Neuro endocrinology letters最新文献

{"title":"A narrative review of relationship obsessive-compulsive disorder: Characteristics, causes and cognitive-behavioural interventions..","authors":"Jan Prasko, Marie Ociskova, Ilona Krone, Julius Burkauskas, Julija Gecaite-Stonciene, Frantisek Hodny, Marija Abeltina, Milos Slepecky","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>The paper describes the characteristics of relationship obsessive-compulsive disorder (R-OCD), including the types of obsessions and compulsions, the common triggers and the impact on psychological well-being and relationship functioning. It also offers basic cognitive-behavioural strategies to help patients change their attitudes towards obsessive thoughts and reduce compulsive behaviours.</p><p><strong>Methods: </strong>This article is a narrative review of the literature and case studies on R-OCD. To search for relevant sources, we used PubMed, PsycINFO and Web of Science databases with the keywords \"relationship obsessive compulsive disorder\", \"R-OCD\", \"relationship OCD\" and \"partner-focused OCD\". We included only studies published in English from January 1990 to June 2023. The paper provides examples of how basic cognitive-behavioural strategies help individuals with R-OCD.</p><p><strong>Results: </strong>People with R-OCD experience intrusive thoughts about whether they have the right feelings for their partner, whether their partner loves them, whether the relationship is suitable or whether their partner has flaws. These thoughts trigger the urge to perform various rituals to alleviate anxiety, such as repeated checking, reassurance or comparison. However, this behaviour leads to disruption of the relationship and long-term maintenance of the anxiety. Examples of basic cognitive-behavioural strategies can be applied in clinical practice to help individuals change their attitudes towards relational obsessive thoughts and reduce compulsive behaviours.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 4","pages":"262-280"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive behaviour in mentally altered patients in prehospital setting as a threat to emergency medical service personnel: potential predictors identification.","authors":"Lukáš Handl, Robin Šín, Tomáš Nagy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Patients are the most common source of violence against EMS personnel. This study aims at elucidating specific clinical features in patients with mental alteration and aggressive behaviour increasing risk of violence.</p><p><strong>Material and methods: </strong>This consecutive cross-sectional retrospective study analysed consecutive patients treated for prespecified list of primary diagnoses by one EMS provider in the Czech Republic between 1 January 2021 and 31 December 2023. The effect of individual features of medical history and present symptoms on the occurrence of violence, need for the Police assistance and use of restraints was evaluated, using linear regression model.</p><p><strong>Results: </strong>410 patients were evaluated. Verbal and brachial violence was present in 21.5 and 12.9 %, respectively. Police assistance was needed in 48.3 %, restraints were used in 4.6 %. The most significant predictor for violence, need for Police or restraints was agitation (OR 7.02, CI 4.14 - 11.90; OR 2.60, CI 1.60 - 4.24, OR 11.02, CI 3.49 - 34.80 respectively). Other predictors of violence included history of acute psychotic attacks and psychotic disorders, or outpatient psychiatry care. Among other predictors for Police assistance was presence of delusions, paranoia and history of outpatient psychiatry care.</p><p><strong>Conclusion: </strong>Prehospital care for patients with mental status alteration and aggressive behaviour is complex. Some clinical features seem to increase the risk of violence. Future research in the evaluation of agitated and violent patients is warranted to find strategies of risk mitigation for EMS personnel.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 4","pages":"239-249"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between salivary melatonin and interoceptive awareness.","authors":"Misa Kurihara, Hideki Ohira","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the relationship between salivary melatonin levels and interoceptive awareness in humans.</p><p><strong>Methods: </strong>We recruited 75 participants aged 18-55 years and measured their salivary melatonin concentrations using an enzyme immunoassay and their interoceptive awareness using the scores of the Multidimensional Assessment of Interoceptive Awareness (MAIA) scale.</p><p><strong>Results: </strong>Melatonin levels negatively correlated with total interoceptive awareness scores. On the subscales, melatonin levels were negatively correlated with noticing, attention regulation, emotional awareness, self-regulation, body listening, and trust, and were positively correlated with not-distracting; however, there was no correlation with not-worrying.</p><p><strong>Conclusion: </strong>Individuals with high melatonin levels are unlikely to be aware of their bodily sensations and emotional states or to regulate attention and emotions; however, they appear to have a calm mind.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 4","pages":"250-254"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen sulfide improved learning and memory deficits by reversing the inhibition of methylmercuric chloride on BDNF/TrkB signaling pathway.","authors":"Xiumei Cheng, Xinyi Cao, Yichun Yang, Lingxiao Wang, Yuxuan Yang, Yunjian Pan, Yongliang Zheng, Churong Wei, Yougen Luo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Methylmercuric chloride (MMC) has neurotoxicity, while hydrogen sulfide (H2S) has shown inhibitory properties against nerve damage induced by various factors. The study aimed to investigate the impact of H2S on MMC-induced learning and memory impairment in mice and to explore the underlying mechanisms.