Photobiomodulation, photomedicine, and laser surgery最新文献

{"title":"Neoadjuvant Radiotherapy Combined with Transurethral Photoselective Vaporization of Bladder Tumors and Postoperative Adjuvant Radiotherapy and Chemotherapy for T3 Muscle-Invasive Bladder Cancer: A Retrospective Case Series Study.","authors":"Yatong Chen, Fei Luo, Jian Li, Tingji Zhang","doi":"10.1089/photob.2024.0150","DOIUrl":"https://doi.org/10.1089/photob.2024.0150","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To evaluate the efficacy and safety of neoadjuvant radiotherapy combined with transurethral photoselective vaporization of bladder tumors (PVBT), followed by postoperative adjuvant radiotherapy and chemotherapy, in the treatment of T3 muscle-invasive bladder cancer (MIBC). <b><i>Background:</i></b> Transurethral resection of bladder tumors combined with radiotherapy and chemotherapy, also known as trimodal therapy (TMT), is the recommended bladder-preserving approach for MIBC and has demonstrated favorable outcomes in T2 MIBC. However, T3 MIBC remains a challenging candidate for TMT due to its relatively poor prognosis. Therefore, optimizing the \"triple therapy\" strategy for T3 MIBC is essential. <b><i>Methods:</i></b> This was a retrospective case series. Patients with T3 MIBC who underwent preoperative neoadjuvant radiotherapy combined with PVBT, followed by postoperative adjuvant radiotherapy and chemotherapy, between January 2018 and December 2020 were included. Tumor response after neoadjuvant radiotherapy, the incidence of PVBT-related complications, and adverse effects of radiotherapy and chemotherapy were assessed. Tumor recurrence and survival outcomes were monitored through outpatient follow-ups and telephone consultations. Risk factors for recurrence were analyzed using statistical methods. <b><i>Results:</i></b> A total of 48 patients were included. Four weeks after neoadjuvant radiotherapy, complete response, partial response, stable disease, and disease progression were observed in 3 (6.3%), 23 (47.9%), 20 (41.7%), and 2 (4.2%) patients, respectively. The objective response rate and disease control rate were 54.2% and 95.8%, respectively. Radiation- or chemotherapy-related toxicity occurred in 23 patients (47.9%), all of whom experienced only grade I-II adverse effects, with no grade III-IV toxicity reported. During a follow-up period of 14-58 months, 22 patients (45.83%) experienced recurrence, and 3 patients died due to distant organ metastases. Multi-variate Cox regression analysis identified tumor diameter (≤3.0 cm vs. >3.0 cm) and tumor multiplicity (single vs. multiple) as significant risk factors for recurrence. <b><i>Conclusions:</i></b> Preoperative neoadjuvant radiotherapy combined with PVBT, followed by postoperative adjuvant radiotherapy and chemotherapy, is an effective and well-tolerated treatment for T3 MIBC.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride-Activated Via Er:YAG, Diode, and Femtosecond Lasers for Reversing Bleached Enamel for Improved Orthodontic Bonding.","authors":"Muhammad Abdullah Kamran, Abdullah Mohammed Asiri, Ayman Mousa A Alfaifi, Atheer Hadi A Almukawwi, Joharah Mughaddi Alwadai, Saeed J Alqahtani","doi":"10.1089/photob.2025.0024","DOIUrl":"https://doi.org/10.1089/photob.2025.0024","url":null,"abstract":"<p><p><b><i>Aim:</i></b> This investigation aimed to assess the efficacy of reversal methods on bleached enamel via fluoride-activated Er:YAG, diode, femtosecond laser, focusing on Vickers hardness (VH), shear bond strength (SBS), calcium (Ca⁺⁺)/phosphorus (P) ratio, and the interface between brackets and enamel. <b><i>Materials and Methods:</i></b> A total of 112 human maxillary premolars with intact enamel, which had been extracted, were included. About 96 specimens underwent bleaching using a 40% hydrogen peroxide (HP) Office bleaching agent. The remaining 16 samples were taken as control. The enamel samples were divided into six groups (2-7) based on the bleaching reversal technique (<i>n</i> = 16). Samples in Group 1 contained unbleached samples of sound enamel (<i>n</i> = 10). Group 1: Samples did not undergo bleaching; Group 2: bleached samples with no reversal; Group 3: bleached enamel reversal via fluoride activated by Er:YAG laser; Group 4: bleached enamel reversal via fluoride activated by diode laser; Group 5: bleached enamel reversal via fluoride activated by femtosecond laser; Group 6: bleached enamel reversal via Na-Ascorbate; and Group 7: bleached enamel reversal with fluoride. From controls and interventional groups, two pairs of samples were assessed for VH and one pair of samples for EDX to assess Ca/P. All samples were bonded with brackets for SBS assessment and bracket-enamel interface. Analysis of variance, followed by post hoc multiple comparison tests, was used to tabulate results for SBS, VH, and the Ca/P ratio. <b><i>Results:</i></b> Ca/P ratio, VH, and SBS in bleached enamel reversed via Er:YAG laser + fluoride and femtosecond laser + fluoride demonstrated the efficacy of reversal similar to bleached enamel reversed by a conventional method, Na-Ascorbate, and control. <b><i>Conclusions:</i></b> Fluoride-treated bleached enamel, activated via Er, YAG, or femtosecond lasers, was effective in reversing the undesirable effects of bleaching, improving SBS of orthodontic brackets, Ca/P ratio, and enamel hardness.