Photobiomodulation, photomedicine, and laser surgery最新文献

{"title":"Blue Light-Emitting Diode Irradiation Without a Photosensitizer Alters Oral Microbiome Composition of Ligature-Induced Periodontitis in Mice.","authors":"Keita Toyoshima,&nbsp;Yujin Ohsugi,&nbsp;Peiya Lin,&nbsp;Keiji Komatsu,&nbsp;Takahiko Shiba,&nbsp;Yasuo Takeuchi,&nbsp;Tomomitsu Hirota,&nbsp;Tsuyoshi Shimohira,&nbsp;Yosuke Tsuchiya,&nbsp;Sayaka Katagiri,&nbsp;Takanori Iwata,&nbsp;Akira Aoki","doi":"10.1089/photob.2023.0061","DOIUrl":"10.1089/photob.2023.0061","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study investigated the suppressive effects of blue light-emitting diode (LED) irradiation on bone resorption and changes in the oral microbiome of mice with ligature-induced periodontitis. <b><i>Background:</i></b> Wavelength of blue light has antimicrobial effects; however, whether blue LED irradiation alone inhibits the progression of periodontitis remains unclear. <b><i>Methods:</i></b> Nine-week-old male mice ligated ligature around the right maxillary second molar was divided into ligation alone (Li) and ligation with blue LED irradiation (LiBL) groups. The LiBL group underwent blue LED (wavelength, 455 nm) irradiation four times in a week at 150 mW/cm² without a photosensitizer on the gingival tissue around the ligated tooth at a distance of 5 mm for 5 min. The total energy density per day was 45 J/cm². Bone resorption was evaluated using micro-computed tomography at 8 days. Differences in the oral microbiome composition of the collected ligatures between the Li and LiBL groups were analyzed using next-generation sequencing based on the 16S rRNA gene from the ligatures. <b><i>Results:</i></b> Blue LED irradiation did not suppress bone resorption caused by ligature-induced periodontitis. However, in the LiBL group, the α-diversity, number of observed features, and Chao1 were significantly decreased. The relative abundances in phylum <i>Myxococcota</i> and <i>Bacteroidota</i> were underrepresented, and the genera <i>Staphylococcus</i>, <i>Lactococcus</i>, and <i>Lactobacillus</i> were significantly overrepresented by blue LED exposure. Metagenomic function prediction indicated an increase in the downregulated pathways related to microbial energy metabolism after irradiation. The co-occurrence network was altered to a simpler structure in the LiBL group, and the number of core genera decreased. <b><i>Conclusions:</i></b> Blue LED irradiation altered the composition and network of the oral microbiome of ligature-induced periodontitis in mice.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation Literature Watch April 2023.","authors":"James D Carroll","doi":"10.1089/photob.2023.0125","DOIUrl":"10.1089/photob.2023.0125","url":null,"abstract":"","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Light-Assisted Power Bleaching Techniques on the Penetration of Hydrogen Peroxide into the Pulp Chamber.","authors":"Fatemeh Pournaghiazar,&nbsp;Soodabeh Kimyai,&nbsp;Mehrnaz Motiei","doi":"10.1089/photob.2022.0150","DOIUrl":"10.1089/photob.2022.0150","url":null,"abstract":"<p><p><b><i>Background:</i></b> In-office bleaching is one of the most commonly used procedures for discolored tooth treatment. Although the efficacy of tooth bleaching has been investigated, depending on the applied technique and the used materials, bleaching procedures might irritate the tooth pulp and induce surface changes in enamel. The aim of this study was to evaluate the effect of four different bleaching techniques on the penetration of hydrogen peroxide (HP) into the pulp chamber. <b><i>Materials and methods:</i></b> Seventy-two single-rooted sound human teeth were used. The samples were prepared and evaluated in four groups. Group 1: 35% HP gel alone (HP Gel); group 2: Nd:YAG laser (0.25 W and 10 Hz with a fiber tip size of 200 μm) irradiation was added (HP Gel+laser); group 3: HP gel mixed with graphite particles (10th of millimeter in size) derived from crashed pencil lead in association with Nd:YAG laser (HP Gel+laser+graphite); and group 4: HP gel in association with light-emitting diode (LED) (litex 686, 50 Hz, 450-490 nm) (HP Gel+LED). The amount of HP penetrating into the pulp chamber was evaluated using acetate buffer and standard graphs. Data were analyzed with one-way