Photobiomodulation, photomedicine, and laser surgery最新文献

{"title":"<i>In Vitro</i> Evaluation of Temperature Variation in Dental Tissues During Er:YAG Laser-Assisted Ceramic Veneer Removal.","authors":"Daniela Maria Cerqueira Leite, Daniela Fatima Teixeira Silva, João Victor de Sousa Araujo, Gleice Conceição Germano, Vinicius Pereira Dos Anjos, Praveen Ravindra Arany, Denise Maria Zezell","doi":"10.1177/25785478261474664","DOIUrl":"10.1177/25785478261474664","url":null,"abstract":"<p><strong>Purpose: </strong>Temperature increases in dental tissues during ceramic veneer removal with erbium lasers may compromise pulp viability (>5.5°C) and periodontal ligament health (>11°C). This study aimed to evaluate temperature variations during Er:YAG laser-assisted removal of ceramic laminates.</p><p><strong>Methods: </strong>Seventy single-rooted human teeth extracted from the FOUSP Biobank repository (CAEE 02854118.3.0000.0075) were endodontically treated and divided into seven groups (<i>n</i> = 10). Lithium disilicate ceramic laminates measuring 4.0 × 4.0 × 0.7 mm were then cemented using Variolink Esthetic LC resin cement (Ivoclar). Temperature was measured with three fast-response thermocouples (type K, 125 mm thickness) at three different sites: inside the tooth filled with thermal paste and fixed externally with composite resin on the root surfaces. The Er:YAG laser (2940 nm; LiteTouch, Israel) was applied at a 1 mm distance from the veneer, operating at 20 Hz for 10.4 s, with energy settings ranging from 150 to 400 mJ, corresponding to average powers of 3.0 W, 3.5 W, 5.0 W, 6.0 W, 6.5 W, 7.0 W, and 8.0 W. Data normality was assessed using the Kolmogorov-Smirnov test, and comparisons were performed using Kruskal-Wallis and Mann-Whitney <i>U</i> tests (α = 0.05).</p><p><strong>Results: </strong>All laser parameters successfully promoted veneer debonding. The highest temperature increase (ΔT) was observed in the 8.0 W group (21.8°C in the pulp, 42.5°C in the periodontal ligament, and 9.7°C on the lingual crown surface), followed by the 7.0 W group (4.6°C, 27.0°C, and 6.3°C, respectively) and the 6.0 W group (5.7°C, 12.3°C, and 4.1°C, respectively). Statistically significant differences were found among these groups (<i>p</i> < 0.05). For all measurement sites, average powers ≥ 6.0 W exceeded established thermal safety thresholds.</p><p><strong>Conclusions: </strong>Er:YAG laser-assisted ceramic veneer removal can be performed within safe thermal limits when average laser power settings remain below 5.7 W. These findings contribute to establishing safer clinical parameters for aesthetic laser applications while preserving pulp and periodontal tissue integrity.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"569-578"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Photobiomodulation Variables Assessment Battery: Development and Validation.","authors":"Alice Linnea Howis, Alyssa Igarta, Will Dixon","doi":"10.1177/25785478261475285","DOIUrl":"10.1177/25785478261475285","url":null,"abstract":"<p><p>Transcranial photobiomodulation (tPBM) response variability is partly driven by biophysical characteristics such as skin tone and hair properties that attenuate photon penetration, and by lifestyle factors including sleep quality, alcohol use, and nicotine consumption that disrupt the mitochondrial and vascular pathways on which tPBM acts. To date, no validated self-report tool exists to capture these moderators systematically. To address this gap, the tPBM Variables Assessment Battery was developed and psychometrically evaluated. It integrates adapted versions of established measures (Brief Pittsburgh Sleep Quality Index, E-cigarette Dependence Scale, Hair Scale Assessment PRO, Monk Skin Tone Scale, and Heaviness of Smoking Index), validated wellbeing evaluators (Ryff's Psychological Wellbeing), and custom measures (Hairstyle Classification, Hair Color Classification). Face and content validity met recommended expert thresholds, internal consistency was acceptable across adapted subscales, and criterion validity analyses confirmed meaningful associations between the lifestyle components and PROMIS-10 global health outcomes. The battery is low-burden, digitally deployable, and psychometrically defensible, offering a practical tool for characterizing the variables most likely to moderate tPBM response in home-use studies.