Neuro endocrinology letters最新文献

{"title":"Mediation Mendelian Randomization Analysis of the Effect of Immune Cells on Autism Spectrum Disorder Mediated by Inflammatory Factors.","authors":"Xueying Zhou, Deyi Xu, Fangjie Shang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that impairs communication. Increasing research indicates that maternal immune activation (MIA) is one of the most important environmental factors that increase the risk of autism spectrum disorder (ASD) in offspring. Maternal immune activation produces elevated cytokine levels that cross the placental barrier and disrupt fetal neurodevelopment, increasing ASD risk. However, the specific causal pathways and mediating mechanisms remain unclear, limiting our understanding.</p><p><strong>Methods: </strong>This mediation Mendelian randomization study examined causal pathways linking immune cell traits (exposures) and inflammatory factors (mediators) to ASD risk.The research merged immune data (731 phenotypes + 48 cytokines) and ASD data from a cohort comprising 18,382 cases and 27,969 controls. Various MR approaches were used to reduce potential biases, along with thorough descriptions of statistical procedures and instrumental variable selection.</p><p><strong>Results: </strong>The study's findings propose potential causal relationships among cytokines representing inflammatory factors, immune cells, and ASD through mediation Mendelian randomization. Reverse MR was then employed to investigate the possibility of reverse causality. CD8+ T cell %leukocyte (OR = 1.099, 95% CI: 1.039-1.163, p = 0.001), CCR2+ CD62L+ myeloid dendritic cells (OR = 0.933, p = 0.029), and CD45+ immature myeloid-derived suppressor cells (OR = 1.056, p = 0.001) showed evidence of causal association with ASD risk.Furthermore, reduced Artemin levels and elevated FLT3L and 2B4 levels were significantly linked to ASD risk, indicating that abnormalities in immunomodulatory factors may play a crucial role in the pathogenesis of ASD. Additionally, ASD occurrence may result in alterations in Natural Killer cell receptor 2B4 levels.</p><p><strong>Conclusion: </strong>This mediation Mendelian randomization study provides evidence that immune dysfunction is associated with ASD pathophysiology through inflammatory mediators, requiring functional validation before clinical application.Cytokines act as mediators in the pathogenesis of ASD, providing a theoretical basis for understanding its immunoinflammatory pathogenesis and offering insight into treatment.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 6","pages":"315-322"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformative Potential of Outsider Art for Neurodivergent Artists.","authors":"Pavel Sochor, Dagmar Sochorova, Milan Kubiatko","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Theoretical background: </strong>The intersections of inclusion, resilience, and socialisation within artistically stimulating environments are increasingly recognised in the education of individuals with Intellectual and Developmental Disabilities (IDD) and Autism Spectrum Disorders (ASD). However, scholarly attention remains limited regarding pre-professional support systems that integrate artefiletic (reflective) educational principles with studio practice.</p><p><strong>Objective: </strong>This paper explores how artistic engagement in the field of outsider art offers transformative opportunities for advancing human rights and fostering sociocultural participation.</p><p><strong>Methodology: </strong>The study employs a qualitative longitudinal case study design (2016-2024), utilising participatory observation and unstructured interviews to track the development of a neurodivergent artist (\"Ms. Petra\") within a university-based inclusive studio in the Czech Republic.</p><p><strong>Results: </strong>Findings demonstrate that long-term studio engagement enabled the participant to transition from a medical model of disability to a sociocultural one. Specifically, the artistic practice served as a non-verbal catalyst for emotional articulation, strengthened self-identity, and established a sustainable support network involving family and university facilitators.</p><p><strong>Conclusion: </strong>The research confirms that resilience is a learned educational outcome fostered by safe, democratic studio environments. The proposed holistic studio model offers a transferable framework for supporting the lifelong learning and professionalisation of artists with dual exceptionality.