Impact of an over-the-counter "sleep lotion" on human salivary melatonin levels and sleep quality: a randomized controlled trial.

Neuro endocrinology letters Pub Date : 2024-08-12
Clairissa Ponce, Amanda D Razon, Joey Chao, Sydney K Nakagawa, Megan M Peterson, Angelina Y Roque, Maya A Vanderpool, Michael J Ferracane, Lisa E Olson
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Abstract

Objective: To compare the impact of a commercial "sleep lotion" versus a placebo control lotion on salivary melatonin and sleep quality.

Methods: The presence of melatonin in the lotion was confirmed and quantitated with High Performance Liquid Chromatography (HPLC). In this randomized, controlled, double-blind crossover trial, undergraduate student participants applied lotions on two separate nights and we quantitated melatonin in saliva samples with enzyme linked immunosorbent assays. We also assessed sleep quality with a modified Pittsburgh Sleep Quality Index.

Clinicaltrials: gov ID NCT06053385.

Results: Sixty-three participants (age 20.5 ± 1.2 years; 81% female) enrolled in the study and provided at least one saliva sample. The sleep lotion contained 0.24 ± 0.01% melatonin (g/100 g lotion) which dramatically impacted salivary melatonin levels, increasing them up to ~1000 fold compared to the placebo lotion (n = 36 participants with all six timepoints). The lotion improved sleep quality in a subsample of the poor sleepers (n = 18). However, the sleep quality in the overall sample was not significantly different on the active versus placebo lotion nights.

Conclusion: In a small undergraduate student sample, a commercial melatonin-containing lotion improved sleep in those with poor sleep quality. Caution should be taken by consumers using over-the-counter melatonin lotions because the undisclosed dosage can be high and well absorbed by the skin.

非处方 "睡眠乳液 "对人体唾液褪黑激素水平和睡眠质量的影响:随机对照试验。
目的比较商业 "睡眠乳液 "与安慰剂对照乳液对唾液褪黑素和睡眠质量的影响:方法:采用高效液相色谱法(HPLC)确认并定量分析乳液中褪黑素的含量。在这项随机、对照、双盲交叉试验中,本科生参与者分别在两个晚上涂抹乳液,我们用酶联免疫吸附试验对唾液样本中的褪黑激素进行了定量。我们还用改良的匹兹堡睡眠质量指数评估了睡眠质量。Clinicaltrials: gov ID NCT06053385.Results:63名参与者(年龄为20.5 ± 1.2岁;81%为女性)参加了研究,并提供了至少一份唾液样本。睡眠乳液含有 0.24 ± 0.01% 的褪黑素(克/100 克乳液),对唾液中的褪黑素水平有显著影响,与安慰剂乳液相比,褪黑素水平提高了约 1000 倍(n = 36 名参与者,所有六个时间点)。乳液改善了睡眠质量较差者(18 人)的睡眠质量。然而,总体样本的睡眠质量在使用活性乳液和安慰剂乳液的夜晚没有显著差异:结论:在一个大学生小样本中,含褪黑素的商用乳液改善了睡眠质量差者的睡眠。消费者在使用非处方褪黑素乳液时应谨慎,因为未公开的剂量可能很高,而且很容易被皮肤吸收。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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