Neuro endocrinology letters最新文献

{"title":"Clinical use of chlorhexidine gluconate antimicrobial dressings for subclavian central venous catheters in patients undergoing hematopoietic stem cell transplantation.","authors":"Xiao-Dong Xu, Shu-Jia Liu, Xiao-Lin Liu, Dan Li, Yu Wang, Xia Yan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated whether chlorhexidine gluconate (CHG) antimicrobial dressings reduce catheter‑related local infection and improve dressing stability in for subclavian central venous catheters (CVCs) in patients undergoing hematopoietic stem cell transplantation (HSCT).</p><p><strong>Methods: </strong>A total of 120 patients who underwent HSCT and received subclavian CVC placement in the laminar airflow ward of the Department of Hematology at the study hospital between November 2019 and November 2021 were enrolled. Participants were randomly allocated, using a random number table, to an intervention group or a control group (60 patients each). The intervention group received subclavian CVC fixation and maintenance with CHG antimicrobial dressings, whereas the control group used conventional transparent 3M dressings under the same standardized care protocol. Routine catheter maintenance was performed once weekly in both groups, with continuous intervention over a 5-week period. Outcomes assessed included the incidence of CVC-related local infection (manifested as redness, swelling, and pain at the puncture site), the frequency of dressing changes, and the number of cases of dressing loosening.</p><p><strong>Results: </strong>The incidence of catheter‑related local infection was 46.67% in the control group and 23.33% in the intervention group. The mean number of dressing changes was 6.7 (range, 2-14) in the control group and 5.4 (range, 1-11) in the intervention group. Dressing loosening occurred in 19 control group patients and 9 intervention group patients. All between-group differences were statistically significant (p < 0.05), indicating fewer local infections, fewer dressing changes, and less dressing loosening with CHG antimicrobial dressings.</p><p><strong>Conclusion: </strong>In this randomized study, CHG antimicrobial dressings significantly reduced CVC‑related local infection, improved dressing fixation, and lowered the frequency of dressing changes in HSCT patients with subclavian CVCs. These findings support the use of CHG dressings to optimize catheter maintenance and may help reduce nursing workload in this high risk population.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 4","pages":"268-273"},"PeriodicalIF":0.6,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic association between years of education and intracranial aneurysm: A two-sample Mendelian randomization study.","authors":"Yicheng Cui, Shangsong Yang, Zhipeng Xiao, Meihua Li, Wenqiang Xin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether genetically proxied educational attainment influences the risk of intracranial aneurysm.</p><p><strong>Method: </strong>We conducted a two-sample Mendelian randomization analysis using genome wide association study summary statistics from individuals of European ancestry. The inverse variance weighted method was the primary estimator, complemented by MR Egger, weighted median, weighted mode, and simple mode analyses, with years of schooling and college completion as educational exposures combined with intracranial aneurysm GWAS data.</p><p><strong>Results: </strong>We selected two groups of genes associated with genetic susceptibility to education as exposure factors. When using years of education from the UK Biobank based GWAS as the exposure, the inverse variance weighted method indicated an inverse association between genetically proxied longer schooling and intracranial aneurysm risk. MR Egger regression suggested that directional pleiotropy was unlikely to strongly bias the results and yielded an inverse association between years of schooling and intracranial aneurysm. The weighted median estimator yielded a similar direction and magnitude of effect. When using college completion as the exposure, the inverse variance weighted method also indicated an inverse association with intracranial aneurysm risk, and sensitivity analyses produced estimates of similar direction and magnitude. MR-Egger regression intercept testing did not provide evidence of substantial directional pleiotropy.</p><p><strong>Conclusion: </strong>These Mendelian randomization findings are consistent with a potentially protective association of higher genetically proxied educational attainment with intracranial aneurysm risk in individuals of European ancestry.