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Photodynamic Therapy in the Treatment of Oral Diseases: A Reality or Myth?","authors":"Tahsinul Haque, Hamad Albagieh, Fatema Akhter, Abdulrhman Alkahwaji","doi":"10.1089/photob.2024.0114","DOIUrl":"https://doi.org/10.1089/photob.2024.0114","url":null,"abstract":"<p><p><b><i>Background:</i></b> A growingAQ3 number of investigations have demonstrated promising outcomes related to the application of photodynamic therapy (PDT) in dentistry. PDT involves the application of light and photosensitizer (PS) or photoactive dye that can generate reactive oxygen species (ROS) on irradiation with light of an appropriate wavelength to be absorbed by the PS. <b><i>Results and Conclusion:</i></b> ROS initiates a series of biological and photochemical processes that lead to irreversible damage resulting in the death of microbes. Several light-absorbing dyes have been used in the literature as potential PS for PDT and varying wavelengths have been evaluated. Different outcomes, limitations, and suggestions have been mentioned by various researchers, hence, this review aimed to identify several oral conditions and diseases where PDT could be utilized efficaciously as the sole therapy or as an adjunctive modality and assess from numerous published literature whether PDT exerts a significant influence on the treatment of oral conditions and diseases.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Preventive and Rehabilitative Effects of Photobiomodulation on Orthodontically Induced Root Resorption: A Systematic Review of Animal Studies.","authors":"Lin Kong, Jingyi Hou, Ying Zhao","doi":"10.1089/photob.2025.0059","DOIUrl":"https://doi.org/10.1089/photob.2025.0059","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To critically assess the preventive and rehabilitative effects of photobiomodulation (PBM) on orthodontically induced root resorption (OIRR). <b><i>Methods:</i></b> Six databases (PubMed, Embase, Cochrane, Web of Science, Scopus and OpenGrey) were electronically searched up to September 12, 2024 to retrieve animal studies about PBM and OIRR. The risk of bias (ROB) of included studies was assessed by the SYRCLE's tool. The effects of PBM on OIRR are regarded as OIRR prevention and OIRR rehabilitation by irradiation during or after orthodontic tooth movement. The PBM protocols for reducing and rehabilitating OIRR were summarized separately. <b><i>Results:</i></b> A total of 15 studies were ultimately included in this review. Regarding OIRR rehabilitation, all 4 relevant studies confirmed that laser significantly reduced root resorption degree, root resorption area (RRA) and root resorption volume, respectively. As for 13 studies investigating OIRR prevention, 9 studies (5 involving laser and 4 involving light-emitting diode [LED]) supported the positive effects of PBM, 3 studies (2 involving laser and 1 involving LED) showed no effects, 1 study reported that laser irradiation increased RRA and LED did no effect. 10 studies ranked unclear ROB and 5 studies presented high ROB. Due to considerable clinical and statistical heterogeneity among included studies, the meta-analysis was not performed. <b><i>Conclusion:</i></b> Within current evidence of animal studies, laser-based PBM might be promising to rehabilitate OIRR. Considerable controversy still exists on the preventive effect of PBM on OIRR. Further study is needed to detect effective dose and irradiation methods of PBM on OIRR prevention.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review on Metal-Organic Frameworks as Dual-Functional Nanocarriers: Advancing Chemo-Photothermal Therapy for Precision Cancer Treatment.","authors":"Dilpreet Singh, Akshay Thakur","doi":"10.1089/photob.2025.0034","DOIUrl":"10.1089/photob.2025.0034","url":null,"abstract":"<p><p><b><i>Background:</i></b> Metal-organic frameworks (MOFs) have emerged as promising multifunctional nanocarriers in cancer therapy due to their high porosity, tunable architecture, and ability to integrate dual treatment modalities. <b><i>Objective:</i></b> Among these, MOF-based chemo-photothermal therapy (CPTT) has gained significant attention as it enhances the efficacy of traditional chemotherapy through localized hyperthermia, thereby overcoming drug resistance and improving tumor targeting. <b><i>Materials and Methods:</i></b> MOFs can encapsulate chemotherapeutic agents while simultaneously acting as photothermal conversion agents upon near-infrared irradiation. <b><i>Results:</i></b> This