Neuro endocrinology letters最新文献

{"title":"Modeling Spatial-Temporal Dependencies in Emotion-Related fMRI: A Nonparametric Bayesian Application to the NeuroEmo Dataset.","authors":"Reza Taherian, Seyyed Mohammad Tabatabaei, Farzaneh Amanpour, Hamid Alavi Majd","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize the spatiotemporal brain activation patterns evoked by five culturally validated emotion categories-Calm, Afraid, Delighted, Depressed, and Excited-in an Indian sample, and to demonstrate the advantages of a nonparametric Bayesian general linear model (GLM) for naturalistic fMRI data.</p><p><strong>Materials & methods: </strong>Functional MRI data were obtained from 40 healthy, right handed Indian adults (mean age 28.3 ± 9.14 years; 31 males, 9 females) via OpenNeuro (ds005700). Participants viewed 30 s film clips from the Affective Film Dataset from India, interleaved with white noise baselines. Data were preprocessed in SPM12, and regional time series were extracted from 90 cortical/subcortical AAL ROIs using MarsBaR 0.45. We applied the NPBayes fMRI toolbox to fit a spatiotemporal Bayesian GLM with a hierarchical Dirichlet process prior for subject clustering, and spatial basis-function regularization. Posterior inference used Variational Bayes, and activation was declared via posterior probability of inclusion (PPI) thresholded to control a 5% Bayesian false discovery rate.</p><p><strong>Results: </strong>All emotion conditions engaged early and higher order visual cortices. Calm elicited focal lingual-cuneus activation; Afraid recruited middle/inferior temporal regions; Delighted and Excited amplified visual responses-with Excited also activating parietal attention networks; Depressed combined visual engagement with posterior cingulate/precuneus. The Bayesian framework revealed latent subject subgroups and provided threshold free, reproducible activation maps.</p><p><strong>Conclusion: </strong>Nonparametric Bayesian general linear model analysis of culturally relevant film stimuli yields nuanced insights into emotion-brain dynamics, controls Type I error without arbitrary thresholds, and uncovers interindividual heterogeneity, offering a robust tool for affective neuroimaging.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 8","pages":"441-448"},"PeriodicalIF":0.6,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Mutation Site Structure Prediction and Family Characteristics of Maturity-Onset Diabetes of the Young (MODY) with Ketosis: Caused by HNF4α Gene Mutation.","authors":"Jie Lu, Jilai Zhang, Xianling Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>This article aims to examine the clinical and familial characteristics of HNF4α-MODY pa-tients who presented with diabetic ketoacidosis (DKA) or diabetic ketosis (DK). Furthermore, it seeks to explore potential pathogenic mechanisms of the HNF4α mutation and to enhance understanding of ketosis susceptibility in this population.</p><p><strong>Methods: </strong>We collected detailed medical histories and family histories of two diabetes patients. Whole-exome high-throughput sequencing was performed to identify potential genetic muta-tions. The pathogenicity of the mutations was predicted with PolyPhen-2 and Mutation Taster software. PyMOL software was utilized to analyze the impact of the mutations on the protein structure of HNF4α.</p><p><strong>Results: </strong>Both probands exhibited a decline in pancreatic islet function following disease onset, leading to ineffective sulfonylurea treatment and the development of DKA or DK. Whole-exome se-quencing revealed distinct heterozygous HNF4α mutations in each family. Proband 1, along with her father and elder daughter, carry the c.1331C>T (p. P444L) mutation. Proband 2 and her father harbored the c.929G>C (p. G310A) mutation. Protein structure predictions indi-cates that the c.1331C>T (p. P444L) mutation induces structural changes in the HNF4α pro-tein. Additionally, the c.929G>C (p. G310A) mutation is identified to disrupt hydrogen bonding interactions between the amino acid at position 310 and its surrounding residues.</p><p><strong>Conclusion: </strong>The G310A variant likely disrupts homodimer stability, impairing islet function, similar to neighboring pathogenic mutations. On the other hand, the P444L variant is considered likely pathogenic, with its variable expressivity within the family being characteristic of MODY. This study demonstrates that some HNF4α-MODY patients may present with DKA or DK, highlighting the condition's clinical heterogeneity.