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 4","pages":"249-258"},"PeriodicalIF":0.6,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative processes in schema therapy: Theoretical background, clinical methods, and case illustrations.","authors":"Marie Ociskova, Jan Prasko, Ilona Krone, Roman Liska, Julija Gecaite-Stonciene, Julius Burkauskas, Jozef Visnovsky, Marija Abeltina, Ben Eden, Alicja Juskiene, Milos Slepecky, Marta Popelkova, Erika Jurisova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To develop a mechanism-oriented framework that specifies how narrative processes operate within schema therapy, detailing a core sequence of change (activation of emotionally salient autobiographical memories, shift in narrative position, emergence of corrective internal voices, and reconsolidation of meaning) through which narrative-based interventions support identity-level change in individual and group settings.</p><p><strong>Methods: </strong>This paper adopts a theory-building approach combining a narrative review with an interpretive qualitative analysis of clinical case illustrations from schema therapy. Case material is used to model recurring mechanisms of narrative change rather than to evaluate treatment efficacy.</p><p><strong>Results: </strong>Across imagery rescripting, chairwork, therapeutic letters, the River of Life, and the Inner House method, a consistent pattern of narrative change emerged. Core mechanisms included activation of emotionally salient autobiographical memories, a shift in narrative position from child-in-experience to adult author, emergence of corrective internal voices corresponding to the Healthy Adult and Kind Parent modes, and reconsolidation of meaning. These changes transferred into current identity and interpersonal functioning, with reduced dominance of punitive introjects, increased self-compassion, and greater narrative coherence. In group settings, corrective relational experiences were amplified through shared narrative processing.</p><p><strong>Discussion: </strong>Narrative processes in schema therapy are discussed in relation to narrative identity research, trauma-related memory fragmentation, and emerging findings on memory reconsolidation, with neurobiological links framed as plausible but still tentative. Potential clinical risks, including emotional overactivation and narrative destabilization, highlight the need for careful pacing and integration with stabilization, cognitive-behavioral strategies, mindfulness, and resource-oriented interventions.</p><p><strong>Conclusion: </strong>Narrative processes constitute a central pathway through which schema therapy facilitates identity-level change beyond symptom reduction. A mechanism-based narrative framework may strengthen clinical formulation and inform future research on how and for whom narrative interventions are most effective.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 4","pages":"225-248"},"PeriodicalIF":0.6,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oliceridine Reduces the EC50 of Remifentanil Required to Attenuate Tracheal Intubation Responses During Anesthesia Induction.","authors":"Zong-Qiong Lu, Peng Cheng, Wei Wang, Ke-Yu He","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine whether preemptive oliceridine reduces the half maximal effective concentration (EC₅₀) of remifentanil required to attenuate hemodynamic responses to tracheal intubation during propofol target‑controlled infusion anesthesia.</p><p><strong>Method: </strong>In this prospective randomized trial, 50 patients received either 1.5 mg intravenous oliceridine or an equivalent volume of saline (placebo) before anesthesia induction. All patients underwent induction with target-controlled infusion of propofol at an effect-site concentration of 3.0 μg/mL, in combination with remifentanil. The remifentanil concentration for each subsequent patient was determined using Dixon's up-and-down sequential allocation method, based on the preceding patient's hemodynamic response. The primary outcome was the remifentanil EC₅₀ required to prevent a tracheal intubation response, defined as a ≥20% increase in heart rate or blood pressure from baseline or the presence of tearing, muscle tremor, or coughing/choking, with EC₅₀ estimated using probit analysis.</p><p><strong>Results: </strong>The remifentanil EC₅₀ was significantly lower in the oliceridine group (2.52 ng/mL; 95% CI: 2.19-2.80) than in the control group (3.52 ng/mL; 95% CI: 3.27-3.81), corresponding to an approximate 29% reduction in the target effect‑site concentration required to blunt the intubation response. This difference was accompanied by significantly lower induction doses of both remifentanil and propofol (p < 0.01). Additionally, patients who received oliceridine demonstrated lower pain scores immediately after extubation (p < 0.05).</p><p><strong>Conclusion: </strong>Preemptive oliceridine significantly reduced the remifentanil EC₅₀ for suppressing tracheal intubation responses, demonstrating an opioid‑sparing effect in this setting. This effect‑site reduction may support hemodynamic stability and help limit remifentanil exposure during anesthesia induction.