Neuro endocrinology letters最新文献

{"title":"Periodontitis, Fusobacterium nucleatum, and Colorectal Carcinoma. A Review.","authors":"Michal Straka, Petra Borecová, Matej Straka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our review study addresses chronic periodontitis and its potential complications in the distal segments of the intestine and rectum. Subgingival colonization by gram-negative anaerobic bacteria such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Eikenella corrodens, and Fusobacterium nucleatum may, through haematogenous dissemination into non-oral tissues and organs, cause severe systemic diseases. In connection with colorectal carcinoma, the third most frequently diagnosed malignant tumor, special attention has been focused on the anaerobic rod Fusobacterium nucleatum, one of the key periodontal pathogens involved in periodontal pocket infections. A growing amount of direct and indirect evidence supports its role in the development, progression, and persistence of colorectal carcinoma in the distal colon and rectum. F. nucleatum possesses numerous virulence factors that underlie its remarkable infectious potential, not only within the oral cavity but also in the colonic environment, where they facilitate its integration into the dysbiotic microbiome and directly contribute to carcinogenesis in this region. Disruption of the physiological microbiota and colonization by F. nucleatum are now considered major drivers of malignant tumorigenesis in the distal colon. Several studies confirm the oral origin of F. nucleatum and its potential haematogenous spread into the intestinal microenvironment. Eradication of F. nucleatum from the colon is regarded as a crucial factor in achieving successful treatment outcomes for colorectal cancer (CRC). However, systemic administration of broad spectrum antibiotics adversely affects the composition of the normal gut microbiome, leading to microbial imbalance. For this reason, the elimination of F. nucleatum in the colon and rectum relies on a whole range of antibacterial agents that minimally disrupt the gut microbiota. Our eradication strategy for F. nucleatum emphasizes close cooperation between dentists or periodontologists and gastroenterologists or oncologists, targeting high-risk populations: patients with IBD, colorectal adenomas ≥1 cm, multiple polyps, or first-degree relatives with CRC diagnosed before age 60. These at risk patients undergo dental evaluation for periodontitis and gingivitis by collaborating dentists. Identified cases are treated using localized, comprehensive, and early eradication strategies targeting F. nucleatum and other periodontal pathogens within the periodontal pocket microenvironment. The primary objective of early interdisciplinary cooperation is to detect early stages of periodontitis with periodontal pocket depths of up to 4 mm. In such early forms of periodontitis, elimination of infection can be achieved through local approaches including scaling, deep scaling, and curettage, combined with the application of antibacterial solutions, varnishes, antimicrobial impregnated fibers, and, where appropriate, the use of periodontal lasers.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 4","pages":"232-248"},"PeriodicalIF":0.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating dream work into group schema therapy for individuals with borderline patients.","authors":"Jan Prasko, Ilona Krone, Matej Kasal, Ieva Bite, Jakub Vanek, Julija Gecaite-Stonciene, Martin Mikula, Julius Burkauskas, Marija Abeltina, Alicja Juskiene, Erika Jurisova, Milos Slepecky, Jozef Visnovsky, Marie Ociskova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Borderline personality disorder (BPD) is associated with significant difficulties in emotional regulation and a higher prevalence of nightmares, which increase emotional instability and decrease quality of life. Dreams represent valuable therapeutic material that can reveal internal conflicts and support self-awareness.</p><p><strong>Objective: </strong>This article explores dreamwork in group schema therapy (GST) aimed at the early maladaptive schemas (EMS) and modes. The ultimate goal of these approaches is to support the Healthy Adult mode in processing the emotional needs of patients with BPD.</p><p><strong>Methods: </strong>TThe article presents the theoretical foundations and therapeutic techniques, including imagery, dream rescripting, chairwork, and amplification of dream images. Case vignettes illustrate how dreamwork can help recognise and process a patient's internal conflicts and thus aid the therapy process.