Photobiomodulation, photomedicine, and laser surgery最新文献

{"title":"Photobiomodulation Treatment with a Home-Use Device for COVID-19: A Randomized Controlled Trial for Efficacy and Safety.","authors":"Lew Lim, Nazanin Hosseinkhah, Mark Van Buskirk, Andrea Berk, Genane Loheswaran, Zara Abbaspour, Mahta Karimpoor, Alison Smith, Kai Fai Ho, Abhiram Pushparaj, Michael Zahavi, Alexander White, Jonathan Rubine, Brian Zidel, Christopher Henderson, Russell Gene Clayton, David Roy Tingley, David Joseph Miller, Mahroo Karimpoor, Michael R Hamblin","doi":"10.1089/pho.2023.0179","DOIUrl":"10.1089/pho.2023.0179","url":null,"abstract":"<p><p><b><i>Background:</i></b> Photobiomodulation therapy (PBMT) using devices to deliver red and/or near-infrared light to tissues has shown promising effects in clinical settings for respiratory diseases, including potential benefits in managing symptoms associated with COVID-19. <b><i>Objective:</i></b> To determine if at-home self-administered PBMT for patients with COVID-19 is safe and effective. <b><i>Methods:</i></b> This was a randomized controlled trial (RCT) carried out at home during the COVID-19 pandemic (September 2020 to August 2021). The treatment group self-administered the Vielight RX Plus PBMT device (635 nm intranasal and 810 nm chest LEDs) and were monitored remotely. Eligible patients scored 4-7 (out of 7) for severity on the Wisconsin Upper Respiratory Symptom Survey (WURSS-44). Patients were randomized equally to Control group receiving standard-of-care (SOC) only or Treatment group receiving SOC plus PBMT. The device was used for 20 min 2X/day for 5 days and, subsequently, once daily for 30 days. The primary end-point was time-to-recovery (days) based on WURSS-44 question 1, \"How sick do you feel today?\". Subgroup analysis was performed, and Kaplan-Meier and Cox Proportional Hazards analysis were employed. <b><i>Results:</i></b> One hundred and ninety-nine eligible patients (18-65 years old) were divided into two subgroups as follows: 136 patients with 0-7 days of symptoms at baseline and 63 patients with 8-12 days of symptoms. Those with 0-7 days of symptoms at baseline recovered significantly faster with PBMT. The median for Treatment group was 18 days [95% confidence interval (CI), 13-20] versus the Control group 21 days (95% CI, 15-28), <i>p</i> = 0.050. The treatment:control hazard ratio was 1.495 (95% CI, 0.996-2.243), <i>p</i> = 0.054. Patients with symptom duration ≥7 days did not show any significant improvement. No deaths or severe adverse events (SAEs) occurred in the Treatment group, whereas there was 1 death and 3 SAEs requiring hospitalization in the Control group. <b><i>Conclusions:</i></b> Patients with ≤7 days of COVID-19 symptoms recovered significantly faster with PBMT compared to SOC. Beyond 7 days, PBMT showed no superiority over SOC. <b><i>Trial Registration:</i></b> ClinicalTrials.gov NCT04418505.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"42 6","pages":"393-403"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation in the Treatment of Dysgeusia in Patients with Long COVID: Comment.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1089/photob.2024.0040","DOIUrl":"https://doi.org/10.1089/photob.2024.0040","url":null,"abstract":"","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Blue Light (450-460 nm) Phototherapy for <i>Pseudomonas aeruginosa</i>-Infected Wounds.","authors":"Andreas Zoric, Mahsa Bagheri, Maria von Kohout, Tara Fardoust, Paul C Fuchs, Jennifer L Schiefer, Christian Opländer","doi":"10.1089/pho.2023.0180","DOIUrl":"https://doi.org/10.1089/pho.2023.0180","url":null,"abstract":"<p><p><b><i>Background:</i></b> Nosocomial wound infection with <i>Pseudomonas aeruginosa</i> (PA) is a serious complication often responsible for septic mortality of burn patients. High-intensity antimicrobial blue light (aBL) treatment may represent an alternative therapy for PA infections. <b><i>Methods:</i></b> Antibacterial effects of an light-emitting diode (LED) array (450-460 nm; 300 mW/cm²; 15/30 min; 270/540J/cm²) against PA were determined by suspension assay, biofilm assay, and a human skin wound model and compared with 15-min topically applied 3% citric acid (CA) and wound irrigation solution (Prontosan^®; PRT). <b><i>Results:</i></b> The aBL reduced the bacterial number (2.51-3.56 log₁₀ CFU/mL), whereas PRT or CA treatment achieved a 4.64 or 6.60 log₁₀ CFU/mL reduction in suspension assays. The aBL reduced biofilm formation by 60%-66%. PRT or CA treatment showed reductions by 25% or 13%. In this study, aBL reduced bacterial number in biofilms (1.30-1.64 log₁₀ CFU), but to a lower extent than PRT (2.41 log₁₀ CFU) or CA (2.48 log₁₀ CFU). In the wound skin model, aBL (2.21-2.33 log₁₀ CFU) showed a bacterial reduction of the same magnitude as PRT (2.26 log₁₀ CFU) and CA (2.30 log₁₀ CFU). <b><i>Conclusions:</i></b> The aBL showed a significant antibacterial efficacy against PA and biofilm formation in a short time. However, a clinical application of aBL in wound therapy requires effective active skin cooling and eye protection, which in turn may