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 7","pages":"402-409"},"PeriodicalIF":0.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-organ single-cell integration identifies liver-specific fibroblast programs and HGF-MET/AGT-AGTR1B axes that link fibrosis to hepatocarcinogenesis.","authors":"Shuna Zhang, Pei Sun, Jian Zhang, Xin Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Fibrosis is a pan-organ wound-healing program, yet stromal mechanisms that are liver-selective and connect liver fibrosis to hepatocellular carcinoma (HCC) remain incompletely defined.</p><p><strong>Methods: </strong>We assembled public single-cell RNA-seq datasets from fibrotic heart, kidney, liver, and lung with matched controls and applied a unified Seurat integration workflow, differential expression and pathway enrichment, Slingshot pseudotime, and CellChat ligand-receptor inference. We used cross-organ subtraction of shared pan-fibrotic signatures to nominate liver-enriched fibroblast (FB) genes and pathways, intersected these candidates with HCC single-cell datasets and FB trajectories to prioritize fibrosis-aligned, tumor-progression genes, and compared intercellular communication across organs focusing on hepatocyte-FB pairs.</p><p><strong>Results: </strong>Integration recovered robust FB clusters in each organ without dominant batch effects, supported by canonical FB markers (PDGFRA, LAMB1). Liver FB programs showed endocrine-metabolic rewiring (e.g., insulin/glucagon/FOXO signaling) alongside suppression of xenobiotic/GPCR modules. In HCC, FB subclustering resolved healthy and pathogenic FB states, and Slingshot captured a continuous healthy-to-pathogenic activation axis. Differential expression identified 126 liver-specific upregulated and 239 downregulated DEGs; overlap with HCC pseudotime highlighted SULF2/TIMP3 (fibrosis , progression ) and TNFAIP8 (fibrosis , progression ). Cross-organ CellChat comparisons further prioritized HGF-MET and AGT-AGTR1B as liver-selective axes relative to heart, kidney, and lung, with stellate-to-hepatocyte (HGF-MET) and hepatocyte-to-stellate (AGT-AGTR1B) ligand-receptor expression correlations observed in liver fibrosis and replicated in independent HCC datasets.</p><p><strong>Conclusions: </strong>Cross-organ single-cell integration prioritizes liver-selective stromal circuitry and nominates hepatocyte-FB axes (HGF-MET, AGT-AGTR1B) as plausible links between fibrogenic remodeling and a pro-tumorigenic niche, yielding testable hypotheses at the interface of regeneration, RAS biology, and tumor initiation.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 7","pages":"371-380"},"PeriodicalIF":0.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Endonasal Transsphenoidal Surgery (EETS) for PitNETs: Outcomes in a Single Institution Over a Decade.","authors":"Jamie Rosen, Zenab Sher, Pratibha Natesh, Mekha Kadavileveetil, Miran Albatayneh, Rudra Shah, Mehdi Maqsood, Sanjni Bhudia, Amy Hodder, Henry Ananwune, Fatima Noshad, Radu Beltechi, Gregory Kaltsas, Amjad Shad, Harpal Randeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the outcomes, histopathology and recurrence of pituitary neuroendocrine tumours following Endoscopic Endonasal Transsphenoidal Surgery (EETS) in a single institution, over a period of ten years.</p><p><strong>Methods: </strong>A retrospective, cross-sectional study evaluated our experience and outcomes of EETS in 152 patients between 2013 and 2024. We analysed patient demographics and histopathology, as well as surgical complications. Outcomes such as tumour recurrence and improvement of visual field defects were recorded.</p><p><strong>Results: </strong>There were 64 males (42.1%) and 88 female patients (57.9%). Presentations included visual field disturbance, incidentaloma, acromegaly, headaches and Cushing's disease. 133 (87.5%) were macroadenomas and 14 (9.2%) microadenomas. Cavernous sinus invasion was observed in 35 patients (23.0%). Histologically, 72 (47.4%) gonadotroph tumours, 25 (16.4%) somatotroph tumours, 12 (7.9%) non-staining PitNETs/Null cell tumours, 12 (7.9%) corticotroph tumours, 11 (7.2%) plurihormonal tumours, 4 (2.6%) silent corticotroph tumours, 3 (2.0%) cysts, 1 (0.7%) prolactinoma, 1 (0.7%) thyrotroph tumour, and 11 (7.2%) were miscellaneous. Recurrence occurred in 29 (19.1%) patients, out of which 18 (11.8%) required further surgery. 