Neuro endocrinology letters最新文献

{"title":"Impact of Helicobacter pylori- and Porphyromonas gingivalis-associated metabolic syndrome on local and systemic disorders.","authors":"Jannis Kountouras, Michael Doulberis, Elisabeth Vardaka, Stergios A Polyzos, Dimitrios Tzilves, Georgia Lazaraki, Maria Touloumtzi, Apostolis Papaefthymiou, Maria C Mouratidou, Dimitri Tzivras, Evangelos Kazakos","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To the Editor, In their review, Straka et al. (2026) discussed the role of Helicobacter pylori infection (Hp-I) in gastric and oral pathologies and highlighted the benefits of Hp eradication at both gastric and oral sites when combined with concomitant periodontal therapy (Straka et al. 2026). In this context, it is worth further emphasizing the broader impact of Hp and Porphyromonas gingivalis (Pg) in metabolic syndrome (MetS) and in bacteria-driven local and systemic disorders. Hp-I remains highly prevalent worldwide, affecting more than 4.4 billion individuals (Kountouras 2025). As a Group I carcinogen, Hp plays a central role in gastric carcinogenesis through Correa's cascade, namely the progression from chronic gastritis to atrophy, intestinal metaplasia, dysplasia, and ultimately gastric cancer (Kountouras et al. 2008). In addition, Pg and its virulence factors, particularly gingipains, have also been implicated in this carcinogenic sequence (Salazar et al. 2013). Beyond its primary colonization of the gastric mucosa, Hp may also inhabit the oral cavity, including dental plaque, saliva, periodontal pockets, and especially dental pulp, thereby acting as an important extragastric reservoir (Momtaz et al. 2012). This oral-gastric axis may contribute to persistent infection, reinfection after eradication, and enhanced transmission (Momtaz et al. 2012). Likewise, the oral cavity is a major reservoir for Pg, which can disseminate systemically through the bloodstream and influence distant organs (Farrugia et al. 2021). Hp-I, together with alterations in the oral-gut microbiota, may disturb the microecological balance of this axis. Both Hp and Pg are strongly associated with oral diseases, particularly periodontitis, a dysbiosis-driven inflammatory disorder. Periodontitis itself has been linked to the initiation and progression of malignancies, especially oral cancers (Farhad et al. 2024). Although Hp and Pg colonize different anatomical niches, they appear to share important pathogenic mechanisms (Doulberis et al. 2021). A major determinant of Pg virulence is the gingipain family, a group of cysteine proteases involved in tissue destruction, immune evasion, and bacterial invasion. Emerging evidence also suggests that Hp may express functionally similar proteolytic enzymes, indicating overlapping or complementary pathogenic strategies (Doulberis et al. 2021). Notably, co-incubation of Hp and Pg has been reported to enhance Pg virulence, supporting a synergistic interaction that may aggravate both local and systemic disorders (Doulberis et al. 2021). These shared features underline the potential value of targeting both pathogens in antimicrobial strategies.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 3","pages":"137-139"},"PeriodicalIF":0.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information and communication technologies and social media in nursing practice: From the perspective of nurses and patients.","authors":"Peter Zito, Lubica Libova, Ľuboslava Pavelova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To identify and analyze differences in information and communication technology (ICT) knowledge and use between nurses and patients, and to examine how age and educational attainment are associated with these differences in the context of perioperative outpatient nursing care, based on data collected concurrently from both groups.</p><p><strong>Material and methods: </strong>The tested group consisted of 81 nurses and 209 patients. The average age of the nurses was 41 years, and the average age of the patients was 36 years. This was a cross sectional, prospectively planned quantitative study. A self constructed questionnaire was used to assess levels of ICT knowledge and use. Data were analyzed using descriptive statistics and inferential tests (Chi square, Mann-Whitney U, and Wilcoxon tests) with a significance level of α = 0.05.</p><p><strong>Results of the research: </strong>We found statistically significant differences in the level of knowledge about ICT and social media between nurses and patients. Both groups considered ICT knowledge important, but patients rated it as more important than nurses (M = 2.78 vs 2.69; p < 0.001). This indicates a discrepancy between patients' expectations and nurses' perceptions within the same perioperative outpatient services.