</p><p><strong>Methods: </strong>A mouse model of learning and memory impairment was established by MMC gavage, and sodium hydrosulfide (NaHS) was used as an H2S donor for intervention. Cell viability and live/dead cell ratio in HT22 neuronal cells were assessed by CCK-8 assay and Calcein/PI staining, respectively. The Morris water maze test was performed to evaluate the learning and memory abilities of mice. Western blotting was utilized to determine protein expressions of BDNF and TrkB. The effects of H2S on MMC-induced learning and memory impairment were investigated based on the BDNF/TrkB pathways.</p><p><strong>Results: </strong>(1) MMC treatment decreased cell viability and reduced the ratio of live cells in HT22 cells, while H2S reversed these changes. (2) MMC prolonged escape latency, decreased platform crossing frequency, and reduced quadrant distance percentage of the platform in the Morris water maze test, while H2S reversed the above changes. (3)MMC downregulated BDNF and TrkB expression levels, while H2S suppressed these changes induced by MMC. (4)Treatment with 7, 8-DHF (a TrkB agonist) significantly attenuated MMC-induced prolonged escape latency and reduced platform crossing frequency.</p><p><strong>Conclusions: </strong>Our findings demonstrated that H2S ameliorated learning memory deficits in mice by reversing the inhibitory effects of MMC on BDNF/TrkB signaling pathway.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 4","pages":"281-288"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruptured Lenticulostriate Artery Aneurysm Associated with Moyamoya Disease: A Case Report and Literature Review.","authors":"Zheng Feng, Yongquan Chang, Xingyi Jin, Chao Fu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Clinically, ruptured lenticulostriate artery (LSA) aneurysm associated with moyamoya disease (MMD) is rare but represents a potential hemorrhagic risk. Its optimal management remains unknown.</p><p><strong>Case description: </strong>A 66-year-old woman developed a left basal ganglia hemorrhage with intraventricular extension secondary to an MMD-associated distal LSA aneurysm that was subsequently treated with endovascular embolization. In this report, we review all previous cases of ruptured LSA aneurysms related to MMD.</p><p><strong>Conclusion: </strong>LSA aneurysm rupture should be considered in the setting of hemorrhagic MMD, especially in combination with basal ganglia hematoma. Proximal and distal LSA aneurysms appear to have different types of hemorrhage. This case highlights that management of such aneurysms should be individualized based on the balance of benefits and risks.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 4","pages":"289-293"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of gonadotropin-releasing hormone on the nervous system.","authors":"Jorge Juan Alberto Baca-Alonso, J Luis Quintanar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gonadotropin-releasing hormone (GnRH) plays a crucial role in regulating the human endocrine system. Synthesized primarily in the hypothalamus, GnRH manages the balance of reproductive hormones. This review highlights GnRH's various functions, particularly its impact on fertility, sexual development, and overall reproductive health through the regulation of gonadal development and function. Beyond its direct role in reproductive processes, GnRH also influences neuroprotection, cognition, and mood regulation, as shown by its activity in different regions of the nervous system. Research into GnRH and its analogs has revealed promising therapeutic potential for treating neurological disorders, indicating its broader impact beyond reproduction. Understanding GnRH's diverse roles not only emphasizes its importance in reproductive physiology but also highlights its involvement in neurological functions. Therefore, exploring the mechanisms behind GnRH's actions opens new avenues for research and therapeutic interventions, promising advancements in both reproductive medicine and neurological health.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 3","pages":"188-196"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supervised Combined Therapy for a Pediatric Patient After a Cerebral Stroke: Selected Special Pedagogical, Occupational Therapy, and Psychological Approaches in a Case Study of the Czech Republic.","authors":"Michal Vostrý, Ilona Pešatová, Barbora Lanková, Ivana Štolová, Otakar Fleischmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The article presents the results of a research study on a patient after an ischemic cerebral stroke, as presented in a case study. The aim of the research was to determine the impact of combined therapy, utilizing long-term and intensive special pedagogical care, occupational therapy and psychology, on the development of the patient's motor and communication abilities. The contribution deals with the possibilities of development and support for individuals in childhood after experiencing the illness, with the potential correction of identified deficits from a multidisciplinary perspective.</p><p><strong>Case report: </strong>The case study highlights a patient at the age of 7.2 years, following an ischemic cerebral stroke during the post-hospitalization period. Based on the analysis of medical documentation, we have developed a therapy proposal that reflects the individual needs of the patient from the perspective of special pedagogy, occupational therapy and psychology, taking into account the patients of school age.</p><p><strong>Conclusion: </strong>The results of the research study indicate that when working with a patient after an ischemic cerebral stroke, regular collaboration of a multidisciplinary team, along with effective integration of the various components of comprehensive rehabilitation, is necessary. Furthermore, this case study serves as a poignant example of the efficacy of such integrated therapy approaches in addressing the complex needs of pediatric stroke survivors. It not only highlights the potential for substantial functional recovery but also emphasizes the essential role of ongoing collaboration among diverse healthcare professionals.