51 (33.6%) patients experienced complications, such as cerebrospinal fluid (CSF) leak in 15 (9.9%) patients. A greater proportion of patients demonstrated normal visual fields postoperatively. Postoperative complications were similar to those reported in literature. Of note, recurrent tumours tended to have a low Ki-67 index of 0-3%.</p><p><strong>Conclusion: </strong>Our findings are in line with those reported in literature, including histopathology of tumour subtypes and surgical complication rates. Visual field defects significantly improved following EETS. We note that predictors of postoperative recurrence cannot rely on the Ki-67 index alone; radiological, biochemical, and other histopathological markers need to be considered.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 7","pages":"394-401"},"PeriodicalIF":0.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early estimated pulse wave velocity as a prognostic marker in critically ill patients with hemorrhagic stroke: A retrospective analysis of the MIMIC-IV database.","authors":"Qichen Luo, Huankai Zhang, Shujun Ye, Xiaoman Sun, Renzhe Lin, Zhiliang Huang, Longsheng Zhang, Duo Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The estimated pulse wave velocity (ePWV) calculated using chronological age and blood pressure has been used as a valuable measure of vascular aging. This study aimed to investigate the relationship between early ePWV and all-cause mortality in critically ill patients with hemorrhagic stroke.</p><p><strong>Methods: </strong>This study included hemorrhagic stroke patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Participants were categorized into four quartiles based on the ePWV values. The primary outcome was 30-day mortality, and the secondary outcomes were 90-day and 1-year mortality. Cox proportional risk models and restricted cubic spline analyses were conducted to assess the hazard ratio (HR) and 95% confidence interval (CI) for the association between ePWV and outcomes. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of ePWV.</p><p><strong>Results: </strong>For 30-day mortality, after adjusting for all confounders, the association remained significant with ePWV considered as a continuous variable (HR, 95% CI: 1.21 [1.16, 1.26]; p < 0.001). The HR with 95% CI for the second, third, and fourth quartile groups were 1.40 (1.07, 1.83), 1.82 (1.37, 2.42), and 3.15 (2.30, 4.32), respectively, compared to the first quartile group. Also, ePWV was found to have a linear relationship with 30-day mortality. Similar findings were found for 90-day mortality and 1-year mortality. When ePWV was incorporated into conventional disease severity scoring systems, the predictive performance of these systems was significantly improved.</p><p><strong>Conclusions: </strong>This study revealed that higher levels of early ePWV are significantly associated with increased all-cause mortality in critically ill patients with hemorrhagic stroke. ePWV may be a promising prognostic marker for critically ill patients with hemorrhagic stroke.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 7","pages":"381-393"},"PeriodicalIF":0.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of intra-arterial tirofiban in acute ischemic stroke without large-vessel occlusion.","authors":"Lin Qiu, Minfen Xiong, Xinwu Li, Lingxu Xu, Zhongqiu Li, Ping Ouyang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Intra-arterial tirofiban has emerged as a potential alternative for those patients with acute ischemic stroke (AIS). This study evaluated the effectiveness and safety of intra-arterial tirofiban in AIS patients without large- or medium-vessel occlusions.</p><p><strong>Material and methods: </strong>Sixty patients with AIS who were within 24 hours of symptom onset and did not have significant blockages in large or medium blood vessels were assigned to treatment and control groups via a non-randomized, patient-preference allocation protocol: the control group (n = 30) received intravenous tirofiban and dual antiplatelet therapy, and the treatment group (n = 30) received intra-arterial tirofiban via catheterization, followed by the same medication regimen. The neurological function, functional outcomes, and safety evaluations were measured at 90 days.