ANOVA test, using SPSS 17. Post hoc Tukey test was used for between-group comparisons (α = 0.05). <b><i>Results:</i></b> Statistical analyses showed that the HP Gel+laser+graphite group had significantly higher level of HP penetration than other groups (<i>p</i> < 0.001). Moreover, pulp chamber penetration of HP in the HP Gel+laser group was greater than the LED and control groups (<i>p</i> < 0.001). The difference between control and LED groups was not significant (<i>p</i> = 0.99). <b><i>Conclusions:</i></b> Laser bleaching associated with HP Gel and graphite particles resulted in increased penetration of HP into the pulp chamber compared with the LED and control groups.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly-Ether Ether-Ketone Post Conditioned with Sulfuric Acid, Rose Bengal Activated by Photodynamic Therapy and Sandblasting on Pushout Bond Strength to Radicular Dentin Luted with Methyl Methacrylate and Composite-Based Cement.","authors":"Thamer Almohareb, Khold Al Ahdal, Ahmed M Maawadh, Ahoud S Alshamrani, Aminah M El Mourad, Fatima Y Al-Bishry, Ali Alrahlah","doi":"10.1089/photob.2023.0079","DOIUrl":"10.1089/photob.2023.0079","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Assessment of post surface conditioners [sulfuric acid (SA), Rose Bengal (RB), and sandblasting (SB)] and different luting cements [methyl methacrylate (MMA)-based cement and composite-based cement] on pushout bond strength (PBS) of poly-ether ether-ketone (PEEK) post bonded to canal dentin. <b><i>Materials and methods:</i></b> Endodontic treatment was performed on 120 single-rooted human premolar teeth. The preparation of the post space was performed and 4 mm of gutta-percha was retained in the apical region of the root. One hundred and twenty PEEK posts were fabricated from a PEEK blank utilizing a Computer aided design-Computer aided manufacture (CAD-CAM) system. The PEEK posts were allocated randomly into four groups based on post surface conditioning (<i>n</i> = 30). Group A: SA, Group B: RB, Group C: SB, and Group D: No conditioning (NC). Each group was further divided into two subgroups based on the luting cement used for bonding (<i>n</i> = 15). Group A1, B1, C1, and D1 specimens were cemented using composite-based resin cement. However, Group A2, B2, C2, and D2 posts were luted with MMA-based resin cement. PBS assessment using a universal testing machine was performed. Failure modes were analyzed under a stereomicroscope. The data relating to the effects of surface treatment and luting types of cement were analyzed using one-way analysis of variance (ANOVA) and Tukey's post hoc test (<i>p</i> = 0.05). <b><i>Results:</i></b> Coronal section of Group B2: RB+Super-Bond C&B [9.61 ± 0.75 megapascals (MPa)] displayed the highest bond scores of PEEK after root dentin. Whereas it was also discovered that Group D1: NC+Panavia^®V5 (2.05 ± 0.72 MPa) presented the lowest PBS scores. Intergroup comparison analysis revealed that Group A2: SA+Super-Bond C&B and Group B2: RB+Super-Bond C&B displayed no significant difference in their bond scores. <b><i>Conclusions:</i></b> RB and SA possess the potential to be used as a PEEK post conditioner. MMA-based cement displayed better performance than composite-based cement.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenylalanine-Arginine-β-Naphthylamide Enhances the Photobactericidal Effect of Methylene Blue on <i>Pseudomonas aeruginosa</i>.","authors":"Lixia He,&nbsp;Shanlin Yang,&nbsp;Weijun Xuan,&nbsp;Xiumei Zhen,&nbsp;Qi Qi,&nbsp;Yongqi Qi,&nbsp;Qingxiang Li,&nbsp;Meixia Du,&nbsp;Michael R Hamblin,&nbsp;Liyi Huang","doi":"10.1089/photob.2023.0005","DOIUrl":"10.1089/photob.2023.0005","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To investigate the effectiveness, dosing sequence, concentration, and mechanism of antimicrobial photodynamic inactivation (aPDI) using methylene blue (MB) plus phenylalanine-arginine-β-naphthylamide (PAβN) against <i>Pseudomonas aeruginosa</i>. <b><i>Methods:</i></b> <i>P. aeruginosa</i> bacterial suspension was incubated with MB for different times (5-240 min), and then, 10 J/cm² red light was irradiated. The efflux pump inhibitor (EPI) PAβN (10-100 μg/mL) was combined with MB (1-20 μM) in different sequences (PAβN-first, PAβN+MB, PAβN-after). Colony-forming