Photobiomodulation, photomedicine, and laser surgery最新文献

{"title":"Efficacy of Photobiomodulation Therapy on the Acupuncture Points on Pain, Maximum Mouth Opening, and Quality of Life in Patients with Temporomandibular Joint Disorders: A Double-Blinded Randomized Clinical Trial.","authors":"Maryam Shirnasab, Nahid Karbasi, Mohaddeseh Davari, Rasool Bagheri, Raheb Ghorbani, Parisa Sabbaghian, Fatemeh Sohrabpour","doi":"10.1177/25785478251385389","DOIUrl":"https://doi.org/10.1177/25785478251385389","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Temporomandibular joint disorders (TMDs) are multi-factorial conditions with a chronic progression that affects individual's quality of life (QOL). <b><i>Background:</i></b> Currently, there is no definitive treatment for TMDs. Few clinical trials have investigated the potential effects of Photobiomodulation therapy on the acupuncture points on these disorders. <b><i>Methods:</i></b> Twenty patients with TMD, referred to the facial pain clinic at Semnan Faculty of Dentistry, were randomly assigned into two groups: treatment (<i>n</i> = 10) and placebo (<i>n</i> = 10).Treatment group received low-power Photobiomodulation therapy for 3 min at each of 10 acupuncture points, including GB20, SI19, ST6, ST7, and LI4. The placebo group received only the guiding light of the device on the same points. Treatment consisted of 10 sessions (twice a week). QOL was assessed using the OHIP-14 and SF-36 questionnaires at the beginning and end of treatment. <b><i>Result:</i></b> Significant differences were observed between the treatment and placebo groups according to pain relief and maximum mouth opening (<i>p</i> < 0.05; Mann-Whitney). However, no significant difference was observed between the groups for the QOL using OHIP-14. In contrast, the SF-36 showed significant improvements in the physical health subscale in the treatment group. <b><i>Conclusions:</i></b> Photobiomodulation therapy on the acupuncture is a complementary, noninvasive therapy that may benefit patients with TMDs.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvements in Resting-State Functional Connectivity of the Cerebellum after Transcranial Photobiomodulation in Adults with a History of Repetitive Head Acceleration Events.","authors":"Finian Keleher, Carrie Esopenko, Hannah M Lindsey, Mary R Newsome, Paula K Johnson, Divya Jain, Elizabeth S Hovenden, Dayna Thayn, Courtney McCabe, Hilary A Russell, Robert C Welsh, Christine M Mullen, Carmen Velez, Emma N Read, Michael J Larson, Lance E Davidson, Spencer W Liebel, David F Tate, Lawrence S Carr, Elisabeth A Wilde","doi":"10.1177/25785478251376477","DOIUrl":"10.1177/25785478251376477","url":null,"abstract":"<p><p><b><i>Objective:</i></b> The current study sought to explore the impact of a novel noninvasive treatment called transcranial photobiomodulation (PBM) on resting-state functional connectivity (rsFC) of the cerebellum in individuals with a history of repetitive head acceleration events (RHAEs). <b><i>Background:</i></b> RHAEs are associated with cumulative neurological compromise, including chronic alterations in rsFC; however, few treatments have been investigated to mitigate these effects. A recent study by our team demonstrated that PBM treatment led to improvements in measures of balance and motor function in adults with RHAE exposure. Due to the cerebellum's role in motor functioning and its connectivity with cerebral regions targeted by PBM, we sought to examine changes in the rsFC of the cerebellum following PBM treatment. <b><i>Methods:</i></b> Thirty individuals with RHAE used an at-home PBM headset with an intranasal cannula for 20 min every other day for a period of 8-10 weeks. A total of 240 J/cm² of red and near-infrared light was administered to cortical nodes of the default mode network (DMN) and subcortical structures in each session. Using resting-state functional magnetic resonance imaging, rsFC was measured before and after treatment in 11 cerebellar seed regions associated with the DMN, salience network (SN), and frontoparietal network (FPN). <b><i>Results:</i></b> We observed an overall decrease in between-network connectivity and an increase in within-network connectivity after PBM treatment, particularly in the SN and FPN. <b><i>Conclusions:</i></b> These results suggest that PBM may improve network efficiency of the cerebellum by regulating overactive connections and increasing network segregation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"475-489"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Enhancement of Cisplatin Anticancer Efficacy by Photobiomodulation Therapy: A Systematic Review.","authors":"Emad Jafarzadeh, Fereshtehsadat Jalali, Jaber Zafari, Fatemeh Fakhari","doi":"10.1177/25785478251372762","DOIUrl":"10.1177/25785478251372762","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Cisplatin (Cis), a key cancer chemotherapy drug, faces limitations such as dose-dependent side effects and resistance. Photobiomodulation therapy (PBMT) shows promise as an adjuvant therapy to enhance Cis efficacy and reduce side effects. <b><i>Methods:</i></b> A systematic review was conducted to evaluate the combined effects of PBMT and Cis on various