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 4","pages":"259-267"},"PeriodicalIF":0.6,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedation Dose of Remimazolam for Older Adults Undergoing Hip Arthroplasty with Neuraxial Anesthesia and Its Impact on Postoperative Delirium.","authors":"Yan-Qi Hou, Tu-Ping Li, Zhi-Cong Ma","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Remimazolam tosylate is an ultra‑short‑acting benzodiazepine sedative. This study aimed to determine a suitable intraoperative remimazolam dose for older adults undergoing hip arthroplasty with neuraxial anesthesia and to explore its association with postoperative delirium (POD) and perioperative stress responses.</p><p><strong>Methods: </strong>In this randomized study, 153 older adults undergoing hip arthroplasty with neuraxial anesthesia were allocated to four groups: saline control (N), remimazolam 0.1 mg/(kg•h) (R1), 0.2 mg/(kg•h) (R2), and 0.3 mg/(kg•h) (R3). Primary outcomes were intraoperative sedation success (modified Observer's Assessment of Alertness/Sedation scale), plasma cortisol and norepinephrine concentrations at operating room entry and exit, and incidence of POD.</p><p><strong>Results: </strong>In the R2 group, sedation success was 100%, and the mean awakening time was 6.82 ± 0.64 min, shorter than in the R3 group (8.16 ± 0.93 min), which exhibited deeper sedation and longer recovery. No statistically significant differences were observed in POD incidence across groups (2.86-6.00%; p = 0.922), and the study was underpowered to detect modest between‑group differences. Compared with saline, the remimazolam groups had lower cortisol and norepinephrine concentrations at operating room exit, whereas within‑group changes from entry to exit did not reach statistical significance (p > 0.05).</p><p><strong>Conclusion: </strong>Compared with saline, the remimazolam groups had lower cortisol and norepinephrine concentrations at operating room exit, whereas within‑group changes from entry to exit did not reach statistical significance (p > 0.05). Within the observed POD incidence range (2.86-6.00%), remimazolam did not appear to increase POD over the first 7 postoperative days compared with saline, although the study was not powered to detect modest differences.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 4","pages":"274-284"},"PeriodicalIF":0.6,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OGTT-Evoked Neuromedin U Response and Gastrointestinal Pattern of Regional mRNA Expression in MSG-Induced Obesity in Rats.","authors":"Ismail Hakki Akbudak, Fatih Altintas, Hasan Akca, Tunahan Anber, Melek Tunc-Ata, Vural Kucukatay","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Neuromedin U (NMU) is a neuropeptide broadly expressed in the gastrointestinal (GI) tract and central nervous system (CNS), implicated in energy balance and glucose homeostasis. Recent studies have suggested that NMU may act as a \"decretin\" hormone by inhibiting glucose-stimulated insulin secretion (GSIS); however, in vivo findings remain inconclusive. This study evaluated plasma NMU responses during an oral glucose tolerance test (OGTT) and regional intestinal NMU expression in a monosodium glutamate (MSG)‑induced hypothalamic obesity (MHO) model in rats.</p><p><strong>Methods: </strong>Thirty male Wistar rats were divided into control and MHO groups. MHO was induced by subcutaneous MSG injections during the neonatal period. After five months, metabolic parameters, oral glucose tolerance test (OGTT), plasma NMU levels, and NMU mRNA expression in the duodenum, jejunum, and ileum were analyzed using ELISA and RT-qPCR.</p><p><strong>Results: </strong>The MHO group exhibited elevated fasting glucose, decreased basal insulin levels, and increased abdominal adiposity compared to controls, indicating a metabolically obese phenotype in this model. Basal plasma NMU levels were similar between groups. At 60 minutes post-glucose load, plasma NMU decreased significantly relative to baseline in both groups, with no difference between MHO and control rats. Intestinal NMU expression followed a proximal-to-distal declining pattern, consistent with previous reports, and did not differ between MHO and control rats.</p><p><strong>Conclusion: </strong>These findings suggest that NMU expression within the gastrointestinal tract remains regionally regulated and unaltered in experimental obesity. Furthermore, the significant decline in plasma NMU at 60 minutes is compatible with modulation during hyperglycemia but does not establish a causal role in glucose regulation. This pattern appears to be preserved in the MHO model despite metabolic dysfunction. Future studies employing receptor inhibition or NMU administration are warranted to elucidate its physiological role in insulin regulation.