mini-review explores the recent advancements in MOF-based CPTT, highlighting key developments such as stimuli-responsive drug release, metal-enhanced photothermal effects, and hybrid MOF nanostructures. Furthermore, we discuss their potential for theranostic applications, integrating imaging and therapy, and address the key challenges associated with biocompatibility, stability, and clinical translation. The enhanced therapeutic efficacy, biocompatibility, and remarkable targeting make the system as dual system for theranostics as well as targeting purpose. <b><i>Conclusions:</i></b> The future of MOF-based CPTT lies in the development of biodegradable, targeted, and multifunctional MOFs, offering a pathway toward personalized, precision-driven oncological treatments.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"219-227"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Color Changes of Eyebrow Tattoo after Laser: A Retrospective Case Series.","authors":"Mohammed Ibrahim AlJasser, Yasser A Ghobara, Abdulaziz Madani, Mohammed G Turkmani, Fahad M Alsaif, Ahmed Alissa, Naief Alnomair","doi":"10.1089/photob.2025.0025","DOIUrl":"10.1089/photob.2025.0025","url":null,"abstract":"<p><p><b><i>Background:</i></b> Paradoxical darkening is a well-known complication with laser therapy for tattoos. However, there are limited reports of other color shifts after treating tattoos with laser. The aim of this study is to characterize cases of unusual eyebrow tattoo color change after laser. <b><i>Methods:</i></b> All cases of eyebrow tattoo color change after laser therapy from two dermatology clinics were reviewed. <b><i>Results:</i></b> A total of 10 females with unusual lighter color change after laser were identified. This was noticed by all patients within a few days after the first laser session. The color shift occurred after picosecond (PS) 755 nm (<i>n</i> = 5), PS 1064 nm (<i>n</i> = 4), and Q-switched 1064 nm (<i>n</i> = 1) laser therapy. The initial color shift was red or orange-red in eight patients and yellow in two patients. Treatment of color change was performed in six patients, with significant improvement. Two were treated with PS 755 nm laser and four were treated with PS 532 nm laser. After the first PS 532 nm laser session, the tattoo turned yellow in three patients. None of the patients developed paradoxical darkening of the light-colored tattoo after additional laser treatment. <b><i>Conclusions:</i></b> Some eyebrow tattoos might turn red, orange, or yellow after laser therapy. This color shift usually responds to subsequent therapy with PS 532 nm laser.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"240-244"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Blue Light (450-460 nm) Phototherapy for <i>Pseudomonas aeruginosa</i>-Infected Wounds.","authors":"Andreas Zoric, Mahsa Bagheri, Maria von Kohout, Tara Fardoust, Paul C Fuchs, Jennifer L Schiefer, Christian Opländer","doi":"10.1089/pho.2023.0180","DOIUrl":"10.1089/pho.2023.0180","url":null,"abstract":"<p><p><b><i>Background:</i></b> Nosocomial wound infection with <i>Pseudomonas aeruginosa</i> (PA) is a serious complication often responsible for septic mortality of burn patients. High-intensity antimicrobial blue light (aBL) treatment may represent an alternative therapy for PA infections. <b><i>Methods:</i></b> Antibacterial effects of an light-emitting diode (LED) array (450-460 nm; 300 mW/cm²; 15/30 min; 270/540J/cm²) against PA were determined by suspension assay, biofilm assay, and a human skin wound model and compared with 15-min topically applied 3% citric acid (CA) and wound irrigation solution (Prontosan^®; PRT). <b><i>Results:</i></b> The aBL reduced the bacterial number (2.51-3.56 log₁₀ CFU/mL), whereas PRT or CA treatment achieved a 4.64 or 6.60 log₁₀ CFU/mL reduction in suspension assays. The aBL reduced biofilm formation by 60%-66%. PRT or CA treatment showed reductions by 25% or 13%. In this study, aBL reduced bacterial number in biofilms (1.30-1.64 log₁₀ CFU), but to a lower extent than PRT (2.41 log₁₀ CFU) or CA (2.48 log₁₀ CFU). In the wound skin model, aBL (2.21-2.33 log₁₀ CFU) showed a bacterial reduction of the same magnitude as PRT (2.26 log₁₀ CFU) and CA (2.30 log₁₀ CFU). <b><i>Conclusions:</i></b> The aBL showed a significant antibacterial efficacy against PA and biofilm formation in a short time. However, a clinical application of aBL in wound therapy requires effective active skin cooling and eye protection, which in turn may limit clinical implementation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"252-262"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Er Laser Treatment on the Surface Roughness of Enamel and Bacterial Adhesion.","authors":"Lu Tang, Xiaoyun Tang, Nan Yang, Miao Li, Ying Zhao","doi":"10.1089/photob.2024.0145","DOIUrl":"10.1089/photob.2024.0145","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To investigate the effects of