</p><p><strong>Results: </strong>Dreamwork in GST helps patients better understand their emotional needs and schemas. The increased awareness helps to modify dysfunctional behaviour and improve emotional stability. The group therapy format allows patients to share their experiences and receive support from others, which increases the feeling of belonging and security.</p><p><strong>Discussion: </strong>Dreamwork in GST creates a safe space for processing internal conflicts related to EMS and connections with real possibilities in the patient's life. Dreamwork also brings challenges, such as the risk of slipping into intellectualisation or being overwhelmed by strong emotions and unable to resolve impactful dreams. Dedicated courses and research are needed to warrant effective implementation and elaboration of these methods.</p><p><strong>Conclusion: </strong>Dreamwork in GST might be an effective tool for promoting self-awareness, processing emotional conflicts, and strengthening the Healthy Adult and Kind Parent modes.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 4","pages":"221-231"},"PeriodicalIF":0.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypolipidemic, anti-inflammatory, and neurotrophic effects of a multicomponent nutraceutical containing berberine, bergamot, and amaranth in mild-to-moderate hypercholesterolemia.","authors":"Piercarlo Minoretti, Simone Lista, Kayvan Khoramipour, Paula Crespo-Escobar, Alejandro Santos-Lozano, Enzo Emanuele","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Nutraceutical combinations represent a potential strategy for managing mild hypercholesterolemia in patients who cannot tolerate or do not require statin therapy. In this two-group prospective comparative study, we evaluated the effects of a nutraceutical formulation containing berberine (500 mg), bergamot extract (200 mg), and Amaranthus cruentus extract (30 mg) on lipid, inflammatory, and neurotrophic parameters in low-risk subjects with mild-to-moderate hypercholesterolemia.</p><p><strong>Methods: </strong>Sixty subjects with low-density-lipoprotein cholesterol (LDL-C) 115-180 mg/dL, total cholesterol (TC) 200-260 mg/dL, triglycerides <250 mg/dL, and cardiovascular risk < 20% received either one tablet daily (Group 1, n = 30) or two tablets daily (Group 2, n = 30) of the study supplement for 8 weeks. Primary outcomes included TC, LDL-C, oxidized LDL (oxLDL), and high-density-lipoprotein cholesterol (HDL-C). Secondary outcomes were triglycerides, high-sensitivity C-reactive protein (hs-CRP), and serum brain-derived neurotrophic factor (BDNF).</p><p><strong>Results: </strong>Both regimens significantly reduced TC and LDL-C at 8 weeks. Group 2 demonstrated superior reductions in LDL-C (-25.2% versus -14.5%, p < 0.05), oxLDL (-23.1% versus -11.8%, p < 0.05), and hs-CRP (-31.3% versus -6.7%, p < 0.001) compared with Group 1. Group 2 also showed significant increases in HDL-C (+14.9% versus +2.2%, p < 0.05) and BDNF levels (+16.3% versus +2.7%, p<0.001). Both regimens were well-tolerated with no adverse events or hepatic/muscular parameter changes.</p><p><strong>Conclusion: </strong>This nutraceutical formulation effectively and safely reduced TC and LDL-C in low-risk subjects with mild hypercholesterolemia. The twice-daily regimen provided superior lipid improvements and increased HDL-C and BDNF levels, indicating additional antioxidant, anti-inflammatory, and neuroprotective properties warranting further investigation.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 4","pages":"232-248"},"PeriodicalIF":0.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145590546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal fT4 blood level during pregnancy in euthyroid pregnant women correlates positively with neonate's Apgar score.","authors":"Piotr Paszyński, Radosław Słopień, Agata Tomaszewska, Barbara Owecka, Kamil Kosal, Maciej Owecki","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>The study investigated, whether the FT4 and TSH blood levels in euthyroid pregnant women correlate with neonatal Apgar score.</p><p><strong>Material and methods: </strong>The study group included 102 euthyroid pregnant women and their newborns. All women underwent clinical assessment (including pregnancy and perinatal interview and physical examination) and laboratory tests involving TSH and FT4 blood concentrations measurements three times, in each trimester. The neonate's overall condition was assessed with the Apgar scale.