limit clinical implementation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Blue Light (450-460 nm) Phototherapy for <i>Pseudomonas aeruginosa</i>-Infected Wounds.","authors":"Andreas Zoric, Mahsa Bagheri, Maria von Kohout, Tara Fardoust, Paul C Fuchs, Jennifer L Schiefer, Christian Opländer","doi":"10.1089/photob.2023.0180","DOIUrl":"https://doi.org/10.1089/photob.2023.0180","url":null,"abstract":"<p><p><b><i>Background:</i></b> Nosocomial wound infection with <i>Pseudomonas aeruginosa</i> (PA) is a serious complication often responsible for the septic mortality of burn patients. <b><i>Objective:</i></b> High-intensity antimicrobial blue light (aBL) treatment may represent an alternative therapy for PA infections and will be investigated in this study. <b><i>Methods:</i></b> Antibacterial effects of a light-emitting diode array (450-460 nm; 300 mW/cm²; 15/30 min; 270/540 J/cm²) against PA were determined by suspension assay, biofilm assay, and a human skin wound model and compared with 15-min topically applied 3% citric acid (CA) and wound irrigation solution (Prontosan^®; PRT). <b><i>Results:</i></b> aBL reduced the bacterial number [2.51-3.56 log₁₀ colony-forming unit (CFU)/mL], whereas PRT or CA treatment achieved a 4.64 or 6.60 log₁₀ CFU/mL reduction in suspension assays. aBL reduced biofilm formation by 60-66%. PRT or CA treatment showed reductions by 25% or 13%. Here, aBL reduced bacterial number in biofilms (1.30-1.64 log₁₀ CFU), but to a lower extend than PRT (2.41 log₁₀ CFU) or CA (2.48 log₁₀ CFU). In the wound skin model, aBL (2.21-2.33 log₁₀ CFU) showed a bacterial reduction of the same magnitude as PRT (2.26 log₁₀ CFU) and CA (2.30 log₁₀ CFU). <b><i>Conclusions:</i></b> aBL showed a significant antibacterial efficacy against PA and biofilm formation in a short time. However, a clinical application of aBL in wound therapy requires effective active skin cooling and eye protection, which in turn may limit clinical implementation.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"42 5","pages":"356-365"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation Literature Watch August 2023.","authors":"James D Carroll","doi":"10.1089/photob.2024.0047","DOIUrl":"https://doi.org/10.1089/photob.2024.0047","url":null,"abstract":"","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"42 5","pages":"389-392"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing Carbon Dioxide Laser-Induced Postinflammatory Hyperpigmentation with Prophylactic Photobiomodulation: A Case Study.","authors":"Augustin C Barolet, Daniel Barolet","doi":"10.1089/photob.2023.0184","DOIUrl":"10.1089/photob.2023.0184","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study aimed to investigate the effectiveness of prophylactic photobiomodulation (PBM) in reducing postinflammatory hyperpigmentation (PIH) induced by carbon dioxide (CO₂) laser resurfacing in a patient with periorbital syringomas. <b><i>Background:</i></b> PIH is a common condition characterized by abnormal skin pigmentation after an inflammatory process occurring in up to 20-30% of patients undergoing CO₂ laser resurfacing. <b><i>Methods:</i></b> The patient was treated with PBM using a pulsed home-use device at 630 nm before and after CO₂ laser treatment. The patient was asked to treat the right periorbital area before and after the CO₂ laser treatment, which was continued once a day for 2 consecutive weeks. <b><i>Results:</i></b> At 12 weeks, PIH was significantly reduced on the treated side compared with the contralateral untreated side (leading to persistent erythema at 6 months). <b><i>Conclusions:</i></b> This is the first report of prophylactic treatment of CO₂ laser-induced dyschromia using PBM.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"42 5","pages":"339-342"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Laser Treatment in Pilonidal Disease: A Single-Arm Meta-Analysis.","authors":"Changying Xie, Rou Zeng, Xuchao Yu","doi":"10.1089/photob.2024.0028","DOIUrl":"10.1089/photob.2024.0028","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study aimed to collate all published studies on laser therapy for pilonidal disease and demonstrate the safety and effectiveness of minimally invasive techniques. <b><i>Methods:</i></b> A comprehensive literature search, with no language limitations, was performed using PubMed, Embase, and Web of Science from inception to April 23, 2023. Two reviewers independently screened the literature according to the inclusion and exclusion criteria and evaluated the bias risk of included studies. Meta-analysis was performed using RevMan software (version 5.4). (PROSPERO Registration ID Number CRD42023420803). <b><i>Results:</i></b> The analysis included 1214 patients from 13 studies, who fulfilled the pre-defined inclusion criteria. With a median follow-up of 12 (range, 7.8-25) months, 1000 (84.4%) patients achieved healing after primary laser treatment. The mean complication and recurrence rates were 12.7% and 7.6%, respectively. <b><i>Conclusions:</i></b> Laser ablation for pilonidal sinus disease is a new minimally invasive technique with good treatment efficacy, low postoperative recovery, and shorter recovery periods following employment.