The effect of gonadotropin-releasing hormone on the nervous system.

Abstract

Gonadotropin-releasing hormone (GnRH) plays a crucial role in regulating the human endocrine system. Synthesized primarily in the hypothalamus, GnRH manages the balance of reproductive hormones. This review highlights GnRH's various functions, particularly its impact on fertility, sexual development, and overall reproductive health through the regulation of gonadal development and function. Beyond its direct role in reproductive processes, GnRH also influences neuroprotection, cognition, and mood regulation, as shown by its activity in different regions of the nervous system. Research into GnRH and its analogs has revealed promising therapeutic potential for treating neurological disorders, indicating its broader impact beyond reproduction. Understanding GnRH's diverse roles not only emphasizes its importance in reproductive physiology but also highlights its involvement in neurological functions. Therefore, exploring the mechanisms behind GnRH's actions opens new avenues for research and therapeutic interventions, promising advancements in both reproductive medicine and neurological health.