促性腺激素释放激素对神经系统的影响

Neuro endocrinology letters Pub Date : 2024-08-12
Jorge Juan Alberto Baca-Alonso, J Luis Quintanar
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引用次数: 0

摘要

促性腺激素释放激素(GnRH)在调节人体内分泌系统方面起着至关重要的作用。GnRH 主要在下丘脑中合成,负责管理生殖激素的平衡。本综述重点介绍 GnRH 的各种功能,特别是它通过调节性腺发育和功能对生育、性发育和整体生殖健康的影响。除了在生殖过程中的直接作用外,GnRH 还会影响神经保护、认知和情绪调节,这体现在它在神经系统不同区域的活动中。对 GnRH 及其类似物的研究揭示了治疗神经系统疾病的巨大潜力,这表明 GnRH 在生殖之外还有更广泛的影响。了解 GnRH 的多种作用不仅能强调其在生殖生理方面的重要性,还能突出其在神经功能方面的参与。因此,探索 GnRH 作用背后的机制为研究和治疗干预开辟了新途径,有望推动生殖医学和神经系统健康的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of gonadotropin-releasing hormone on the nervous system.

Gonadotropin-releasing hormone (GnRH) plays a crucial role in regulating the human endocrine system. Synthesized primarily in the hypothalamus, GnRH manages the balance of reproductive hormones. This review highlights GnRH's various functions, particularly its impact on fertility, sexual development, and overall reproductive health through the regulation of gonadal development and function. Beyond its direct role in reproductive processes, GnRH also influences neuroprotection, cognition, and mood regulation, as shown by its activity in different regions of the nervous system. Research into GnRH and its analogs has revealed promising therapeutic potential for treating neurological disorders, indicating its broader impact beyond reproduction. Understanding GnRH's diverse roles not only emphasizes its importance in reproductive physiology but also highlights its involvement in neurological functions. Therefore, exploring the mechanisms behind GnRH's actions opens new avenues for research and therapeutic interventions, promising advancements in both reproductive medicine and neurological health.

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