Photobiomodulation, photomedicine, and laser surgery最新文献

{"title":"Photobiomodulation Promotes Motor Recovery Following Decompressive Craniectomy for Traumatic Brain Injury.","authors":"Daniel C Bartelt, Steffen G Osborn, Levi P Sowers, Alexander Bassuk, Matthew A Howard, Brian T Andrews, Terry C Yin","doi":"10.1089/photob.2025.0021","DOIUrl":"https://doi.org/10.1089/photob.2025.0021","url":null,"abstract":"<p><p><b><i>Background:</i></b> Photobiomodulation (PBM), a noninvasive therapy using red and near-infrared light, has shown promising benefits in neuropathology. However, the transmission of PBM to the central nervous system through the scalp's soft tissues and skull is unknown. We hypothesize that decompressive craniectomy (DC) for moderate-to-severe traumatic brain injury (TBI) improves PBM penetrance and enhances neurorehabilitation. <b><i>Method:</i></b> Adult male and female Long-Evans rats were utilized to evaluate PBM tissue penetrance and its efficacy on motor deficit recovery following TBI and DC. TBI was induced using a hit-and-run closed-head model, which replicates clinical closed-head trauma. PBM transmittance was measured ex vivo using rat scalp soft tissue and hemicranium samples, with optical power and energy meter readings to quantify penetrance. Functional motor recovery was assessed using a beam walk test to quantify limb deficits defined by forelimb and hindlimb slips. <b><i>Results:</i></b> Analysis demonstrated attenuation of 660 nm and 850 nm PBM intensity during transcranial transmission, with scalp skin and cranial bone reducing irradiance from 70.5 mW/cm² to 3.96 mW/cm² for 660 nm PBM and from 82 mW/cm² to 4.96 mW/cm² for 850 nm PBM. Beam walk testing revealed significantly fewer hindlimb slips in PBM-treated rats (660 nm: 1.54, 850 nm: 1.86) compared with untreated TBI controls (4.3 slips), suggesting improved motor recovery. <b><i>Conclusion:</i></b> Our study indicates that both PBM are attenuated by both scalp soft tissues and the hemicranium, yet both penetrate sufficiently following DC for moderate-to-severe TBI. Our findings suggest that PBM enhances neurorehabilitation outcomes with improved motor recovery in rats with TBI.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Level Laser Facilitating Proliferation, Migration, and Reactive Oxygen Species Production in L929 Mouse Fibroblasts.","authors":"Aoteng Sun, Mingyu Xue, Xiujuan Sun, Yudu Yu, Ting Guo, Ying Zhang","doi":"10.1089/photob.2025.0018","DOIUrl":"https://doi.org/10.1089/photob.2025.0018","url":null,"abstract":"<p><p><b><i>Background:</i></b> Photobiomodulation therapy has been widely used in various branches of regenerative medicine because it has the advantages of noninvasive, drug-free, and safe form of light therapy. However, the complexity of the parameters of low-level laser (LLL) hinders its wider clinical application. <b><i>Materials and Methods:</i></b> Mouse fibroblasts (L929) were cultured in vitro using an 810-nm diode laser with low-level mode (E1C 0.1 W, continuous; E1R 0.1 W, intermittent; E2C 0.5 W, continuous; E2R 0.5 W, intermittent). Cell migration ability was detected by in vitro scratch test. Cell proliferation ability was detected by cell counting kit-8 (CCK-8) assay. Reactive oxygen species (ROS) fluorescence intensity was detected by an inverted fluorescence microscope. Production of ROS was detected by flow cytometry. <b><i>Results:</i></b> Scratch results show that E1C and E2R significantly increased the cell migration rate compared with the E0 group (<i>p</i> < 0.001). E1R also enhanced cell migration (<i>p</i> < 0.01). CCK-8 results show that the increase in the optical density of E1R, E1C, and E2R was higher than that of E0 (<i>p</i> < 0.001). The E2C group did not facilitate cell proliferation. The results of ROS fluorescence analysis and flow cytometry analysis showed that the ROS produced by L929 cells irradiated with different modes of LLL were different. The ROS production of E2C cells was the highest, followed by E2R, E1C, and E1R, and the E0 group was the lowest, with a significant difference (<i>p</i> < 0.01). <b><i>Conclusions:</i></b> An 810-nm diode laser of 0.1 W with continuous pulse mode and 2 cm away from the wound can maintain the appropriate level of ROS, as well as effectively promote cell proliferation and migration.