units were then determined by serial dilution. <b><i>Results:</i></b> Using MB 10 μM plus 10 J/cm², the killing effect of MB-aPDI on <i>P. aeruginosa</i> increased first and then decreased with longer incubation time. The killing effect of MB+PAβN-aPDI on <i>P. aeruginosa</i> was better than that of MB-aPDI (<i>p</i> < 0.05) by up to 2 logs. PAβN-first had the best killing effect, whereas PAβN-after had the worst killing effect. The killing effect increased with PAβN concentration and at 100 μg/mL reached 5.1 logs. <b><i>Conclusions:</i></b> The EPI PAβN enhanced the bactericidal effect of MB-aPDI on <i>P. aeruginosa</i>, especially when added before MB. It is proposed that MB is a substrate of the resistance-nodulation-division family efflux pump.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>MicroRNA-26</i> and Related Osteogenic Target Genes Could Play Pivotal Roles in Photobiomodulation and Adipose-Derived Stem Cells-Based Healing of Critical Size Foot Defects in the Rat Model.","authors":"Hanieh Mohebbi,&nbsp;Elham Siasi,&nbsp;Armin Khosravipour,&nbsp;Mohammadali Asghari,&nbsp;Abdollah Amini,&nbsp;Atarodalsadat Mostafavinia,&nbsp;Mohammad Bayat","doi":"10.1089/photob.2022.0128","DOIUrl":"10.1089/photob.2022.0128","url":null,"abstract":"<p><p><b><i>Objective:</i></b> In this study, we aimed to explore the role of MicroRNA-26 in photobiomodulation (PBM)- and adipose-derived stem cell (ADS)-based healing of critical-sized foot fractures in a rat model. <b><i>Background:</i></b> PBM and ADS treatments are relatively invasive methods for treating bone defects. Specific and oriented cellular and molecular functions can be induced by applying an appropriate type of PBM and ADS treatment. <b><i>Methods:</i></b> A critical size foot defect (CSFD) is induced in femoral bones of 24 rats. Then, a human demineralized bone matrix scaffold (hDBMS) was engrafted into all CSFDs. The rats were randomly allocated into four groups (<i>n</i> = 6): (1) control (hDBMS); (2) hDBMS+human ADSs (hADSs), hADSs engrafted into CSFDs; (3) hDBMS+PBM, CSFD exposed to PBM (810 nm wavelength, 1.2 J/cm² energy density); and (4) hDBMS+(hADSs+PBM), hADSs implanted into the CSFD and then exposed to PBM. At 42 days after CSFD induction, the rats were killed, and the left CSFD was removed for mechanical compression tests and the right CSFD was removed for molecular and histological studies. <b><i>Results:</i></b> The results indicate that miRNA-26a, BMP, SMAD, RUNX, and OSTREX had higher expression in the treated groups than in the control group. Further, the biomechanical and histological properties of CSFDs in treated groups were improved compared with the control group. Correlation tests revealed a positive relationship between microRNA and improved biomechanical and cellular parameters of CSFDs in the rat model. <b><i>Conclusions:</i></b> We concluded that the <i>MicroRNA-26</i> signaling pathway probably plays a significant role in the hADS-, PBM-, and hADS+PBM-based healing of CSFDs in rats. Clinical Trial Registration number: IR.SBMU.MSP.REC.1398.980.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nonrandomized Trial of the Effects of Near-Infrared Photobiomodulation Therapy on Bell's Palsy with a Duration of Greater Than 8 Weeks.","authors":"Dong Wu,&nbsp;Yan-Ling Zhao,&nbsp;Jing-Yi Sun,&nbsp;Ru-Jun Dai,&nbsp;Kai Cao,&nbsp;Rong-Kun Qu,&nbsp;Yu Wang,&nbsp;Yun-Qing Wu","doi":"10.1089/photob.2023.0056","DOIUrl":"https://doi.org/10.1089/photob.2023.0056","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To determine whether photobiomodulation therapy (PBMT) by class IV Multiwave Locked System laser treatment as an adjunctive therapy could relieve symptoms in patients with Bell's palsy with a duration of greater than 8 weeks. <b><i>Materials and methods:</i></b> This nonrandomized controlled trial was conducted from January 2020 to December 2022. Patients were eligible if they had Bell's palsy with a duration of greater than 8 weeks at the out-patient department of otorhinolaryngology in Beijing Tongren Hospital. The control group consisted of patients recruited between January 1, 2020, and December 31, 2020. The PBMT group consisted of patients recruited between January 1, 2021, and December 31, 2022. In this study, the PBM used has a wavelength of 808 