</p><p><strong>Conclusion of the research: </strong>By comparing responses of nurses and patients within the same perioperative outpatient services, we showed that ICT and social media are perceived as important by both groups, but with different priorities. Education in the home environment using modern ICT, aligned with these distinct perspectives, has the potential to contribute to the prevention of postoperative complications.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 3","pages":"174-180"},"PeriodicalIF":0.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological Profiles in Women with Lipedema: Exploratory Analysis of Platelet Distribution Width and Mean Platelet Volume. .","authors":"Arzu Dinc Yavas","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Lipedema is a chronic adipose tissue disorder predominantly affecting women, often misdiagnosed as obesity or lymphedema. Emerging evidence points to microvascular dysfunction and chronic inflammation in its pathophysiology. This study aimed to compare complete blood count (CBC) parameters and derived inflammatory indices between women with lipedema and age-matched healthy controls, focusing on the potential diagnostic value of platelet indices such as PDW and MPV.</p><p><strong>Methods: </strong>We conducted a retrospective observational study including 45 women with clinically confirmed lipedema and 40 age matched healthy controls. CBC parameters and derived inflammatory indices were compared between groups without adjustment for body mass index (BMI).</p><p><strong>Results: </strong>The study included 45 women with lipedema and 40 healthy controls with similar age distributions. No statistically significant between group differences were observed in complete blood count parameters after correction for multiple comparisons, although PDW and MPV were numerically higher in the lipedema group.</p><p><strong>Conclusion: </strong>In this exploratory study, PDW and MPV were numerically higher in women with lipedema than in controls, but these differences lost statistical significance after correction for multiple comparisons. These findings argue against PDW or MPV as standalone diagnostic markers of lipedema and indicate that future research should prioritize larger, BMI-matched cohorts and multimodal approaches that integrate platelet indices with tissue-level or imaging markers.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 2","pages":"165-173"},"PeriodicalIF":0.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral myo-inositol plus D-chiro-inositol (3.6:1) reduces insulin resistance pathway biomarkers in acne-involved skin among subjects with metabolic comorbidities: A gene expression study.","authors":"Mario Vaccaro, Enzo Emanuele, Piercarlo Minoretti, Celia García-Chico, Kayvan Khoramipour, Alejandro Santos-Lozano, Simone Lista, Simone Ribero","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Hyperinsulinemia and insulin resistance promote acne pathogenesis through reduced Forkhead box protein O1 (FOXO1) signaling and increased mechanistic target of rapamycin (MTOR) and insulin-like growth factor-1 (IGF1) activity. While oral myo-inositol (MI) and D-chiro-inositol (DCI) supplementation may improve insulin sensitivity, evidence regarding direct pathway modulation in acne-involved skin remains limited. In this exploratory, single-arm, uncontrolled study, we sought to investigate the effects of oral MI/DCI (3.6:1 ratio) on cutaneous expression of these biomarkers in adults with acne and metabolic comorbidities (polycystic ovary syndrome or metabolic syndrome).</p><p><strong>Methods: </strong>Forty-five adults with active inflammatory acne on the back were enrolled across three subgroups of 15 - including women with polycystic ovary syndrome (PCOS), women with metabolic syndrome (MetS), and men with MetS. All participants received oral MI/DCI (1100 mg + 300 mg daily) for 12 weeks in a single-arm, open-label, pre-post biopsy study. Paired punch biopsies of acne-involved skin were obtained before and after supplementation, and FOXO1, MTOR, and IGF1 mRNA expression was quantified by qRT-PCR. Clinical response was assessed by Investigator Global Improvement rating.</p><p><strong>Results: </strong>Following the 12-week supplementation, FOXO1 expression increased (Cohen's d = +1.13; p < 0.001), whereas MTOR (Cohen's d = -3.46; p < 0.001) and IGF1 (Cohen's d = -1.62; p < 0.001) decreased significantly compared with baseline. Changes were directionally consistent across all subgroups. Clinical improvements were observed in 82.2% of participants. Plasma testosterone in men remained stable (p = 0.638).</p><p><strong>Conclusions: </strong>In this exploratory, uncontrolled study, 12 weeks of oral MI/DCI supplementation (3.6:1 ratio) was associated with significant changes in insulin resistance pathway gene expression in acne-involved skin. These findings provide preliminary mechanistic support for further randomized, controlled trials evaluating MI/DCI as a potential adjunctive strategy in acne associated with metabolic comorbidities.