</p><p><strong>Results: </strong>A significant positive correlation was described between FT4 concentrations in the study group in the first and second trimester and the newborns' condition assessed on the Apgar scale at 1 minute (Spearman's Rs rank correlation, R = 0.2418; p = 0.014 for the first trimester, and R = 0.2015; p = 0.043 for the second trimester); FT4 concentrations in the first trimester and Apgar score at 3 minutes (Spearman's Rs rank correlation, R = 0.2066; p = 0.038) and between FT4 in the second trimester and the results of Apgar score in the 5th minute (Spearman's Rs rank correlation, R = 0.2231; p = 0.024). Otherwise, maternal TSH concentrations did not significantly correlate with neonatal Apgar score. Analysis of the correlation between the tested thyroid hormones and the birth weight of newborns, as well as delivery date, did not show any significant correlations CONCLUSION: Our study disclosed the impact of maternal FT4 concentration on neonatal outcome expressed by Apgar score. The results presented reveal potential clinically relevant benefits derived from profound thyroid screening during pregnancy.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 4","pages":"213-220"},"PeriodicalIF":0.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Genetic Spectrum of Titinopathy: A Turkish Pediatric Case Series.","authors":"Gülen Gul Mert, Cansu Miçooğulları, Ahmet Keçebaş, Faruk İncecik, Suzan Zorludemir, Sevcan Bozdoğan, Mihriban Özlem Hergüner","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Our aim is to contribute to the literature by presenting pediatric titinopathy cases with different clinical and genetic profiles, including the newly identified homozygous TTN mutation.</p><p><strong>Methods: </strong>We retrospectively evaluated five pediatric patients with genetically confirmed titinopathy who presented to the Cukurova University Pediatric Neurology Department between January 2015 and May 2025. Clinical features, pattern of muscle weakness, electromyography (EMG), creatine kinase (CK) levels, muscle biopsy findings, cardiac and respiratory involvement, and genetic analyses via next-generation sequencing (NGS) were documented.</p><p><strong>Results: </strong>Five pediatric patients from three consanguineous families were diagnosed with titinopathy. Patients' median age was 14 years (30 months-17 years). The mean age of walking in the patients was 28.5 months. Four patients from two consanguineous families carried a novel homozygous c.15218-2A>G mutation in the TTN gene, not previously reported as pathogenic. These cases exhibited a wide spectrum of muscle involvement, variable facial, respiratory, and cardiac manifestations, and histopathological features of myotubular or centronuclear myopathy. One unrelated patient had a known pathogenic homozygous c.35296G>A mutation, associated with limb-girdle and facial muscle weakness and mild cardiomyopathy. Despite genetic similarities, phenotypic expression varied even within families. All CK levels were normal.</p><p><strong>Conclusion: </strong>This study expands the clinical and molecular understanding of titinopathies by identifying a novel TTN mutation associated with marked phenotypic variability, even within the same family. The findings underscore the significant heterogeneity of TTN-related myopathies and reinforce the necessity of comprehensive clinical and genetic evaluations for accurate diagnosis and effective genetic counseling.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 3","pages":"137-141"},"PeriodicalIF":0.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of blood flow restriction training using plural parallel cuff on walking functions of older people.","authors":"Masahiro Matsunaga, Masahiro Kimura, Junko Hashimoto, Yusuke Tominari, Keiko Ishii, Hirohito Tsuboi, Kohta Suzuki","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Previous studies have shown that older people who usually walk faster have a lower risk of death. The present study investigated the effects of blood flow restriction training using the newly developed plural parallel cuff (multi-cuff training) on psychological and physiological parameters, aiming to improve walking function in older people.</p><p><strong>Design, material and methods: </strong>Forty-two older adults participated in the present study. They were randomly allocated to two groups with the same average age: one group trained with a cuff wrapped on both legs (multi-cuff training) during strength training, and the second group trained without cuffs (control), with training protocols being similar for both groups. This study had a crossover design: after 3 weeks, the training was switched between the groups.