and 905 nm, 1.2 W power (808 nm is 1 W, 905 nm is 200 mW), continuous mode emission (808 nm) and pulsed mode emission (905 nm), 8.35 J/cm² dosimetry, administered 3 times per week, 72 times of total treatment. The primary outcome measures included the House-Brackmann facial nerve grading system, the Sunnybrook facial grading system, and the Facial Clinimetric Evaluation Scale (FaCE). Secondary outcome measures comprised electroneurography, electromyography, and the blink reflex. <b><i>Results:</i></b> A total of 54 participants were included (27 in the control group and 27 in the photobiomodulation group). After 6 months, the House-Brackmann grading system [risk difference, -0.59, confidence interval (95% CI), -0.81 to -0.38, relative risk, 0.27, 95% CI, 0.13-0.56, <i>p</i> < 0.001], Sunnybrook facial grading system (21.14, 95% CI, 11.71-30.58; <i>p</i> < 0.001), and FaCE (-0.20, 95% CI, 0.41-0.02; <i>p</i> = 0.07) had significant difference between the two groups. Latency of ala nasi muscle (10.92, 95% CI, 5.58-16.27; <i>p</i> < 0.001) was not statistically significant after treatment compared with the control group; however, most of the electrophysiological examinations have significant difference between the two groups, respectively. <b><i>Conclusions:</i></b> The results of this study suggest that PBMT may relieve symptoms for patients with Bell's palsy with a duration of greater than 8 weeks. Trial Registration: ClinicalTrials.gov Identifier: NCT05585333.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 810 nm Diode Laser Irradiation on the Time of Initiation and Depth of Anesthesia for Endodontic Treatment of Mandibular First Molars with Symptomatic Irreversible Pulpitis: A Clinical Trial.","authors":"Elham Khoshbin,&nbsp;Leila Ghasemi,&nbsp;Rooholah Behroozi,&nbsp;Zahra Khosravi,&nbsp;Afsaneh Rahmati,&nbsp;Loghman Rezaeisoufi,&nbsp;Hamed Karkehabadi","doi":"10.1089/photob.2023.0068","DOIUrl":"https://doi.org/10.1089/photob.2023.0068","url":null,"abstract":"<p><p><b><i>Objective:</i></b> In endodontic treatments, performing appropriate anesthesia in patients with irreversible pulpitis in mandibular molars may result in pain and severe problems. The irradiation of low-level lasers could be effective in this regard due to its anti-inflammatory and regenerative properties. This study aimed to assess the effect of 810 nm diode laser on the time of initiation and depth of anesthesia for endodontic treatment of mandibular first molars with symptomatic irreversible pulpitis. <b><i>Materials and methods:</i></b> This randomized controlled clinical trial evaluated 60 patients requiring endodontic treatment of mandibular first molars with symptomatic irreversible pulpitis and pain score ≥114 according to the Heft-Parker visual analog scale (HP-VAS). The teeth were randomized into two groups of diode laser and control. In the diode laser group, 810 nm diode laser with 300 mW power and 15 J/cm² energy density was irradiated to the buccal surface of tooth crowns for 20 sec at 2 mm distance immediately before anesthesia administration. Laser in off mode was used in the control group. Inferior alveolar nerve block was then performed using 2% lidocaine with 1:80,000 epinephrine. After anesthetic injection, the mandibular first molar and canine teeth (control) were tested by an electric pulp tester every 2 min. Two consecutive negative responses to 80 mA indicated the initiation of anesthesia. HP-VAS forms were filled out by patients to assess their level of pain during the procedure. Data were analyzed by the Student's <i>t</i> and Chi-square tests, and analysis of variance (α = 0.05). <b><i>Results:</i></b> No remarkable difference was noted between the laser group and control groups in pain severity or anesthesia onset (<i>p</i> > 0.05). <b><i>Conclusions:</i></b> Low-level (810 nm) diode laser did not affect the time of initiation or depth of anesthesia in endodontic treatment of mandibular first molars with symptomatic irreversible pulpitis. Clinical trials registration: Iranian Registry of Clinical Trials (IRCT20181222042076N1).