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 6","pages":"347-355"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive transcranial magnetic stimulation promotes motor function recovery in mice after spinal cord injury through preserving mitochondrial integrity .","authors":"Xinlong Wang, Gaiqin Pei, Chen Xie, Miao Wu, Yaxin Gao, Yaoying Zhang, Chao Shen, Tong Tang, Zhaodi Wang, Wenjun Qian","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Despite the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) for spinal cord injury (SCI), little is known about its specific effects on mitochondria. This study therefore aimed to elucidate the effects of rTMS on mitochondrial structural integrity following SCI.</p><p><strong>Methods: </strong>Female wild-type C57BL/6J mice were randomly divided into four groups: normal group; spinal cord injury group; sham-rTMS group and rTMS group. Hindlimb motor function was evaluated using the Basso Mouse Scale (BMS). The mitochondrial integrity was assessed by transmission electron microscopy, and the expression of the outer membrane protein TOM20 was analyzed by Western blot and immunohistochemistry.</p><p><strong>Results: </strong>Compared to the SCI group, rTMS group induced a coordinated recovery, characterized by significantly improved BMS scores, enhanced mitochondrial structural integrity, and increased levels of the mitochondrial membrane protein TOM20 (p < 0.05).</p><p><strong>Conclusion: </strong>Our findings demonstrate that rTMS promotes motor recovery after SCI via the preservation of mitochondrial structure.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 6","pages":"335-339"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Analysis of 14 Cases with Androgen-Secreting Ovarian Sex Cord-Stromal Tumors: Diagnosis, Treatment, and Literature Review.","authors":"Yi-Quan Sang, Xian-Ling Wang, Zhao-Hui Lyu, Jian-Ming Ba, Yu Pei, Qing-Hua Guo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the clinical data of 14 patients with androgen-secreting ovarian sex cord-stromal tumors (OSCSTs), a rare cause of female hyperandrogenism (HA), aiming to enhance differential diagnosis and reduce misdiagnosis of these diseases.</p><p><strong>Methods: </strong>Fourteen female patients with pathologically confirmed OSCSTs were retrospectively enrolled in this study.General clinical data were retrospectively collected from medical records, encompassingclinical manifestations, diagnostic and therapeutic interventions. A systematic literature review about the management of OSCSTs were performed.</p><p><strong>Results: </strong>Among 14 female patients with OSCSTs, age ranged from 12 to 69 years (mean ± SD: 34.4 ± 20.1 years), with symptom duration prior to diagnosis spanning 1-6 years (2.3 ± 1.4 years). Adolescent and reproductive-aged patients (n = 10) universally exhibited oligomenorrhea/amenorrhea with virilization, while postmenopausal patients (n = 4) presented with virilization alone. Preoperative testosterone levels were markedly elevated in all these patients (range 3.90-119.6 nmol/L; normal: 0.2-2.6). Imaging evaluation revealed ovarian masses on ultrasound in 78.6% (11/14) of cases. After complete tumors resection, testosterone reduced significantly to 0-6.51 nmol/L within 48 hours with complete resolution of hyperandrogenism symptoms. Adjuvant chemotherapy was administered in two patients with moderately/poorly differentiated Sertoli-Leydig cell tumors (Ki67 >30%). At one-month follow-up, testosterone normalized (0.5-2.6 nmol/L) in all patients with concomitant resolution of menstrual irregularities and improvement in virilizing symptoms.</p><p><strong>Conclusion: </strong>OSCSTs are rare but clinically significant causes of hyperandrogenism, characterized by symptoms of HA such as oligomenorrhea, acne, hirsutism, and clitoromegaly. It has always been misdiagnosed due to overlapping features with PCOS and adrenal disorders. Early identification and complete surgical resection are critical for biochemical remission and symptom resolution.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 5","pages":"259-264"},"PeriodicalIF":0.