</p><p><strong>Results: </strong>Multi-cuff training significantly rejuvenated the estimated walking age compared to the control.</p><p><strong>Conclusion: </strong>The multi-cuff training program improves the walking function of older people with no major problems.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 3","pages":"177-187"},"PeriodicalIF":0.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathology and the autonomic nervous system in borderline personality disorder. Part 2. The Influence of Early Adversities, Dissociation and Self-stigma on the Treatment.","authors":"Vlastimil Nesnidal, Jan Prasko, Kamila Belohradova, Jakub Vanek, Frantisek Hodny, Milos Slepecky, Marie Ociskova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>This study examines the influence of childhood adversities, dissociation, and self-stigma on autonomic nervous system function and treatment outcomes in hospitalised patients with borderline personality disorder (BPD).</p><p><strong>Methods: </strong>Seventy-five BPD inpatients underwent a six-week intensive psychotherapy treatment program. Changes in psychopathology and autonomic nervous system function were monitored. (heart rate variability, LF/HF ratio).</p><p><strong>Results: </strong>The study confirmed a positive impact of the treatment program on reducing BPD symptomatology, anxiety, and depressive symptoms. Findings indicate that the initial dissociation level does not correlate with changes in symptomatology. In contrast, changes in dissociation during treatment are associated with reductions in anxiety and depressive symptoms. Regarding HRV, our data show that although there were no significant changes in HRV during treatment, higher baseline LF/HF values correlated with smaller changes in symptom severity, which could indicate a possible link between autonomic nervous dysregulation and the stability of BPD symptoms.</p><p><strong>Discussion: </strong>Our findings emphasise the importance of monitoring physiological and psychological factors in BPD treatment, highlighting potential predictors of therapeutic response.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 3","pages":"162-176"},"PeriodicalIF":0.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between loneliness and computation of relationship value appears modulated by autonomic nervous functions.","authors":"Masahiro Matsunaga, Keiko Ishii, Yohsuke Ohtsubo, Katsuya Uenoyama, Yasuki Noguchi, Hidenori Yamasue, Kohta Suzuki","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Recently, loneliness and social isolation have become common social problems. Previous research has shown that loneliness affects the brain's structure and function as well as the function of the autonomic nervous system. Our previous study found that loneliness has a negative impact on the computation of relationship value in response to commitment signals from friends. This study investigated whether heart rate variability (HRV), which is thought to reflect autonomic nervous function, is related to loneliness in young Japanese adults and whether experimental improvement of autonomic nervous activities alters the relationship value computation process in response to friends' commitment signals.</p><p><strong>Design, material and methods: </strong>In Experiment 1, Japanese undergraduate students were assessed for loneliness and a resting electrocardiogram to determine HRV. In Experiment 2, other undergraduate students, separated into control and treatment groups, participated in a psychological task assessing responses to commitment signals from friends. The treatment group was subjected to autonomic nervous modulation before and while performing the task.</p><p><strong>Results: </strong>Experiment 1 (n = 210) indicated that loneliness was negatively correlated with the high-frequency percentage (HF%) and positively correlated with the low-frequency (LF) component/HF ratio. Experiment 2, a pilot intervention study (n = 38), indicated that experimental improvement of HRV improved the subjective rating of the perceived commitment-confirming effect related to loneliness, specifically under high-cost commitment signal conditions.</p><p><strong>Conclusion: </strong>These findings suggest that changes in cognitive functions caused by loneliness may be modifiable; by improving autonomic nervous function, it is possible to improve cognitive functions that have changed due to loneliness. However, as a pilot intervention study (Experiment 2) with a small sample, these pilot findings require replication in larger, adequately powered trials..</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 3","pages":"188-197"},"PeriodicalIF":0.