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Trial Comparing Three Wavelengths in Photobiomodulation Therapy for Hair Loss.","authors":"Yi-Fan Wang, Yu-Chiao Chen","doi":"10.1089/photob.2025.0020","DOIUrl":"10.1089/photob.2025.0020","url":null,"abstract":"<p><p><b><i>Background:</i></b> Commercial lasers and light combs have limitations such as restricted wavelengths, inconsistent energy delivery, and variable results. While photobiomodulation therapy (PBMT) at 650 nm has been extensively studied for hair growth, research on PBMT at 1550 nm and 14,000 nm (far infrared radiation, FIR) remains limited. <b><i>Objective:</i></b> This study aims to evaluate and compare the effectiveness of PBMT, including 650 nm, 1550 nm, and 14,000 nm, in promoting hair growth and improving scalp health. <b><i>Method:</i></b> A controlled study with 68 participants (18-60 years old) assigned them to either PBMT 650 nm, 1550 nm, 14,000 nm, or a control group. Treatment lasts 3 months, with maintenance treatments every 4-6 weeks for up to 9 months. Hair density, scalp condition, and loss were assessed at baseline 3, 6, and 9 months. <b><i>Results:</i></b> PBMT at 650 nm, 1550 nm, and 14,000 all improved hair growth over 9 months. Hair density increased in the PBMT groups (100→114 hairs/cm², 99→115 hairs/cm², and 101→107 hairs/cm²), while the control group declined (100→98 hairs/cm²). Among the 68 participants, 42 had oily scalps initially. This condition improved in all treatment groups, with oily scalp cases nearly halved in each treatment group. <b><i>Conclusion:</i></b> PBMT (650 nm, 1550 nm, and 14,000 nm) effectively promotes hair growth and reduces hair loss. Further research is needed to refine protocols, explore combinations, and extend follow-up periods.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"288-293"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Fractional Carbon Dioxide Laser and Fractional Microneedle Radiofrequency Treatment for Rhinophyma: A Case Report.","authors":"Gökçe Işıl Kurmuş, Erol Koç","doi":"10.1089/photob.2025.0023","DOIUrl":"10.1089/photob.2025.0023","url":null,"abstract":"<p><p><b><i>Background:</i></b> Rhinophyma, an advanced form of rosacea, primarily affects older men and is characterized by nasal hypertrophy and irregular surface texture. Traditional treatments include pharmacologic interventions and various surgical techniques. <b><i>Objective:</i></b> To present the clinical outcome of a novel combined treatment using fractional carbon dioxide laser (FCL) and fractional microneedle radiofrequency (FmRF) in a patient with rhinophyma. <b><i>Methods:</i></b> A 62-year-old male with prominent nasal seborrhea, hypertrophy, and surface irregularities underwent combined treatment with FCL and FmRF. The treatment sessions were performed under topical anesthesia with post-procedure care including emollients and sun protection. <b><i>Results:</i></b> The patient experienced marked cosmetic improvement, including reduced nasal bulk and smoother surface texture, without adverse events such as scarring or pigmentary alteration. The recovery period was short, and patient satisfaction was high. <b><i>Conclusions:</i></b> This case represents the first report of combining FCL and FmRF for the treatment of rhinophyma. The favorable clinical and cosmetic outcome suggests this method may be a promising alternative to conventional surgical approaches. Further studies are needed to validate its efficacy and safety in broader populations.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"320-322"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride-Activated Via Er:YAG, Diode, and Femtosecond Lasers for Reversing Bleached Enamel for Improved Orthodontic Bonding.","authors":"Muhammad Abdullah Kamran, Abdullah Mohammed Asiri, Ayman Mousa A Alfaifi, Atheer Hadi A Almukawwi, Joharah Mughaddi Alwadai, Saeed J Alqahtani","doi":"10.1089/photob.2025.0024","DOIUrl":"10.1089/photob.2025.0024","url":null,"abstract":"<p><p><b><i>Aim:</i></b> This investigation aimed to assess the efficacy of reversal methods on bleached enamel via fluoride-activated Er:YAG, diode, femtosecond laser, focusing on Vickers hardness (VH), shear bond strength (SBS), calcium (Ca⁺⁺)/phosphorus (P) ratio, and the interface between