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"606-624"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review on the Effectiveness of Photobiomodulation Therapy on Enhancing Musculoskeletal Rehabilitation Outcomes after Total Knee and Hip Arthroplasty.","authors":"Hadaya Mosaad Eladl, Saja Nashmi Alrashedi, Nesma M Allam, Dalia Mahmoud Abdelmonem Elsherbini, Mohamed El-Sherbiny, Mohamed Mahmoud Abdelfattah Abdelrahman, Moaz Abulfaraj","doi":"10.1177/25785478261475529","DOIUrl":"10.1177/25785478261475529","url":null,"abstract":"<p><strong>Background: </strong>Total knee and hip arthroplasty (TKA/THA) effectively alleviate chronic pain and improve joint function and quality of life. However, postoperative recovery is often hindered by pain, edema, restricted range of motion (ROM), and muscle weakness, necessitating structured physical rehabilitation. Photobiomodulation Therapy (PBMT) has been proposed as an adjunct modality to enhance rehabilitation outcomes. This systematic review evaluates the efficacy of PBMT in reducing postoperative pain and edema as well as improving ROM and functional performance compared with placebo or standard physical therapy in post-arthroplasty patients.</p><p><strong>Methods: </strong>A systematic search of PubMed, ProQuest, ScienceDirect, and Google Scholar was conducted from inception to May 31, 2025. Only prospective controlled trials assessing PBMT effects on postoperative pain, swelling, ROM, or functional performance following TKA or THA were included. Case reports, uncontrolled studies, and trials focusing on unrelated outcomes were excluded. Article selection involved title, abstract, and full-text screening, with additional studies identified through reference lists. The review is registered in PROSPERO (CRD420251123169).</p><p><strong>Results: </strong>Four randomized controlled trials (RCTs; <i>n</i> = 133 participants) met the inclusion criteria, three studies focused on TKA, and one study examined THA. PBMT significantly improved postoperative pain and edema reduction in three trials, while two studies demonstrated enhanced ROM and functional outcomes compared with control or placebo interventions. PEDro scores ranged from 8 to 10, indicating moderate-to-high methodological quality.</p><p><strong>Conclusions: </strong>PBMT shows promising short-term benefits in reducing postoperative pain and swelling and improving functional performance after knee or hip arthroplasty. However, due to heterogeneity in treatment parameters and limited high-quality trials, conclusive evidence remains insufficient. Future large-scale RCTs with standardized PBMT parameters and extended follow-up are warranted to confirm its clinical efficacy.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"597-605"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Protective Effect and Underlying Mechanisms of <i>Sarcandra glabra</i> Extract Against UVB-Induced Photodamage in Zebrafish.","authors":"Yurun Zhang, Yadi Yu","doi":"10.1177/25785478261467216","DOIUrl":"10.1177/25785478261467216","url":null,"abstract":"<p><p><i><b>Objective:</b></i> Ultraviolet B (UVB) irradiation primarily causes skin photoaging by disrupting redox homeostasis, triggering inflammatory responses, and accelerating collagen loss. <i>Sarcandra glabra</i> extract (SGE) is a traditional Chinese herbal extract rich in bioactive compounds and exhibits potential anti-inflammatory and antioxidant activities.<i>Methods:</i> This study used a zebrafish model to investigate the protective effect and molecular mechanism of SGE against UVB-induced photodamage. <i>Results:</i> High-performance liquid chromatography (HPLC) analysis identified rosmarinic acid as the main bioactive component in SGE, with a mass fraction of 4.67%, while safety evaluations showed that it showed no significant toxicity toward zebrafish at concentrations of 10 μg/mL or lower. After establishing the UVB zebrafish photodamage model, different SGE concentrations were administered, which alleviated UVB-induced mortality, repaired caudal fin damage, reduced the apoptosis rate, and decreased the intracellular reactive oxygen species levels in zebrafish in a dose-dependent manner. Further, SGE significantly enhanced the superoxide dismutase, catalase, and glutathione peroxidase activity, while decreasing the malondialdehyde content in the UVB-irradiated zebrafish, effectively mitigating oxidative stress injury. At the molecular level, SGE significantly inhibited the abnormal upregulation of the <i>cox-2</i> and <i>IL-1β</i> inflammation-related genes induced by UVB. It also promoted the transcriptional expression of the <i>col1a1a</i> and <i>col1a1b</i> type I collagen-encoding genes, breaking the detrimental oxidative stress-inflammation-collagen loss cycle.<i>Conclusions:</i> The findings of this study indicate that SGE possesses excellent anti-inflammatory, antioxidant, and anti-UVB photodamage properties and can be used as a natural bioactive ingredient in skincare products.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"521-530"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation as an Adjunct to Resistance Training in Older Adults: A Systematic Review and Meta-Analysis.","authors":"Hongxiu Chen, Wichai Eungpinichpong, Somkiat Asawaphureekorn, Nuttaset Manimmanakorn, Yicheng Yang, Yuan Xie, Xingze Wang","doi":"10.1177/25785478261469320","DOIUrl":"10.1177/25785478261469320","url":null,"abstract":"<p><strong>Background: </strong>Photobiomodulation (PBM) has been proposed as an adjunct to resistance training to enhance strength adaptations; however, findings from randomized controlled trials (RCTs) remain inconsistent. This study aimed to evaluate whether adjunctive PBM improves maximal strength gains when combined with periodized resistance training in older adults.