laser-treated enamel surface roughness on the adhesion of <i>Streptococcus mutans</i>. <b><i>Methods:</i></b> A total of 176 premolars extracted for subtractive orthodontic treatment were collected. Samples were randomly divided into four groups: control group, 35% phosphoric acid, Er:YAG laser, Er,Cr:YSGG laser. Surface roughness was detected using three-dimensional white light interferometric surface topography (<i>n</i> = 8/group), and surface morphology was observed by scanning electron microscope [(SEM), <i>n</i> = 8/group]. Samples were cultured in <i>S. mutans</i> solution for 12 h, 1 day, and 2 days. The colony forming units on the enamel surface were calculated (<i>n</i> = 8 per time point). The biofilm and activity of <i>S. mutans</i> were observed by SEM (<i>n</i> = 2/group) and confocal laser scanning microscope (<i>n</i> = 2/group). Correlation analysis was carried out between bacterial adhesion on the enamel surface at different time points and the surface roughness of the enamel treated by different methods. <b><i>Results:</i></b> After Er:YAG and Er,Cr:YSGG laser etching, the surface roughness of enamel increased (<i>p</i> < 0.05), but there was no difference in <i>S. mutans</i> adhesion and biofilm morphology after 1 day compared with traditional phosphoric acid etching (<i>p</i> > 0.05). <i>S. mutans</i> adhesion was positively correlated with the enamel roughness in the early stage. <b><i>Conclusions:</i></b> Er:YAG and Er,Cr:YSGG laser etching may be an alternative to traditional phosphoric acid etching.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"245-251"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Water Mist Flow Rate in Erbium - Yttrium Aluminum Garnet Laser Ablated Bone.","authors":"Zhengdong Xiong, Hao Wu, Ke Li, Ziran Liu, Jiliang Xu, Guanyu Zhang, Shanshan Tu, Shengjie Ma","doi":"10.1089/photob.2025.0028","DOIUrl":"10.1089/photob.2025.0028","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> The aim of this study is to investigate the impact of water mist flow rate on the energy stability of Erbium - doped Yttrium Aluminum Garnet (Er:YAG) laser and ablation of bone. <b><i>Materials and Methods:</i></b> The pig tibiae surface was ablated with Er:YAG laser (100 mJ, 20 Hz, 100 μs) at the flow rate of water mist of 0, 3, 6, 9, 12 mL/min, respectively, for 1 min each. An energy meter was used to record the energy of each laser pulse under different water mist flow rates. A thermocouple was inserted into the bone marrow cavity to record the temperature changes. Infrared thermography, stereomicroscope, and electronic balance were employed to record the surface temperature, morphology, and mass changes, respectively. <b><i>Results:</i></b> As the water mist flow rate escalates, the laser energy experiences a notable attenuation of 27.4%, and the stability parameter Root Mean Square (RMS) escalates by a factor of 30. Despite the relatively minor temperature change within the bone marrow cavity, obviously different surface morphologies are evident. In cases where water mist is less than 3 mL/min, the surface temperature soars, resulting in carbonization. Conversely, when the water mist is greater than 9 mL/min, the ablating mass deteriorates significantly, to merely 25.2% of the value without water mist cooling. <b><i>Conclusions:</i></b> The water mist can affect the laser energy reaching the bone surface and its stability. When the water mist is insufficient, surface temperatures rise, causing carbonization. Conversely, it significantly reduces the ablating mass. Therefore, it is crucial to adjust the amount of water mist appropriately in erbium laser ablated bone. Given such large fluctuations in laser energy, the accuracy of erbium laser bone ablation is dramatically reduced, and the use of water mist cooling should be carefully considered.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"234-239"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Epidermodysplasia Verruciformis Successfully Treated by Surgery Combined with Photodynamic Therapy.","authors":"Junyou Zheng, Fang Fang, Wenbo Bu","doi":"10.1089/photob.2025.0013","DOIUrl":"10.1089/photob.2025.0013","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To explore an effective treatment for extensive and multiple epidermodysplasia verruciformis (EV). <b><i>Methods:</i></b> A 30-year-old female with a 10-year history of EV lesions underwent surgery to remove verrucous plaques and residual lesions, followed by photodynamic therapy once a week for three times. <b><i>Results:</i></b> After a one-year follow-up, no recurrence was observed, and the patient was satisfied with the outcome. <b><i>Conclusion:</i></b> Surgery combined with photodynamic therapy seems promising for treating extensive and multiple EV, but more research is needed for verification.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"263-264"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}