Neuro endocrinology letters最新文献

{"title":"The use of imagery in group schema therapy.","authors":"Jan Prasko, Julius Burkauskas, Julija Gečaitė-Stončienė, Frantisek Hodny, Jakub Vaněk, Jan Pasztor, Kamila Bělohradová, Ieva Bite, Marta Zatkova, Erika Jurisova, Ilona Krone, Alicja Juskiene, Milos Slepecky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article describes using imagery approaches during group schema therapy (GST). Imagery approaches are an important tool for identifying and changing maladaptive schema modes and early maladaptive schemas. It summarises the theoretical background of the group imagery method and practical case vignettes. The text describes methods for using imagery in therapeutic groups, building a safe place, imagery rescribing painful experiences, and dialogue between schema modes. It also stresses challenging matters, like problems with imagery, difficulties trusting another person, and resistance to change. Using imagery in GST is a powerful approach to increase patient results during the therapy.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 7-8","pages":"433-448"},"PeriodicalIF":0.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of parental screening tool S-PMV11: Convergent validity with Bayley-III in assessing developmental functioning.","authors":"Lucia Ráczová, Erika Jurišová, Marta Popelková, Tomáš Sollár","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>With the increasing use of developmental screening tools, there is a growing need to validate parental screening methods for the early detection of developmental difficulties in children, regarding their psychometric properties.</p><p><strong>Methods: </strong>This study evaluates the convergent validity of the S-PMV11 parental screening tool by comparing its outcomes with the Bayley Scales of Infant and Toddler Development (Bayley-III), the gold standard for direct assessment.</p><p><strong>Results: </strong>We analyzed data from 30 children and found significant correlations between S-PMV11 scores and Bayley-III assessments across cognitive, language, and motor skill domains. Notably, expressive communication showed the strongest correlation, indicating that parents are reliable assessors of developmental risks.</p><p><strong>Conclusion: </strong>Despite limitations related to potential overestimation in Bayley-III, our findings support the S-PMV11 as a valid tool for early identification of developmental challenges, enhancing early intervention strategies in pediatric healthcare.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 7-8","pages":"449-456"},"PeriodicalIF":0.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease characteristics and cognitive impairment in multiple sclerosis: A short-term observation is not enough.","authors":"Bianka Suchá, Pavel Šiarnik, Stela Biathová, Stanislava Klobucká, Žofia Rádiková, Katarína Klobučníková, Peter Turčáni, Branislav Kollár","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a disease that affects the central nervous system. One of its manifestations is cognitive impairment (CI), which can negatively affect the quality of life in people with MS (pwMS). This study aimed to investigate the nature of CI in MS and its associations with various disease characteristics.</p><p><strong>Methods: </strong>Symbol Digit Modalities Test and cognitive tests adapted for the Slovak population as part of the NEUROPSY battery were used. For the assessment of depression, the Patient Health Questionnaire-9 was used. To assess the degree of functional disability, the Expanded Disability Status Scale, Timed 25-Foot Walk, and 9-Hole Peg Test were used. Plasma neurofilament light chain level (pNfL, a promising marker of neurodegeneration) was assessed. Variables in the CI vs. non-CI group were compared.</p><p><strong>Results: </strong>In cognition, we observed statistically significant differences between the CI and the non-CI group in multiple measures. In the degree of functional disability, we found statistically significant differences between the groups in all measures. However, we found no statistically significant differences in depression, pNfL, type of disease-modifying therapy, or education. The Digit Span Forward (longest line) (OR: 0.375, 95%CI: 0.156-0.901, p = 0.028) and Trail Making Test-B (OR: 0.066, 95%CI: 0.013-0.339, p = 0.001) were the only independent variables in a model that predicted CI in binary logistic regression analysis.</p><p><strong>Conclusion: </strong>Our cross-sectional study design failed to reveal the association of CI with various disease characteristics, or markers of neurodegeneration. For this purpose, longitudinal observation of pwMS, and future prospective studies are highly warranted.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 7-8","pages":"419-426"},"PeriodicalIF":0.