cancers. After searching five databases using relevant keywords, nine studies were included, encompassing both in vitro and in vivo models. <b><i>Results:</i></b> Most in vitro studies showed a synergistic effect, with enhanced cancer cell inhibition, apoptosis induction, and reduced cell viability compared with Cis alone. The animal model confirmed these findings, showing PBMT mitigated Cis-induced acute renal failure. <b><i>Conclusion:</i></b> Mechanistically, PBMT may increase reactive oxygen species generation, cytochrome c release, modulate cellular metabolism, and involve the miR-124/STAT3 signaling pathway. Combining PBMT with Cis appears to be a safe and effective cancer treatment strategy, synergistically inhibiting cancer cell growth and reducing side effects. Further clinical trials are needed to validate these findings.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"468-474"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Biological Mechanisms to Clinical Applications: A Review of Photobiomodulation in Dental Practice.","authors":"Yosra Ayed, Afaf Al-Haddad, Asma Kassab, Aishah Alhodhodi, Najla Dar-Odeh, Yassmeen S Ragheb, Samia Mekki Elbaghir, Shadia Abdelhameed Elsayed","doi":"10.1177/25785478251372824","DOIUrl":"10.1177/25785478251372824","url":null,"abstract":"<p><p><b><i>Background:</i></b> Photobiomodulation (PBM) therapy involves the use of low-dose, nonionizing light to reduce pain and inflammation, promote wound healing, and enhance tissue regeneration. PBM-based therapy of various dental conditions is associated with improved treatment outcomes. This study aims to critically review the literature to highlight the underlying molecular biological mechanisms and clinical applications of PBM in modern dental practice. <b><i>Methods:</i></b> This critical review employed literature search in PubMed/Medline, Google Scholar, and ScienceDirect databases to determine biological basis of PBM with a particular focus on its clinical dental applications. English literature published in the past 25 years were eligible for inclusion. Selected studies were analyzed to evaluate the therapeutic biochemical effects of PBM, with a focus on its dental applications. <b><i>Results:</i></b> PBM exerts its biological effects by influencing cytochrome c oxidase, increasing adenosine triphosphate, and improving DNA replication and RNA transcription. Various transcription factors and signaling pathways are involved through the activation of secondary messengers such as reactive oxygen species, nitric oxide, and cyclic adenosine monophosphate. The favorable biological effects of PBM can be beneficial for various dental applications in pulp therapy, management of postsurgical complications, and temporomandibular joint disorders. <b><i>Conclusions:</i></b> PBM represents a promising and effective treatment modality for the management of several challenging dental problems in the pediatric and adult populations, offering improved treatment outcomes, namely enhanced wound healing and reduced inflammation. Further research is recommended to optimize technical settings and standardize current protocols in the aim of enhancing clinical outcomes, exploring more applications, and improving patient satisfaction.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"457-467"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Endoscopic Biliary Stent Combined with Photodynamic Therapy: A New Strategy for the Palliative Treatment of Extrahepatic Cholangiocarcinoma.","authors":"Jia Wang, Qingdong Mao, Junheng Liu, Kuijin Xue, Peng Qi, Yanchun Jin, Hui Ju, Baoguo He, Bin Cao","doi":"10.1177/25785478251376142","DOIUrl":"10.1177/25785478251376142","url":null,"abstract":"<p><p><b><i>Background:</i></b> Photodynamic therapy (PDT) combined with biliary stenting reportedly has better efficacy and safety in the treatment of extrahepatic cholangiocarcinoma (EHC). Considering the shortcomings of traditional PDT methods, we proposed a novel modified approach, defined as initial biliary stent placement followed by PDT, for the treatment of EHC. The study aimed to evaluate the effect and safety of biliary stent placement prior to PDT versus only stent placement on the treatment of EHC. <b><i>Methods:</i></b> A total of 30 patients diagnosed with EHC between January 2017 and December 2024 were included in the retrospective study. Ten patients underwent biliary stent placement, followed by PDT (Stenting with PDT group). Survival time, surgical success rate, and postoperative adverse events were compared to 20 patients receiving biliary stent placement alone (Stenting only group). <b><i>Results:</i></b> The success rate of all operations in both groups was 100%. After 96 months of follow-up, the stenting with PDT group had significantly longer median survival after stent placement than the stenting only group (10.5 vs. 4.0 months, <i>p</i> = 0.028). There were no statistically significant differences in the rates of postoperative total adverse events (5 [25%] vs. 2 [20%], <i>p</i> = 1.000), asymptomatic hyperamylasemia (1 [5%] vs. 1 [10%], <i>p</i> = 1.000), acute pancreatitis (4 [20%] vs. 1 [10%], <i>p</i> = 0.272), and postoperative acute cholangitis (0 vs. 1 [10%], <i>p</i> = 0.333) between the two groups. <b><i>Conclusions:</i></b> Compared with stenting alone, modified stenting combined with PDT resulted in longer survival in patients with unresectable EHC without significant adverse events.