</p><p><strong>Methods: </strong>RCTs were identified through systematic searches of PubMed, Scopus, Embase, PEDro, Web of Science, the Cochrane Library, and CNKI from inception to January 2026. Eligible studies examined PBM delivered via low-level laser therapy or light-emitting diodes in combination with resistance training or other strength-oriented loading tasks. Prespecified meta-analyses were restricted to trials combining PBM with periodized resistance training that reported one-repetition maximum (1RM) outcomes; other studies were included in a narrative synthesis.</p><p><strong>Results: </strong>Eleven RCTs (<i>n</i> = 456) were included. Five trials (PBM plus resistance training: <i>n</i> = 74; control: <i>n</i> = 72) met the criteria for meta-analysis. PBM combined with resistance training did not significantly improve maximal muscle strength compared with sham PBM (SMD = 0.26, 95% CI -0.08 to 0.59; <i>p</i> = 0.14; <i>I</i>² = 4%). Subgroup analyses showed a nonsignificant trend favoring PBM for unilateral 1RM, with no effect for bilateral outcomes and no significant subgroup differences. Sensitivity analyses indicated that the unilateral effect was dependent on individual studies. In nonresistance training contexts, some studies reported potential benefits for fatigue-, recovery-, or function-related outcomes, particularly in frail or critically ill older adults, although findings were inconsistent.</p><p><strong>Conclusion: </strong>Current evidence does not demonstrate a clear additional benefit of PBM on maximal strength when combined with resistance training in older adults, although a small effect cannot be excluded. PBM may have selective value in improving recovery-related outcomes and supporting training tolerance in vulnerable populations. Larger, well-designed RCTs are needed to clarify its role.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"557-568"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation with Structured Rehabilitation Improves Mechanical Function and Functional Aging in Degenerative Musculoskeletal Disease: A Controlled Cohort Study.","authors":"Apurba K Ganguly, Sudip K Banerjee, Vidya Sagar Gv, Dinesh K Singal, Anondeep Ganguly","doi":"10.1177/25785478261471039","DOIUrl":"10.1177/25785478261471039","url":null,"abstract":"<p><strong>Background: </strong>Degenerative musculoskeletal disorders involve progressive mechanical dysfunction and accelerated functional aging. Conventional measures fail to capture multidimensional recovery. We developed a Composite Mechanical Dysfunction Index (CMDI) combining functional, gait, asymmetry, mobility, strength, and anthropometric metrics to quantify global impairment and a Composite Multidomain Improvement Index (CMII) to quantify treatment-related recovery. We evaluated whether photobiomodulation therapy plus structured rehabilitation (PBMT + SR) improves CMII and influences functional aging metrics.</p><p><strong>Methods: </strong>In a prospective controlled cohort study, 216 participants with radiographically confirmed degenerative musculoskeletal disorders received PBMT + SR (<i>n</i> = 108) or standard care (<i>n</i> = 108) for 16 weeks. Mechanical function was assessed across six domains (WOMAC, gait, asymmetry, mobility, strength, anthropometrics) and combined into the CMII. Functional aging was evaluated using a performance-based regression model derived from controls. A limitation is that single-therapy groups (PBMT alone, rehabilitation alone) were not included.</p><p><strong>Results: </strong>PBMT + SR was associated with significantly greater multidomain improvement versus controls (<i>p</i> < 0.0001). The intervention group achieved a CMII of 2.01 (ΔCMII = 1.73 between groups). Improvements spanned pain, gait, and neuromuscular symmetry domains. CMII changes correlated with functional performance-based age estimates, indicating an estimated ∼3-year favorable shift in functional age alignment relative to controls.