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and Anxiety. Depression and anxiety in women during physiological pregnancy.","authors":"Milos Veleminsky, Maria Boledovicova, Olga Dvorackova, Jana Stejskalova, Milos Veleminsky, Peter G Fedor-Freybergh, Peter Uharcek, Emilia Lichtenberg-Kokoszka, Jana Hamanova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The quality of prenatal care for women during pregnancy, in terms of monitoring somatic development, is generally high. The study aims to evaluate the psychosocial situation (well being) of pregnant women during a physiological pregnancy. The care of psychosocial issues of pregnant women is not systematic and often does not occur at all. Prenatal depression and anxiety are associated with an increased risk of depression even after delivery. To accomplish the goal, the authors chose both the modified Freybergh scale - the Sabbatsberg anxiety - frustration Self-Rating Scale (SDS) and a questionnaire created by the authors of this study. A total of 324 women from various regions were randomly approached, of which 277 were selected for the final evaluation. The scale contains seven categories, each with ten questions. Pregnant women repeatedly took the self-assessment over the duration of their pregnancy. The result is a summary point evaluation. The seven individual groups of questions focused on the evaluation of stress, fear, depression, regression, feelings of guilt, frustration, and aggression. The scale of answers to individual questions offered five options. The questionnaire itself had 14 monitored items and evaluated the difference in symptoms in women with and without psychological distress. The degree of psychological distress was processed using descriptive statistics. Furthermore, it was classified into four equal groups (175 points each), identified as none, mild, moderate and high deprivation. The adjusted effect of the monitored parameters on the psychological distress score was studied using a mixed model. The results of the study draw attention to psychological distress in pregnant women with physiological pregnancies. It is vital to monitor symptoms of psychological distress during physiological pregnancies. In addition, preventive prenatal programs to reduce or prevent psychological distress during pregnancies must be implemented and widely available.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 7-8","pages":"523-538"},"PeriodicalIF":0.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-episode mild depression in young adults is a pre-proatherogenic condition even in the absence of subclinical metabolic syndrome: lowered lecithin-cholesterol acyltransferase as a key factor.","authors":"Michael Maes, Asara Vasupanrajit, Ketsupar Jirakran, Bo Zhou, Chavit Tunvirachaisakul, Abbas F Almulla","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Major depression is classified into distinct subtypes: simple (SDMD) and major dysmood disorder (MDMD). MDMD patients exhibit elevated atherogenicity and decreased reverse cholesterol transport (RCT). However, comprehensive data regarding lipid metabolism is absent in first episode (FE)-SDMD.</p><p><strong>Aims: </strong>In this case-control study, plasma lipid levels, lecithin-cholesterol acyltransferase (LCAT), free cholesterol, apolipoprotein (Apo)A1, ApoB, and ApoE are compared between academic students with first episode SDMD (FE-SDMD) (n = 44) or SDMD (n = 64) and control students (n = 44), after excluding those with metabolic syndrome (MetS).</p><p><strong>Results: </strong>LCAT is decreased, and free cholesterol and ApoE increased in subjects with SDMD and FE-SDMD as compared with controls. There were no significant alterations in high-density lipoprotein cholesterol (HDLc), ApoA1, RCT, ApoB and triglycerides in SDMD. LCAT, free cholesterol and atherogenicity indices are significantly associated with suicidal behaviors and the SDMD phenome. The effects of LCAT on those phenome features is completely mediated by free cholesterol and brooding. SDMD and FE-SDMD patients without signs of subclinical MetS show lowered LCAT and increased free cholesterol as compared with normal controls. There are significant interactions between the SDMD and FE-SDMD diagnosis and subclinical MetS, which result in decreased HDLc and RCT, and an increased ApoB/ApoA ratio.</p><p><strong>Discussion: </strong>FE-SDMD and SDMD are pre-proatherogenic states, because of decreased LCAT, and increased free cholesterol and ApoE, and their intersections with subclinical MetS. These aberrations may drive atherogenicity, and activation of peripheral and central oxidative, neuro-immune, and degenerative pathways. Individuals with FE-SDMD should be screened and treated for increased atherogenicity risk by measuring free cholesterol and ApoE.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 7-8","pages":"475-491"},"PeriodicalIF":0.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth loss, periodontal infection and their relationship to cognitive impairment and other dementias: A review.","authors":"Michal Straka, Marek Šupler, Matej Straka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our review study addresses the issue of tooth loss, which is caused by loss of masticatory function and its impact on cognitive functions, dementia, and Alzheimer's disease. Numerous studies have confirmed a positive correlation between premature tooth loss, reduction in masticatory function and significant cognitive decline observed through learning disabilities, including overcoming ordinary life problems to early and advanced forms of dementia. Reduced numbers of teeth in the main food processing area, i.e., loss of large molars, have been implicated as a possible cause of cognitive impairment. In research in this area, some groups of major etiopathogenetic causes of this issue have also been established. A significant etiopathogenetic cause of tooth loss is the disappearance of their mechanoreceptors in the periodontium, causing the disappearance of sensorimotor excitation via the cranial nerve V and the associated atrophic changes in the trigeminal brain nuclei and their