</p><p><strong>Results: </strong>Both groups experienced a substantial decrease in NIHSS scores post-treatment (p < 0.05). The treatment group had significantly lower NIHSS scores at 24 hours, 72 hours, and 14 days compared to the control group (p < 0.05). The treatment group had a treatment efficacy rate of 91.1% at 14 days, while the control group had a rate of 80.0% (p < 0.05). At 90 days, both groups showed significant improvements in mRS and BI scores (p < 0.05), with the treatment group having a lower median mRS score and a higher median BI score compared to the control group (p < 0.05). There were no statistically significant differences in the incidence of adverse events between the two groups (p > 0.05).</p><p><strong>Conclusion: </strong>Intra-arterial tirofiban administration benefits AIS patients without large- or medium-vessel occlusions, improving neurological function, reducing disability, and enhancing functional independence.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 7","pages":"410-415"},"PeriodicalIF":0.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-existence of Myasthenia Gravis and Addison's Disease Without Thymoma: A Case Report.","authors":"Asuman Orhan Varoglu, Ezgi Aslan, Asude Aksoy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Myasthenia Gravis (MG) and Addison's Disease (AD) co-existing is very rare. The estimated prevalence of this co-occurrence is less than 1 in 100 000, underscoring its clinical significance. We present a female case with coexisting AD and MG. A 45-year-old female arrived at our clinic complaining of breathing difficulties for a month, a drooping left eyelid, and swallowing difficulties for 10 days. She has been treated with 5 mg/day prednisone for AD for three years. Long-term corticosteroid therapy may modulate immune responses and influence the timing of MG onset. Neurological evaluation revealed partial ptosis in the left eye and mild tetraparesis (4/5 strength).</p><p><strong>Case report: </strong>Cortisol level was 0.8 µg/dL, and adrenocorticotropic hormone (ACTH) level was 987 ng/L, an adrenal crisis was excluded. The anti-acetylcholine receptor antibody (anti-AChR antibody) level was 8.37 nmol/L (> 0.4 nmol/L). Repetitive nerve stimulation, neostigmine, and Simpson tests were compatible with MG. Therefore, she was diagnosed with MG.</p><p><strong>Conclusions: </strong>Acetylcholine antibodies in MG may indicate that other autoimmune diseases may be added to the clinic in these patients. Keeping in mind the presence of the underlying MG may be life-saving for those who do not react well to therapy or in the case of newly added findings in AD patients.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 6","pages":"366-368"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Serum Total Bilirubin Levels and Diabetes Mellitus: a cross-sectional study of residents in Wuhu, China.","authors":"Tong Wang, Huan Wu, Xinyu Ma, Yue Wu, Fan Su, Wendan Mei, Yicheng Fang, Chenxu Wang, Yufeng Wen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the relationship between serum total bilirubin (TBIL) and diabetes mellitus (DM) in a large health checkup population in China.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 2011-2016 at the Physical Examination Center of the First Affiliated Hospital of Wannan Medical College, involving 302,515 subjects. Logistic regression and restricted cubic splines were used to determine the associations between TBIL and DM. The relationship between TBIL and fasting plasma glucose (FPG) was explored through the application of generalized linear models.</p><p><strong>Results: </strong>Quartiles of TBIL were negatively associated with DM after multivariable adjustment, compared with Q1, the ORs of Q2, Q3 and Q4 for DM were 0.971 (95% CI: 0.923-1.022), 0.922 (95% CI: 0.876-0.971), and 0.880 (95% CI: 0.836-0.927), respectively (p < 0.001). The restricted cubic spline model showed a non-linear relationship between TBIL and DM (p < 0.001), with the ORs for DM increasing progressively, reaching a threshold at the TBIL level of 14.54 µmol/L. The relationship between TBIL and FPG was also non-linear, with a threshold at TBIL of 20.10 µmol/L. FPG decreased with TBIL when TBIL < 20.10 µmol/L and increased when TBIL ≥ 20.10 µmol/L (p < 0.001). After stratifying by gender and age, the results revealed similar patterns.