</p><p><strong>Conclusion: </strong>PBMT combined with SR was associated with substantial multidomain improvements in degenerative musculoskeletal disorders, captured by the CMII. These improvements correlated with favorable shifts in functional aging metrics. However, the absence of single-therapy arms limits causal inferences, and randomized trials are needed to isolate the effects of PBMT versus rehabilitation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"531-540"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of High-Power Laser Therapy on Myoelectrical Activities of Suboccipital Muscles and Quality of Life in Patients with Cervicogenic Headache.","authors":"Ahmed Karem Youssef, Abd El-Aleem Abd El-Fatah Attia, Ashraf A Darwesh, Shihab M Al-Khadrawy, Maher Khalil Ibrahim Botros, Hoda M Zakaria, Zizi M Ibrahim, Mohamed H Marzouk","doi":"10.1177/25785478261472294","DOIUrl":"10.1177/25785478261472294","url":null,"abstract":"<p><strong>Background: </strong>Cervicogenic headache (CGH) is a secondary disorder caused by cervical musculoskeletal dysfunction in the cervical vertebrae, with involvement of the upper three cervical segments. The pain initiates in the neck and is often intensified by head or neck movements. This condition imposes a considerable socioeconomic burden, affecting both community well-being and public health systems.</p><p><strong>Objective: </strong>To explore how high-power laser therapy influences pain intensity, suboccipital muscle activity, functional disability, and quality of life (QoL) in patients with CGH.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted on 40 participants (both males and females) diagnosed with CGH for a duration of at least 6 months, experiencing unilateral neck pain radiating to the suboccipital region. Participants were randomly allocated into two equal groups. The study group (A) received high-power Laser therapy in addition to a conventional physical therapy program, while the control group (B) received a placebo laser alongside the same conventional physical therapy program. Both groups received 3 times per week for 6 weeks, with each session lasting approximately 45-60 min. Outcome measures included the visual analog scale for pain intensity measurement, electromyography (EMG) to assess suboccipital muscle myoelectric activity, the Headache Impact Test-6 questionnaire to assess participants' functional health and well-being, the Neck Disability Index to assess functional impairment, and the 36-Item Short Form Health Survey to evaluate QoL. Assessments were performed before and after the intervention (6 weeks).</p><p><strong>Results: </strong>Group A showed statistically significant improvements in pain intensity, EMG parameters, functional disability, headache impact, and QoL compared with Group B.</p><p><strong>Conclusions: </strong>High-power laser therapy, when used alongside conventional physiotherapy, may be an effective approach for reducing symptoms and improving functional outcomes in patients with CGH.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"541-549"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation Therapy for Symptom Management in Essential Palatal Myoclonus: Two Case Studies with Long-Term Follow-Up Two Cases: 7-Year/2-Month Follow-Up.","authors":"Manaf T Agha, Eddie Basson, Pavel Polenik, Jan Tunér, Arun Darbar, Mawadda Ahmed","doi":"10.1177/25785478261465521","DOIUrl":"10.1177/25785478261465521","url":null,"abstract":"<p><strong>Background: </strong>Palatal myoclonus (PM) is a rare movement disorder characterized by involuntary rhythmic contractions of the soft palate and adjacent musculature. Conventional therapies, including pharmacologic agents and botulinum toxin injections, frequently provide inconsistent or temporary relief and may be associated with adverse effects. This report evaluates photobiomodulation therapy (PBMT) as a noninvasive neuromodulatory treatment.</p><p><strong>Cases: </strong>The two cases were managed by different clinicians in separate clinical settings under standardized protocol guidance from the primary author, allowing assessment of inter-operator reproducibility. Two patients with essential PM were treated using near-infrared diode laser PBMT. Case 1: A 26-year-old female presented with persistent PM (2.5 Hz) accompanied by dysphagia, audible clicking, and sleep disturbance. Pharmacotherapy (clonazepam and gabapentin) was discontinued due to intolerance. PBMT using a 940 nm diode laser (8.7 J/cm²) was applied over 20 sessions. Case 2: A 28-year-old male developed PM-like symptoms (3 Hz) following third molar extraction, associated with clicking, migraine, and myofascial pain. Neurological investigations were inconclusive. PBMT with a 980 nm diode laser (13.3 J/cm²) was administered over 2-month period.</p><p><strong>Results: </strong>In Case 1, contraction frequency decreased from 2.5 Hz to 0.11 Hz after treatment and remained stable between 0.12-0.36 Hz over a 7-year follow-up, with marked improvement in swallowing and sleep quality. In Case 2, contraction frequency decreased from 3 Hz to 0.3 Hz within 60 days, accompanied by functional and symptomatic improvement.</p><p><strong>Conclusion: </strong>Near-infrared PBMT produced a substantial and sustained reduction in PM activity without adverse effects. Comparable outcomes using 940 nm and 980 nm wavelengths suggest a neuromodulatory rather than purely tissue-heating mechanism.