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 4","pages":"204-214"},"PeriodicalIF":0.6,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Sectional Evaluation of Risk Factors and Preliminary Development of a Sarcopenia Risk Scoring Model in Patients with Type 2 Diabetes Mellitus. .","authors":"Ru-Le Shen, Shu-Ying Zheng, Xiao-Xi Zhou, Ling Liu, Chao Tang, Zhang-Ning Zhou, Xiao-Hui Zhou","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study aimed to identify clinical factors associated with sarcopenia in adults with type 2 diabetes mellitus (T2DM) aged ≤ 65 years and to develop a preliminary nomogram-based risk scoring model using routinely collected clinical indicators.</p><p><strong>Methods: </strong>We enrolled 81 patients with T2DM aged ≤ 65 years who were admitted to Huzhou Central Hospital between July 2023 and September 2025. Demographic characteristics, anthropometric measurements, and laboratory parameters were collected. Appendicular skeletal muscle mass, handgrip strength, and gait speed were measured, and sarcopenia was diagnosed according to Asian Working Group for Sarcopenia criteria. Univariate analysis, least absolute shrinkage and selection operator (LASSO) regression, and multivariable logistic regression were used to identify independent risk factors and construct a nomogram-based prediction model. Model performance was evaluated using receiver operating characteristic (ROC) analysis, calibration plots, and decision curve analysis (DCA).</p><p><strong>Results: </strong>Compared with patients without sarcopenia, those with sarcopenia had lower HDL-C and albumin levels and higher HbA1c concentrations (all p < 0.05). LASSO regression identified HDL-C, HbA1c, height, and BMI as key predictors, and multivariable analysis confirmed low HDL-C, high HbA1c, shorter height, and lower BMI as independent risk factors. The nomogram demonstrated good discrimination (AUC = 0.844) and calibration, and decision curve analysis indicated favorable clinical net benefit.</p><p><strong>Conclusion: </strong>Reduced height, lower BMI, elevated HbA1c, and decreased HDL-C are significant risk factors for sarcopenia in patients with T2DM. The developed risk scoring model demonstrated good discriminative ability within this single-center cohort and may serve as a preliminary tool for clinical risk stratification, but it requires validation in larger, independent samples.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 4","pages":"215-224"},"PeriodicalIF":0.6,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic masculinity and depression in men: A schema therapy perspective.","authors":"Marie Ociskova, Jan Prasko, Marija Abeltina, Jozef Visnovsky, Julija Gecaite-Stonciene, Julius Burkauskas, Ilona Krone, Marta Popelkova, Erika Jurisova, Ben Eden","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Toxic masculinity has increasingly been discussed as a significant psychosocial factor affecting men's mental health, particularly in relation to depression, self-stigma, and low rates of help-seeking. In clinical practice, however, the concept remains ambiguous and may be applied in a reductive or pathologizing manner. This article aims to provide a clinically sensitive understanding of toxic masculinity within the framework of schema therapy.</p><p><strong>Aim: </strong>The aim of this article is to explore the relationship between toxic masculinity, early maladaptive schemas, and depressive symptomatology in men, and to demonstrate how schema therapy can facilitate long-term change without pathologizing male identity.</p><p><strong>Method: </strong>This paper is a narrative review complemented by systematized clinical experience of schema therapists. Four composite heuristic vignettes are presented. These vignettes do not represent individual patients but are composite cases reflecting common clinical patterns. Each vignette includes schema-therapeutic conceptualization, a discussion of transgenerational transmission of masculine norms, and examples of therapeutic interventions.</p><p><strong>Clinical illustrations: </strong>Toxic masculinity is clinically expressed through specific early maladaptive schemas (e.g., emotional deprivation, unrelenting standards, emotional inhibition) and protective schema modes (Detached Protector, Overcontroller, Punitive/Demanding Critic). Depression in men often manifests through masked, externalizing, or somatic forms. Schema therapeutic interventions-including limited reparenting, imagery rescripting, chairwork, therapeutic letters, and transgenerational re-scripting-enable gradual access to unmet emotional needs and the strengthening of the Healthy Adult mode.</p><p><strong>Conclusion: </strong>Toxic masculinity is conceptualized as a learned and modifiable pattern embedded in early maladaptive schemas and schema modes rather than as a stable personality trait. Schema therapy provides an integrative clinical framework that links gendered social norms with early maladaptive schemas and schema modes, and offers clinically applicable strategies for promoting sustainable change without pathologizing male identity.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 2","pages":"140-158"},"PeriodicalIF":0.