{"title":"Photobiomodulation as a Potential Adjuvant Therapy to Improve Cochlear Implant Efficiency.","authors":"So-Young Chang, Min Young Lee","doi":"10.1089/photob.2024.0097","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Objective:</i></b> Photobiomodulation (PBM) is a noninvasive therapeutic modality with widespread applications for modulating various biological processes. Although the exact mechanisms of action remain uncertain, PBM promotes homeostasis through diverse pathways, including reducing inflammation and enhancing tissue recovery. Hearing loss is irreversible in mammals due to the limited regenerative capacity of cochlear hair cells. Cochlear implants offer a solution by electrically stimulating the auditory nerve, bypassing damaged hair cells in individuals with severe hearing loss. However, postoperative inflammatory responses and cochlear nerve fiber damage can compromise implant efficacy. <b><i>Materials and Methods:</i></b> We investigated current strategies to minimize secondary cochlear damage after cochlear implantation and evaluated the potential of PBM as an adjuvant therapeutic approach. <b><i>Results:</i></b> The auditory cell protective effects of PBM could significantly enhance the performance of EAS devices in individuals with residual hearing. Further, postoperative CI is accompanied by an inflammatory response characterized by the upregulation of specific cytokines. <b><i>Conclusion:</i></b> Considering the neuroregenerative potential of PBM, its application as a neuroprotective strategy warrants further validation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photobiomodulation, photomedicine, and laser surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/photob.2024.0097","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Photobiomodulation (PBM) is a noninvasive therapeutic modality with widespread applications for modulating various biological processes. Although the exact mechanisms of action remain uncertain, PBM promotes homeostasis through diverse pathways, including reducing inflammation and enhancing tissue recovery. Hearing loss is irreversible in mammals due to the limited regenerative capacity of cochlear hair cells. Cochlear implants offer a solution by electrically stimulating the auditory nerve, bypassing damaged hair cells in individuals with severe hearing loss. However, postoperative inflammatory responses and cochlear nerve fiber damage can compromise implant efficacy. Materials and Methods: We investigated current strategies to minimize secondary cochlear damage after cochlear implantation and evaluated the potential of PBM as an adjuvant therapeutic approach. Results: The auditory cell protective effects of PBM could significantly enhance the performance of EAS devices in individuals with residual hearing. Further, postoperative CI is accompanied by an inflammatory response characterized by the upregulation of specific cytokines. Conclusion: Considering the neuroregenerative potential of PBM, its application as a neuroprotective strategy warrants further validation.
目的:光生物调节(PBM)是一种非侵入性治疗方式,可广泛应用于调节各种生物过程。尽管确切的作用机制仍不确定,但光生物调节可通过多种途径促进体内平衡,包括减少炎症和促进组织恢复。由于耳蜗毛细胞的再生能力有限,哺乳动物的听力损失是不可逆的。人工耳蜗通过电刺激听觉神经,绕过受损的毛细胞,为重度听力损失患者提供了一种解决方案。然而,术后炎症反应和耳蜗神经纤维损伤会影响植入效果。材料和方法:我们研究了当前最大限度减少人工耳蜗植入术后继发性耳蜗损伤的策略,并评估了 PBM 作为辅助治疗方法的潜力。结果PBM 的听觉细胞保护作用可显著提高 EAS 设备在残余听力患者中的性能。此外,术后 CI 还伴随着以特定细胞因子上调为特征的炎症反应。结论考虑到 PBM 的神经再生潜力,其作为神经保护策略的应用值得进一步验证。