合成神经活性类固醇。

Neuro endocrinology letters Pub Date : 2024-04-07
Štefan Alušík, Zoltán Paluch, Dagmar Kalátová
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引用次数: 0

摘要

本综述讨论的主题是合成神经活性类固醇。首先简要介绍了神经活性类固醇的作用模式,然后简要概述了临床上使用的最著名的合成神经活性类固醇及其退出市场的原因。本文对 6 种特定合成神经活性类固醇的各个方面进行了研究,这些类固醇要么已被批准用于治疗,要么目前正处于临床试验的后期阶段,并列出了它们的适应症、现有经验和不良反应。作者的结论是,神经活性类固醇的治疗潜力仍未得到充分利用。希望这类药物能在本文讨论的神经和精神疾病的管理和治疗中得到更广泛的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthetic neuroactive steroids.

This review discusses the topic of synthetic neuroactive steroids. A brief introduction to the mode of action of neuroactive steroids is followed by a short overview of the best-known synthetic neuroactive steroids used in clinical practice and the reasons for their withdrawal from the market. The paper examines various aspects of 6 specific synthetic neuroactive steroids which either have been approved for treatment or are currently in advanced phases of clinical trials, and lists their indications, current experience, and undesirable adverse effects. The authors conclude that the therapeutic potential of neuroactive steroids is still not made full use of. It is to be hoped that this particular class of drugs will find more widespread use also in the management and treatment neurological and psychiatric disorders other than those discussed in this article.

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