best-corrected visual acuity (BCVA) and evaluate of biomarkers using state-of-the-art high-resolution imaging with swept-source optical coherence tomography OCT (SS-OCT) and OCT angiography (SS-OCTA) in dry AMD patients treated with PBM.</p><p><strong>Materials and methods: </strong>This prospective, noncomparative, interventional case series pilot study examined the following biomarkers before and after PBM treatment: BCVA, central macular thickness (CMT), subfoveal choroidal thickness (SCT), capillary density (CD), avascular area of the superficial plexus (AASP), and avascular area of the deep plexus (AADP). All parameters were assessed at baseline and 1 week after treatment. A questionnaire (exploratory, not a validated endpoint) was carried out at the end of the treatment.</p><p><strong>Results: </strong>The study included 25 eyes (19 patients), predominantly in the Age-Related Eye Disease Study category II. A statistically significant change in BCVA was observed (<i>p</i> = 0.001). No statistically significant changes were observed in CMT, SCT, CD, AASP, or AADP (<i>p</i> > 0.05). The treatment was well tolerated, with few mild side effects, and no patient developed wet AMD.</p><p><strong>Conclusion: </strong>PBM-Valeda therapy demonstrated a favorable short-term safety profile in patients with dry AMD. The key finding of this study was the stability of SS-OCT and SS-OCTA biomarkers (CMT, SCT, CD, AASP, and AADP), with no adverse changes observed. These results reinforce the short-term safety of PBM. Reported side effects were minimal, with no evidence of retinotoxicity. This is the first prospective study to explore SS-OCT and SS-OCTA biomarkers in patients with dry AMD undergoing PBM therapy, providing preliminary safety data for future controlled trials.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"78-87"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Nanosecond Pulsed Nd:YAG Laser-Induced Cavitation Bubbles in Different Endodontic Irrigants with Far-Field Focused Irradiation.","authors":"Yuhao Bai, Runjie Wei","doi":"10.1177/25785478251409030","DOIUrl":"10.1177/25785478251409030","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the characteristics of laser-induced cavitation bubbles in different endodontic irrigants using a nanosecond neodymium-doped yttrium aluminum garnet (Nd:YAG) laser with far-field focused irradiation.</p><p><strong>Background: </strong>The nanosecond pulsed Nd:YAG laser is known to generate cavitation bubbles in water through laser-induced optical breakdown; however, its effects on different endodontic irrigating solutions remain unclear.</p><p><strong>Methods: </strong>A Q-switched Nd:YAG laser was used to evaluate eight endodontic irrigants, including distilled water, normal saline (0.9% NaCl), 17% ethylene diamine tetraacetic acid (EDTA), 2% chlorhexidine (CHX), and various sodium hypochlorite (NaOCl) solutions (0.5%, 1.0%, 3.0%, 5.25%). High-speed photography captured plasma and cavitation bubbles at 50 mJ/pulse and 30 mJ/pulse energy levels. The images of 10 consecutive bubbles were analyzed to assess bubble dynamics parameters, including diameter, area, duration, expansion velocity, and time to reach maximum dimensions. These parameters were statistically evaluated using the Kruskal-Wallis H test and Mann-Whitney <i>U</i> test.</p><p><strong>Results: </strong>Plasma generation occurred at both energy levels across all eight irrigants. The largest bubble diameter (4.83 mm) was recorded in 17% EDTA at 50 mJ/pulse, and the smallest (3.66 mm) was recorded in 0.5% NaOCl at 30 mJ/pulse. The highest bubble expansion velocity (19.31 mm/ms) was recorded in distilled water at 50 mJ/pulse, and the lowest (16.17 mm/ms) was recorded in 5.25% NaOCl at 50 mJ/pulse. The time to reach maximum bubble dimensions ranged from 0.17 ms to 0.24 ms.</p><p><strong>Conclusions: </strong>The nanosecond-pulsed Nd:YAG laser exhibited the ability to induce plasma formation and cavitation bubbles within the eight evaluated endodontic irrigants. This development establishes a fundamental basis for prospective applications in endodontic irrigation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"44 2","pages":"109-118"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation Therapy as Adjunct to Scaling and Root Planing for Patients with Type 2 Diabetes Mellitus Complicated by Chronic Periodontitis: A Systematic Review and Meta-Analysis.","authors":"Mingkang Gong","doi":"10.1177/25785478251406000","DOIUrl":"10.1177/25785478251406000","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) and chronic periodontitis (CP) have a bidirectional association; scaling and root planing (SRP) alone has limited efficacy in their comorbidity, with controversial photobiomodulation therapy (PBMT) adjunctive efficacy.