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"42 5","pages":"375-382"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Root Canal Disinfection in Permanent Molars with Apical Lesion by Antimicrobial Photodynamic Therapy: Protocol for a Blind Randomized Clinical Trial.","authors":"Nilton Alves, Naira Figueiredo Deana, Jaime Abarca, Héctor Monardes, Pablo Betancourt, Carlos Zaror","doi":"10.1089/photob.2023.0186","DOIUrl":"10.1089/photob.2023.0186","url":null,"abstract":"<p><p><b><i>Objective:</i></b> The proposed study aims to compare the effectiveness of conventional endodontic treatment (ET) with that of ET associated with antimicrobial photodynamic therapy (aPDT) in patients with apical lesion. <b><i>Methods:</i></b> Controlled, double-blind, randomized clinical trial (RCT); superiority study with three parallel arms. Randomization will be conducted in exchange blocks of six, with allocation 1:1:1. The control group will receive conventional ET, while experimental group 1 (EG1) will receive conventional ET + aPDT with laser at 660 nm, fluence of 600 J/cm²; EG2 will receive conventional ET + aPDT with laser at 660 nm, fluence of 1200 J/cm². The primary outcome will be canal disinfection before treatment, measured by analysis of colony formation (CFU/mL) and the success rate measured after 6 months on the clinical and radiographic evaluations. The mean and standard deviation will be calculated for continuous outcomes, and the CFU/mL mean between groups will be evaluated by ANOVA test. The Chi-squared test will be calculated for binary outcomes. A logistic regression analysis will be performed to assess differences in the success rate between groups, adjusted for the covariates. The Stata 18 software will be used, with a significance threshold of 5%. <b><i>Conclusions:</i></b> Few RCTs have evaluated the effectiveness of aPDT in root canal disinfection in patients with permanent dentition presenting apical lesion. New RCTs with larger numbers of participants are needed to support using aPDT as an adjuvant to conventional ET in root canal disinfection for routine use in clinical practice. The trial was registered prospectively in ClinicalTrials.gov (NCT05916859).</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"42 5","pages":"366-374"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation Literature Watch July 2023.","authors":"James D Carroll","doi":"10.1089/photob.2024.0011","DOIUrl":"10.1089/photob.2024.0011","url":null,"abstract":"","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"324-326"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Photobiomodulation Therapy on the Expression of Hypoxic Inducible Factor, Vascular Endothelial Growth Factor, and Its Specific Receptor: A Randomized Control Trial in Patients with Diabetic Foot Ulcer.","authors":"Giti Torkaman, Mahsa Hoseini-Sanati, Mehdi Hedayati, Maryam Mofid, Manouchehr Iranparvar Alamdari","doi":"10.1089/photob.2023.0152","DOIUrl":"10.1089/photob.2023.0152","url":null,"abstract":"<p><p><b><i>Background:</i></b> Impaired angiogenesis is a significant factor contributing to delayed healing in diabetic foot ulcers (DFUs) due to inadequate oxygenation. <b><i>Objective:</i></b> This study aimed to investigate the impact of photobiomodulation (PBM) using a Ga-As laser on the release of serum hypoxia-inducible factor 1-α (HIF-1α), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2, and nitric oxide (NO) in diabetic patients with DFUs. <b><i>Materials and methods:</i></b> In this double-blind RCT, a total of 30 patients with grade II DFUs were enrolled. The patients were randomly divided into two groups: the PBM (<i>n</i> = 15) and the placebo (<i>n</i> = 15). In the PBM group, a Ga-As laser (904 nm, 2 J/cm², 90 W) was given for 3 days/week for 4 weeks (11 sessions). In the placebo group, the power was turned off. Both groups received similar standard wound care. Before and after interventions, the levels of serum HIF-1α, VEGF, NO, and sVEGFR<b>-</b>2 were measured. In addition, the percentage decrease in the wound surface area (%DWSA) was measured. <b><i>Results:</i></b> Following the intervention, the results revealed that the PBM group had significantly lower levels of VEGF than the placebo group (<i>p</i> = 0.005). The %DWSA was significantly higher in the PBM group compared to the placebo group (<i>p</i> = 0.003). Moreover, VEGF showed a significant negative correlation with %DWSA (<i>p</i> < 0.001). <b><i>Conclusions:</i></b> The observed decrease in serum levels of VEGF and an increase in %DWSA, compared to the placebo group, suggests that PBM effectively improves angiogenesis. Furthermore, the significant correlation found between VEGF levels and %DWSA emphasizes the importance of evaluating wound surface in patients as a dependable indicator of enhanced wound angiogenesis. Clinical Trial Registration: NCT02452086.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"275-284"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}