brackets and enamel. <b><i>Materials and Methods:</i></b> A total of 112 human maxillary premolars with intact enamel, which had been extracted, were included. About 96 specimens underwent bleaching using a 40% hydrogen peroxide (HP) Office bleaching agent. The remaining 16 samples were taken as control. The enamel samples were divided into six groups (2-7) based on the bleaching reversal technique (<i>n</i> = 16). Samples in Group 1 contained unbleached samples of sound enamel (<i>n</i> = 10). Group 1: Samples did not undergo bleaching; Group 2: bleached samples with no reversal; Group 3: bleached enamel reversal via fluoride activated by Er:YAG laser; Group 4: bleached enamel reversal via fluoride activated by diode laser; Group 5: bleached enamel reversal via fluoride activated by femtosecond laser; Group 6: bleached enamel reversal via Na-Ascorbate; and Group 7: bleached enamel reversal with fluoride. From controls and interventional groups, two pairs of samples were assessed for VH and one pair of samples for EDX to assess Ca/P. All samples were bonded with brackets for SBS assessment and bracket-enamel interface. Analysis of variance, followed by post hoc multiple comparison tests, was used to tabulate results for SBS, VH, and the Ca/P ratio. <b><i>Results:</i></b> Ca/P ratio, VH, and SBS in bleached enamel reversed via Er:YAG laser + fluoride and femtosecond laser + fluoride demonstrated the efficacy of reversal similar to bleached enamel reversed by a conventional method, Na-Ascorbate, and control. <b><i>Conclusions:</i></b> Fluoride-treated bleached enamel, activated via Er, YAG, or femtosecond lasers, was effective in reversing the undesirable effects of bleaching, improving SBS of orthodontic brackets, Ca/P ratio, and enamel hardness.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"310-319"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Photobiomodulation on Salivary Nitrite in Patients with Chemotherapy-Induced Oral Mucositis: A Randomized Clinical Trial.","authors":"Marwa Khalil, Omar Hamadah, Maher Saifo","doi":"10.1089/photob.2024.0151","DOIUrl":"10.1089/photob.2024.0151","url":null,"abstract":"<p><p><b><i>Background:</i></b> Oral mucositis (OM) is a severe inflammatory and ulcerative condition of the oral mucosa commonly induced by chemotherapy. Photobiomodulation (PBM) therapy has been proposed for preventing and treating OM. However, the understanding of light interaction with biological tissues and the variability in light sources and protocols limit its widespread application. This study aimed to evaluate the impact of PBM on salivary nitrite levels, a marker of oxidative stress associated with inflammation and tissue damage. <b><i>Materials and Methods:</i></b> This prospective, randomized, double-blind clinical trial included 45 patients, evenly divided into three age- and sex-matched groups. Group 1 received basic oral care instructions prior to chemotherapy. Group 2 received these instructions plus PBM using a 650 nm intraoral diode laser. Group 3 received basic oral care instructions combined with PBM using both a 650 nm intraoral diode laser and a 980 nm extraoral diode laser. OM severity was assessed using World Health Organization criteria, and salivary nitrite levels were measured using the Griess reagent kit (Biotium®) according to the manufacturer's instructions 1 and 2 weeks after the first chemotherapy session. <b><i>Results:</i></b> Our study included 45 patients who were evenly distributed into three groups, matched for age, sex, tumor type, and type of chemotherapy. Significant differences in OM severity were observed among the groups at both 1 and 2 weeks (<i>p</i> = 0.000). Salivary nitrite levels also showed significant differences between groups at these time points (<i>p</i> = 0.00). Significant differences were found between the control group and both laser treatment groups, but no significant difference was noted between the two laser treatment groups. <b><i>Conclusions:</i></b> PBM effectively reduces OM severity, whether used intraorally alone or combined with extraoral application. This effect is likely due to PBM's ability to lower salivary nitrite levels, indicating reduced oxidative stress and inflammation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"294-301"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant Radiotherapy Combined with Transurethral Photoselective Vaporization of Bladder Tumors and Postoperative Adjuvant Radiotherapy and Chemotherapy for T3 Muscle-Invasive Bladder Cancer: A Retrospective Case Series Study.","authors":"Yatong Chen, Fei Luo, Jian Li, Tingji Zhang","doi":"10.1089/photob.2024.0150","DOIUrl":"10.1089/photob.2024.0150","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To evaluate the efficacy and safety of neoadjuvant radiotherapy combined with transurethral photoselective vaporization of bladder tumors (PVBT), followed by postoperative adjuvant radiotherapy and chemotherapy, in the treatment of T3 muscle-invasive bladder cancer (MIBC). <b><i>Background:</i></b> Transurethral resection of bladder tumors combined with radiotherapy and chemotherapy, also known as trimodal therapy (TMT), is the recommended bladder-preserving approach for MIBC and has demonstrated favorable outcomes in T2 MIBC. However, T3 MIBC remains a challenging candidate for TMT due to its relatively poor prognosis. Therefore, optimizing the \"triple therapy\" strategy for T3 MIBC is essential. <b><i>Methods:</i></b> This was a retrospective case series. Patients with T3 MIBC who underwent preoperative neoadjuvant radiotherapy combined with PVBT, followed by postoperative adjuvant radiotherapy and chemotherapy, between January 2018 and December 2020 were included. Tumor response after neoadjuvant radiotherapy, the incidence of PVBT-related complications, and adverse effects of radiotherapy and chemotherapy were assessed. Tumor recurrence and survival outcomes were monitored through outpatient follow-ups and telephone consultations. Risk factors for recurrence were analyzed using statistical methods. <b><i>Results:</i></b> A total of 48 patients were included. Four weeks after neoadjuvant radiotherapy, complete response, partial response, stable disease, and disease progression were observed in 3 (6.3%), 23 (47.9%), 20 (41.7%), and 2 (4.2%) patients, respectively. The objective response rate and disease control rate were 54.2% and 95.8%, respectively. Radiation- or chemotherapy-related toxicity occurred in 23 patients (47.9%), all of whom experienced only grade I-II adverse effects, with no grade III-IV toxicity reported. During a follow-up period of 14-58 months, 22 patients (45.83%) experienced recurrence, and 3 patients died due to distant organ metastases. Multi-variate Cox regression analysis identified tumor diameter (≤3.0 cm vs. >3.0 cm) and tumor multiplicity (single vs. multiple) as significant risk factors for recurrence. <b><i>Conclusions:</i></b> Preoperative neoadjuvant radiotherapy combined with PVBT, followed by postoperative adjuvant radiotherapy and chemotherapy, is an effective and well-tolerated treatment for T3 MIBC.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"302-309"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Photodynamic Therapy in the Treatment of Oral Diseases: A Reality or Myth?","authors":"Tahsinul Haque, Hamad Albagieh, Fatema Akhter, Abdulrhman Alkahwaji","doi":"10.1089/photob.2024.0114","DOIUrl":"10.1089/photob.2024.0114","url":null,"abstract":"<p><p><b><i>Background:</i></b> A growingAQ3 number of investigations have demonstrated promising outcomes related to the application of photodynamic therapy (PDT) in dentistry. PDT involves the application of light and photosensitizer (PS) or photoactive dye that can generate reactive oxygen species (ROS) on irradiation with light of an appropriate wavelength to be absorbed by the PS. <b><i>Results and Conclusion:</i></b> ROS initiates a series of biological and photochemical processes that lead to irreversible damage resulting in the death of microbes. Several light-absorbing dyes have been used in the literature as potential PS for PDT and varying wavelengths have been evaluated. Different outcomes, limitations, and suggestions have been mentioned by various researchers, hence, this review aimed to identify several oral conditions and diseases where PDT could be utilized efficaciously as the sole therapy or as an adjunctive modality and assess from numerous published literature whether PDT exerts a significant influence on the treatment of oral conditions and diseases.