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"490-497"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation as a Therapeutic Strategy for Major Depressive Disorder: Mechanisms and Prospects.","authors":"Shaojuan Hu, Xinyuan Li, Bin Guo, Wenxin Xu, Timon Cheng-Yi Liu, Luodan Yang","doi":"10.1177/25785478251371716","DOIUrl":"10.1177/25785478251371716","url":null,"abstract":"<p><p><b><i>Background:</i></b> Depression is a prevalent mental disorder characterized by mental suffering and emotional distress. Its pathogenesis involves the concurrent action of multiple factors, including genetic predisposition, stress exposure, hypothalamic-pituitary-adrenal axis dysregulation, imbalances in neurotransmitters and their receptors, inflammatory responses, and mitochondrial malfunction. Photobiomodulation (PBM), a noninvasive therapeutic approach, has shown potential in treating mood disorders such as depression and has emerged as a promising intervention for various pathologies; however, unified standards for PBM irradiation parameters (e.g., based on species, gender, age) are currently lacking. <b><i>Objective:</i></b> This review aims to introduce the potential mechanisms underlying depression and summarize the latest pre-clinical and clinical progress of PBM in the treatment of this mood disorder. <b><i>Materials and Methods:</i></b> As a narrative review, this work synthesizes and analyzes existing literature on the pathological mechanisms of depression and the application of PBM in depression treatment. Results Polytherapy with PBM targeting multiple biological pathways exerts beneficial effects on depression. Specifically, PBM enhances mitochondrial function in the brain, promotes neurogenesis and synaptogenesis, regulates neurotransmitter homeostasis, and provides neuroprotection through anti-inflammatory and antioxidant actions, while simultaneously supplying energy to brain tissues. Additionally, the curative effect of PBM is found to be associated with multiple factors, including irradiation parameters, species, gender, and age, highlighting the lack of unified parameter standards in current research. <b><i>Conclusions:</i></b> PBM exhibits therapeutic potential for depression by modulating key pathological pathways (e.g., mitochondrial function, neurogenesis, inflammation). The latest pre-clinical and clinical evidence supports its role as a promising noninvasive intervention. However, the establishment of unified PBM irradiation parameters is essential for standardizing its clinical application in depression treatment. Future research should focus on optimizing parameter standards to enhance the efficacy and reproducibility of PBM therapy.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"441-456"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Er:YAG Laser Activated Chlorhexidine and Nano Chitosan Against <i>Enterococcus faecalis</i>-An In Vitro Study.","authors":"Manimozhi M, Kiran Kumar N, Biji Brigit, Abhishek M, Swetha Geervani V","doi":"10.1177/25785478251372767","DOIUrl":"10.1177/25785478251372767","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This in vitro study aimed to compare the antibacterial properties of 2% chlorhexidine (CHX) and 0.2% nano chitosan, with and without Er:YAG laser activation using a side-firing tip, against <i>Enterococcus faecalis</i>. It evaluates their potential to improve disinfection in endodontic treatments and assesses the impact of laser activation on antimicrobial efficacy. <b><i>Background:</i></b> Successful endodontic treatment relies on effective root canal disinfection, often hindered by <i>E. faecalis</i>, which invades dentinal tubules. While sodium hypochlorite is effective, it can cause cytotoxicity and dentin damage. CHX is a biocompatible alternative, and nanochitosan offers promising antimicrobial properties with low toxicity. However, conventional irrigation methods are often insufficient. Er:YAG laser activation enhances irrigant penetration into dentinal tubules, improving antimicrobial effects. <b><i>Method:</i></b> Extracted human premolars were inoculated with <i>E. faecalis</i> and divided into four groups: Group A (2% CHX), Group B (0.2% nano chitosan), Group C (2% CHX + Er:YAG laser), and Group D (0.2% nano chitosan + Er:YAG laser). Bacterial counts were measured using colony-forming units on Mueller Hinton agar. <b><i>Results:</i></b> CHX showed superior antibacterial efficacy compared with nanochitosan. Laser activation significantly enhanced the antimicrobial effect of both irrigants, with Group C (CHX + laser) showing the greatest reduction in bacterial colonies. <b><i>Conclusion:</i></b> Er:YAG laser activation improves the antimicrobial effectiveness of both CHX and nano chitosan, particularly in combination, offering a promising approach for root canal disinfection. Furthermore, clinical studies are needed to confirm these findings in vivo.