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 2","pages":"127-134"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147985003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric acid-to-albumin ratio and mortality in stroke patients: a DAQS-stratified analysis.","authors":"Ping Zhuang, Zhen Yong Zheng, XiaoDie Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>The objectives of our study are to explore the associations of uric acid to albumin ratio (UAR) with all-cause and cardiovascular mortality in stroke patients, and to examine whether UAR-mortality associations differ between stroke patients stratified by dietary antioxidant quality score (DAQS).</p><p><strong>Methods: </strong>This cohort study included 1125 stroke patients from the NHANES 2007-2018. The DAQS was calculated based on the intake of six anti-oxidative nutrients. Multivariate Cox proportional hazards models were used to investigate the associations of UAR with all-cause and cardiovascular mortality in the total stroke cohort and within subgroups stratified by DAQS.</p><p><strong>Results: </strong>UAR showed a positive linear association with all-cause mortality in unadjusted and adjusted models (HR = 1.49, p = 0.003). For cardiovascular mortality, the association with continuous UAR was significant before but not after adjustment (HR = 1.43, p = 0.108). Compared with low UAR (≤1.34), high UAR (>1.34) was associated with higher all-cause (HR = 1.37, = 0.030) and cardiovascular mortality (HR = 1.64, p = 0.040). In exploratory DAQS-stratified analyses, elevated UAR was related to higher all-cause (HR = 1.58) and cardiovascular mortality (HR = 1.83; both p < 0.05) only among patients with low DAQS, whereas associations in the high-DAQS subgroup were generally non-significant and imprecise.</p><p><strong>Conclusion: </strong>Higher UAR after stroke was robustly associated with increased all-cause mortality, with weaker and less consistent evidence for cardiovascular mortality. Exploratory DAQS-stratified analyses suggested excess risk with high UAR mainly among patients with low DAQS, while findings in the smaller high-DAQS subgroup were non-significant and imprecise; these subgroup and cardiovascular results are hypothesis-generating.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 2","pages":"80-93"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Within-Session Reductions in Negative Mood During a 4-Week Upright Sitting Practice in Japanese Young Adults: An Exploratory Observational Study.","authors":"Takuma Usuda, Takuji Yamaguchi, Ailing Hu, Zenji Kawakami, Saori Karasawa, Munetaka Yamamoto, Hiroyuki Kobayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>This exploratory study examined changes in stress-related indicators, including subjective mood states, autonomic nervous system activity, and salivary biomarkers, during a 4-week period in which healthy young adults performed an instructed upright sitting posture.</p><p><strong>Design: </strong>This study employed a single-arm, within-subject, repeated-measures observational design.</p><p><strong>Materials and methods: </strong>Eighteen healthy university students (10 males and 8 females) completed a 4-week upright sitting posture practice. Assessments took place at baseline (Week 0), mid-practice (Week 2), and end-of-practice (Week 4). At each visit, participants underwent a 10-minute seated rest; pre-session assessments using the Profile of Mood States, Second Edition (POMS2), autonomic indices, and salivary biomarkers; a 5-minute upright sitting period; and post-session assessments. Autonomic activity was indexed by heart rate (HR) and heart rate variability (HRV), and salivary cortisol, chromogranin A, oxytocin, and α-amylase were measured.</p><p><strong>Results: </strong>Across assessment weeks, sessions that included the instructed upright sitting posture were accompanied by within-session pre-post improvements in most POMS2 mood indices, with large effects for several negative mood subscales and Total Mood Disturbance. Significant main effects of Week were observed for Confusion-Bewilderment, Tension-Anxiety, and Total Mood Disturbance, whereas other mood indices did not show consistent change. HR showed significant main effects of Measurement Timing and Week, while HRV indices and salivary biomarkers did not show consistent or statistically significant patterns. At Week 4, comfortable maintenance time-the self-reported maximum duration participants felt they could maintain the instructed posture-was positively associated with total practice time; this association was considered hypothesis-generating.