</p><p><strong>Conclusion: </strong>Our study identified that moderate to low levels of TBIL are significantly negatively correlated with DM. In contrast, high levels of TBIL are positively correlated with DM, with a threshold of 14.54 µmol/L. A non-linear relationship was also observed between TBIL and FPG, with a threshold of 20.10 µmol/L.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 6","pages":"340-346"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Assess Environmental Etiological Factors of Mental Disorders: A Narrative Review Focused on Stress.","authors":"Ladislav Hosak, Jirina Hosakova, Kristyna Hurdova, Dana Koncelikova, Klara Latalova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clarifying the etiology of mental disorders should lead to significant therapeutic and preventive measure improvements. Mental disorders are caused by genetic, epigenetic, and environmental factors. A valid assessment of environmental etiological factors is complicated due to a lack in methodologies. We aim to demonstrate how to optimally assess the environmental etiological factors with a special focus on stress. We searched the PubMed database up to December 2024 for relevant state-of-the-art references. The most frequently used stress assessment method involves self-reporting questionnaires. Blood or salivary cortisol, heart rate, respiratory rate, plethysmography readings, and electrodermal activity are biological markers of acute stress. Other biological markers such as hair and nail cortisol levels, telomere length, mitochondrial DNA copy number, and epigenetic markers are indicative of a history of stress. A quantitative prospective assessment of environmental etiological factors including their frequency, severity, total exposure length, timing, and possible accumulation is still needed. In addition, protective environmental factors of mental disorders should not be neglected.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 6","pages":"323-334"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRA morphologic study of the vertebrobasilar artery system in patients with primary hemifacial spasm.","authors":"Hao Zhang, Jinming Yan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>This study assessed the efficacy of 3.0T magnetic resonance angiography (MRA) in individuals with primary hemifacial spasm (pHFS) by investigating the relationship between alterations in the morphology of the vertebrobasilar artery system and pHFS.</p><p><strong>Methods: </strong>A comparison was made between pHFS patients and healthy controls with respect to vertebral artery diameter, displacement rate, and other relevant parameters to explore the potential role of morphologic abnormalities in the vertebrobasilar arteries in the pathogenesis of pHFS. Independent t-tests and Wilcoxon rank-sum tests were used with statistical significance set at a p < 0.05.</p><p><strong>Results: </strong>A total of 100 pHFS patients and 150 healthy participants underwent 3.0T MRA scans for this analysis. The right vertebral artery (VA) diameter in the pHFS group was larger than the healthy control (HC) group (2.71 mm vs. 2.47 mm; p < 0.05) and the left VA deviation distance in the pHFS group was greater than the HC group (7.99 mm vs. 5.27 mm; p < 0.05). The basilar artery deviation distance in the pHFS group was greater than the HC group (7.41 mm vs. 4.78 mm; p < 0.05). The VA deviation rates in the pHFS group were significantly higher than the HC group (89% vs. 72% and 96% vs. 84.67%, respectively; p < 0.05). The VA scores on the symptomatic and non-symptomatic sides were significantly different (p < 0.05). VA migration increased with age (p = 0.034, r = 0.225).</p><p><strong>Conclusion: </strong>The results imply a potential association between morphologic irregularities in the vertebrobasilar arteries and pHFS. Limitations of the study included substantial missing data for displacement measurements (64%-67%), age differences between groups, and selection bias from the surgical population.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 6","pages":"356-365"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}