</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histomorphometric Analysis of the Healing Capacity of Low-Level Laser on Thermally Induced Tongue Ulcers for Gamma-Irradiated Rats.","authors":"Salwa Farid Ahmed,&nbsp;Ali Mohamed Saafan,&nbsp;Amr H Rasmy,&nbsp;Mostafa A Bakr","doi":"10.1089/photob.2023.0017","DOIUrl":"https://doi.org/10.1089/photob.2023.0017","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study aimed to assess the efficacy of low-level laser therapy (LLLT) for treating thermal tongue ulcers in gamma-irradiated rats. <b><i>Background:</i></b> Postradiotherapeutic trauma may cause cell death, tissue damage, organ dysfunction, and loss of hematological components. <b><i>Materials and methods:</i></b> Thermal ulcers were induced on the dorsal surfaces of tongues of gamma-irradiated rats (15 Gy). Rats were divided into three groups, group 1 received no treatment, group 2 was subjected to a single dose of diode laser 807 nm with energy density 4 J/cm², and group 3 was subjected to the same dose of LLLT but fractionated into three sessions at days 1, 3, and 5 after ulcers induction. Ulcers were assessed clinically for their areas and healing percentage. Specimens were examined for the quality of ulcer closure and expression of IL-1β and TGF-β1. <b><i>Results:</i></b> Results revealed significant improvement of ulcer healing clinically and histologically in both treatment groups compared to control. Moreover, IL-1β and TGF-β1 expression in both treatment groups was high at the earlier stage of healing then declined by time to reach a normal level. However, untreated group showed higher expression of IL-1β and TGF-β1 compared to treatment groups. In addition, IL-1β expression decreased by time but still of high level and TGF-β1 expression increased then declined. <b><i>Conclusions:</i></b> We concluded that gamma radiation-impaired mucosal healing could be related to the over expression of IL-1β and TGF-β1. LLLT, whether one session or fractionated, could be an effective treatment for postradiotherapeutic ulcers. The healing power of LLLT might be due to modulation of IL-1β and TGF-β1. Clinical Trial Registration number is 25A122.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingivectomy with Diode Laser Versus the Conventional Scalpel Surgery and Nonsurgical Periodontal Therapy in Treatment of Orthodontic Treatment-Induced Gingival Enlargement: A Systematic Review.","authors":"Avideh Maboudi,&nbsp;Reza Fekrazad,&nbsp;Atena Shiva,&nbsp;Negareh Salehabadi,&nbsp;Mahmood Moosazadeh,&nbsp;Hodis Ehsani,&nbsp;Omid Yazdani","doi":"10.1089/photob.2023.0060","DOIUrl":"https://doi.org/10.1089/photob.2023.0060","url":null,"abstract":"<p><p><b><i>Background and objective</i>:</b> Some studies support the superiority of diode laser gingivectomy to scalpel surgery and nonsurgical treatments. However, a systematic review on this topic is lacking. This study aimed to compare gingivectomy with diode laser versus the conventional scalpel surgery and nonsurgical periodontal therapy (NSPT) in the treatment of orthodontic treatment-induced gingival enlargement (GE). <b><i>Materials and methods</i>:</b> In this systematic review, an electronic search of the relevant literature was conducted in Web of Science, Medline/PubMed, Scopus, Cochrane Central Register of Controlled Trials, and ProQuest with no language restriction. Randomized clinical trials published between 1985 and 2020 on comparative treatment of orthodontic treatment-induced GE by diode laser gingivectomy and scalpel surgery or NSPT regarding intraoperative and postoperative bleeding and/or pain were included. Risk of bias was assessed by the Cochrane 1 tool. <b><i>Results</i>:</b> Of the initially retrieved 288 articles, 40 were duplicates and excluded; 236 articles were excluded following title and abstract screening, and 5 others were excluded following full-text assessment. Finally, 7 studies underwent systematic review. In the risk-of-bias assessment, 5 studies scored 2, and 2 studies scored 3 out of 6. Intraoperative and postoperative bleeding and pain were found to be significantly lower in the laser group. <b><i>Conclusions</i>:</b> Within the limitations of this systematic review and with respect to the quality of evidence, the present results revealed lower level of pain and bleeding in diode laser gingivectomy compared with the conventional scalpel surgery and NSPT for treatment of orthodontic treatment-induced GE.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}