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 2","pages":"94-102"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of genetic, clinical features, and prognosis in pediatric patients diagnosed with cardiomyopathy.","authors":"Alev Arslan, Nigar Shrinova, Seyda Besen, Mahmut Gökdemir","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pediatric cardiomyopathy (PCM) comprises a genetically heterogeneous, high risk group of myocardial disorders and is a leading cause of pediatric heart failure and transplantation. Genotype-phenotype correlations and outcome data remain limited, particularly in populations with high consanguinity.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 53 children with cardiomyopathy classified as hypertrophic (HCM), dilated (DCM), left ventricular noncompaction (LVNC), or restrictive cardiomyopathy (RCM). We analyzed demographics, consanguinity, echocardiographic parameters, genetic testing results (available in 26/53 patients, 49.1%), device therapy, transplantation, and mortality.</p><p><strong>Results: </strong>The cohort included 20 HCM (37.7%), 17 DCM (32.1%), 13 LVNC (24.5%), and 3 RCM (5.7%) patients, with a median age at diagnosis of 6.5 years (interquartile range [IQR] 2.0-10.0). Consanguinity was documented in 24 of 53 patients (45.3%). A pathogenic or likely pathogenic (P/LP) variant was identified in 9 of 26 tested patients (34.6%), corresponding to 17.0% of the total cohort (9/53). When variants of uncertain significance (VUS) are included, 20 of 26 tested patients (76.9%) harbored at least one rare variant; however, 11 of these 20 findings (42.3% of tested patients) were VUS, which are not counted toward diagnostic yield and remain subject to reclassification. Baseline ejection fraction was markedly reduced in DCM (median 35%, IQR 28-37%), whereas HCM and RCM had preserved systolic function at diagnosis. During a median follow up of 3.0 years, 15 patients (28.3%) underwent implantable cardioverter defibrillator implantation, 6 (11.3%) underwent heart transplantation, and 18 (34.0%) died; mortality was highest in DCM (58.8%) and RCM (66.7%).</p><p><strong>Conclusion: </strong>Among the 26 of 53 patients who underwent genetic testing, PCM in this cohort showed a P/LP diagnostic yield of 34.6% (9/26) and substantial mortality, particularly in DCM and RCM phenotypes. High consanguinity was associated with a notable P/LP yield and a frequent VUS burden; whether consanguinity contributes to earlier or more severe disease requires confirmation in larger, prospective studies. These findings support offering comprehensive genetic testing to pediatric cardiomyopathy patients, especially in high consanguinity settings, to enable molecular diagnosis and structured family counseling. In this cohort, a substantial proportion of tested patients had P/LP variants, and many others carried VUS that will require ongoing re evaluation. Future prospective studies should assess how specific genetic findings, combined with imaging and functional parameters, can be incorporated into validated risk stratification and management algorithms. s.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 2","pages":"72-79"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing kind parent mode in schema therapy and supervisions.","authors":"Jan Prasko, Marie Ociskova, Ilona Krone, Jakub Vanek, Marija Abeltina, Julija Gecaite-Stonciene, Milos Slepecky, Julius Burkauskas, Marta Zatkova, Tomas Sollar, Ieva Bite, Alicja Juskiene","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article examines the development of the Kind (Good) Parent mode in schema therapy and supervision. A narrative review of literature on schema modes, Healthy Adult functioning, self-compassion, and experiential methods is integrated with therapists' and supervisors' clinical experience. We define the Kind Parent mode, distinguish it from related modes, and describe how it manifests in self-communication and communication with others. We outline cognitive, behavioral, experiential, imagery based, and supervisory methods, including guided discovery, cognitive restructuring, role playing, chairwork, and imagery rescripting, that can strengthen this mode in patients and supervisees. Because kindness toward oneself is often difficult for both patients and therapists, explicitly cultivating the Kind Parent mode may support self-love, emotional regulation, and relationships, while complementing existing work with the Healthy Adult mode.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 2","pages":"103-115"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of a patient diagnosed with cerebral hemorrhage complicated by atypical pulmonary embolism in the rehabilitation department: Case report and anatomical factors analysis.","authors":"Yaping Wang, Bing Han, Jiejiao Zheng, Yongjun Zheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This report documents the occurrence, clinical management, and outcome of a patient diagnosed with an atypical pulmonary embolism (PE) complicating subacute cerebral hemorrhage in a rehabilitation setting. By integrating the relevant literature, this study aimed to provide a clinical reference for the diagnosis and treatment of atypical PE in patients undergoing post-hemorrhagic rehabilitation.