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamma-Glutamyltransferase Levels and Hypertension Risk: A U-Shaped Relationship in a Large Chinese Health Checkup Population .","authors":"Xinyu Ma, Huan Wu, Tong Wang, Yue Wu, Yufeng Wen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The association of Gamma-glutamyltransferase (GGT) with hypertension remains unclear due to previous studies. This study aims to investigate the relationship between GGT and hypertension in a large health checkup population from Wuhu, China.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at the First Affiliated Hospital of Wannan Medical College from 2011 to 2016. A total of 303,431 individuals who underwent physical examination and biochemical testing were enrolled in this study. Multivariable logistic regression model and restricted cubic spline models were employed to examine the relationship between GGT levels and hypertension.</p><p><strong>Results: </strong>Compared to individuals with normal blood pressure, GGT levels were higher in the hypertensive group (23.15 [14.00-34.98] vs. 37.00 [21.00-51.00] U/L, p < 0.001), and the prevalence of elevated GGT was also higher (9.59% vs. 25.12%, p < 0.001). After adjusting for age, sex, smoking, drinking, BMI, triglycerides, total cholesterol, total protein, and albumin (Model 4), GGT quartiles were significantly associated with hypertension (p < 0.001). Compared with Q1, the odds ratios (ORs) for hypertension were 0.958 (95% CI: 0.926-0.991), 0.717 (95% CI: 0.691-0.743), and 2.421 (95% CI: 2.340-2.504), respectively. The restricted cubic spline model demonstrated a nonlinear association between GGT and hypertension (p < 0.001). The odds ratio (OR) for hypertension initially decreased and then increased as GGT levels rose. When GGT levels ranged from 15.03 U/L to 24.61 U/L, the OR for hypertension was less than 1.0. Similar trends were observed after grouping by gender.</p><p><strong>Conclusions: </strong>This study found a positive association between GGT and hypertension at both low and high GGT levels, while a negative association was observed at moderate GGT levels.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 5","pages":"286-294"},"PeriodicalIF":0.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empty Sella and Cushing's Disease: Lessons Learned from a Diagnostically Challenging Case.","authors":"Jiahui Tang, Yang Li, Nianwei Wu, Xuan Li, Peizhi Zhou, Xingwu Ran, Nanwei Tong, Qingguo Lü","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Pituitary adenomas are the primary cause of Cushing's disease (CD), yet they can produce negative MRI findings when coexisting with empty sella syndrome, complicating diagnosis. This case illustrates how advanced imaging and endocrine testing overcome this diagnostic challenge.</p><p><strong>Case description: </strong>A 54-year-old woman was admitted to our hospital due to facial plethora, hyperglycemia and forearm pustules. The endocrine function test suggested CD at first. However, the initial enhanced MRI revealed an empty sella. Based on the positive results of bilateral inferior petrosal sinus sampling, we performed high-resolution dynamic enhanced MRI of pituitary gland. Finally, we discovered pituitary nodules on the background of empty sella. The patient accepted surgical treatment and the postoperative outcomes were favorable.</p><p><strong>Conclusion: </strong>Empty sella does not exclude the diagnosis of CD. Standardized endocrine function tests and advanced imaging technology play decisive roles in the qualitative and etiological diagnosis of CD, and we also emphasize the importance of clinical thinking.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 5","pages":"295-302"},"PeriodicalIF":0.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive schema therapy: Integrating positive schemas into the therapeutic process.","authors":"Jan Prasko, Mary Ociskova, Jakub Vanek, Ilona Krone, Marija Abeltina, Martin Mikula, Julija Gecaite-Stonciene, Alicja Juskiene, Roman Liska, Jozef Visnovsky, Ieva Bite, Julius Burkauskas, Tomas Sollar, Milos Slepecky, Marta Popelkova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The article examines the concept and methods of positive schema therapy. It is based on the theory of schema therapy and adaptive schemas, which enrich the perspectives of positive psychology, positive CBT and strengths-based CBT. Based on case vignettes, show practical methods associated with this approach.