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"498-503"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Light Photobiomodulation: A Systematic Review of New Approaches for Treating Bone Repair.","authors":"Wentao Bao, Jingyun Zhuang, Fei Liu, Jingshan Hu, Xianxiong Chen, Yuxi Jiang","doi":"10.1177/25785478251381479","DOIUrl":"https://doi.org/10.1177/25785478251381479","url":null,"abstract":"<p><p><b><i>Background:</i></b> Green light photobiomodulation (GPBM, 500-565 nm) promotes tissue healing, reduces inflammation, and alleviates pain, with emerging potential in bone repair. This review evaluates GPBM's therapeutic effects on bone-related cells (proliferation, differentiation, migration), inflammation, vascularization, and neuronal responses. <b><i>Methods:</i></b> We assessed the influence of different GPBM parameters, possible underlying molecular mechanisms, and prospects for in vivo applications based on available studies. <b><i>Results:</i></b> GPBM acts through mitochondria, opsins, and transient receptor potential vanilloid (TRPV) channels. The most effective irradiation method uses low irradiance (5.3-100 mW/cm²) with a single exposure of ∼5 J/cm². Excessively low irradiance is ineffective, while excessively high irradiance may cause inhibitory effects. GPBM enhances bone-related cell functions, suppresses inflammation, and promotes vascular and neuronal responses. <b><i>Conclusions:</i></b> GPBM shows promise for bone repair, but further research is needed to optimize parameters, clarify molecular mechanisms, and standardize clinical trial protocols to ensure reliable in vivo outcomes.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation Therapy for Accelerating Soft Tissue Anesthesia Reversal and Preventing Self-Inflicted Injuries in Pediatric Dentistry: A Systematic Review.","authors":"Mohammad Noroozian, Rozhina Jalalian, Reza Fekrazad","doi":"10.1177/25785478251381988","DOIUrl":"https://doi.org/10.1177/25785478251381988","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Prolonged soft tissue anesthesia (STA) after dental treatments in children poses a risk of soft tissue injury (STI). This study aimed to systematically review the role of photobiomodulation therapy (PBMT) in reducing the duration of STA and incidence of STI after dental procedures. <b><i>Methods:</i></b> This systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO registration code: CRD42024622981). <b><i>Results:</i></b> Five eligible studies were included, involving 32-60 participants between 4 and 10 years, utilizing a diode laser with various wavelengths (635, 660, 808, and 810 nm), energy densities (6-11.5 J/cm²), irradiation times (12-30 sec), and irradiation points (6-12). The results demonstrated a significant reduction in duration of STA in all studies (<i>p</i> < 0.05); however, the reduction in the incidence of STI remained inconclusive. <b><i>Conclusions:</i></b> PBMT may serve as a painless and acceptable method to reduce the duration of STA in pediatric dentistry; however, its positive role in preventing STI remains inconclusive in patients with normal intellectual abilities supervised by alert caregivers.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of a Multi-Modal Strategy Involving Laser Therapy and Steroid Injections for the Treatment of Keloids in Patients with Darker Skin Phototypes: A Case Series.","authors":"Swapnil Shah, Arun Inamdar, Laura Pieri, Irene Fusco, Jorilda Biba, Francesca Madeddu, Tiziano Zingoni","doi":"10.1177/25785478251381984","DOIUrl":"https://doi.org/10.1177/25785478251381984","url":null,"abstract":"<p><p><b><i>Background:</i></b> Keloids and hypertrophic scars appear more frequently in people with darker skin tones, such as those of African, Asian, or Hispanic descent. The combination of CO₂ laser, pulsed dye laser (PDL), and triamcinolone was successful in treating a keloid. <b><i>Aim:</i></b> The purpose of this research was to assess the clinical efficacy of a multi-modal treatment protocol comprising a 595 nm PDL, fractional ablative CO₂ laser, 1540 nm nonablative laser, and intralesional corticosteroid injections for keloid management in Indian patients. <b><i>Methods:</i></b> A total of 30 patients with keloids were treated with a combination of two different lasers (595 nm pulsed/10,600 nm and 1540 nm fractional laser) and intralesional steroids injections. Clinical images were collected before treatment and at 9 months after the last treatment, and adverse effects were monitored throughout the study. Patients were assessed with the Detroit Keloid Scale before treatment and at follow-up. <b><i>Results:</i></b> After completing treatments, almost all patients showed improvement; in particular, a decrease in redness was noted, and the keloids appeared flatter. This improvement was also recorded through the Detroit Keloid Scale, where a significant 6-point decrease on the scale was recorded between baseline and follow-up (<i>p</i> < 0.01). <b><i>Conclusions:</i></b> This combined therapy is a good option for people with darker skin tones since it has been proven as an effective tool for managing keloid, especially for enhancing texture and decreasing redness with a lower risk of postinflammatory hyperpigmentation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}