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 3","pages":"157-166"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building skills in cognitive behavioral supervision.","authors":"Jan Prasko, Marija Abeltina, Marie Ociskova, Julija Gecaite-Stonciene, Roman Liska, Alicja Juskiene, Milos Slepecky, Lina Bagdonaviciene","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of supervision is to ensure that clients' needs are met and to monitor the effectiveness of therapeutic interventions and the therapeutic relationship. Cognitive behavioural therapy (CBT) supervision is the systematic cooperation of the supervisee with the supervisor, which aims at increasing the therapists' competencies when working with specific clients. The advantage of supervision is the possibility to shape and develop the therapist's practical skills through specific techniques. This paper aims to review currently available CBT supervision strategies that boost the development of therapists' skills and provide possible examples. Various techniques are discussed, including behavioural, cognitive, imagery and psychodrama methods that facilitate supervisors in enhancing therapists' skills. In addition, complementary approaches are discussed, such as role-playing, modelling, chaining, or imitation to present at a particular moment of the therapy, increase the insight into the client's perspective or the treatment itself, and search for an alternative approach to improve the therapeutic outcomes for the client. Overall, the article describes the supervisor's need to have a flexible variety of skills and know which learning methods might be most effective for boosting the supervisee's skill level and needs with a particular client.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 3","pages":"197-214"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Artificial Intelligence Solution Combining Convolutional Neural Network and Analytical Approach Showed Higher Accuracy in A-lines Detection on Lung Ultrasound in Thoracic Surgery Patients Compared with Radiology Resident.","authors":"Martin Števík, Marek Malík, Štefánia Vetešková, Zuzana Trabalková, Maroš Hliboký, Michal Kolárik, Ján Magyar, Marek Bundzel, Martina Szabóová, František Babič, Marián Grendár, Kamil Zeleňák, Viktória Máčajová, Beáta Drobná Sániová, Anton Dzian","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Lung ultrasound reduces the number of chest X-rays after thoracic surgery and thus the radiation. COVID-19 pandemic has accelerated research in lung ultrasound artifacts detection using artificial intelligence. This study evaluates the accuracy of artificial intelligence in A-lines detection in thoracic surgery patients using a novel hybrid solution that combines convolutional neural networks and analytical approach and compares it with a radiology resident and radiology experts' results.</p><p><strong>Design: </strong>Prospective observational study.</p><p><strong>Material and methods: </strong>Single-center study evaluates the accuracy of artificial intelligence and a radiology resident in A-line detection on lung ultrasound footages compared with the consensual opinion of two expert radiologists as the reference. After resident's first reading, the artificial intelligence results were presented to the resident and he was asked to revise the results based on artificial intelligence.</p><p><strong>Results: </strong>82 consecutive patients underwent 82 ultrasound examinations. 328 ultrasound recordings were evaluated. Accuracy, sensitivity, specificity, positive and negative predictive values of artificial inelligence in A-line detection were 0.866, 0.928, 0.834, 0.741 and 0.958 respectively. The resident's values were 0.558, 0.973, 0.346, 0.432 and 0.962 respectively. The resident's values after correction based on artificial intelligence results were 0.854, 0.991, 0.783, 0.701 and 0.994 respectively.</p><p><strong>Conclusion: </strong>Artificial intelligence showed high accuracy in A-line detection in thoracic surgery patients and was more accurate compared to a resident. Artificial intelligence could play important role in lung ultrasound artifact detection in thoracic surgery patients and in residents' education.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 3","pages":"229-237"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects and mechanisms of deer blood phospholipids (DBP) on zearalenone-induced oxidative damage in swine Sertoli cells.","authors":"Yile Sun, Hongmei Gao, Yiwei Wang, Guoshi Liu, Bingyuan Wang, Huansheng Han","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The swine Sertoli cells (SCs) are more vulnerable to the environmental insults than other species. We observed that zearalenone (ZEA), a prevalent food contaminant, caused SCs oxidative damage and inhibits their proliferation. Therefore, a naturally occurring antioxidant, i.e., the deer blood phospholipids (DBP) has been selected to test its potentially protective effects on SCs.</p><p><strong>Methods: </strong>Collect fresh samples of swine testicles, isolated, cultured and identified primary swine SCs. The ROS levels in SCs 24 h induced by different concentrations of ZEA were detected, and the oxidative damage model was established. After DBP was added to the SCs 24 h after the damage, the oxidative and antioxidant indexes were detected by ELISA kit. Finally, the protective mechanism of DBP was explained by RNA-seq.</p><p><strong>Results: </strong>The results showed that DBP effectively protected against the reproductive toxicity induced by ZEA. The protective effects of DBP were mainly mediated by its potent antioxidative capacity. DBP upregulated the activities of the endogenous antioxidant enzymes including CAT and GSH-PX and reduced intracellular ROS level and MDA. In addition, DBP also promoted the SCs proliferation. The transcriptome sequencing combined with DEGs, GO and KEGG analyses suggested that DBP treatment enriched various signaling pathways of potentially biological significance including MAPK and PI3K-Akt signaling pathways. Both pathways also promote the cell proliferation. EdU assay further confirmed the beneficial effects of DBP on SCs proliferation.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 3","pages":"215-228"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}