</p><p><strong>Clinical significance: </strong>PBMT may represent a safe and repeatable treatment option for essential PM, a condition with limited effective therapies. Controlled clinical studies are required to confirm optimal parameters and long-term efficacy.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"550-556"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Intravascular Laser Irradiation of Blood in Functional Outcomes of Ischemic Stroke Patients: A Double-Blind Randomized Control Pilot Study.","authors":"Yu-Chi Su, Ta-Chung Chao, Wen-Yuan Chang, Chien-Yao Huang, Chih-Ya Chang, Ke-Ting Pan, Shih-Ming Huang, Liang-Cheng Chen","doi":"10.1177/25785478261465534","DOIUrl":"10.1177/25785478261465534","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the clinical efficacy of intravenous laser irradiation of blood (ILIB) therapy as an adjunct treatment for patients with ischemic stroke.</p><p><strong>Background: </strong>Despite the diverse medical applications of ILIB, there was no strong evidence on the efficacy of ILIB for improving the clinical outcomes of ischemic stroke.</p><p><strong>Methods: </strong>A total of 22 patients with ischemic stroke were randomly assigned to either the ILIB or the control group. The ILIB group received intravenous laser therapy, whereas the control group received the same intervention but without the output power. The after outcome measures were assessed at baseline and at 3 days, 1 month, and 3 months post intervention: National Institute of Health Stroke Scale score, modified Rankin Scale score, Stroke Impact Scale (SIS) score, Fugl-Meyer assessment-Motor Function (FMA-MF) score, and 6-minute walking test (6-MWT) performance.</p><p><strong>Results: </strong>In total, 10 and 12 participants were randomized to the ILIB and control groups, respectively. Compared with the control group, the ILIB group showed significantly better SIS scores at the 3-month follow-up (<i>p</i> = 0.019), significantly higher FMA-MF scores at the 3-day and 3-month follow-ups (<i>p</i> = 0.003 and <i>p</i> = 0.022), and significantly better 6-MWT performance at the 3-day follow-up (<i>p</i> = 0.018).</p><p><strong>Conclusions: </strong>ILIB therapy provided short-term improvements in functional outcomes, including SIS, FMA-MF scores, and 6-MWT, in patients with ischemic stroke.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"513-520"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of High-Intensity Laser Therapy on Disc Size and Functional Outcome in Patients with Lumbar Disc Herniation.","authors":"Wessam Abd Al-Fatah Mohammed, Nahed Ahmed Salem, Ahmed Mohamed Mohasseb, Hoda M Zakaria, Zizi M Ibrahim, Ashraf A Darwesh","doi":"10.1177/25785478261465275","DOIUrl":"10.1177/25785478261465275","url":null,"abstract":"<p><strong>Background: </strong>Lumbar disc herniation (LDH) is a prevalent major cause of low back pain and radicular syndromes in the lower extremities. Elevated disc herniation volumes and the subsequent progression of spinal canal compromise are positively correlated with higher severity of radicular symptoms, functional disability, and neurological deficits.</p><p><strong>Objective: </strong>To investigate the impact of high-intensity laser therapy (HILT) on disc size and functional outcomes in patients with LDH.</p><p><strong>Methods: </strong>This study enrolled 40 patients of both sexes (40% male and 60% female), ages from 30 to 45 years, all presenting with lumbosacral radiculopathy secondary to L4-L5 or L5-S1 disc herniation. Participants were randomly assigned to two equal groups. Group A (study group) received HILT group treated with a combined standard physical therapy exercise program, while Group B (control group) underwent a sham HILT procedure alongside the same physical therapy exercise program. Interventions were conducted three times a week over 6 weeks. The primary outcome was the change in disc herniation size in anteroposterior, transverse, and posterior vertical diameter as measured by magnetic resonance imaging. The secondary outcomes included pain intensity assessed by the visual analogue scale (VAS) and functional disability assessed by the Oswestry Disability Index (ODI).</p><p><strong>Results: </strong>The HILT group demonstrated statistically significant reductions in all disc size parameters compared to the control group (<i>p</i> < 0.05). Additionally, the HILT group showed significantly higher reduction in VAS scores (63.88% vs. 26.04%) and ODI scores (53.5% vs. 24.58%) compared with the control group (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>HILT serves as a potent noninvasive modality for reducing the herniated lumbar discs size and providing significant pain relief and improving functional outcomes in individuals with lumbosacral radiculopathy.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"505-512"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}