</p><p><strong>Methods: </strong>A literature review was conducted on adaptive schemas, their measurement using the Young Positive Schema Questionnaire (YPSQ) and therapeutic interventions supporting the development of the Healthy Adult and Kind Parent modes. In addition, special attention was paid to integrating schema therapy methods within therapeutic interventions of positive psychology and CBT based on resources. Selected case studies of various psychological problems and disorders are presented as examples of therapeutic work using positive schema therapy methods.</p><p><strong>Results: </strong>Positive schema therapy has been shown in additional studies to be an effective tool for increasing emotional resilience, coping with stressful situations, and improving emotional regulation and the overall quality of life. Adaptive schemas such as self-compassion, social belonging, and emotional openness significantly support the development of the Healthy Adult mode.</p><p><strong>Conclusion: </strong>Positive schema therapy is an innovative approach in psychotherapeutic practice, expanding clinical methods of schema therapy work. Despite limited empirical support, it has the potential to develop further, introducing new procedures to strengthen the positive aspects of client´s experiences and behaviour when dealing with psychological problems.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 5","pages":"270-285"},"PeriodicalIF":0.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence of Scoliosis in Children with Mitral Valve Prolapse.","authors":"Alev Arslan, Senay Demir","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the prevalence and characteristics of scoliosis in asthenic children diagnosed with mitral valve prolapse (MVP).</p><p><strong>Material and methods: </strong>This study aims to characterize scoliosis prevalence and examine relationships with mitral valve morphology, regurgitation severity, and skeletal phenotypes (pectus excavatum, hypermobility, skin laxity) in asthenic children with primary MVP based on echocardiographic findings. Individuals with known systemic connective tissue disorders were excluded. Scoliosis was assessed radiographically using Cobb angle measurements with a threshold of ≥10° for diagnosis. Statistical analysis was performed using SPSS 26.0.</p><p><strong>Results: </strong>The study included 49 asthenic children (25 females, 24 males) aged 9 to 17 years who were diagnosed MVP. The mean age of participants was 13.2 ± 2.2 years. Physical examination revealed pectus excavatum in 46.9%, joint hypermobility in 39%, and skin laxity in 16.3% of patients. Scoliosis (Cobb ≥10°): 47% (23/49, [95% CI: 33-61%]); potential scoliosis (5-10°): 27% (13/49, [95% CI: 16-40%]); any abnormal curvature: 73% (36/49, [95% CI: 59-84%]). Valve morphology: diffuse thickening 61% (30/49); localized elongation 39% (19/49). No significant association between scoliosis and valve morphology (p > 0.05) or MR severity (p > 0.05). Pectus excavatum significantly associated with elongated valve structure (p = 0.001). Pectus excavatum was significantly more common in patients with an elongated, straight valve structure (p = 0.001).</p><p><strong>Conclusions: </strong>High scoliosis prevalence (47%) in asthenic MVP children is independent of cardiac severity, suggesting intrinsic skeletal tissue vulnerability. Neuroendocrine and immune mechanistic investigation warranted.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 5","pages":"265-269"},"PeriodicalIF":0.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145672997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Sodium-Potassium Ratio in Low-Sodium Diet Population and Its Association with Stroke: Insights from NHANES Database.","authors":"Liguo Li, Hongguang Fu, Ya Su, Junsong Jing","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To delve into the potential association between the dietary sodium-potassium ratio and stroke in the low-sodium diet population.</p><p><strong>Methods: </strong>Cross-sectional analysis was done utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 7 cycles from 2003 to 2016. 