branching in the Locus Coeruleus area. It may cause further neurodegenerative involvement in this area, one of the centers of the adrenergic system involved in cognitive function. Relatively well-studied factors are the lack of blood supply to the cerebral area during inadequate mastication caused by loss of molars and the consequent hypoxia of brain and nerve structures. In the research and development of Alzheimer's disease, there have been many recent references to the fact that the primary bacterium causing periodontitis, Porphyromonas gingivalis, can infect the neurons of the cranial nerve V ending close to the Locus Coeruleus and thus tau proteins, after tooth extractions, can spread to other subcortical nuclei in the brain. These findings are of great relevance to clinical practice in dentistry as we strive to prevent tooth loss in the distal compartment, which is made possible by the tremendous expansion of endodontic techniques and technologies to save de facto every tooth and its periodontium with the mechanoreceptors necessary to preserve sensorimotor nerve excitability and sensorimotor nerve networks. We uncompromisingly eliminate every periodontal infection in the subgingival region as part of our preventive-therapeutical procedures.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 7-8","pages":"468-474"},"PeriodicalIF":0.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are abnormalities in lipid metabolism, together with adverse childhood experiences, the silent causes of immune-linked neurotoxicity in major depression?.","authors":"Michael Maes, Ketsupar Jirakran, Asara Vasupanrajit, Bo Zhou, Chavit Tunvirachaisakul, Drozdstoj St Stoyanov, Abbas F Almulla","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Severe or recurring major depression is associated with increased adverse childhood experiences (ACEs), heightened atherogenicity, and immune-linked neurotoxicity (INT). Nevertheless, the interconnections among these variables in outpatient major depression (OMDD) have yet to be determined. We aim to determine the correlations among INT, atherogenicity, and ACEs in OMDD patients compared to normal controls.</p><p><strong>Methods: </strong>This study includes 66 OMDD patients (of whom 33 had metabolic syndrome, MetS) and 67 controls (31 of whom had MetS) and used Multiplex Immunoassay to assess serum levels of forty eight cytokines/chemokines/growth factors.</p><p><strong>Results: </strong>The free cholesterol/reverse cholesterol transport ratio, apolipoprotein (Apo) B and E, and a comprehensive atherogenicity index were all significantly associated with increased INT in subjects without MetS. ACEs were substantially correlated with INT in individuals with MetS. INT (only in MetS) and atherogenicity indices (only in people without MetS) were significantly associated with the clinical phenome features of OMDD, including the recurrence of illness (ROI, including lifetime suicidal behaviors), the lifetime phenome (neuroticism, lifetime anxiety disorders and dysthymia), and the current phenome (including current suicidal behaviors). A significant proportion of the variability (58.3%) in the lifetime + current phenome could be accounted for by INT, interactions between INT and atherogenicity (labeled \"atherommune index\"), ApoE, three ACE subtypes (all positively correlated), and age (inversely correlated). A common latent construct could be extracted from ROI, lifetime phenome, current phenome, INT, and atherommune index. 36.1% of this factor's variance was accounted for by three ACE subtypes.</p><p><strong>Conclusion: </strong>We have developed a novel OMDD model, namely a pathway phenotype, labeled the \"atherommune-phenome,\" which demonstrates that the interplay between INT and atherogenicity is essential to OMDD.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 6","pages":"393-408"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-frequency repetitive transcranial magnetic stimulation of affected hemisphere on motor recovery in patients in the acute stage of ischemic stroke: Preliminary results .","authors":"Katarína Valovičová, Branislav Kollár, Stanislava Klobucká, Zoltán Goldenberg, Simona Švaňová, Andrea Strečanská, Peter Turčáni, Pavel Šiarnik","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neurostimulation technique that uses magnetic field to comprehensively influence events in the brain. Its use in patients after stroke focuses mainly on influencing brain neuroplasticity and therefore has the potential to improve motor functions in these patients. This study investigates the effect of rTMS on motor function recovery in patients in the acute stage of ischemic stroke.</p><p><strong>Design: </strong>This study was designed as a randomized double-blind placebo-controlled trial.</p><p><strong>Materials and methods: </strong>A total of 26 patients with motor impairment in the acute stage of ischemic stroke were enrolled. Participants were randomly assigned to receive 5 sessions of 10 Hz ipsilesional rTMS or placebo rTMS, in addition to standard pharmacotherapy and rehabilitation. Clinical evaluations of motor impairment and activity were performed, along with electrophysiological parameters of motor evoked potential (MEP), at baseline (1 -6 days after stroke) and after the completion of the 5 rTMS sessions (10 -14 days after stroke).</p><p><strong>Results: </strong>The 10 Hz rTMS group demonstrated significantly greater improvements in most clinical motor function assessments compared to the placebo group. However, no significant changes in the electrophysiological parameters of MEPs were observed.