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"278-287"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense Pulsed Light for the Treatment of Dry Eye Disease: A Bibliometric and Visualized Analysis.","authors":"Junran Li, Bo Yu, Muyao Xin, Yu Sun, Emmanuel Eric Pazo, Xiaoli Xing","doi":"10.1089/photob.2024.0144","DOIUrl":"10.1089/photob.2024.0144","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Bibliometric study of intense pulsed light (IPL) for dry eye disease (DED) and meibomian gland dysfunction (MGD) to characterize current worldwide patterns and offer visual representations of previous and emerging trends. <b><i>Background:</i></b> DED is a prevalent eye condition and IPL has been reported to be an effective therapy for dry eyes. <b><i>Method:</i></b> This cross-sectional study examined IPL for DED research evolution and theme trends from 2015 to 2024, using bibliometric analysis of WoSCC data. We examined 4334 IPL articles for publication year, journals, authors, institutions, countries/regions, references, and keywords. <b><i>Results:</i></b> We found 111 articles from 2015 to 2024 articles and the annual publication rate was less than 10 from 2015 to 2017, but has steadily increased after 2018. Global publication volumes have increased by 1300% in the past decade, from 2 in 2015 to 28 in 2022. Currently, the number of articles stands at 10 in 2024. IPL for DED was published in 43 journals. Currently, the top journals publishing on this topic according to volume include Photobiomodulation, Photomedicine, and Laser Surgery, Journal of Clinical Medicine, and Cornea. <b><i>Conclusions:</i></b> The number of publications and citations on research related to IPL for DED treatment has steadily increased across numerous countries, institutions, and authors over the past decade. The current study illuminates the current trends, global collaboration patterns, fundamental knowledge, research hotspots, and emerging frontiers of IPL treatment. The primary focus now has been the development of innovative solutions for the treatment of DED and MGD by combining IPL with presenting DED treatment regime.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"265-277"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Combined Collagen Stimulation Procedure Consisting of 675 nm Laser Device and Hyaluronic Acid-Based Filler Injections for Facial Rejuvenation.","authors":"Riccardo Lazzari, Giustino Gallo, Francesca Madeddu, Laura Pieri, Irene Fusco, Tiziano Zingoni, Francesca Arrigoni","doi":"10.1089/photob.2025.0011","DOIUrl":"https://doi.org/10.1089/photob.2025.0011","url":null,"abstract":"<p><p><b><i>Background:</i></b> There has been an increase in interest in using in-office cosmetic treatments to promote collagen in the skin and deeper tissues. <b><i>Aim:</i></b> The current study assesses the safety and efficacy of the combination of a 675 nm laser wavelength and the injection of soft tissue fillers based on hyaluronic acid (HA) during facial rejuvenation treatments. <b><i>Materials and methods:</i></b> A total of 16 patients treated for facial skin rejuvenation and reduction of facial laxity were divided into two groups: Group 1 underwent three sessions of a 675 nm laser system combined with three sessions of HA filler and Group 2 received three sessions of the 675 nm laser system alone. One treatment every 30 days for 3 months was performed. Images were acquired at baseline (T₀), after the second session (T_m), and 1 month after the last treatment (T_f). A dermal analysis system was employed for skin analysis. The 10-point visual analog scale and the 5-point Global Aesthetic Improvement Scale (GAIS) were used. <b><i>Results:</i></b> In both groups, but more promisingly in Group 1, the skin showed an improvement in its elasticity reported with an increase in Young's modulus, a decrease in retraction time, and an increase in viscoelasticity. Qualitative analysis of high-frequency dermal ultrasound images showed significant increases in new collagen density and dermal thickness. These results were confirmed with the GAIS. No side effects were recorded. <b><i>Conclusion:</i></b> The findings indicate that the combination of 675 nm laser and HA filler was well-tolerated and safe and has shown promising results for treating skin aging.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}