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathology and the autonomic nervous system in borderline personality disorder. Part 1. The Influence of Early Adversities, Dissociation, Self-stigma, Parenting and Attachment on Disorder Severity.","authors":"Vlastimil Nesnidal, Jan Prasko, Kamila Belohradova, Jakub Vanek, Frantisek Hodny, Marie Ociskova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Borderline Personality Disorder (BPD) is a complex psychiatric condition characterized by significant emotional instability, impulsivity, and intense interpersonal difficulties. This study examines the relationship between early traumatic experiences, attachment, dissociation, self-stigmatization, autonomic nervous system activity, specifically heart rate variability (HRV), and the severity of BPD symptoms.</p><p><strong>Objective: </strong>To explore the associations between psychosocial and physiological factors and the severity of BPD symptoms, with a focus on early adverse experiences, adult attachment styles, HRV, and self-stigmatization.</p><p><strong>Methods: </strong>The study sample consisted of 75 hospitalized BPD patients. HRV was measured, and self-report questionnaires were used to assess early traumas (Childhood Trauma Questionnaire), parenting style (Parental Bonding Instrument), adult attachment style (Experiences in Close Relationships Scale), and dissociation (Dissociative Experience Scale). Self-stigmatization was evaluated using the Internalized Stigma of Mental Illness (ISMI) scale, while symptom severity was assessed using self-report and clinician-administered scales, including the CGI-BPD, Beck Depression Inventory-II, and Beck Anxiety Inventory.</p><p><strong>Results: </strong>Significant correlations were found between early traumas, attachment, and the severity of BPD symptomatology. Higher levels of emotional abuse in childhood correlated with earlier onset and greater symptom severity. HRV analysis indicated a link between sympathetic nervous system activation and specific BPD symptoms, particularly in patients with high levels of attachment anxiety. Self-stigmatization was associated with increased symptom severity and reduced treatment response.</p><p><strong>Conclusion: </strong>The findings confirm that early traumatic experiences, adult attachment, and self-stigmatization are key factors in understanding symptom severity and emotional dysregulation in BPD. Targeted interventions addressing these areas may significantly improve treatment outcomes for BPD patients.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 3","pages":"142-161"},"PeriodicalIF":0.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety Profile of Meloxicam: Analysis of Adverse Event Reports in the Czech Republic.","authors":"Jana Mlíchová, Vojtěch Mészáros, Ondřej Šimandl, Eva Kmoníčková, Dagmar Kalátová, Zoltán Paluch","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Meloxicam is a preferential cyclooxygenase-2 inhibitor widely prescribed for rheumatic diseases. Given its long clinical use, further assessment of its safety profile remains relevant.</p><p><strong>Aim of study: </strong>This study aimed to evaluate the safety profile of meloxicam in the Czech Republic using national pharmacovigilance data, and to compare reported adverse events (AEs) with findings from the WHO VigiAccess database.</p><p><strong>Methods: </strong>We analyzed all meloxicam-related AEs reported to the State Institute for Drug Control (SÚKL) between January 2015 and December 2020, as well as related data extracted from the World Health Organization's pharmacovigilance VigiAccess database. AEs were classified according to MedDRA terminology. National drug utilization data were obtained from SÚKL to provide an estimate of meloxicam exposure, expressed in defined daily doses (DDD).</p><p><strong>Results: </strong>Over six years, 24 AE reports were identified in the Czech Republic (population 10.7 million). During the same period, meloxicam consumption reached 71,512,140 DDD, corresponding to 4.64 DDD/1000 inhabitants/day. The most frequently reported AEs were hypersensitivity reactions (10 cases), followed by gastrointestinal events (4 cases), nervous system disorders (4 cases), and isolated cardiovascular toxicity (1 case of heart failure).</p><p><strong>Conclusion: </strong>In the context of national exposure, only a limited number of meloxicam-related AEs were reported.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 3","pages":"198-202"},"PeriodicalIF":0.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}