</p><p><strong>Conclusion: </strong>The application of 10 Hz rTMS to the ipsilesional hemisphere shows promise in improving motor functions in patients in the acute stage of ischemic stroke. Although the results suggest potential therapeutic benefit, more research with larger sample sizes and comprehensive outcome measures is required to optimize rTMS protocols and fully understand its effects on motor recovery.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 6","pages":"409-417"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood trauma and dissociation in patients with panic disorder, obsessive-compulsive disorder, and borderline personality disorder. Part 1: Relationships between demographic, clinical, and psychological factors.","authors":"Krystof Kantor, Jan Prasko, Marie Ociskova, Jakub Vanek, Frantisek Hodny, Kamila Belohradova, Antonin Kolek, Jozef Visnovsky, Vlastimil Nesnídal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Panic disorder (PD), obsessive-compulsive disorder (OCD), and borderline personality disorder (BPD) are associated with various psychosocial factors that may influence their onset and psychopathology. Dissociation encompasses a wide range of manifestations, from benign experiences to severe mental health issues. Research comparing childhood trauma and dissociation, general psychopathology, and the onset of the disorder among patients with PD, OCD, and BPD has not yet been published.</p><p><strong>Results: </strong>The severity of dissociative symptoms negatively correlated with the onset of the disorder, whereas it positively correlated with the disorder's overall severity and general symptomatology. Patients with more severe childhood trauma had an earlier onset of the disorder and more severe depressive and dissociative symptoms. They rated higher on the overall severity of the disorder. Physical abuse and neglect were associated with more severe PD, OCD, and BPD. Patients with BPD had higher levels of dissociation than those with PD or OCD. BPD was also connected with more severe childhood trauma than PD and OCD patients. Comorbidity exacerbated the severity of the psychiatric disorders.</p><p><strong>Conclusions: </strong>Childhood trauma and dissociation play a significant role in anxiety and depressive symptoms in patients with PD, OCD, and BPD.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 6","pages":"365-378"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Behavior of Nasopharynx Malignancies: a Retrospective Study in a Ten-Year Sample.","authors":"Tomas Kostlivy, Petr Skopek, Pavel Klail, Petr Hrabacka, Michal Riant, Alena Skalová, Bretislav Gal, Radek Kucera, Vaclav Simanek, David Slouka","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Malignant tumors of the nasopharynx make up 3% of malignancies in the ENT area. The most common nasopharyngeal malignancy is nasopharyngeal carcinoma (NPC), followed by lymphomas. Other nasopharyngeal tumors are very rare. In this study, we aimed to assess the age distribution and behavior of the primary nasopharyngeal malignancies, NPC, and lymphoma over a ten-year period in a tertiary hospital patient group.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Material and methods: </strong>A total of 48 patients participated in this retrospective monocentric study. The group consisted of 13 females (27.1%) and 35 males (72.9%) diagnosed with nasopharyngeal malignancy and treated between 2012 and 2022. The patients' ages ranged from 14 to 83 years, with a mean age of 57.5 and a median of 55 years. The variables monitored in the study were histology, symptoms (such as nasal obstruction, Eustachian tube function, presence of glue ear, neck mass, weight loss), smoking status, TNM classification, and survival.</p><p><strong>Results: </strong>In NPC grading and staging, two statistically significant variables were found to be associated with survival: distant metastases (p < 0.0001) and stage of the process (p = 0.0153). We did not find age and gender to be significant variables for lymphomas (p = 0.4066; p = 0.1797, respectively) or for NPC (p = 0.8630; p = 0.0573, respectively). Neither did we find any significant cut-off levels. In our analysis of therapy, we discovered that the use of chemoradiotherapy and palliative care in the NPC group is statistically significantly connected with disease-specific survival (p = 0.0094; p = 0.0004). This, however, was not the case in the lymphoma group. For the NPC group, we found statistically significant symptoms only in weight loss (p = 0.0081) and smoking (p = 0.0483).</p><p><strong>Conclusion: </strong>Our research confirmed that nasopharyngeal tumors are rare, with the most common type being nasopharyngeal carcinoma. In our patient group, 76.9% of cases involved nasopharyngeal cancer, which was five times more common in men than in women, and typically occurred in individuals over the age of 50. Lymphomas and other tumors accounted for less than a quarter of the cases. The overall five-year survival rate for nasopharyngeal malignancies in our group was 42.3%. We also observed an interesting gender perspective: 75% of women (6 women) survived for five years, whereas 72.2% of men died within five years of diagnosis.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"45 6","pages":"353-361"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}