由复发缓解型多发性硬化症引起的慢性疲劳综合征、抑郁和焦虑症状与eb病毒和人类疱疹病毒6的再激活有关。

Neuro endocrinology letters Pub Date : 2025-04-28
Michael Maes, Abbas F Almulla, Elroy Vojdani, Elizabet Dzhambazova, Drozdstoj Stoyanov, Yingqian Zhang, Aristo Vojdani
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引用次数: 0

摘要

背景:复发缓解型多发性硬化症(RRMS)的定义是针对eb病毒(EBV)核抗原1 (EBNA)和人疱疹病毒-6 (HHV-6)和EBV的脱氧尿苷三磷酸酶(dutpase)的IgG/IgA/IgM反应升高。这些反应表明病毒正在被复制和重新激活。慢性疲劳综合征、抑郁和焦虑的患病率增加与RRMS中免疫激活的迹象有关。然而,缺乏关于病毒再激活与RRMS神经精神症状之间关系的数据。方法:研究58例RRMS缓解期患者和63例正常对照者的IgG/IgA/IgM对EBNA、EBV和HHV-6-dUTPases的反应。采用McDonald标准建立ms的诊断,采用扩展残疾状态量表(EDSS)和多发性硬化症严重程度评分评估RRMS导致的残疾。我们评估汉密尔顿抑郁(HAMD)和焦虑(HAMA)评定量表以及纤维疲劳(FF)量表的得分。从EDSS、MSSS、FF、HAMD和HAMA评分中提取一个潜在构念。结果:我们发现IgG和IgM-HHV-6-dUTPAses的联合作用占该结构变异的63.7%。此外,FF、HAMA和HAMD总分与IgG和IgM-HHV-6-dUTPAses显著相关,约占方差的38.7%至51.0%。三个神经精神评定量表得分也与dutpase的IgA反应性和IgG/IgA/IgM对EBNA的反应性显著相关。结论:HHV-6和EBV的再激活和复制在RRMS引起的慢性疲劳综合征以及抑郁和焦虑症状中起着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic fatigue syndrome, depression, and anxiety symptoms due to relapsing-remitting multiple sclerosis are associated with reactivation of Epstein-Barr virus and Human Herpesvirus 6.

Background: Relapsing-remitting multiple sclerosis (RRMS) is defined by elevated IgG/IgA/IgM responses targeting Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA) and deoxyuridine-triphosphatases (dUTPases) of Human herpsesvirus-6 (HHV-6) and EBV. These responses suggest that the viruses are being replicated and reactivated. An increased prevalence of chronic fatigue syndrome, depression, and anxiety is associated with signs of immune activation in RRMS. Nevertheless, there is a lack of data regarding the association between viral reactivation and neuropsychiatric symptoms of RRMS.

Methods: This study investigated the IgG/IgA/IgM responses to EBNA, and EBV and HHV-6-dUTPases, in 58 remitted RRMS patients and 63 normal controls. The McDonald criteria were employed to establish the diagnosis of MS. The Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Severity Score were employed to evaluate disabilities caused by RRMS. We evaluated the scores of the Hamilton Depression (HAMD) and Anxiety (HAMA) Rating Scales, and Fibro-Fatigue (FF) scale. One latent construct was extracted from the EDSS, MSSS, FF, HAMD, and HAMA scores.

Results: We discovered that the combined effects of IgG and IgM-HHV-6-dUTPAses accounted for 63.7% of the variance in this construct. Furthermore, the total FF, HAMA, and HAMD scores were substantially associated with the IgG and IgM-HHV-6-dUTPAses, accounting for approximately 38.7% to 51.0% of the variance. The three neuropsychiatric rating scale scores were also significantly correlated with IgA reactivity directed to both dUTPases and IgG/IgA/IgM to EBNA.

Conclusion: The reactivation and replication of HHV-6 and EBV significantly contributes to chronic fatigue syndrome, as well as symptoms of depression and anxiety due to RRMS.

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