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-6 and TNFα are associated with depressive symptoms among men in a community-based cohort, with a tentative trend for IL-17A: Findings from the Shika Study in Japan.","authors":"Hirohito Tsuboi, Hiroyuki Sakakibara, Yuuki Minamida-Urata, Yui Takakura, Hiromasa Tsujiguchi, Akinori Hara, Keita Suzuki, Sakae Miyagi, Masaharu Nakamura, Chie Takazawa, Takayuki Kannon, Jiaye Zhao, Yukari Shimizu, Aki Shibata, Aya Ogawa, Fumihiko Suzuki, Yasuhiro Kambayashi, Atsushi Tajima, Hiroyuki Nakamura","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Emerging evidence suggests that low-grade systemic inflammation contributes to depressive symptoms; however, population-based longitudinal evidence, particularly from community samples, remains limited. This study examined the associations between serum cytokine levels and depressive symptoms among community-dwelling adults in Japan.</p><p><strong>Participants and methods: </strong>Participants were drawn from the Shika Study cohort (N = 182; 98 men, 84 women; mean age: 62.2 ± 9.34 years for men, 60.9 ± 9.49 for women). They provided blood samples in 2017 and completed the Japanese versions of the Center for Epidemiologic Studies Depression Scale (CES-D) in 2017 and its revised version (CESD-R) in 2019. Serum TNFα, IL-6, IL-10 and IL-17A were quantified using a multiplex human immunoassay.</p><p><strong>Results: </strong>Among men, serum IL-6 levels were positively associated with CES-D scores in 2017 after adjustment for age, visceral adiposity, smoking, and alcohol consumption (standardised regression coefficient (β) = 0.25, p = 0.024). Baseline TNF-α was significantly associated with higher CES-D-R scores in 2019 (β = 0.23, p = 0.026), whereas IL-17A showed only a non-significant trend (β = 0.13, p = 0.231). No significant associations were observed among women or for IL-10.</p><p><strong>Conclusion: </strong>In this exploratory community-based study, higher IL-6 levels were modestly associated with concurrent depressive symptoms in men, and baseline TNFα showed a similarly modest association with depressive symptoms two years later as measured by the CESD-R. IL-17A showed a tentative trend that requires replication. These findings suggest possible sex-specific links between peripheral inflammation and depressive symptoms, but the results should be interpreted as hypothesis generating.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 3","pages":"181-192"},"PeriodicalIF":0.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Handgrip Strength and Type 2 Diabetes Mellitus in Community Dwelling Older Adults in Nanjing, China.","authors":"Jie Wang, Yan Guo, Yongzhen Mo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to examine the relationship between handgrip strength (HGS) and the prevalence of type 2 diabetes mellitus (T2DM) among older adults residing in community settings in Nanjing, China.</p><p><strong>Methods: </strong>In this cross-sectional study, 279 participants aged 60 years and older were assessed using a questionnaire, and T2DM diagnosis was confirmed through a review of medical records, defined as a documented physician diagnosis of type 2 diabetes and/or current use of antidiabetic medication. Participants were categorized into three groups based on HGS tertiles: low HGS group (< 12.0 kg, n = 92), middle HGS group (12.0-26.5 kg, n = 94), and high HGS group (> 26.5 kg, n = 93). Data analysis was conducted using analysis of variance, the χ² test, and multivariable logistic regression.</p><p><strong>Results: </strong>The mean age of participants was 72.43 ± 6.38 years, and 38.0% were male (n = 106). The average body mass index (BMI) was 23.40 ± 3.14 kg/m², and the prevalence of T2DM, hypertension, and heart disease was 15.1%, 44.8%, and 19.8%, respectively. No significant differences were observed among the three groups in BMI, systolic blood pressure, diastolic blood pressure, or the prevalence of hypertension and heart disease, whereas the prevalence of T2DM was highest in the low HGS group (21.7%) and lowest in the high HGS group (8.6%). In the fully adjusted model, each 1 kg increase in HGS was associated with a 3.3% lower odds of T2DM (odds ratio 0.967, 95% confidence interval 0.944-0.989).</p><p><strong>Conclusions: </strong>Higher HGS was associated with a lower prevalence of T2DM among community dwelling older adults in Nanjing. These findings indicate that HGS may serve as a potential target for intervention and as a simple indicator for identifying older individuals at increased risk of T2DM in community settings. In Chinese community health centers, incorporating HGS into routine check ups for older adults could help prioritize individuals for further glucose testing and counseling about strength building physical activity.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"47 3","pages":"159-164"},"PeriodicalIF":0.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}