7141 samples were selected. Participants were categorized into stroke and non-stroke groups following population characteristics, and the association between dietary sodium-potassium ratio and stroke was analyzed across various categorical variables. Stratification of the dietary sodium-potassium ratio was done using quartiles. Weighted logistic regression models were constructed by adjusting various confounders to examine the sodium-potassium ratio's relationship with stroke. ubgroup analyses stratified by BMI were performed; interaction terms were evaluated with significance threshold p < 0.1. The relation between the sodium-potassium ratio and stroke risk was explored by Restricted Cubic Splines (RCS).</p><p><strong>Results: </strong>Among the 7,141 participants with a dietary sodium intake ≤ 2,300 mg, the dietary sodium-to-potassium ratio was significantly higher in those who had experienced a stroke (ratio = 1.19 (0.51)) compared to those who had not (ratio = 1.11 (0.52)) (p < 0.05). An increased sodium-to-potassium ratio was associated with a higher risk of stroke in the following subgroups: women (Odds Ratio (OR) = 1.31, 95% CI: 1.05-1.62, p = 0.013), individuals with a BMI of 25-30 kg/m² (OR = 2.02, 95% CI: 1.40-2.91, p < 0.001), those with a history of smoking (OR = 1.79, 95% CI: 1.20-2.67, p = 0.004), alcohol consumers (OR = 1.29, 95% CI: 1.00-1.67, p = 0.047), those without coronary heart disease (OR = 1.33, 95% CI: 1.10-1.62, p = 0.003) or diabetes (OR = 1.33, 95% CI: 1.08-1.63, p = 0.006), but with hypertension (OR = 1.28, 95% CI: 1.03-1.59, p = 0.022). Stratified analysis by BMI indicated that the association between the sodium-to-potassium ratio and stroke was strongest and most consistent among overweight individuals (BMI 25-30 kg/m²), with all ORs exceeding 2 and p < 0.001. Additionally, a U-shaped relationship was observed between the dietary sodium-to-potassium ratio and stroke risk. A ratio within the range of 0.46-1.00 was associated with a reduced risk of stroke, with the lowest risk observed at a ratio of 0.76.</p><p><strong>Conclusion: </strong>In low-sodium diet population, association between dietary sodium-potassium ratio and stroke risk follows a \"U\" shaped correlation. However, prospective investigations are warranted to provide additional evidence to support findings.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 5","pages":"303-312"},"PeriodicalIF":0.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between middle cerebral artery doppler flow parameters and intraventricular hemorrhage in preterm infants.","authors":"Selvi Gülaşı, Mustafa Kurthan Mert, Eren Kale Çekinmez, Murat Başaranoğlu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether middle cerebral artery (MCA) Doppler flow parameters measured in the first week of life are associated with intraventricular hemorrhage (IVH) in preterm infants.</p><p><strong>Methods: </strong>A prospective cohort study was conducted in a level 4A neonatal intensive care unit (NICU) at Adana City Training and Research Hospital between March 2022 and April 2023. Preterm infants born weighing ≤1250 g and ≥500 g were included. MCA flow parameters, including peak systolic velocity (PSV), peak diastolic velocity (PDV), pulsatility index (PI), resistivity index (RI) and time-averaged maximum velocity (TAMAX) were measured via transfontanel Doppler ultrasonography within the first five days of life every day. The association between MCA Doppler parameters and IVH development was analyzed.</p><p><strong>Results: </strong>Ninety-two preterm infants were included. IVH was detected in 34.7% (n = 32). Infants with IVH had lower gestational age and birth weight. Logistic regression revealed that lower birth weight, the presence of PDA, and early-onset sepsis increased IVH risk. Both increased and decreased MCA Doppler parameters (PSV, PDV, PI and TAMAX) preceded IVH.</p><p><strong>Conclusion: </strong>MCA Doppler flow fluctuations were associated with IVH in preterm infants. These associations warrant further investigation to determine whether MCA Doppler measurements can prospectively identify infants at risk for IVH.</p><p><strong>What is known: </strong>Cerebral autoregulation is a developmental process that can be disrupted in neonates with congenital heart disease, hypoxic-ischemic encephalopathy, and those born preterm.</p><p><strong>What is new: </strong>Novel methods to assess cerebral autoregulation in these populations can be used to target patient-specific hemodynamic parameters.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 4","pages":"205-212"},"PeriodicalIF":0.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}