</p><p><strong>Case: </strong>The medical history and imaging data from a patient diagnosed with atypical PE during the subacute phase after intracerebral hemorrhage in a rehabilitation setting were analyzed. After diagnostic confirmation, anticoagulation and symptomatic therapies were initiated. A literature review exploring anatomical factors underlying PE in this clinical context was performed. After multidisciplinary treatment, the patient's PE lesions disappeared and indicators, such as blood pressure and heart rate, returned to normal.</p><p><strong>Conclusion: </strong>Intracerebral hemorrhage complicated by atypical PE is a relatively uncommon occurrence in the rehabilitation ward. In this case, conservative low-dose nadroparin calcium anticoagulation was associated with marked biochemical improvement and complete bilateral pulmonary artery clearance on follow-up CTA, without recurrent intracranial hemorrhage. Although no domestic or international guidelines currently address intracerebral hemorrhage complicated by atypical PE, our experience suggests that early prevention, timely diagnosis, individualized anticoagulation, and multidisciplinary collaboration can enable safe and effective management in carefully selected patients.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 2","pages":"116-126"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis, Oral Helicobacter pylori Reservoirs, and Gastric Cancer: Implications for Adjunctive Periodontal Therapy.","authors":"Michal Straka, Petra Borecová, Kamila Csóková, Erik Gerža, Isabella Julie James, Matej Straka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this review study, we address the epidemiological, causal, and clinical associations between the oral and gastric occurrence of Helicobacter pylori and its role in the etiopathogenesis of gastric cancer, gastritis, as well as peptic ulcer disease and dyspeptic disorders of the stomach and duodenum. We summarize and critically analyze numerous meta-analytical studies addressing the oral occurrence of H. pylori and its eradication from the stomach and oral cavity using conventional pharmacological eradication therapy. In the process of analysis, we examine whether the oral cavity can serve as a reservoir of H. pylori during reinfections of the gastric mucosa, while not all studies confirm the survival of H. pylori in the oral cavity. However, the majority of studies, including their meta-analytical outputs, conclude that H. pylori may survive in saliva and potentially persists in the oral cavity by exploiting the microaerophilic to anaerobic environment of periodontal pockets, as well as the structures of supra- and subgingival dental calculus and various locations of oral biofilms, which are inaccessible to both innate and adaptive immune defense mechanisms of the patient. While a minority of studies regard oral H. pylori as transient (Al-Ahmad, 2012), the weight of current evidence - particularly from PCR-based and co-culture studies (Scholz et al., 2025) - supports a biologically plausible reservoir role. The structures of periodontal pockets, oral biofilms, and dental calculi lack effective blood supply, moreover, these sites are not routinely accessible to home oral hygiene measures. For the removal and elimination of the mentioned structures, targeted periodontological treatment combined with various methodologies of professional oral hygiene is required. The elimination of H. pylori using these approaches has been confirmed by many studies, from which several clinically relevant therapeutic implications for clinical practice in dentistry and periodontology arise. These findings support a strong recommendation that dental practitioners provide thorough periodontal treatment and eliminate the environment of periodontal pockets through comprehensive periodontal therapy combined with the removal of oral biofilms and dental calculi in patients with a diagnosed finding of H. pylori in the GIT who are undergoing pharmacological eradication treatment. In line with the observed improvement in gastric H. pylori eradication when periodontal therapy is added - with odds ratios of 2.15 (95% CI: 1.47-3.14) and 2.64-4.11 across independent meta-analyses - gastroenterologists, internists, and oncologists should systematically consider referring H. pylori‑positive patients to dentists for periodontological and hygiene procedures, accompanied by regular recall appointments.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 1","pages":"53-63"},"PeriodicalIF":0.6,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}