</p><p><strong>Objective: </strong>To quantify PBMT + SRP's effects on periodontal [probing depth (PD), clinical attachment level (CAL)], glycemic [fasting plasma glucose (FPG), glycated hemoglobin (HbA1c)], and inflammatory [high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α)] indices in patients with T2DM + CP and explore heterogeneity (PBMT parameters, study region) for clinical optimization.</p><p><strong>Methods: </strong>Following PRISMA 2020, we searched six databases (PubMed, Cochrane Library, etc.) from inception to August 24, 2025, for PBMT-adjuvanted SRP randomized controlled trials (RCTs). Bias was assessed via RoB 2.0, meta-analysis via RevMan 5.4, with preset subgroup analyses.</p><p><strong>Results: </strong>Six RCTs (<i>n</i> = 319) were included. At 3 months of follow-up, PBMT + SRP significantly improved key periodontal indices (PD: MD = -0.87 mm, 95% CI: [-1.00, -0.74]; CAL: MD = -0.47 mm, 95% CI: [-0.65, -0.29]; both <i>p</i> < 0.00001), glycemic control (FPG: MD = -0.79 mmol/L, 95% CI: [-1.41, -0.17], <i>p</i> = 0.01), and systemic inflammation (hs-CRP: MD = -0.99 mg/L, 95% CI: [-1.12, -0.86]; TNF-α: MD = -2.78 pg/mL, 95% CI: [-3.17, -2.39]; both <i>p</i> < 0.00001) versus SRP alone. HbA1c showed borderline significant reduction (MD = -0.81%, 95% CI: = [-1.62, -0.01], <i>p</i> = 0.05). Subgroup analyses suggested 808/810 nm + 0.8-1.5 W as potentially optimal PBMT parameters, though high-power efficacy relied on one small-sample study (<i>n</i> = 40). Notable limitations included high inter-study heterogeneity (most <i>I</i>² > 90%) and maximum 6-month follow-up.</p><p><strong>Conclusions: </strong>PBMT adjunctive to SRP significantly improves periodontal indices (PD, CAL), FPG, and hs-CRP in patients with T2DM and CP, with borderline HbA1c reduction and good safety. Subgroup analyses identify 808/810 nm + 0.8-1.5 W as potentially optimal PBMT parameters, though high-power efficacy relies on one small-sample study. Given high inter-study heterogeneity (most <i>I</i>² > 90%) and short follow-up (maximum 6 months), conclusions require validation by standardized, large-sample, long-term, high-quality RCTs.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"61-77"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense Pulsed Light for Perennial Allergic Conjunctivitis: A Prospective Interventional Study with Untargeted Tear Metabolomics.","authors":"Qiu Yan, Dan Li","doi":"10.1177/25785478251411050","DOIUrl":"10.1177/25785478251411050","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of an intense pulsed light (IPL)-augmented regimen for moderate-to-severe perennial allergic conjunctivitis (PAC) and to elucidate its potential mechanisms through tear inflammatory factor profiling and untargeted metabolomics.</p><p><strong>Methods: </strong>In this prospective, single-arm, interventional study, 18 patients underwent two IPL sessions at two-week intervals. Outcomes included symptom visual analog scale (VAS) scores and sign scores, bulbar redness index (BRI), tear breakup time (TBUT), and tear inflammatory factors, including immunoglobulin E (IgE), matrix metalloproteinase-9 (MMP-9), and lymphotoxin-alpha (LTA). Untargeted metabolomics of tear fluid was performed using LC-MS/MS to identify differential metabolites and pathways.</p><p><strong>Results: </strong>Symptom VAS [median difference: -25.0 (95% CI: -31.0, -21.0); <i>p</i> < 0.01] and sign [-4.0 (-6.0, -4.0); <i>p</i> < 0.01] scores improved significantly, with 79.4% symptom reduction, a shift from frequent to occasional itching, and large effect sizes (Cohen's d: 2.18 symptoms, 2.70 signs). TBUT and BRI showed no significant changes. Tear IgE and MMP-9 tended to decrease and LTA to increase (nonsignificant). MMP-9 positively correlated with posttreatment BRI (<i>r</i> = 0.570, <i>p</i> < 0.05), while LTA negatively correlated with baseline BRI (<i>r</i> = -0.573, <i>p</i> < 0.05). Untargeted metabolomics identified 65 differential metabolites: purine-related compounds (e.g., adenine, guanine) and stearic acid were downregulated; oleic acid, 9-OxoODE, etc., were upregulated. Purine metabolism was significantly altered (Raw <i>p</i> = 0.0013, false discovery rate [FDR] = 0.104), while unsaturated fatty acid biosynthesis changes were not significant (Raw <i>p</i> = 0.49, FDR = 1). No serious adverse events occurred.</p><p><strong>Conclusion: </strong>An IPL-augmented regimen may alleviate moderate-to-severe PAC, which is consistent with the modulation of purine and unsaturated fatty acid metabolism. This modulation is characterized by suppressed purine activity and proinflammatory lipids while enhancing anti-inflammatory and antioxidant unsaturated fatty acids. These changes collectively dampen inflammation and promote immune homeostasis.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"44 2","pages":"94-108"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic Shock Waves Associated with Lasers to Accelerate Tattoo Removal Procedures: A Real-World Study.","authors":"Giuseppe Scarcella","doi":"10.1177/25785478251398320","DOIUrl":"10.1177/25785478251398320","url":null,"abstract":"<p><strong>Background: </strong>The combination of lasers and acoustic shock waves has shown promising results in accelerating tattoo removal.</p><p><strong>Objective: </strong>To assess the effectiveness of treatments combining lasers and shock waves regarding the number of sessions required for successful tattoo removal.</p><p><strong>Methods: </strong>A prospective, observational, real-world, single-center study including adults (>18 years) with ≥one professional tattoo of any color on any body part, excluding the head, partially removed or not. Devices were the QS laser RevLite® SI (Cynosure Lutronic, USA), the picosecond laser PicoWay® (Candela, USA), the CO₂ laser DUOGlide® with a SCAR 3 scanner (DEKA M.E.L.A. srl, Italy), and the GENTLE Pro® shock waves system (Zimmer MedizinSysteme GmbH, Germany). Treatment protocols consisted of QS/picosecond laser passes alternated with shock wave passes (three each) (classic protocol) and one QS/picosecond laser and one shock wave pass, a QS/picosecond second laser pass, and a final fractional CO₂ laser pass (reinforced protocol). Sessions were performed at two-month intervals.</p><p><strong>Results: </strong>We included 22 patients (68.2% women and 68.2% Fitzpatrick phototype III) with a mean (range) age of 42 (22-68) years and 25 tattoos in total. Most tattoos were black (92.0%) and were removed using the picosecond laser (80.0%) and following the classic (40.0%) and the reinforced (60.0%) protocols in a total of 66 treatment sessions. In 22 tattoos undergoing more than one session, results were good or excellent in 68.2% of them after 2-4 sessions, with no adverse effects.</p><p><strong>Conclusion: </strong>Acoustic shock wave therapy constitutes a safe adjuvant treatment to accelerate laser-based tattoo removal.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"48-54"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear-Film Stability After Upper Blepharoplasty with Fractional CO₂ Laser: A Retrospective 5-Month Series.","authors":"Juliana de Filippi Sartori, Irene Fusco, Tammy Hentona Osaki, Tiziano Zingoni, Midori Hentona Osaki, Rodrigo Barbosa de Souza, Jose Alvaro Pereira Gomes, Norma Allemann","doi":"10.1177/25785478251404840","DOIUrl":"10.1177/25785478251404840","url":null,"abstract":"<p><strong>Background: </strong>Blepharoplasty rectifies functional and aesthetic problems of the periorbital area.</p><p><strong>Objective: </strong>This study tests the effectiveness of a combined procedure of blepharoplasty and fractional ablative CO_2, resurfacing on a total of 16 patients diagnosed with dermatochalasis and surgical indication for upper blepharoplasty.</p><p><strong>Methods: </strong>Patients underwent a combined procedure of blepharoplasty and fractional ablative CO₂ resurfacing. The examinations performed were: measurement of the height of the lacrimal meniscus, tear break-up time (FBUT), Schirmer test and Ocular Surface Disease Index questionnaire.</p><p><strong>Results: </strong>All values returned to baseline 150 days (5 months) from surgery with improvement of the FBUT value. No significant change or worsening in values was observed after laser application and periorbital blepharoplasty.</p><p><strong>Conclusions: </strong>The application of fractional CO₂ laser and blepharoplasty could lead to both psychological and social improvement in patients, reducing the potential risks that can lead to dry eye syndrome.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"55-58"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}